GREMLIN Database
KPPR - Probable phosphoribulokinase
UniProt: P0AEX5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12365
Length: 289 (287)
Sequences: 357 (153)
Seq/√Len: 9.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_G150_L4.5630.99
39_V82_T4.2430.99
98_L109_Q3.8430.98
135_G147_V3.6740.97
142_N145_Q3.6570.97
98_L106_P3.4710.96
210_T229_F3.4040.95
48_T51_E3.1780.93
75_D78_L2.9670.90
32_L280_Q2.8900.89
106_P109_Q2.6250.83
87_G146_H2.6160.83
43_S94_S2.5810.82
230_V262_V2.5750.82
203_L275_M2.5100.80
9_A150_L2.4630.79
55_A58_K2.4140.78
24_A272_E2.2900.74
37_A120_L2.2500.72
98_L116_P2.2340.72
109_Q113_T2.2330.72
150_L202_H2.1690.69
44_F82_T2.1470.69
76_F136_V2.0810.66
147_V259_T2.0560.65
20_T156_I2.0540.65
24_A268_G2.0500.65
202_H260_L2.0320.64
93_K119_P1.9820.62
82_T92_G1.9660.61
121_P124_T1.9400.60
121_P193_Y1.8780.58
55_A59_A1.8350.56
46_R52_M1.8010.54
22_S203_L1.7830.54
202_H235_R1.7810.53
203_L278_L1.7750.53
67_S185_R1.7700.53
96_K106_P1.7530.52
76_F143_V1.7350.51
84_I88_Q1.7260.51
262_V267_M1.6960.50
188_E192_N1.6550.48
233_H256_H1.6500.48
24_A27_K1.6430.47
137_V142_N1.6350.47
169_T179_V1.5770.45
268_G272_E1.5700.44
249_L284_E1.5610.44
248_M252_S1.5510.44
137_V144_A1.5370.43
47_Y52_M1.5240.42
66_I185_R1.5190.42
22_S275_M1.5190.42
10_V22_S1.5120.42
243_P246_L1.5030.41
67_S230_V1.4870.41
10_V275_M1.4860.41
262_V268_G1.4850.41
283_M286_K1.4640.40
151_V268_G1.4630.40
237_L258_N1.4550.39
226_D266_K1.4440.39
50_P53_D1.4430.39
233_H258_N1.4330.39
27_K156_I1.4200.38
68_Y186_S1.3940.37
257_I272_E1.3770.36
10_V235_R1.3750.36
21_T31_Q1.3700.36
9_A202_H1.3630.36
157_V229_F1.3540.35
203_L240_I1.3420.35
235_R275_M1.3370.35
151_V156_I1.3370.35
8_I151_V1.3320.34
178_A181_D1.3310.34
24_A180_M1.3300.34
48_T53_D1.3280.34
22_S26_R1.3250.34
175_S178_A1.3230.34
7_V137_V1.2960.33
275_M281_R1.2920.33
34_L116_P1.2920.33
79_L143_V1.2910.33
233_H248_M1.2800.32
281_R285_G1.2790.32
184_V191_I1.2720.32
135_G143_V1.2720.32
199_S215_N1.2530.31
138_T193_Y1.2520.31
244_W248_M1.2510.31
120_L127_L1.2470.31
19_T102_D1.2470.31
70_G98_L1.2370.31
157_V195_T1.2260.30
203_L238_E1.2260.30
225_L286_K1.2020.30
43_S76_F1.2020.30
71_P193_Y1.1990.29
156_I199_S1.1980.29
252_S266_K1.1860.29
26_R165_L1.1790.29
119_P122_E1.1670.28
157_V276_L1.1620.28
9_A43_S1.1550.28
35_H121_P1.1540.28
120_L123_P1.1410.27
202_H257_I1.1280.27
19_T224_S1.1260.27
24_A280_Q1.1220.27
43_S143_V1.1210.27
9_A147_V1.1120.26
85_E278_L1.1090.26
100_T118_Q1.1090.26
169_T176_R1.1080.26
33_N281_R1.1070.26
31_Q237_L1.1030.26
21_T279_V1.0900.26
66_I203_L1.0760.25
84_I146_H1.0510.24
59_A62_A1.0510.24
229_F262_V1.0490.24
9_A200_R1.0470.24
71_P189_D1.0400.24
249_L275_M1.0380.24
70_G193_Y1.0330.24
262_V282_L1.0320.24
48_T57_R1.0310.24
70_G76_F1.0310.24
101_Y153_V1.0280.24
5_H116_P1.0260.24
32_L273_L1.0250.24
174_H186_S1.0230.23
46_R203_L1.0180.23
31_Q186_S1.0030.23
68_Y174_H1.0010.23
210_T253_F0.9980.23
54_M58_K0.9970.23
239_G272_E0.9940.23
47_Y55_A0.9900.22
87_G287_K0.9770.22
182_S186_S0.9770.22
21_T186_S0.9760.22
85_E89_S0.9730.22
147_V150_L0.9720.22
242_F254_I0.9690.22
80_E145_Q0.9650.22
39_V124_T0.9640.22
88_Q118_Q0.9620.22
229_F253_F0.9570.21
242_F256_H0.9540.21
98_L104_A0.9540.21
82_T120_L0.9470.21
258_N263_P0.9390.21
76_F106_P0.9350.21
147_V202_H0.9290.21
147_V157_V0.9250.21
157_V165_L0.9220.20
26_R108_N0.9210.20
202_H259_T0.9180.20
153_V186_S0.9180.20
37_A121_P0.9170.20
75_D286_K0.9160.20
26_R275_M0.9130.20
87_G127_L0.9120.20
175_S202_H0.9110.20
47_Y88_Q0.9050.20
7_V52_M0.9050.20
111_P287_K0.9040.20
20_T221_G0.9020.20
151_V203_L0.8970.20
127_L250_Q0.8930.20
169_T240_I0.8900.20
219_A258_N0.8880.20
107_W275_M0.8880.20
27_K268_G0.8810.19
35_H202_H0.8770.19
141_H193_Y0.8760.19
210_T279_V0.8730.19
42_D130_E0.8720.19
165_L275_M0.8720.19
78_L93_K0.8660.19
165_L203_L0.8650.19
21_T68_Y0.8610.19
62_A142_N0.8610.19
193_Y245_L0.8590.19
76_F141_H0.8580.19
185_R222_I0.8570.19
76_F259_T0.8560.19
56_I195_T0.8560.19
19_T47_Y0.8530.19
19_T36_A0.8500.18
94_S150_L0.8500.18
91_K119_P0.8470.18
272_E280_Q0.8470.18
150_L199_S0.8470.18
150_L200_R0.8430.18
35_H145_Q0.8430.18
249_L262_V0.8380.18
281_R286_K0.8380.18
30_A254_I0.8360.18
37_A251_G0.8350.18
22_S165_L0.8350.18
35_H87_G0.8310.18
96_K107_W0.8270.18
31_Q68_Y0.8260.18
267_M283_M0.8250.18
31_Q184_V0.8230.18
157_V272_E0.8160.18
169_T195_T0.8160.18
8_I126_V0.8130.18
77_G141_H0.8120.18
182_S218_A0.8120.18
23_L171_E0.8110.17
32_L68_Y0.8090.17
53_D188_E0.8060.17
10_V119_P0.8060.17
32_L276_L0.8020.17
20_T176_R0.8020.17
111_P236_N0.8010.17
7_V142_N0.8000.17
72_E93_K0.7960.17
101_Y186_S0.7940.17
21_T184_V0.7930.17
248_M266_K0.7890.17
154_V220_K0.7870.17
20_T150_L0.7830.17
3_A287_K0.7800.17
71_P104_A0.7800.17
279_V287_K0.7740.17
122_E193_Y0.7730.17
171_E192_N0.7720.17
19_T120_L0.7720.17
257_I276_L0.7710.17
252_S255_S0.7710.17
75_D249_L0.7700.16
124_T127_L0.7700.16
43_S157_V0.7700.16
21_T53_D0.7650.16
25_F34_L0.7640.16
20_T199_S0.7570.16
254_I258_N0.7570.16
43_S126_V0.7550.16
7_V79_L0.7540.16
257_I268_G0.7480.16
32_L240_I0.7450.16
37_A169_T0.7410.16
19_T142_N0.7370.16
113_T179_V0.7350.16
170_S282_L0.7350.16
10_V229_F0.7310.16
93_K262_V0.7280.16
32_L239_G0.7280.16
230_V275_M0.7280.16
256_H263_P0.7260.15
47_Y124_T0.7250.15
233_H254_I0.7220.15
8_I279_V0.7200.15
251_G257_I0.7190.15
45_H172_R0.7180.15
156_I257_I0.7170.15
27_K272_E0.7160.15
67_S75_D0.7150.15
79_L139_P0.7150.15
210_T244_W0.7130.15
21_T174_H0.7130.15
4_K84_I0.7130.15
176_R179_V0.7120.15
195_T199_S0.7120.15
272_E276_L0.7100.15
151_V195_T0.7090.15
66_I142_N0.7060.15
127_L146_H0.7010.15
86_Y124_T0.7010.15
53_D68_Y0.7000.15
238_E280_Q0.6990.15
180_M221_G0.6990.15
77_G139_P0.6960.15
39_V102_D0.6950.15
85_E91_K0.6930.15
227_E256_H0.6910.15
80_E251_G0.6910.15
9_A221_G0.6900.15
276_L279_V0.6890.15
128_F208_V0.6880.15
44_F50_P0.6860.15
166_I218_A0.6860.15
33_N286_K0.6830.15
111_P286_K0.6820.14
22_S98_L0.6800.14
153_V182_S0.6780.14
211_V219_A0.6730.14
34_L151_V0.6720.14
30_A124_T0.6710.14
81_Q85_E0.6700.14
273_L280_Q0.6690.14
32_L247_A0.6670.14
53_D102_D0.6660.14
60_R188_E0.6640.14
76_F102_D0.6630.14
75_D184_V0.6630.14
233_H237_L0.6630.14
32_L58_K0.6600.14
123_P225_L0.6600.14
94_S278_L0.6560.14
27_K221_G0.6540.14
38_E221_G0.6530.14
200_R259_T0.6530.14
100_T179_V0.6510.14
105_V184_V0.6490.14
44_F139_P0.6420.14
7_V179_V0.6410.14
176_R202_H0.6400.14
147_V156_I0.6380.14
166_I186_S0.6330.13
273_L276_L0.6310.13
56_I65_H0.6310.13
3_A285_G0.6270.13
40_E111_P0.6270.13
66_I169_T0.6260.13
93_K243_P0.6260.13
96_K108_N0.6250.13
34_L147_V0.6240.13
138_T141_H0.6200.13
118_Q285_G0.6190.13
100_T176_R0.6190.13
25_F187_M0.6180.13
174_H237_L0.6170.13
45_H49_R0.6160.13
18_T42_D0.6150.13
70_G109_Q0.6140.13
222_I264_G0.6120.13
98_L105_V0.6120.13
210_T281_R0.6100.13
26_R253_F0.6090.13
35_H65_H0.6080.13
175_S225_L0.6070.13
80_E143_V0.6070.13
159_L245_L0.6050.13
27_K202_H0.6050.13
53_D186_S0.6020.13
24_A278_L0.6010.13
96_K100_T0.6000.13
207_R228_S0.5970.13
10_V26_R0.5960.13
9_A156_I0.5940.13
233_H242_F0.5930.13
5_H71_P0.5920.13
91_K282_L0.5890.13
115_T182_S0.5890.13
241_D256_H0.5880.13
98_L267_M0.5870.13
126_V175_S0.5870.13
48_T156_I0.5870.13
153_V237_L0.5850.13
80_E84_I0.5840.12
10_V278_L0.5840.12
47_Y101_Y0.5830.12
99_H172_R0.5820.12
62_A81_Q0.5780.12
36_A225_L0.5770.12
92_G179_V0.5750.12
68_Y184_V0.5740.12
137_V145_Q0.5740.12
38_E142_N0.5730.12
47_Y139_P0.5720.12
26_R236_N0.5680.12
53_D78_L0.5680.12
58_K62_A0.5670.12
28_I80_E0.5670.12
30_A276_L0.5650.12
105_V240_I0.5650.12
92_G120_L0.5640.12
239_G276_L0.5640.12
83_F279_V0.5620.12
33_N229_F0.5610.12
31_Q254_I0.5590.12
22_S36_A0.5580.12
107_W180_M0.5580.12
240_I284_E0.5580.12
57_R249_L0.5580.12
195_T272_E0.5550.12
233_H244_W0.5550.12
79_L209_P0.5540.12
143_V279_V0.5530.12
106_P259_T0.5520.12
166_I237_L0.5520.12
37_A170_S0.5520.12
159_L211_V0.5510.12
30_A107_W0.5500.12
46_R150_L0.5480.12
119_P137_V0.5470.12
65_H102_D0.5450.12
233_H260_L0.5440.12
28_I52_M0.5430.12
21_T237_L0.5410.12
202_H283_M0.5400.12
47_Y284_E0.5370.12
53_D281_R0.5350.12
51_E77_G0.5350.12
146_H231_V0.5340.12
280_Q287_K0.5320.12
211_V255_S0.5310.12
43_S147_V0.5280.11
20_T56_I0.5280.11
47_Y63_G0.5270.11
56_I59_A0.5250.11
20_T268_G0.5240.11
137_V140_Q0.5220.11
175_S181_D0.5220.11
65_H165_L0.5220.11
57_R119_P0.5220.11
76_F94_S0.5200.11
150_L156_I0.5190.11
116_P271_M0.5170.11
151_V273_L0.5170.11
96_K109_Q0.5140.11
51_E55_A0.5120.11
105_V224_S0.5090.11
59_A141_H0.5060.11
85_E141_H0.5060.11
118_Q229_F0.5050.11
67_S159_L0.5050.11
221_G268_G0.5040.11
165_L202_H0.5030.11
70_G106_P0.5030.11
54_M137_V0.5020.11
109_Q116_P0.5010.11
230_V249_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a7jA 5 0.9619 100 0.545 Contact Map
1odfA 1 0.7612 100 0.839 Contact Map
3tqcA 2 0.7059 99.2 0.923 Contact Map
2jeoA 3 0.6955 98.9 0.932 Contact Map
2ga8A 1 0.6851 98.5 0.939 Contact Map
1rz3A 1 0.5606 98.4 0.941 Contact Map
4bfzA 2 0.6886 98.3 0.944 Contact Map
3w34A 2 0.7093 98.2 0.944 Contact Map
1uj2A 3 0.7128 98.2 0.945 Contact Map
4ne2A 2 0.692 98 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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