K1PF - ECOLI - GREMLIN Contacts

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K1PF - 1-phosphofructokinase

UniProt:	P0AEW9	Sequences: MSRRVATITLNPAYDLVGFCPEIERGEVNLVKTTGLHAAGKGINVAKVLKDLGIDVTVGGFLGKDNQDGFQQLFSELGIANRFQVVQGRTRINVKLTEKDGEVTDFNFSGFEVTPADWERFVTDSLSWLGQFDMVCVSGSLPSGVSPEAFTDWMTRLRSQCPCIIFDSSREALVAGLKAAPWLVKPNRRELEIWAGRKLPEMKDVIEAAHALREQGIAHVVISLGAEGALWVNASGEWIAKPPSVDVVSTVGAGDSMVGGLIYGLLMRESSEHTLRLATAVAALAVSQSNVGITDRPQLAAMMARVDLQPFN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10337
Length:	312 (283)
Sequences:	22537 (16839)
Seq/√Len:	1001.0

ECOLI - K1PF PFKB YDJH RBSK YEGV YEII SQUV PSUK KDGK FRLD INGK HLDE
BACSU - YDJE K1PF IOLC KDGK RBSK FRLD
HALSA - Q9HSM7 Q9HP13 Q9HMJ3
SULSO - KDGK Q981E2 Q97W01 Q980X6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
54_I	263_Y	3.170	1.00
136_C	165_I	2.721	1.00
57_T	80_A	2.557	1.00
71_Q	86_V	2.503	1.00
270_S	273_H	2.474	1.00
231_W	275_L	2.462	1.00
224_L	230_L	2.457	1.00
264_G	269_E	2.346	1.00
229_A	257_M	2.265	1.00
7_T	132_F	2.237	1.00
155_T	180_A	2.214	1.00
49_L	54_I	2.171	1.00
213_R	232_V	2.112	1.00
68_D	86_V	2.073	1.00
157_L	162_P	2.055	1.00
188_R	224_L	1.997	1.00
51_D	77_L	1.989	1.00
64_K	87_Q	1.951	1.00
165_I	262_I	1.934	1.00
238_W	272_E	1.922	1.00
295_D	298_Q	1.920	1.00
264_G	277_L	1.919	1.00
154_M	164_I	1.906	1.00
8_I	46_A	1.904	1.00
256_S	281_V	1.843	1.00
134_M	163_C	1.840	1.00
126_L	156_R	1.835	1.00
269_E	273_H	1.826	1.00
72_Q	76_E	1.798	1.00
185_K	258_V	1.796	1.00
47_K	77_L	1.779	1.00
267_M	296_R	1.768	1.00
48_V	259_G	1.766	1.00
231_W	238_W	1.760	1.00
75_S	81_N	1.759	1.00
229_A	279_T	1.758	1.00
163_C	182_W	1.750	1.00
182_W	218_A	1.735	1.00
209_A	232_V	1.731	1.00
224_L	239_I	1.712	1.00
211_A	215_Q	1.710	1.00
288_Q	298_Q	1.696	1.00
253_A	286_V	1.693	1.00
272_E	276_R	1.685	1.00
151_T	176_G	1.674	1.00
73_L	76_E	1.667	1.00
261_L	274_T	1.663	1.00
221_V	261_L	1.657	1.00
230_L	239_I	1.640	1.00
71_Q	75_S	1.629	1.00
134_M	165_I	1.613	1.00
192_E	198_K	1.612	1.00
152_D	155_T	1.607	1.00
183_L	219_H	1.589	1.00
156_R	160_Q	1.570	1.00
282_A	286_V	1.568	1.00
49_L	263_Y	1.538	1.00
211_A	214_E	1.531	1.00
134_M	262_I	1.523	1.00
151_T	155_T	1.522	1.00
12_P	60_G	1.522	1.00
68_D	72_Q	1.518	1.00
64_K	68_D	1.518	1.00
249_S	290_N	1.507	1.00
260_G	281_V	1.504	1.00
219_H	233_N	1.497	1.00
243_P	280_A	1.496	1.00
233_N	236_G	1.492	1.00
36_L	69_G	1.487	1.00
240_A	275_L	1.481	1.00
204_D	207_E	1.476	1.00
231_W	271_S	1.470	1.00
38_A	70_F	1.453	1.00
224_L	227_E	1.433	1.00
210_H	214_E	1.433	1.00
130_G	160_Q	1.432	1.00
158_R	182_W	1.423	1.00
206_I	210_H	1.420	1.00
156_R	159_S	1.412	1.00
167_D	223_S	1.406	1.00
152_D	156_R	1.399	1.00
260_G	277_L	1.380	1.00
163_C	183_L	1.377	1.00
197_R	211_A	1.344	1.00
243_P	276_R	1.339	1.00
240_A	279_T	1.331	1.00
14_Y	69_G	1.317	1.00
181_P	184_V	1.313	1.00
55_D	80_A	1.308	1.00
206_I	237_E	1.306	1.00
43_I	74_F	1.305	1.00
158_R	180_A	1.298	1.00
245_V	287_S	1.295	1.00
168_S	186_P	1.293	1.00
163_C	218_A	1.289	1.00
67_Q	90_T	1.286	1.00
6_A	49_L	1.270	1.00
229_A	275_L	1.259	1.00
243_P	279_T	1.248	1.00
219_H	265_L	1.233	1.00
38_A	73_L	1.229	1.00
224_L	228_G	1.223	1.00
223_S	257_M	1.223	1.00
247_V	286_V	1.210	1.00
261_L	265_L	1.209	1.00
16_L	34_T	1.207	1.00
73_L	77_L	1.207	1.00
185_K	223_S	1.207	1.00
213_R	234_A	1.206	1.00
273_H	276_R	1.203	1.00
219_H	261_L	1.198	1.00
170_R	173_L	1.198	1.00
263_Y	267_M	1.195	1.00
219_H	271_S	1.195	1.00
71_Q	84_Q	1.192	1.00
210_H	232_V	1.179	1.00
64_K	86_V	1.179	1.00
21_P	32_K	1.177	1.00
197_R	207_E	1.176	1.00
72_Q	75_S	1.172	1.00
245_V	286_V	1.172	1.00
69_G	72_Q	1.171	1.00
52_L	260_G	1.167	1.00
135_V	157_L	1.166	1.00
260_G	278_A	1.159	1.00
50_K	79_I	1.146	1.00
68_D	71_Q	1.134	1.00
155_T	159_S	1.129	1.00
261_L	278_A	1.129	1.00
264_G	274_T	1.121	1.00
137_V	164_I	1.118	1.00
188_R	227_E	1.117	1.00
49_L	56_V	1.111	1.00
45_V	136_C	1.109	1.00
284_L	287_S	1.108	1.00
243_P	283_A	1.107	1.00
46_A	56_V	1.104	1.00
21_P	99_K	1.103	1.00
16_L	36_L	1.098	1.00
207_E	210_H	1.088	1.00
183_L	261_L	1.080	1.00
61_F	120_R	1.075	1.00
284_L	288_Q	1.073	1.00
136_C	262_I	1.070	1.00
54_I	266_L	1.067	1.00
19_F	33_T	1.063	1.00
219_H	231_W	1.061	1.00
170_R	174_V	1.047	1.00
247_V	250_T	1.036	1.00
62_L	67_Q	1.036	1.00
47_K	51_D	1.032	1.00
264_G	267_M	1.032	1.00
191_L	222_I	1.032	1.00
126_L	160_Q	1.024	1.00
71_Q	85_V	1.022	1.00
144_G	148_E	1.021	1.00
54_I	267_M	1.021	1.00
127_S	130_G	1.018	1.00
62_L	71_Q	1.013	1.00
218_A	234_A	1.009	1.00
279_T	282_A	1.005	1.00
50_K	78_G	1.004	1.00
48_V	256_S	1.001	1.00
57_T	128_W	1.001	1.00
12_P	70_F	0.999	1.00
183_L	265_L	0.997	1.00
232_V	237_E	0.996	1.00
209_A	222_I	0.989	1.00
261_L	271_S	0.987	1.00
242_P	279_T	0.984	1.00
185_K	261_L	0.982	1.00
191_L	208_A	0.982	1.00
210_H	237_E	0.979	1.00
57_T	83_F	0.979	1.00
81_N	84_Q	0.966	1.00
135_V	162_P	0.961	1.00
38_A	69_G	0.958	1.00
57_T	132_F	0.957	1.00
148_E	152_D	0.953	1.00
50_K	55_D	0.952	1.00
256_S	285_A	0.950	1.00
276_R	280_A	0.947	1.00
8_I	42_G	0.946	1.00
166_F	181_P	0.945	1.00
69_G	73_L	0.941	1.00
31_V	106_F	0.940	1.00
195_A	208_A	0.930	1.00
227_E	239_I	0.927	1.00
236_G	272_E	0.925	1.00
18_G	94_V	0.916	1.00
155_T	176_G	0.913	1.00
274_T	278_A	0.912	1.00
136_C	258_V	0.911	1.00
188_R	192_E	0.909	1.00
52_L	281_V	0.908	1.00
137_V	150_F	0.907	1.00
263_Y	296_R	0.906	1.00
17_V	37_H	0.905	1.00
187_N	190_E	0.901	1.00
263_Y	277_L	0.897	1.00
137_V	154_M	0.895	1.00
16_L	92_I	0.895	1.00
129_L	132_F	0.891	1.00
49_L	259_G	0.891	1.00
228_G	242_P	0.888	1.00
19_F	35_G	0.888	1.00
247_V	287_S	0.886	1.00
234_A	237_E	0.884	1.00
71_Q	81_N	0.881	1.00
270_S	274_T	0.879	1.00
65_D	90_T	0.869	1.00
132_F	162_P	0.868	1.00
246_D	287_S	0.868	1.00
167_D	185_K	0.865	1.00
126_L	159_S	0.865	1.00
12_P	58_V	0.860	1.00
210_H	213_R	0.860	1.00
265_L	274_T	0.858	1.00
209_A	220_V	0.858	1.00
63_G	90_T	0.856	1.00
62_L	84_Q	0.855	1.00
256_S	293_I	0.851	1.00
24_E	27_E	0.847	1.00
7_T	59_G	0.846	1.00
256_S	260_G	0.844	1.00
43_I	292_G	0.836	1.00
70_F	90_T	0.831	1.00
238_W	275_L	0.830	1.00
9_T	153_W	0.829	1.00
20_C	23_I	0.826	1.00
207_E	211_A	0.826	1.00
12_P	43_I	0.823	1.00
45_V	258_V	0.820	1.00
257_M	279_T	0.814	1.00
240_A	272_E	0.808	1.00
240_A	276_R	0.805	1.00
124_D	127_S	0.805	1.00
186_P	191_L	0.799	1.00
248_V	289_S	0.799	1.00
96_L	106_F	0.798	1.00
269_E	277_L	0.795	1.00
15_D	39_A	0.786	1.00
9_T	135_V	0.786	1.00
167_D	186_P	0.786	1.00
61_F	85_V	0.785	1.00
117_D	120_R	0.774	1.00
50_K	56_V	0.772	1.00
25_R	102_E	0.772	1.00
256_S	282_A	0.770	1.00
172_A	175_A	0.769	1.00
245_V	283_A	0.768	1.00
206_I	239_I	0.768	1.00
260_G	264_G	0.766	1.00
178_K	181_P	0.764	1.00
129_L	162_P	0.762	1.00
165_I	185_K	0.760	1.00
46_A	58_V	0.760	1.00
118_W	149_A	0.759	1.00
62_L	86_V	0.756	1.00
114_T	117_D	0.753	1.00
57_T	82_R	0.747	1.00
171_E	175_A	0.746	1.00
22_E	27_E	0.745	1.00
154_M	180_A	0.745	1.00
149_A	153_W	0.744	1.00
221_V	231_W	0.742	1.00
91_R	96_L	0.739	1.00
233_N	271_S	0.739	1.00
116_A	119_E	0.737	1.00
126_L	130_G	0.735	1.00
279_T	283_A	0.735	1.00
95_K	105_D	0.733	1.00
191_L	212_L	0.732	1.00
233_N	238_W	0.731	1.00
213_R	233_N	0.726	1.00
52_L	263_Y	0.722	1.00
226_A	244_S	0.718	1.00
176_G	179_A	0.716	1.00
277_L	299_L	0.715	1.00
93_N	96_L	0.715	1.00
52_L	299_L	0.714	1.00
277_L	296_R	0.712	1.00
151_T	180_A	0.708	1.00
209_A	213_R	0.705	1.00
47_K	292_G	0.704	1.00
134_M	266_L	0.699	1.00
206_I	232_V	0.699	1.00
13_A	91_R	0.692	1.00
90_T	93_N	0.691	1.00
83_F	86_V	0.690	1.00
6_A	266_L	0.690	1.00
282_A	285_A	0.690	1.00
7_T	57_T	0.688	1.00
257_M	278_A	0.688	1.00
52_L	277_L	0.688	1.00
280_A	284_L	0.685	1.00
73_L	292_G	0.685	1.00
197_R	208_A	0.681	1.00
184_V	220_V	0.677	1.00
206_I	230_L	0.673	1.00
228_G	239_I	0.671	1.00
165_I	183_L	0.666	1.00
165_I	258_V	0.666	1.00
60_G	84_Q	0.661	1.00
55_D	133_D	0.661	1.00
35_G	289_S	0.659	1.00
269_E	274_T	0.658	1.00
83_F	128_W	0.657	1.00
103_V	107_N	0.657	1.00
41_K	169_S	0.656	1.00
157_L	164_I	0.655	1.00
128_W	132_F	0.655	1.00
14_Y	36_L	0.655	1.00
252_G	293_I	0.652	1.00
281_V	299_L	0.644	1.00
151_T	154_M	0.644	1.00
135_V	153_W	0.643	1.00
148_E	151_T	0.641	1.00
257_M	275_L	0.635	1.00
147_P	151_T	0.634	1.00
104_T	107_N	0.632	1.00
39_A	44_N	0.631	1.00
229_A	240_A	0.631	1.00
19_F	289_S	0.628	1.00
167_D	255_D	0.628	1.00
213_R	235_S	0.621	1.00
275_L	279_T	0.619	1.00
46_A	79_I	0.615	1.00
205_V	224_L	0.614	1.00
257_M	282_A	0.613	1.00
98_E	102_E	0.612	1.00
170_R	175_A	0.610	1.00
133_D	162_P	0.609	1.00
7_T	128_W	0.607	1.00
55_D	266_L	0.605	1.00
66_N	69_G	0.605	1.00
294_T	299_L	0.600	1.00
178_K	217_I	0.599	1.00
43_I	58_V	0.597	1.00
68_D	75_S	0.596	1.00
284_L	298_Q	0.596	1.00
52_L	259_G	0.595	1.00
208_A	212_L	0.594	1.00
113_V	116_A	0.593	1.00
268_R	274_T	0.592	1.00
119_E	152_D	0.591	1.00
134_M	183_L	0.591	1.00
171_E	174_V	0.590	1.00
284_L	299_L	0.590	1.00
77_L	295_D	0.590	1.00
145_V	148_E	0.589	1.00
177_L	181_P	0.586	1.00
240_A	243_P	0.585	1.00
93_N	107_N	0.580	1.00
18_G	34_T	0.577	1.00
6_A	134_M	0.576	1.00
92_I	96_L	0.575	1.00
133_D	163_C	0.574	1.00
217_I	220_V	0.572	1.00
23_I	104_T	0.568	1.00
206_I	209_A	0.568	1.00
213_R	217_I	0.567	1.00
233_N	237_E	0.566	1.00
49_L	262_I	0.564	1.00
175_A	215_Q	0.564	1.00
25_R	98_E	0.563	1.00
259_G	263_Y	0.563	1.00
45_V	262_I	0.563	1.00
164_I	181_P	0.558	1.00
221_V	257_M	0.558	1.00
191_L	205_V	0.558	1.00
273_H	277_L	0.554	1.00
151_T	174_V	0.546	1.00
38_A	292_G	0.542	1.00
185_K	221_V	0.541	1.00
128_W	131_Q	0.541	1.00
213_R	220_V	0.540	1.00
157_L	161_C	0.539	1.00
226_A	247_V	0.539	1.00
44_N	291_V	0.539	1.00
18_G	31_V	0.537	1.00
191_L	220_V	0.533	1.00
74_F	79_I	0.532	1.00
96_L	104_T	0.532	1.00
197_R	204_D	0.532	1.00
50_K	77_L	0.531	1.00
221_V	275_L	0.531	1.00
205_V	208_A	0.530	1.00
271_S	274_T	0.529	1.00
42_G	46_A	0.528	1.00
102_E	105_D	0.528	1.00
59_G	125_S	0.528	1.00
165_I	265_L	0.527	1.00
181_P	217_I	0.527	1.00
213_R	216_G	0.526	1.00
127_S	131_Q	0.526	1.00
64_K	88_G	0.525	1.00
189_R	193_I	0.523	1.00
95_K	251_V	0.523	1.00
108_F	111_F	0.521	1.00
85_V	120_R	0.521	1.00
19_F	99_K	0.521	1.00
45_V	259_G	0.520	1.00
195_A	211_A	0.519	1.00
134_M	265_L	0.519	1.00
179_A	216_G	0.518	1.00
271_S	275_L	0.516	1.00
265_L	268_R	0.516	1.00
30_L	107_N	0.515	1.00
154_M	177_L	0.515	1.00
93_N	105_D	0.511	1.00
28_V	41_K	0.511	1.00
43_I	47_K	0.510	1.00
90_T	95_K	0.509	1.00
179_A	215_Q	0.508	1.00
125_S	128_W	0.506	1.00
91_R	95_K	0.506	1.00
82_R	85_V	0.505	1.00
116_A	120_R	0.504	1.00
153_W	156_R	0.504	1.00
105_D	251_V	0.503	1.00
146_S	150_F	0.502	1.00
251_V	291_V	0.502	1.00
191_L	232_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ajrA	2	0.9904	100	0.186	Contact Map
2jg1A	2	0.9904	100	0.187	Contact Map
3vasA	1	0.9519	100	0.202	Contact Map
2f02A	2	0.9872	100	0.205	Contact Map
3ie7A	2	0.9712	100	0.21	Contact Map
2abqA	2	0.9712	100	0.217	Contact Map
2jg5A	1	0.9712	100	0.218	Contact Map
2fv7A	2	0.9487	100	0.223	Contact Map
3umoA	4	0.9744	100	0.223	Contact Map
2rbcA	2	0.9455	100	0.223	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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