GREMLIN Database
MALE - Maltose-binding periplasmic protein
UniProt: P0AEX9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10554
Length: 396 (378)
Sequences: 31663 (25268)
Seq/√Len: 1299.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_K62_T3.4971.00
103_A299_K3.1411.00
145_K269_G3.1091.00
382_T385_E3.0361.00
34_V62_T3.0221.00
215_K384_D2.9471.00
159_P223_D2.8701.00
104_E128_K2.8651.00
146_D267_N2.8361.00
32_K60_K2.7481.00
222_V226_K2.5391.00
154_T157_E2.3991.00
223_D227_N2.3981.00
145_K149_P2.3071.00
163_K227_N2.2911.00
59_I301_L2.2741.00
57_T304_E2.2731.00
54_E60_K2.2651.00
68_K71_E2.2241.00
212_A216_A2.2001.00
219_T223_D2.1631.00
106_T128_K2.1521.00
47_A51_K2.1251.00
219_T383_V2.1211.00
143_Y269_G2.1001.00
52_K309_Y2.0971.00
160_A164_E2.0961.00
312_T315_G2.0951.00
52_K55_K2.0881.00
388_K392_T2.0781.00
384_D388_K2.0721.00
34_V64_E2.0651.00
375_N380_R2.0571.00
381_Q389_D2.0391.00
296_S299_K2.0251.00
124_R129_L2.0221.00
304_E307_E2.0111.00
375_N381_Q1.9741.00
48_E51_K1.9101.00
121_D124_R1.9091.00
298_N301_L1.8821.00
216_A219_T1.8511.00
148_L250_M1.8401.00
52_K318_A1.8281.00
117_P121_D1.8111.00
54_E57_T1.8061.00
53_F304_E1.7761.00
30_E60_K1.7741.00
160_A163_K1.7681.00
146_D150_N1.7571.00
102_L291_G1.7551.00
157_E160_A1.7511.00
52_K56_D1.7381.00
235_D238_I1.7381.00
43_Y47_A1.7371.00
210_D388_K1.7351.00
215_K219_T1.7201.00
31_G301_L1.7181.00
51_K55_K1.7131.00
317_E321_K1.6941.00
84_D298_N1.6681.00
50_G54_E1.6441.00
367_Y371_T1.6321.00
344_A348_E1.6321.00
147_L249_A1.6251.00
159_P163_K1.6221.00
313_D317_E1.6171.00
131_A289_S1.6101.00
385_E389_D1.6071.00
376_A386_A1.6011.00
114_K331_K1.5991.00
11_A14_A1.5921.00
53_F57_T1.5881.00
159_P227_N1.5851.00
300_E304_E1.5841.00
315_G318_A1.5781.00
50_G305_F1.5711.00
220_F223_D1.5651.00
156_E159_P1.5581.00
123_V289_S1.5371.00
36_W76_V1.5311.00
103_A294_A1.5231.00
242_A247_E1.5141.00
372_A389_D1.5121.00
86_I293_N1.5071.00
372_A381_Q1.5061.00
12_L15_L1.5011.00
165_L249_A1.4921.00
219_T384_D1.4881.00
72_K76_V1.4721.00
153_K157_E1.4681.00
159_P224_L1.4671.00
222_V376_A1.4641.00
51_K54_E1.4561.00
388_K391_Q1.4441.00
372_A375_N1.4431.00
145_K267_N1.4411.00
385_E388_K1.4371.00
196_K206_D1.4331.00
143_Y271_T1.4231.00
318_A322_D1.4221.00
48_E52_K1.4041.00
301_L304_E1.3931.00
31_G298_N1.3821.00
110_A113_D1.3791.00
141_L271_T1.3691.00
37_I63_V1.3631.00
389_D392_T1.3621.00
381_Q386_A1.3581.00
152_P157_E1.3561.00
345_A348_E1.3551.00
213_G216_A1.3541.00
174_M248_T1.3511.00
77_A82_G1.3441.00
159_P220_F1.3351.00
147_L165_L1.3341.00
56_D312_T1.3291.00
88_W291_G1.3291.00
210_D391_Q1.3271.00
376_A383_V1.3241.00
348_E351_Q1.3211.00
292_I306_L1.3191.00
215_K383_V1.3141.00
241_A245_K1.3111.00
347_M351_Q1.3041.00
156_E160_A1.2961.00
104_E107_P1.2911.00
196_K199_N1.2711.00
144_N147_L1.2641.00
335_E338_A1.2641.00
220_F224_L1.2601.00
243_F268_Y1.2501.00
163_K229_H1.2471.00
85_I302_A1.2461.00
44_N48_E1.2301.00
53_F305_F1.2261.00
223_D226_K1.2251.00
148_L161_L1.2211.00
53_F309_Y1.2191.00
303_K307_E1.2131.00
296_S302_A1.2111.00
44_N47_A1.2111.00
97_A130_I1.2111.00
50_G63_V1.2071.00
212_A215_K1.2031.00
299_K303_K1.1991.00
216_A220_F1.1951.00
161_L164_E1.1881.00
9_I13_S1.1881.00
348_E352_K1.1861.00
72_K75_Q1.1851.00
318_A321_K1.1831.00
53_F59_I1.1791.00
219_T222_V1.1741.00
368_A371_T1.1741.00
381_Q385_E1.1691.00
146_D266_V1.1431.00
140_S270_V1.1411.00
260_N263_T1.1281.00
162_D250_M1.1221.00
193_Y197_Y1.1201.00
372_A390_A1.1201.00
242_A248_T1.1201.00
141_L250_M1.1141.00
19_M22_A1.1141.00
120_W124_R1.1111.00
123_V129_L1.1061.00
30_E58_G1.1051.00
59_I304_E1.1041.00
196_K205_K1.1021.00
144_N266_V1.0981.00
80_G295_A1.0931.00
296_S300_E1.0911.00
112_Q120_W1.0861.00
238_I241_A1.0841.00
111_F114_K1.0831.00
84_D296_S1.0801.00
161_L250_M1.0761.00
371_T375_N1.0731.00
49_V52_K1.0701.00
375_N389_D1.0611.00
222_V383_V1.0551.00
193_Y196_K1.0531.00
313_D331_K1.0451.00
104_E129_L1.0321.00
309_Y315_G1.0251.00
292_I302_A1.0241.00
147_L150_N1.0241.00
329_A332_S1.0221.00
85_I306_L1.0131.00
158_I250_M1.0091.00
8_R12_L1.0091.00
163_K167_A0.9991.00
162_D229_H0.9971.00
86_I291_G0.9971.00
158_I162_D0.9951.00
253_N257_A0.9941.00
364_A367_Y0.9911.00
142_I253_N0.9901.00
314_E317_E0.9891.00
368_A372_A0.9881.00
305_F310_L0.9851.00
75_Q79_T0.9801.00
45_G48_E0.9801.00
50_G61_V0.9731.00
85_I305_F0.9701.00
215_K387_L0.9691.00
300_E303_K0.9681.00
153_K275_T0.9681.00
35_I290_A0.9621.00
147_L170_K0.9571.00
190_D216_A0.9561.00
33_L305_F0.9561.00
8_R11_A0.9561.00
335_E339_K0.9541.00
100_G294_A0.9541.00
294_A299_K0.9541.00
53_F301_L0.9521.00
12_L16_T0.9471.00
302_A306_L0.9451.00
13_S16_T0.9451.00
116_Y330_L0.9451.00
97_A125_Y0.9431.00
109_K112_Q0.9431.00
8_R14_A0.9381.00
70_E92_R0.9371.00
77_A101_L0.9371.00
15_L18_M0.9371.00
314_E318_A0.9331.00
48_E318_A0.9311.00
146_D149_P0.9301.00
367_Y370_R0.9291.00
372_A386_A0.9231.00
292_I303_K0.9201.00
48_E322_D0.9161.00
31_G58_G0.9151.00
117_P120_W0.9151.00
134_I290_A0.9041.00
58_G304_E0.9031.00
218_L376_A0.9011.00
166_K229_H0.8971.00
19_M23_S0.8961.00
293_N296_S0.8961.00
144_N267_N0.8961.00
109_K113_D0.8861.00
131_A291_G0.8851.00
11_A15_L0.8851.00
52_K315_G0.8821.00
73_F86_I0.8811.00
103_A296_S0.8801.00
118_F121_D0.8771.00
382_T386_A0.8761.00
114_K329_A0.8741.00
161_L165_L0.8741.00
341_P344_A0.8731.00
52_K314_E0.8731.00
149_P267_N0.8721.00
241_A244_N0.8701.00
111_F307_E0.8661.00
120_W129_L0.8631.00
61_V305_F0.8581.00
10_L13_S0.8561.00
333_Y337_L0.8531.00
7_A11_A0.8521.00
49_V315_G0.8511.00
333_Y336_E0.8511.00
103_A107_P0.8461.00
151_P161_L0.8451.00
148_L165_L0.8451.00
208_G211_N0.8431.00
76_V81_D0.8431.00
82_G293_N0.8411.00
228_K232_A0.8401.00
366_W370_R0.8381.00
124_R127_G0.8321.00
33_L301_L0.8261.00
187_I214_A0.8261.00
387_L390_A0.8261.00
95_G99_S0.8211.00
259_S263_T0.8211.00
115_L311_L0.8211.00
222_V225_I0.8181.00
33_L298_N0.8171.00
94_G98_Q0.8161.00
170_K173_L0.8141.00
165_L168_K0.8091.00
305_F309_Y0.8071.00
110_A307_E0.8071.00
334_E338_A0.8051.00
344_A347_M0.8051.00
368_A390_A0.8051.00
158_I173_L0.8041.00
164_E168_K0.8031.00
237_S240_E0.8011.00
56_D309_Y0.7991.00
199_N205_K0.7991.00
108_D111_F0.7971.00
187_I192_G0.7971.00
386_A390_A0.7961.00
170_K174_M0.7921.00
387_L391_Q0.7921.00
103_A303_K0.7901.00
96_Y102_L0.7901.00
106_T129_L0.7901.00
170_K247_E0.7881.00
164_E167_A0.7871.00
346_T350_A0.7871.00
221_L225_I0.7841.00
7_A13_S0.7841.00
166_K172_A0.7821.00
140_S346_T0.7811.00
86_I102_L0.7811.00
172_A176_N0.7791.00
155_W159_P0.7791.00
211_N214_A0.7781.00
150_N170_K0.7761.00
207_V391_Q0.7761.00
116_Y119_T0.7731.00
152_P161_L0.7731.00
292_I296_S0.7701.00
317_E332_S0.7691.00
151_P271_T0.7671.00
9_I15_L0.7651.00
54_E61_V0.7641.00
371_T374_I0.7621.00
336_E339_K0.7591.00
106_T124_R0.7591.00
361_Q364_A0.7591.00
71_E75_Q0.7571.00
349_N352_K0.7521.00
143_Y151_P0.7501.00
9_I12_L0.7481.00
10_L14_A0.7471.00
345_A349_N0.7471.00
218_L386_A0.7461.00
36_W64_E0.7441.00
218_L387_L0.7441.00
209_V214_A0.7441.00
320_N323_K0.7431.00
104_E130_I0.7421.00
190_D220_F0.7401.00
369_V390_A0.7401.00
224_L229_H0.7401.00
31_G59_I0.7371.00
103_A293_N0.7331.00
97_A102_L0.7321.00
102_L130_I0.7311.00
258_W262_D0.7291.00
362_M366_W0.7291.00
7_A14_A0.7281.00
159_P162_D0.7251.00
386_A389_D0.7251.00
8_R15_L0.7231.00
162_D166_K0.7231.00
350_A353_G0.7221.00
35_I85_I0.7201.00
74_P95_G0.7191.00
185_P188_A0.7171.00
196_K208_G0.7151.00
16_T19_M0.7141.00
57_T301_L0.7121.00
342_R345_A0.7121.00
7_A10_L0.7081.00
54_E59_I0.7071.00
163_K166_K0.7071.00
159_P229_H0.7061.00
244_N264_S0.7031.00
68_K72_K0.7031.00
183_T187_I0.7001.00
56_D314_E0.6931.00
108_D112_Q0.6921.00
343_I347_M0.6911.00
341_P345_A0.6911.00
307_E312_T0.6891.00
237_S241_A0.6881.00
216_A276_F0.6881.00
260_N264_S0.6871.00
226_K229_H0.6871.00
26_A29_E0.6861.00
117_P330_L0.6811.00
166_K228_K0.6801.00
103_A292_I0.6791.00
325_L328_V0.6781.00
156_E277_K0.6771.00
107_P128_K0.6771.00
374_I378_S0.6761.00
112_Q124_R0.6761.00
143_Y148_L0.6751.00
151_P157_E0.6731.00
334_E337_L0.6721.00
107_P303_K0.6701.00
142_I270_V0.6671.00
146_D246_G0.6651.00
14_A17_T0.6641.00
70_E95_G0.6621.00
87_F290_A0.6621.00
234_T242_A0.6621.00
199_N206_D0.6601.00
179_E182_F0.6591.00
259_S262_D0.6591.00
10_L15_L0.6591.00
6_G10_L0.6581.00
109_K307_E0.6561.00
141_L252_I0.6541.00
162_D172_A0.6541.00
92_R95_G0.6541.00
69_L73_F0.6541.00
211_N215_K0.6531.00
170_K177_L0.6531.00
173_L177_L0.6511.00
224_L230_M0.6501.00
36_W83_P0.6491.00
103_A295_A0.6481.00
155_W220_F0.6471.00
115_L120_W0.6461.00
228_K231_N0.6451.00
144_N246_G0.6451.00
313_D329_A0.6421.00
60_K63_V0.6401.00
64_E76_V0.6401.00
184_W188_A0.6381.00
238_I242_A0.6371.00
166_K171_S0.6331.00
240_E244_N0.6321.00
110_A114_K0.6321.00
105_I306_L0.6311.00
64_E83_P0.6311.00
226_K379_G0.6301.00
108_D303_K0.6261.00
114_K313_D0.6261.00
336_E340_D0.6251.00
74_P78_A0.6241.00
123_V131_A0.6231.00
342_R346_T0.6201.00
242_A245_K0.6191.00
269_G345_A0.6191.00
188_A354_E0.6191.00
290_A306_L0.6181.00
364_A368_A0.6171.00
54_E58_G0.6171.00
18_M21_S0.6161.00
34_V84_D0.6161.00
30_E59_I0.6161.00
71_E74_P0.6151.00
324_P327_A0.6131.00
57_T305_F0.6101.00
143_Y250_M0.6101.00
13_S17_T0.6101.00
163_K223_D0.6101.00
313_D316_L0.6101.00
239_A251_T0.6091.00
108_D307_E0.6081.00
376_A381_Q0.6061.00
93_F131_A0.6051.00
70_E74_P0.6051.00
211_N391_Q0.6021.00
188_A193_Y0.6021.00
97_A100_G0.6011.00
125_Y128_K0.6011.00
49_V309_Y0.6011.00
157_E161_L0.6001.00
303_K306_L0.5991.00
289_S293_N0.5981.00
172_A175_F0.5981.00
30_E57_T0.5981.00
383_V386_A0.5971.00
363_S367_Y0.5971.00
33_L302_A0.5951.00
231_N242_A0.5921.00
383_V387_L0.5911.00
375_N386_A0.5901.00
192_G213_G0.5891.00
275_T278_G0.5881.00
181_Y186_L0.5871.00
214_A218_L0.5861.00
84_D302_A0.5851.00
77_A293_N0.5841.00
346_T349_N0.5841.00
192_G214_A0.5821.00
6_G13_S0.5821.00
262_D268_Y0.5821.00
35_I87_F0.5771.00
225_I230_M0.5761.00
106_T303_K0.5741.00
112_Q115_L0.5731.00
23_S26_A0.5731.00
93_F97_A0.5721.00
187_I217_G0.5721.00
64_E72_K0.5721.00
85_I290_A0.5711.00
217_G221_L0.5701.00
109_K303_K0.5691.00
240_E253_N0.5691.00
137_E286_G0.5691.00
275_T281_S0.5691.00
89_A92_R0.5681.00
165_L250_M0.5671.00
234_T238_I0.5651.00
171_S174_M0.5641.00
105_I303_K0.5641.00
35_I63_V0.5631.00
290_A310_L0.5611.00
145_K266_V0.5601.00
49_V318_A0.5571.00
15_L19_M0.5571.00
186_L189_A0.5541.00
119_T136_V0.5531.00
98_Q126_N0.5521.00
275_T279_Q0.5521.00
333_Y338_A0.5521.00
153_K161_L0.5511.00
169_G173_L0.5511.00
299_K302_A0.5511.00
272_V348_E0.5501.00
142_I268_Y0.5501.00
34_V83_P0.5501.00
101_L104_E0.5491.00
31_G34_V0.5481.00
165_L170_K0.5481.00
269_G272_V0.5451.00
83_P86_I0.5441.00
34_V76_V0.5441.00
289_S292_I0.5421.00
319_V323_K0.5411.00
175_F178_Q0.5401.00
375_N379_G0.5381.00
132_Y306_L0.5381.00
16_T20_F0.5371.00
46_L49_V0.5371.00
340_D344_A0.5371.00
213_G217_G0.5371.00
193_Y208_G0.5351.00
125_Y130_I0.5341.00
49_V310_L0.5331.00
6_G12_L0.5321.00
227_N230_M0.5301.00
17_T21_S0.5261.00
142_I258_W0.5241.00
171_S232_A0.5211.00
181_Y185_P0.5191.00
82_G295_A0.5191.00
328_V332_S0.5161.00
31_G35_I0.5121.00
351_Q354_E0.5121.00
174_M242_A0.5121.00
168_K171_S0.5111.00
162_D224_L0.5111.00
34_V37_I0.5111.00
340_D343_I0.5101.00
94_G125_Y0.5101.00
170_K175_F0.5101.00
178_Q235_D0.5101.00
212_A384_D0.5101.00
171_S178_Q0.5091.00
66_P70_E0.5081.00
153_K158_I0.5071.00
186_L217_G0.5071.00
296_S301_L0.5071.00
108_D300_E0.5061.00
373_V377_A0.5061.00
88_W96_Y0.5051.00
47_A63_V0.5041.00
304_E309_Y0.5031.00
347_M350_A0.5031.00
95_G98_Q0.5011.00
141_L158_I0.5011.00
337_L340_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uorA 1 0.9066 100 0.159 Contact Map
3woaA 1 0.9823 100 0.164 Contact Map
4r2fA 1 0.9015 100 0.166 Contact Map
3j9pD 4 0 100 0.169 Contact Map
2zyoA 1 0.9293 100 0.17 Contact Map
3mq9A 4 0.9217 100 0.176 Contact Map
2nvuB 1 0.9015 100 0.183 Contact Map
2xd3A 1 0.9066 100 0.184 Contact Map
4ozqA 1 0.9268 100 0.186 Contact Map
3oaiA 1 0.9217 100 0.187 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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