GREMLIN Database
MARC - UPF0056 inner membrane protein MarC
UniProt: P0AEY1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11637
Length: 221 (196)
Sequences: 2513 (1660)
Seq/√Len: 118.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_I216_I4.1621.00
36_N39_E3.3591.00
52_F168_A3.2511.00
55_M134_T3.2051.00
78_I210_I3.1041.00
86_F89_F2.9391.00
75_G207_Q2.8611.00
172_W176_R2.6931.00
74_P215_E2.6631.00
45_L172_W2.5941.00
12_L166_L2.5821.00
207_Q211_N2.4311.00
50_Y121_F2.3891.00
54_I126_M2.2291.00
63_Q67_D2.1471.00
186_G189_G2.1401.00
52_F165_F2.1111.00
85_A209_I1.9971.00
11_G163_I1.9731.00
48_S168_A1.9721.00
49_V53_A1.9501.00
28_F32_A1.9141.00
8_I162_L1.8631.00
8_I163_I1.8591.00
56_M161_P1.8351.00
12_L170_I1.8341.00
90_R95_Q1.7811.00
51_V168_A1.7711.00
41_N176_R1.7621.00
60_Y161_P1.7491.00
88_G202_V1.7271.00
19_A167_V1.7041.00
52_F56_M1.6571.00
74_P77_R1.6291.00
214_L217_I1.6081.00
180_A183_R1.6001.00
78_I216_I1.5941.00
142_A157_M1.5891.00
20_N23_T1.5861.00
50_Y125_A1.5791.00
82_L85_A1.5371.00
82_L209_I1.5051.00
55_M130_A1.4981.00
77_R211_N1.4861.00
11_G141_S1.4701.00
15_L138_I1.4421.00
85_A205_G1.4301.00
54_I130_A1.3901.00
28_F44_S1.3871.00
56_M165_F1.3711.00
55_M138_I1.3641.00
40_R179_G1.3511.00
142_A160_P1.3371.00
48_S171_L1.3331.00
59_Y138_I1.3141.00
45_L176_R1.2931.00
28_F124_L1.2851.00
42_R46_M1.2650.99
129_T171_L1.2540.99
75_G210_I1.2520.99
35_M39_E1.2490.99
37_S41_N1.2480.99
23_T26_A1.2410.99
169_V173_G1.2350.99
91_M198_G1.2330.99
81_G209_I1.2330.99
48_S172_W1.2320.99
8_I12_L1.2190.99
177_S180_A1.1950.99
59_Y161_P1.1880.99
153_D156_L1.1860.99
155_V158_V1.1830.99
24_T175_L1.1750.99
138_I164_F1.1750.99
53_A57_V1.1640.99
120_A125_A1.1630.99
15_L164_F1.1620.99
19_A168_A1.1570.99
46_M118_N1.1560.99
201_L205_G1.1450.99
17_P69_F1.1420.99
91_M197_M1.1390.99
81_G212_G1.1360.99
8_I166_L1.1320.99
59_Y142_A1.1250.99
210_I213_I1.1120.99
72_S207_Q1.1110.99
35_M43_Q1.1100.99
77_R215_E1.1030.99
61_A65_V1.0960.98
180_A184_L1.0910.98
19_A134_T1.0880.98
78_I213_I1.0700.98
47_A51_V1.0640.98
134_T138_I1.0640.98
185_V189_G1.0590.98
32_A40_R1.0560.98
17_P20_N1.0560.98
37_S40_R1.0560.98
82_L89_F1.0480.98
78_I209_I1.0400.98
20_N84_V1.0370.98
41_N45_L1.0240.98
26_A29_L1.0240.98
54_I125_A1.0060.97
28_F40_R1.0060.97
45_L49_V1.0040.97
91_M194_S1.0020.97
83_I202_V0.9990.97
173_G177_S0.9860.97
85_A202_V0.9790.97
66_M203_C0.9770.97
18_L133_G0.9720.97
51_V125_A0.9710.97
202_V205_G0.9670.97
85_A89_F0.9650.97
158_V162_L0.9630.97
55_M135_I0.9540.96
59_Y157_M0.9510.96
18_L137_M0.9480.96
83_I87_I0.9440.96
29_L182_M0.9390.96
159_A162_L0.9370.96
78_I212_G0.9230.96
57_V61_A0.9200.96
16_L170_I0.9190.96
157_M161_P0.9180.95
23_T27_L0.9040.95
96_Q99_I0.8970.95
112_E116_S0.8890.95
65_V135_I0.8850.95
37_S179_G0.8770.94
50_Y120_A0.8620.94
28_F178_S0.8610.94
135_I139_I0.8340.93
14_V137_M0.8220.92
79_A206_V0.8200.92
114_E217_I0.8190.92
53_A154_W0.8100.91
92_L198_G0.8050.91
112_E173_G0.8030.91
121_F188_G0.8020.91
64_L67_D0.7990.91
23_T171_L0.7930.91
163_I167_V0.7880.90
167_V170_I0.7870.90
47_A119_I0.7830.90
169_V180_A0.7730.89
130_A164_F0.7710.89
67_D158_V0.7650.89
24_T128_S0.7630.89
72_S75_G0.7610.89
16_L174_S0.7590.89
195_R206_V0.7530.88
20_N197_M0.7480.88
48_S51_V0.7470.88
78_I206_V0.7460.88
39_E43_Q0.7400.87
83_I190_I0.7380.87
113_D116_S0.7370.87
15_L55_M0.7350.87
76_L137_M0.7330.87
55_M164_F0.7310.87
125_A130_A0.7270.86
76_L168_A0.7260.86
46_M50_Y0.7200.86
25_V175_L0.7200.86
20_N26_A0.7130.85
28_F132_P0.7120.85
84_V140_S0.7060.85
188_G192_A0.7060.85
61_A64_L0.7010.84
44_S193_I0.6950.84
90_R93_F0.6930.84
7_A145_V0.6910.83
25_V174_S0.6890.83
20_N58_A0.6890.83
130_A198_G0.6890.83
66_M139_I0.6880.83
39_E42_R0.6820.83
24_T129_T0.6820.83
21_P167_V0.6780.82
90_R99_I0.6770.82
43_Q120_A0.6650.81
76_L136_A0.6630.81
21_P132_P0.6620.81
113_D187_K0.6610.81
71_I97_K0.6590.81
80_G136_A0.6560.80
94_P198_G0.6550.80
46_M120_A0.6530.80
25_V29_L0.6510.80
58_A139_I0.6490.79
41_N172_W0.6440.79
66_M80_G0.6400.79
14_V199_F0.6400.79
112_E187_K0.6400.79
53_A114_E0.6380.78
20_N134_T0.6370.78
17_P202_V0.6360.78
28_F72_S0.6350.78
16_L167_V0.6330.78
74_P210_I0.6330.78
7_A159_A0.6290.77
118_N213_I0.6290.77
12_L16_L0.6270.77
88_G191_E0.6270.77
134_T164_F0.6260.77
75_G79_A0.6260.77
120_A124_L0.6250.77
24_T83_I0.6220.77
17_P199_F0.6200.76
54_I177_S0.6190.76
146_R159_A0.6170.76
196_L200_L0.6150.76
94_P195_R0.6120.75
111_L117_A0.6110.75
69_F140_S0.6080.75
166_L184_L0.6060.75
213_I217_I0.6060.75
141_S160_P0.6040.74
22_L193_I0.6030.74
59_Y196_L0.6000.74
20_N79_A0.5980.74
66_M72_S0.5970.74
83_I128_S0.5930.73
133_G201_L0.5930.73
197_M208_F0.5900.73
18_L204_M0.5890.73
80_G91_M0.5890.73
18_L54_I0.5880.73
155_V184_L0.5880.73
94_P191_E0.5870.72
158_V161_P0.5860.72
83_I138_I0.5860.72
14_V18_L0.5850.72
187_K191_E0.5830.72
126_M199_F0.5810.72
88_G92_L0.5790.71
133_G195_R0.5790.71
22_L66_M0.5780.71
61_A140_S0.5770.71
38_A184_L0.5760.71
84_V204_M0.5740.71
76_L199_F0.5740.71
88_G205_G0.5720.70
6_K61_A0.5660.70
69_F205_G0.5640.69
32_A35_M0.5620.69
162_L166_L0.5620.69
146_R154_W0.5610.69
184_L187_K0.5610.69
62_G131_G0.5600.69
122_V201_L0.5600.69
17_P74_P0.5580.69
128_S131_G0.5580.69
136_A139_I0.5580.69
47_A125_A0.5570.68
68_T204_M0.5530.68
75_G216_I0.5520.68
20_N85_A0.5510.68
38_A41_N0.5480.67
16_L90_R0.5450.67
155_V173_G0.5440.67
59_Y164_F0.5440.67
126_M200_L0.5390.66
159_A163_I0.5380.66
167_V171_L0.5380.66
156_L159_A0.5380.66
193_I217_I0.5380.66
73_I88_G0.5350.65
181_I185_V0.5320.65
22_L197_M0.5290.64
24_T124_L0.5270.64
43_Q47_A0.5250.64
12_L163_I0.5220.63
46_M168_A0.5220.63
64_L196_L0.5220.63
15_L19_A0.5190.63
162_L184_L0.5170.63
53_A157_M0.5170.63
92_L205_G0.5160.63
94_P201_L0.5150.62
26_A128_S0.5140.62
26_A129_T0.5120.62
192_A196_L0.5110.62
58_A129_T0.5110.62
71_I114_E0.5080.61
119_I124_L0.5050.61
31_L119_I0.5050.61
110_E114_E0.5010.60
57_V96_Q0.5010.60
79_A122_V0.5000.60
7_A14_V0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4w6vA 1 0.4389 33.2 0.943 Contact Map
4c7rA 3 0.4525 15 0.951 Contact Map
2cfqA 1 0.4842 13.8 0.952 Contact Map
3w9iA 3 0.9095 13.8 0.952 Contact Map
4ldsA 2 0.4434 11.4 0.954 Contact Map
4k0jA 3 0.7059 10.9 0.954 Contact Map
4zw9A 1 0.5023 9.9 0.955 Contact Map
4j05A 3 0.5023 9.5 0.955 Contact Map
4pypA 1 0.4299 9.4 0.955 Contact Map
3aqpA 1 0.8733 9.1 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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