KPPR - ECOLI - GREMLIN Contacts

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KPPR - Probable phosphoribulokinase

UniProt:	P0AEX5	Sequences: MSAKHPVIAVTGSSGAGTTTTSLAFRKIFAQLNLHAAEVEGDSFHRYTRPEMDMAIRKARDAGRHISYFGPEANDFGLLEQTFIEYGQSGKGKSRKYLHTYDEAVPWNQVPGTFTPWQPLPEPTDVLFYEGLHGGVVTPQHNVAQHVDLLVGVVPIVNLEWIQKLIRDTSERGHSREAVMDSVVRSMEDYINYITPQFSRTHLNFQRVPTVDTSNPFAAKGIPSLDESFVVIHFRNLEGIDFPWLLAMLQGSFISHINTLVVPGGKMGLAMELIMLPLVQRLMEGKKIE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12365
Length:	289 (287)
Sequences:	357 (153)
Seq/√Len:	9.0

ECOLI - KPPR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
135_G	150_L	4.563	0.99
39_V	82_T	4.243	0.99
98_L	109_Q	3.843	0.98
135_G	147_V	3.674	0.97
142_N	145_Q	3.657	0.97
98_L	106_P	3.471	0.96
210_T	229_F	3.404	0.95
48_T	51_E	3.178	0.93
75_D	78_L	2.967	0.90
32_L	280_Q	2.890	0.89
106_P	109_Q	2.625	0.83
87_G	146_H	2.616	0.83
43_S	94_S	2.581	0.82
230_V	262_V	2.575	0.82
203_L	275_M	2.510	0.80
9_A	150_L	2.463	0.79
55_A	58_K	2.414	0.78
24_A	272_E	2.290	0.74
37_A	120_L	2.250	0.72
98_L	116_P	2.234	0.72
109_Q	113_T	2.233	0.72
150_L	202_H	2.169	0.69
44_F	82_T	2.147	0.69
76_F	136_V	2.081	0.66
147_V	259_T	2.056	0.65
20_T	156_I	2.054	0.65
24_A	268_G	2.050	0.65
202_H	260_L	2.032	0.64
93_K	119_P	1.982	0.62
82_T	92_G	1.966	0.61
121_P	124_T	1.940	0.60
121_P	193_Y	1.878	0.58
55_A	59_A	1.835	0.56
46_R	52_M	1.801	0.54
22_S	203_L	1.783	0.54
202_H	235_R	1.781	0.53
203_L	278_L	1.775	0.53
67_S	185_R	1.770	0.53
96_K	106_P	1.753	0.52
76_F	143_V	1.735	0.51
84_I	88_Q	1.726	0.51
262_V	267_M	1.696	0.50
188_E	192_N	1.655	0.48
233_H	256_H	1.650	0.48
24_A	27_K	1.643	0.47
137_V	142_N	1.635	0.47
169_T	179_V	1.577	0.45
268_G	272_E	1.570	0.44
249_L	284_E	1.561	0.44
248_M	252_S	1.551	0.44
137_V	144_A	1.537	0.43
47_Y	52_M	1.524	0.42
66_I	185_R	1.519	0.42
22_S	275_M	1.519	0.42
10_V	22_S	1.512	0.42
243_P	246_L	1.503	0.41
67_S	230_V	1.487	0.41
10_V	275_M	1.486	0.41
262_V	268_G	1.485	0.41
283_M	286_K	1.464	0.40
151_V	268_G	1.463	0.40
237_L	258_N	1.455	0.39
226_D	266_K	1.444	0.39
50_P	53_D	1.443	0.39
233_H	258_N	1.433	0.39
27_K	156_I	1.420	0.38
68_Y	186_S	1.394	0.37
257_I	272_E	1.377	0.36
10_V	235_R	1.375	0.36
21_T	31_Q	1.370	0.36
9_A	202_H	1.363	0.36
157_V	229_F	1.354	0.35
203_L	240_I	1.342	0.35
235_R	275_M	1.337	0.35
151_V	156_I	1.337	0.35
8_I	151_V	1.332	0.34
178_A	181_D	1.331	0.34
24_A	180_M	1.330	0.34
48_T	53_D	1.328	0.34
22_S	26_R	1.325	0.34
175_S	178_A	1.323	0.34
7_V	137_V	1.296	0.33
275_M	281_R	1.292	0.33
34_L	116_P	1.292	0.33
79_L	143_V	1.291	0.33
233_H	248_M	1.280	0.32
281_R	285_G	1.279	0.32
184_V	191_I	1.272	0.32
135_G	143_V	1.272	0.32
199_S	215_N	1.253	0.31
138_T	193_Y	1.252	0.31
244_W	248_M	1.251	0.31
120_L	127_L	1.247	0.31
19_T	102_D	1.247	0.31
70_G	98_L	1.237	0.31
157_V	195_T	1.226	0.30
203_L	238_E	1.226	0.30
225_L	286_K	1.202	0.30
43_S	76_F	1.202	0.30
71_P	193_Y	1.199	0.29
156_I	199_S	1.198	0.29
252_S	266_K	1.186	0.29
26_R	165_L	1.179	0.29
119_P	122_E	1.167	0.28
157_V	276_L	1.162	0.28
9_A	43_S	1.155	0.28
35_H	121_P	1.154	0.28
120_L	123_P	1.141	0.27
202_H	257_I	1.128	0.27
19_T	224_S	1.126	0.27
24_A	280_Q	1.122	0.27
43_S	143_V	1.121	0.27
9_A	147_V	1.112	0.26
85_E	278_L	1.109	0.26
100_T	118_Q	1.109	0.26
169_T	176_R	1.108	0.26
33_N	281_R	1.107	0.26
31_Q	237_L	1.103	0.26
21_T	279_V	1.090	0.26
66_I	203_L	1.076	0.25
84_I	146_H	1.051	0.24
59_A	62_A	1.051	0.24
229_F	262_V	1.049	0.24
9_A	200_R	1.047	0.24
71_P	189_D	1.040	0.24
249_L	275_M	1.038	0.24
70_G	193_Y	1.033	0.24
262_V	282_L	1.032	0.24
48_T	57_R	1.031	0.24
70_G	76_F	1.031	0.24
101_Y	153_V	1.028	0.24
5_H	116_P	1.026	0.24
32_L	273_L	1.025	0.24
174_H	186_S	1.023	0.23
46_R	203_L	1.018	0.23
31_Q	186_S	1.003	0.23
68_Y	174_H	1.001	0.23
210_T	253_F	0.998	0.23
54_M	58_K	0.997	0.23
239_G	272_E	0.994	0.23
47_Y	55_A	0.990	0.22
87_G	287_K	0.977	0.22
182_S	186_S	0.977	0.22
21_T	186_S	0.976	0.22
85_E	89_S	0.973	0.22
147_V	150_L	0.972	0.22
242_F	254_I	0.969	0.22
80_E	145_Q	0.965	0.22
39_V	124_T	0.964	0.22
88_Q	118_Q	0.962	0.22
229_F	253_F	0.957	0.21
242_F	256_H	0.954	0.21
98_L	104_A	0.954	0.21
82_T	120_L	0.947	0.21
258_N	263_P	0.939	0.21
76_F	106_P	0.935	0.21
147_V	202_H	0.929	0.21
147_V	157_V	0.925	0.21
157_V	165_L	0.922	0.20
26_R	108_N	0.921	0.20
202_H	259_T	0.918	0.20
153_V	186_S	0.918	0.20
37_A	121_P	0.917	0.20
75_D	286_K	0.916	0.20
26_R	275_M	0.913	0.20
87_G	127_L	0.912	0.20
175_S	202_H	0.911	0.20
47_Y	88_Q	0.905	0.20
7_V	52_M	0.905	0.20
111_P	287_K	0.904	0.20
20_T	221_G	0.902	0.20
151_V	203_L	0.897	0.20
127_L	250_Q	0.893	0.20
169_T	240_I	0.890	0.20
219_A	258_N	0.888	0.20
107_W	275_M	0.888	0.20
27_K	268_G	0.881	0.19
35_H	202_H	0.877	0.19
141_H	193_Y	0.876	0.19
210_T	279_V	0.873	0.19
42_D	130_E	0.872	0.19
165_L	275_M	0.872	0.19
78_L	93_K	0.866	0.19
165_L	203_L	0.865	0.19
21_T	68_Y	0.861	0.19
62_A	142_N	0.861	0.19
193_Y	245_L	0.859	0.19
76_F	141_H	0.858	0.19
185_R	222_I	0.857	0.19
76_F	259_T	0.856	0.19
56_I	195_T	0.856	0.19
19_T	47_Y	0.853	0.19
19_T	36_A	0.850	0.18
94_S	150_L	0.850	0.18
91_K	119_P	0.847	0.18
272_E	280_Q	0.847	0.18
150_L	199_S	0.847	0.18
150_L	200_R	0.843	0.18
35_H	145_Q	0.843	0.18
249_L	262_V	0.838	0.18
281_R	286_K	0.838	0.18
30_A	254_I	0.836	0.18
37_A	251_G	0.835	0.18
22_S	165_L	0.835	0.18
35_H	87_G	0.831	0.18
96_K	107_W	0.827	0.18
31_Q	68_Y	0.826	0.18
267_M	283_M	0.825	0.18
31_Q	184_V	0.823	0.18
157_V	272_E	0.816	0.18
169_T	195_T	0.816	0.18
8_I	126_V	0.813	0.18
77_G	141_H	0.812	0.18
182_S	218_A	0.812	0.18
23_L	171_E	0.811	0.17
32_L	68_Y	0.809	0.17
53_D	188_E	0.806	0.17
10_V	119_P	0.806	0.17
32_L	276_L	0.802	0.17
20_T	176_R	0.802	0.17
111_P	236_N	0.801	0.17
7_V	142_N	0.800	0.17
72_E	93_K	0.796	0.17
101_Y	186_S	0.794	0.17
21_T	184_V	0.793	0.17
248_M	266_K	0.789	0.17
154_V	220_K	0.787	0.17
20_T	150_L	0.783	0.17
3_A	287_K	0.780	0.17
71_P	104_A	0.780	0.17
279_V	287_K	0.774	0.17
122_E	193_Y	0.773	0.17
171_E	192_N	0.772	0.17
19_T	120_L	0.772	0.17
257_I	276_L	0.771	0.17
252_S	255_S	0.771	0.17
75_D	249_L	0.770	0.16
124_T	127_L	0.770	0.16
43_S	157_V	0.770	0.16
21_T	53_D	0.765	0.16
25_F	34_L	0.764	0.16
20_T	199_S	0.757	0.16
254_I	258_N	0.757	0.16
43_S	126_V	0.755	0.16
7_V	79_L	0.754	0.16
257_I	268_G	0.748	0.16
32_L	240_I	0.745	0.16
37_A	169_T	0.741	0.16
19_T	142_N	0.737	0.16
113_T	179_V	0.735	0.16
170_S	282_L	0.735	0.16
10_V	229_F	0.731	0.16
93_K	262_V	0.728	0.16
32_L	239_G	0.728	0.16
230_V	275_M	0.728	0.16
256_H	263_P	0.726	0.15
47_Y	124_T	0.725	0.15
233_H	254_I	0.722	0.15
8_I	279_V	0.720	0.15
251_G	257_I	0.719	0.15
45_H	172_R	0.718	0.15
156_I	257_I	0.717	0.15
27_K	272_E	0.716	0.15
67_S	75_D	0.715	0.15
79_L	139_P	0.715	0.15
210_T	244_W	0.713	0.15
21_T	174_H	0.713	0.15
4_K	84_I	0.713	0.15
176_R	179_V	0.712	0.15
195_T	199_S	0.712	0.15
272_E	276_L	0.710	0.15
151_V	195_T	0.709	0.15
66_I	142_N	0.706	0.15
127_L	146_H	0.701	0.15
86_Y	124_T	0.701	0.15
53_D	68_Y	0.700	0.15
238_E	280_Q	0.699	0.15
180_M	221_G	0.699	0.15
77_G	139_P	0.696	0.15
39_V	102_D	0.695	0.15
85_E	91_K	0.693	0.15
227_E	256_H	0.691	0.15
80_E	251_G	0.691	0.15
9_A	221_G	0.690	0.15
276_L	279_V	0.689	0.15
128_F	208_V	0.688	0.15
44_F	50_P	0.686	0.15
166_I	218_A	0.686	0.15
33_N	286_K	0.683	0.15
111_P	286_K	0.682	0.14
22_S	98_L	0.680	0.14
153_V	182_S	0.678	0.14
211_V	219_A	0.673	0.14
34_L	151_V	0.672	0.14
30_A	124_T	0.671	0.14
81_Q	85_E	0.670	0.14
273_L	280_Q	0.669	0.14
32_L	247_A	0.667	0.14
53_D	102_D	0.666	0.14
60_R	188_E	0.664	0.14
76_F	102_D	0.663	0.14
75_D	184_V	0.663	0.14
233_H	237_L	0.663	0.14
32_L	58_K	0.660	0.14
123_P	225_L	0.660	0.14
94_S	278_L	0.656	0.14
27_K	221_G	0.654	0.14
38_E	221_G	0.653	0.14
200_R	259_T	0.653	0.14
100_T	179_V	0.651	0.14
105_V	184_V	0.649	0.14
44_F	139_P	0.642	0.14
7_V	179_V	0.641	0.14
176_R	202_H	0.640	0.14
147_V	156_I	0.638	0.14
166_I	186_S	0.633	0.13
273_L	276_L	0.631	0.13
56_I	65_H	0.631	0.13
3_A	285_G	0.627	0.13
40_E	111_P	0.627	0.13
66_I	169_T	0.626	0.13
93_K	243_P	0.626	0.13
96_K	108_N	0.625	0.13
34_L	147_V	0.624	0.13
138_T	141_H	0.620	0.13
118_Q	285_G	0.619	0.13
100_T	176_R	0.619	0.13
25_F	187_M	0.618	0.13
174_H	237_L	0.617	0.13
45_H	49_R	0.616	0.13
18_T	42_D	0.615	0.13
70_G	109_Q	0.614	0.13
222_I	264_G	0.612	0.13
98_L	105_V	0.612	0.13
210_T	281_R	0.610	0.13
26_R	253_F	0.609	0.13
35_H	65_H	0.608	0.13
175_S	225_L	0.607	0.13
80_E	143_V	0.607	0.13
159_L	245_L	0.605	0.13
27_K	202_H	0.605	0.13
53_D	186_S	0.602	0.13
24_A	278_L	0.601	0.13
96_K	100_T	0.600	0.13
207_R	228_S	0.597	0.13
10_V	26_R	0.596	0.13
9_A	156_I	0.594	0.13
233_H	242_F	0.593	0.13
5_H	71_P	0.592	0.13
91_K	282_L	0.589	0.13
115_T	182_S	0.589	0.13
241_D	256_H	0.588	0.13
98_L	267_M	0.587	0.13
126_V	175_S	0.587	0.13
48_T	156_I	0.587	0.13
153_V	237_L	0.585	0.13
80_E	84_I	0.584	0.12
10_V	278_L	0.584	0.12
47_Y	101_Y	0.583	0.12
99_H	172_R	0.582	0.12
62_A	81_Q	0.578	0.12
36_A	225_L	0.577	0.12
92_G	179_V	0.575	0.12
68_Y	184_V	0.574	0.12
137_V	145_Q	0.574	0.12
38_E	142_N	0.573	0.12
47_Y	139_P	0.572	0.12
26_R	236_N	0.568	0.12
53_D	78_L	0.568	0.12
58_K	62_A	0.567	0.12
28_I	80_E	0.567	0.12
30_A	276_L	0.565	0.12
105_V	240_I	0.565	0.12
92_G	120_L	0.564	0.12
239_G	276_L	0.564	0.12
83_F	279_V	0.562	0.12
33_N	229_F	0.561	0.12
31_Q	254_I	0.559	0.12
22_S	36_A	0.558	0.12
107_W	180_M	0.558	0.12
240_I	284_E	0.558	0.12
57_R	249_L	0.558	0.12
195_T	272_E	0.555	0.12
233_H	244_W	0.555	0.12
79_L	209_P	0.554	0.12
143_V	279_V	0.553	0.12
106_P	259_T	0.552	0.12
166_I	237_L	0.552	0.12
37_A	170_S	0.552	0.12
159_L	211_V	0.551	0.12
30_A	107_W	0.550	0.12
46_R	150_L	0.548	0.12
119_P	137_V	0.547	0.12
65_H	102_D	0.545	0.12
233_H	260_L	0.544	0.12
28_I	52_M	0.543	0.12
21_T	237_L	0.541	0.12
202_H	283_M	0.540	0.12
47_Y	284_E	0.537	0.12
53_D	281_R	0.535	0.12
51_E	77_G	0.535	0.12
146_H	231_V	0.534	0.12
280_Q	287_K	0.532	0.12
211_V	255_S	0.531	0.12
43_S	147_V	0.528	0.11
20_T	56_I	0.528	0.11
47_Y	63_G	0.527	0.11
56_I	59_A	0.525	0.11
20_T	268_G	0.524	0.11
137_V	140_Q	0.522	0.11
175_S	181_D	0.522	0.11
65_H	165_L	0.522	0.11
57_R	119_P	0.522	0.11
76_F	94_S	0.520	0.11
150_L	156_I	0.519	0.11
116_P	271_M	0.517	0.11
151_V	273_L	0.517	0.11
96_K	109_Q	0.514	0.11
51_E	55_A	0.512	0.11
105_V	224_S	0.509	0.11
59_A	141_H	0.506	0.11
85_E	141_H	0.506	0.11
118_Q	229_F	0.505	0.11
67_S	159_L	0.505	0.11
221_G	268_G	0.504	0.11
165_L	202_H	0.503	0.11
70_G	106_P	0.503	0.11
54_M	137_V	0.502	0.11
109_Q	116_P	0.501	0.11
230_V	249_L	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a7jA	5	0.9619	100	0.545	Contact Map
1odfA	1	0.7612	100	0.839	Contact Map
3tqcA	2	0.7059	99.2	0.923	Contact Map
2jeoA	3	0.6955	98.9	0.932	Contact Map
2ga8A	1	0.6851	98.5	0.939	Contact Map
1rz3A	1	0.5606	98.4	0.941	Contact Map
4bfzA	2	0.6886	98.3	0.944	Contact Map
3w34A	2	0.7093	98.2	0.944	Contact Map
1uj2A	3	0.7128	98.2	0.945	Contact Map
4ne2A	2	0.692	98	0.948	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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