GREMLIN Database
LIVH - High-affinity branched-chain amino acid transport system permease protein LivH
UniProt: P0AEX7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10538
Length: 308 (266)
Sequences: 30720 (19424)
Seq/√Len: 1191.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_I214_A4.0301.00
85_S210_V3.6761.00
85_S214_A3.1201.00
53_V83_I2.9611.00
89_W210_V2.8661.00
191_L205_I2.8261.00
57_I79_G2.6141.00
23_A164_T2.5931.00
184_C208_T2.5461.00
30_T257_A2.5181.00
97_R202_D2.4951.00
200_N203_R2.4571.00
84_A217_A2.4051.00
174_F180_M2.3491.00
88_G213_A2.3451.00
203_R207_L2.2881.00
172_T176_R2.2541.00
91_I114_M2.2521.00
173_I177_Y2.2281.00
89_W206_A2.1871.00
183_A204_V2.1591.00
241_K268_E2.1491.00
93_R97_R2.1411.00
180_M207_L2.1101.00
170_A174_F1.9791.00
48_M122_V1.9511.00
25_I242_A1.9451.00
81_I218_V1.9301.00
84_A213_A1.9151.00
54_S80_A1.9031.00
74_A78_V1.8711.00
19_G265_G1.8501.00
54_S221_V1.8161.00
187_C204_V1.7631.00
77_F221_V1.7591.00
169_L173_I1.7171.00
116_I119_Q1.7031.00
26_A257_A1.7001.00
32_V212_G1.6991.00
186_A194_A1.6801.00
92_E206_A1.6771.00
67_D75_A1.6751.00
31_M171_L1.6381.00
19_G262_L1.5931.00
23_A261_G1.5731.00
179_R183_A1.5571.00
241_K284_S1.5561.00
38_M107_A1.5541.00
35_I185_R1.5481.00
67_D74_A1.5091.00
114_M118_L1.5071.00
56_M60_A1.5021.00
58_I76_G1.4911.00
81_I221_V1.4891.00
180_M184_C1.4801.00
87_Y118_L1.4761.00
45_E119_Q1.4431.00
253_S256_G1.4351.00
192_K195_S1.4331.00
191_L195_S1.4281.00
168_M258_M1.4161.00
49_I87_Y1.4021.00
56_M125_T1.3941.00
249_G256_G1.3851.00
25_I47_Y1.3791.00
207_L210_V1.3741.00
97_R206_A1.3541.00
47_Y223_L1.3481.00
183_A199_I1.3431.00
67_D73_V1.3411.00
28_G215_M1.3371.00
183_A194_A1.3341.00
75_A78_V1.3271.00
57_I64_M1.3161.00
36_I208_T1.3141.00
24_L222_L1.3091.00
24_L219_A1.2991.00
249_G260_G1.2951.00
199_I204_V1.2761.00
194_A199_I1.2751.00
31_M208_T1.2711.00
23_A258_M1.2531.00
15_G265_G1.2511.00
57_I66_I1.2391.00
11_Q269_A1.2391.00
29_Y242_A1.2381.00
93_R206_A1.2361.00
76_G80_A1.2351.00
206_A210_V1.2311.00
29_Y246_A1.2251.00
135_S138_N1.2191.00
80_A84_A1.2111.00
187_C201_T1.2021.00
147_E150_S1.2011.00
27_I171_L1.1971.00
38_M205_I1.1951.00
43_H216_A1.1931.00
187_C194_A1.1901.00
53_V57_I1.1821.00
38_M209_F1.1791.00
269_A272_S1.1761.00
66_I75_A1.1741.00
78_V82_V1.1701.00
15_G266_I1.1681.00
172_T177_Y1.1341.00
82_V85_S1.1331.00
96_Y202_D1.1241.00
45_E118_L1.1231.00
195_S202_D1.1151.00
210_V214_A1.1081.00
96_Y111_A1.1001.00
213_A217_A1.1001.00
26_A245_A1.0931.00
176_R185_R1.0881.00
167_A215_M1.0771.00
54_S225_Q1.0731.00
26_A246_A1.0721.00
28_G43_H1.0691.00
207_L211_I1.0621.00
19_G261_G1.0611.00
245_A260_G1.0591.00
46_V87_Y1.0521.00
66_I79_G1.0441.00
35_I252_G1.0431.00
56_M126_E1.0431.00
123_S126_E1.0421.00
168_M215_M1.0381.00
94_V110_S1.0341.00
268_E284_S1.0281.00
251_I257_A1.0201.00
279_Y282_V1.0171.00
149_F152_S1.0161.00
220_G224_G1.0151.00
204_V207_L1.0151.00
166_L170_A1.0141.00
25_I219_A1.0121.00
52_Y122_V1.0031.00
91_I110_S0.9951.00
80_A221_V0.9951.00
85_S217_A0.9951.00
171_L211_I0.9941.00
245_A261_G0.9891.00
20_S161_W0.9881.00
238_A241_K0.9871.00
13_F17_T0.9861.00
162_I166_L0.9801.00
40_N43_H0.9791.00
180_M204_V0.9781.00
44_G239_G0.9761.00
55_F59_A0.9721.00
184_C204_V0.9721.00
195_S201_T0.9701.00
211_I215_M0.9681.00
86_A89_W0.9661.00
57_I76_G0.9651.00
57_I60_A0.9641.00
30_T246_A0.9611.00
169_L172_T0.9571.00
52_Y232_P0.9561.00
148_N151_A0.9551.00
212_G216_A0.9531.00
264_L284_S0.9381.00
30_T252_G0.9361.00
255_P259_I0.9351.00
21_T219_A0.9321.00
160_I222_L0.9291.00
126_E129_R0.9281.00
97_R103_K0.9251.00
78_V81_I0.9231.00
115_S119_Q0.9161.00
159_V162_I0.9101.00
33_Y246_A0.9051.00
193_M197_L0.9041.00
152_S155_T0.9011.00
49_I53_V0.8981.00
271_S283_V0.8981.00
95_A110_S0.8971.00
290_L294_V0.8971.00
203_R206_A0.8971.00
81_I217_A0.8901.00
45_E115_S0.8891.00
44_G237_M0.8841.00
182_R185_R0.8811.00
155_T162_I0.8781.00
165_F169_L0.8771.00
29_Y43_H0.8751.00
270_L274_Y0.8721.00
51_S224_G0.8721.00
164_T168_M0.8681.00
26_A261_G0.8661.00
133_L136_L0.8651.00
23_A168_M0.8591.00
126_E131_V0.8581.00
36_I184_C0.8561.00
30_T251_I0.8531.00
32_V40_N0.8521.00
92_E97_R0.8521.00
82_V86_A0.8511.00
31_M211_I0.8481.00
12_M270_L0.8471.00
51_S234_I0.8471.00
172_T255_P0.8461.00
18_L22_Y0.8441.00
50_G84_A0.8441.00
237_M241_K0.8421.00
47_Y238_A0.8421.00
133_L137_F0.8401.00
202_D205_I0.8321.00
24_L164_T0.8301.00
35_I176_R0.8271.00
187_C208_T0.8261.00
50_G80_A0.8241.00
60_A64_M0.8241.00
244_T288_L0.8231.00
216_A220_G0.8221.00
253_S257_A0.8201.00
154_T162_I0.8121.00
53_V56_M0.8041.00
201_T205_I0.7971.00
31_M175_I0.7961.00
46_V216_A0.7951.00
52_Y126_E0.7931.00
55_F230_I0.7931.00
174_F177_Y0.7931.00
107_A209_F0.7891.00
190_D193_M0.7841.00
27_I167_A0.7831.00
25_I28_G0.7791.00
93_R103_K0.7791.00
46_V84_A0.7761.00
269_A273_A0.7761.00
90_S94_V0.7721.00
223_L227_Y0.7681.00
175_I184_C0.7601.00
150_S153_I0.7591.00
54_S58_I0.7581.00
25_I43_H0.7501.00
158_A162_I0.7481.00
257_A261_G0.7471.00
51_S230_I0.7471.00
11_Q273_A0.7471.00
50_G220_G0.7461.00
75_A79_G0.7451.00
27_I257_A0.7431.00
22_Y241_K0.7431.00
214_A217_A0.7371.00
24_L167_A0.7361.00
159_V163_V0.7321.00
202_D206_A0.7321.00
281_D284_S0.7271.00
183_A200_N0.7271.00
286_A290_L0.7251.00
153_I156_M0.7241.00
278_E281_D0.7241.00
47_Y235_G0.7211.00
191_L201_T0.7201.00
86_A90_S0.7201.00
55_F131_V0.7191.00
117_F121_Y0.7181.00
54_S76_G0.7171.00
28_G216_A0.7171.00
187_C205_I0.7131.00
84_A88_G0.7121.00
81_I85_S0.7081.00
161_W165_F0.7041.00
170_A173_I0.7031.00
262_L266_I0.7011.00
50_G83_I0.6971.00
89_W93_R0.6921.00
134_P138_N0.6901.00
214_A218_V0.6901.00
41_F243_F0.6871.00
19_G23_A0.6851.00
47_Y219_A0.6831.00
33_Y243_F0.6811.00
246_A251_I0.6761.00
268_E280_K0.6701.00
49_I84_A0.6701.00
129_R132_A0.6641.00
22_Y245_A0.6601.00
14_N18_L0.6581.00
46_V91_I0.6571.00
20_S164_T0.6551.00
291_V295_M0.6521.00
77_F81_I0.6501.00
30_T35_I0.6491.00
152_S156_M0.6491.00
123_S129_R0.6461.00
16_V20_S0.6451.00
119_Q239_G0.6451.00
64_M67_D0.6451.00
10_Q13_F0.6441.00
149_F153_I0.6401.00
96_Y206_A0.6391.00
73_V136_L0.6381.00
261_G265_G0.6361.00
53_V79_G0.6281.00
180_M211_I0.6281.00
123_S128_S0.6261.00
38_M191_L0.6251.00
92_E96_Y0.6231.00
171_L215_M0.6221.00
46_V213_A0.6221.00
171_L175_I0.6191.00
32_V209_F0.6191.00
46_V118_L0.6171.00
151_A155_T0.6171.00
49_I118_L0.6161.00
127_G131_V0.6151.00
91_I95_A0.6111.00
30_T254_I0.6101.00
54_S220_G0.6101.00
95_A107_A0.6071.00
104_R202_D0.6071.00
46_V50_G0.6061.00
17_T226_F0.6041.00
58_I225_Q0.6031.00
15_G19_G0.6021.00
151_A154_T0.6001.00
217_A221_V0.5991.00
245_A257_A0.5991.00
59_A131_V0.5981.00
173_I176_R0.5971.00
174_F207_L0.5951.00
174_F178_S0.5941.00
57_I83_I0.5901.00
14_N269_A0.5891.00
167_A218_V0.5871.00
28_G32_V0.5861.00
46_V88_G0.5851.00
133_L138_N0.5841.00
42_A91_I0.5831.00
213_A216_A0.5801.00
211_I214_A0.5791.00
15_G269_A0.5781.00
87_Y91_I0.5771.00
128_S131_V0.5761.00
147_E152_S0.5741.00
22_Y238_A0.5711.00
244_T284_S0.5701.00
22_Y261_G0.5691.00
275_L279_Y0.5661.00
36_I205_I0.5661.00
201_T204_V0.5661.00
223_L238_A0.5661.00
168_M172_T0.5651.00
95_A209_F0.5631.00
157_Q226_F0.5621.00
116_I120_N0.5621.00
135_S139_G0.5611.00
194_A201_T0.5601.00
12_M16_V0.5601.00
241_K281_D0.5601.00
50_G216_A0.5601.00
124_L127_G0.5581.00
36_I187_C0.5531.00
31_M174_F0.5511.00
134_P137_F0.5511.00
81_I84_A0.5501.00
271_S275_L0.5451.00
248_L291_V0.5451.00
17_T161_W0.5441.00
88_G210_V0.5441.00
115_S239_G0.5421.00
73_V225_Q0.5401.00
126_E130_D0.5391.00
248_L260_G0.5381.00
205_I208_T0.5381.00
21_T223_L0.5321.00
53_V84_A0.5311.00
210_V213_A0.5301.00
27_I168_M0.5291.00
282_V286_A0.5291.00
40_N212_G0.5271.00
186_A193_M0.5261.00
48_M234_I0.5261.00
245_A264_L0.5261.00
32_V38_M0.5241.00
230_I233_Y0.5231.00
66_I74_A0.5211.00
27_I169_L0.5191.00
111_A115_S0.5181.00
256_G260_G0.5171.00
124_L129_R0.5151.00
185_R252_G0.5151.00
53_V80_A0.5151.00
192_K196_L0.5141.00
136_L139_G0.5141.00
163_V166_L0.5101.00
27_I172_T0.5091.00
16_V19_G0.5081.00
124_L279_Y0.5071.00
118_L122_V0.5061.00
49_I83_I0.5061.00
249_G257_A0.5031.00
112_I116_I0.5021.00
260_G263_I0.5011.00
167_A171_L0.5011.00
57_I80_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.8149 95.7 0.884 Contact Map
2qi9A 2 0.8442 94.3 0.893 Contact Map
4g1uA 2 0.8149 92.7 0.899 Contact Map
2gfpA 2 0.6006 8.8 0.954 Contact Map
2cfqA 1 0.6234 3 0.963 Contact Map
2ksfA 1 0.3377 2.5 0.965 Contact Map
4m64A 1 0.6331 2.1 0.966 Contact Map
1u7gA 3 0.5162 1.9 0.967 Contact Map
3rlbA 1 0.3214 1.7 0.968 Contact Map
2m20A 2 0.1331 1.5 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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