GREMLIN Database
INGK - Inosine-guanosine kinase
UniProt: P0AEW6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11102
Length: 434 (431)
Sequences: 138 (68)
Seq/√Len: 3.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_T136_R4.9400.89
131_C135_S4.6800.87
131_C134_S4.4660.84
131_C136_R3.5920.67
135_S138_D3.5830.67
132_N135_S2.7550.46
35_W430_S2.6970.44
362_A433_D2.6680.44
132_N139_L2.6320.43
310_P315_E2.5860.42
16_N22_L2.5070.40
6_K9_S2.4700.39
202_G433_D2.4600.38
359_G404_V2.4530.38
9_S18_R2.4120.37
326_R329_D2.2730.34
133_T137_T2.2200.33
305_Q336_V2.1990.32
6_K315_E2.1970.32
37_V113_L2.1770.32
34_A394_L2.1610.31
35_W184_I2.1580.31
244_L278_V2.1350.31
134_S137_T2.1140.30
324_A394_L2.1130.30
40_D93_G2.1040.30
133_T138_D2.0800.30
168_P184_I2.0650.29
184_I430_S2.0360.29
16_N24_Q2.0270.28
131_C138_D2.0260.28
131_C137_T1.9990.28
18_R58_Y1.9970.28
202_G425_D1.9950.28
214_E220_N1.9660.27
39_I93_G1.9620.27
19_D23_Q1.9320.26
23_Q28_E1.8720.25
407_Q410_N1.8600.25
97_N358_D1.8520.25
61_S64_H1.8500.25
34_A433_D1.8450.25
202_G434_R1.8400.25
273_K276_D1.8360.24
352_N393_S1.8280.24
133_T139_L1.8010.24
23_Q203_E1.7920.24
19_D22_L1.7850.23
227_L253_M1.7820.23
18_R213_I1.7340.23
22_L203_E1.7280.22
336_V394_L1.6750.21
159_S237_P1.6730.21
6_K18_R1.6700.21
17_A24_Q1.6360.21
67_V172_N1.6300.21
98_T162_R1.6290.21
214_E218_K1.6260.21
16_N30_E1.6260.21
25_F312_A1.6000.20
134_S138_D1.5860.20
132_N136_R1.5850.20
136_R139_L1.5700.20
150_G255_E1.5670.20
17_A32_S1.5660.20
92_G357_G1.5540.19
94_T154_T1.5500.19
60_L152_C1.5500.19
187_A190_L1.5450.19
24_Q29_N1.5370.19
16_N33_A1.5280.19
238_Q241_Q1.5280.19
25_F30_E1.5230.19
19_D310_P1.5150.19
394_L433_D1.5080.19
18_R21_L1.5010.19
250_I362_A1.4990.19
220_N331_Q1.4920.18
36_V111_V1.4890.18
18_R57_R1.4800.18
61_S251_L1.4760.18
254_N257_E1.4700.18
176_A242_Q1.4610.18
203_E395_A1.4400.18
9_S204_P1.4350.18
2_K22_L1.4340.18
9_S196_L1.4340.18
113_L271_S1.4310.17
6_K35_W1.4260.17
19_D24_Q1.4230.17
22_L32_S1.4170.17
25_F29_N1.4110.17
153_F237_P1.4050.17
351_M368_I1.4030.17
6_K368_I1.4020.17
187_A194_S1.4000.17
122_I341_A1.3960.17
29_N203_E1.3950.17
6_K250_I1.3950.17
321_F359_G1.3880.17
205_M232_V1.3880.17
34_A324_A1.3820.17
24_Q49_K1.3790.17
93_G184_I1.3680.17
362_A434_R1.3540.16
18_R23_Q1.3510.16
87_T163_T1.3510.16
203_E412_H1.3500.16
16_N29_N1.3480.16
43_L231_F1.3450.16
22_L30_E1.3450.16
9_S64_H1.3390.16
181_E185_A1.3220.16
6_K31_T1.3220.16
348_E433_D1.3120.16
20_P23_Q1.3100.16
18_R79_E1.3090.16
22_L29_N1.3070.16
94_T130_L1.3060.16
29_N32_S1.3040.16
43_L70_D1.3010.16
18_R66_L1.3010.16
16_N231_F1.3000.16
9_S203_E1.3000.16
417_T428_E1.2990.16
327_H349_K1.2980.16
25_F75_A1.2920.15
19_D64_H1.2890.15
16_N37_V1.2790.15
178_S199_C1.2770.15
153_F292_M1.2770.15
22_L33_A1.2740.15
95_I191_V1.2740.15
15_V40_D1.2730.15
203_E407_Q1.2660.15
24_Q33_A1.2620.15
177_E214_E1.2560.15
114_G353_T1.2540.15
301_K310_P1.2520.15
18_R64_H1.2520.15
28_E31_T1.2480.15
37_V185_A1.2440.15
214_E247_H1.2410.15
16_N23_Q1.2400.15
394_L417_T1.2360.15
9_S19_D1.2340.15
51_D136_R1.2330.15
112_L378_V1.2320.15
348_E386_F1.2280.15
6_K19_D1.2270.15
9_S29_N1.2220.15
105_L284_T1.2200.14
255_E270_A1.2010.14
61_S205_M1.2000.14
113_L278_V1.1990.14
39_I70_D1.1980.14
93_G426_S1.1960.14
25_F28_E1.1950.14
70_D233_I1.1920.14
58_Y69_E1.1910.14
29_N202_G1.1910.14
47_E196_L1.1910.14
271_S281_V1.1900.14
39_I46_I1.1900.14
149_I425_D1.1850.14
6_K203_E1.1770.14
21_L32_S1.1760.14
6_K249_S1.1740.14
351_M407_Q1.1670.14
119_N332_N1.1660.14
19_D203_E1.1620.14
16_N203_E1.1610.14
205_M394_L1.1590.14
283_C412_H1.1560.14
80_L255_E1.1560.14
33_A36_V1.1560.14
57_R79_E1.1520.14
34_A203_E1.1510.14
129_Y204_P1.1510.14
238_Q242_Q1.1460.14
108_D209_T1.1450.14
67_V205_M1.1450.14
9_S79_E1.1370.13
43_L91_A1.1360.13
16_N168_P1.1310.13
76_L178_S1.1280.13
31_T205_M1.1270.13
23_Q30_E1.1200.13
21_L310_P1.1200.13
49_K202_G1.1190.13
18_R30_E1.1180.13
9_S412_H1.1160.13
218_K234_A1.1160.13
69_E72_V1.1150.13
175_R192_L1.1120.13
166_I354_N1.1100.13
64_H197_V1.1070.13
16_N31_T1.1040.13
16_N202_G1.1030.13
261_L340_I1.1000.13
162_R353_T1.0950.13
71_D214_E1.0940.13
20_P24_Q1.0930.13
8_K18_R1.0900.13
17_A49_K1.0870.13
193_T433_D1.0860.13
150_G353_T1.0850.13
9_S22_L1.0840.13
21_L205_M1.0810.13
20_P430_S1.0810.13
340_I429_E1.0800.13
216_A284_T1.0760.13
2_K19_D1.0740.13
192_L348_E1.0710.13
122_I310_P1.0700.13
39_I209_T1.0670.13
55_I159_S1.0650.13
92_G355_G1.0630.13
131_C139_L1.0630.13
57_R213_I1.0570.13
17_A22_L1.0470.12
350_I354_N1.0470.12
286_G357_G1.0460.12
92_G286_G1.0460.12
112_L191_V1.0460.12
172_N390_T1.0430.12
9_S42_T1.0370.12
16_N25_F1.0360.12
24_Q202_G1.0350.12
277_W283_C1.0280.12
157_G368_I1.0260.12
6_K184_I1.0240.12
117_C351_M1.0190.12
60_L65_S1.0120.12
135_S139_L1.0120.12
17_A23_Q1.0080.12
164_F228_G1.0010.12
249_S351_M0.9990.12
80_L270_A0.9970.12
125_Y408_V0.9970.12
18_R31_T0.9950.12
93_G357_G0.9950.12
129_Y282_L0.9950.12
106_A117_C0.9940.12
202_G430_S0.9930.12
398_C429_E0.9930.12
18_R434_R0.9900.12
202_G349_K0.9900.12
22_L425_D0.9840.12
18_R42_T0.9840.12
29_N430_S0.9800.12
242_Q397_V0.9770.12
210_M413_S0.9750.12
398_C434_R0.9720.12
9_S16_N0.9700.12
17_A29_N0.9650.11
30_E34_A0.9650.11
91_A209_T0.9620.11
105_L356_A0.9620.11
19_D240_W0.9600.11
22_L25_F0.9600.11
249_S326_R0.9590.11
9_S21_L0.9580.11
19_D30_E0.9500.11
6_K58_Y0.9500.11
249_S368_I0.9490.11
175_R178_S0.9480.11
429_E434_R0.9450.11
261_L282_L0.9420.11
61_S214_E0.9410.11
28_E34_A0.9400.11
22_L26_Q0.9390.11
214_E327_H0.9330.11
70_D93_G0.9320.11
20_P124_S0.9310.11
6_K64_H0.9300.11
32_S36_V0.9300.11
126_A151_R0.9280.11
23_Q26_Q0.9280.11
108_D235_E0.9270.11
97_N356_A0.9250.11
23_Q34_A0.9240.11
34_A202_G0.9210.11
314_A349_K0.9190.11
32_S425_D0.9150.11
109_R236_N0.9150.11
8_K57_R0.9150.11
100_H166_I0.9140.11
25_F32_S0.9110.11
24_Q28_E0.9100.11
19_D430_S0.9080.11
17_A26_Q0.9080.11
157_G282_L0.9080.11
152_C395_A0.9070.11
16_N118_S0.9030.11
313_I390_T0.9000.11
183_V218_K0.9000.11
35_W336_V0.8990.11
210_M419_G0.8960.11
87_T192_L0.8950.11
9_S24_Q0.8930.11
23_Q42_T0.8930.11
64_H251_L0.8920.11
90_F375_R0.8900.11
90_F395_A0.8890.11
235_E419_G0.8880.11
26_Q32_S0.8850.11
94_T160_G0.8850.11
18_R61_S0.8850.11
30_E33_A0.8840.11
34_A205_M0.8830.11
167_S395_A0.8810.11
102_Y110_S0.8810.11
197_V235_E0.8730.11
17_A156_I0.8720.11
19_D311_G0.8700.11
19_D433_D0.8700.11
28_E33_A0.8700.11
18_R202_G0.8700.11
23_Q202_G0.8670.10
30_E202_G0.8670.10
24_Q31_T0.8660.10
143_Q190_L0.8650.10
25_F31_T0.8590.10
6_K62_A0.8580.10
33_A203_E0.8560.10
22_L235_E0.8540.10
19_D205_M0.8540.10
17_A28_E0.8530.10
341_A412_H0.8530.10
67_V324_A0.8520.10
100_H360_A0.8510.10
24_Q30_E0.8500.10
67_V390_T0.8490.10
20_P25_F0.8480.10
18_R22_L0.8470.10
69_E369_T0.8390.10
16_N21_L0.8350.10
36_V183_V0.8330.10
6_K119_N0.8330.10
26_Q249_S0.8330.10
19_D33_A0.8320.10
187_A386_F0.8310.10
271_S369_T0.8300.10
57_R202_G0.8290.10
6_K168_P0.8230.10
57_R433_D0.8220.10
114_G150_G0.8220.10
51_D131_C0.8210.10
296_T398_C0.8190.10
28_E202_G0.8190.10
6_K351_M0.8190.10
23_Q33_A0.8180.10
101_N105_L0.8180.10
49_K249_S0.8150.10
16_N32_S0.8130.10
246_D292_M0.8120.10
364_L382_S0.8110.10
202_G314_A0.8080.10
26_Q37_V0.8080.10
196_L213_I0.8080.10
22_L42_T0.8070.10
55_I144_G0.8060.10
28_E119_N0.8050.10
18_R118_S0.8040.10
9_S57_R0.8010.10
6_K117_C0.8000.10
162_R229_T0.8000.10
26_Q29_N0.7980.10
153_F167_S0.7980.10
58_Y213_I0.7980.10
23_Q410_N0.7980.10
16_N185_A0.7960.10
209_T430_S0.7940.10
17_A30_E0.7920.10
112_L124_S0.7910.10
76_L386_F0.7910.10
17_A202_G0.7890.10
137_T335_R0.7890.10
410_N433_D0.7890.10
152_C309_L0.7880.10
150_G170_H0.7850.10
144_G192_L0.7840.10
97_N357_G0.7820.10
92_G97_N0.7820.10
31_T37_V0.7790.10
43_L163_T0.7790.10
40_D91_A0.7770.10
23_Q31_T0.7760.10
154_T195_Y0.7710.10
205_M390_T0.7710.10
47_E89_Q0.7670.10
36_V74_E0.7670.10
76_L237_P0.7650.10
16_N19_D0.7620.09
67_V336_V0.7610.09
22_L202_G0.7610.09
194_S236_N0.7560.09
20_P42_T0.7520.09
282_L429_E0.7500.09
57_R70_D0.7460.09
9_S33_A0.7460.09
20_P199_C0.7430.09
8_K204_P0.7420.09
40_D108_D0.7400.09
178_S206_P0.7390.09
169_G353_T0.7360.09
68_I93_G0.7350.09
138_D298_D0.7350.09
6_K388_W0.7330.09
9_S61_S0.7320.09
9_S66_L0.7310.09
195_Y225_L0.7300.09
203_E430_S0.7290.09
19_D314_A0.7270.09
197_V232_V0.7220.09
17_A418_R0.7200.09
9_S23_Q0.7200.09
24_Q430_S0.7190.09
70_D433_D0.7180.09
24_Q203_E0.7180.09
58_Y397_V0.7170.09
62_A159_S0.7150.09
55_I237_P0.7140.09
6_K196_L0.7120.09
64_H205_M0.7120.09
18_R433_D0.7090.09
328_K376_S0.7060.09
178_S388_W0.7060.09
288_I315_E0.7050.09
33_A202_G0.7050.09
425_D430_S0.7050.09
150_G262_T0.7040.09
53_E292_M0.7040.09
28_E419_G0.7030.09
282_L340_I0.7010.09
119_N203_E0.6990.09
217_K244_L0.6980.09
29_N37_V0.6980.09
21_L24_Q0.6980.09
82_Q90_F0.6970.09
6_K66_L0.6950.09
184_I209_T0.6920.09
94_T127_Y0.6910.09
53_E246_D0.6910.09
157_G183_V0.6900.09
401_A413_S0.6890.09
43_L153_F0.6890.09
282_L364_L0.6880.09
10_K15_V0.6870.09
261_L290_L0.6860.09
28_E32_S0.6850.09
394_L401_A0.6800.09
101_N284_T0.6780.09
249_S349_K0.6770.09
229_T253_M0.6770.09
19_D288_I0.6770.09
52_D62_A0.6750.09
18_R24_Q0.6740.09
143_Q223_V0.6730.09
110_S268_L0.6730.09
28_E203_E0.6720.09
56_E84_N0.6710.09
37_V54_F0.6710.09
58_Y187_A0.6690.09
92_G257_E0.6690.09
17_A21_L0.6690.09
257_E357_G0.6690.09
31_T271_S0.6690.09
166_I229_T0.6680.09
16_N109_R0.6670.09
34_A417_T0.6670.09
274_A310_P0.6650.09
50_V62_A0.6640.09
118_S410_N0.6630.09
205_M324_A0.6620.09
204_P410_N0.6580.09
243_F401_A0.6560.09
94_T195_Y0.6540.09
59_G364_L0.6530.09
113_L380_N0.6530.09
47_E57_R0.6520.09
351_M433_D0.6500.09
194_S410_N0.6490.09
162_R166_I0.6480.09
20_P207_E0.6480.09
71_D185_A0.6480.09
94_T226_T0.6460.08
203_E410_N0.6460.08
18_R170_H0.6440.08
8_K282_L0.6430.08
107_D161_E0.6420.08
19_D207_E0.6410.08
185_A246_D0.6410.08
118_S217_K0.6410.08
364_L397_V0.6400.08
166_I228_G0.6400.08
23_Q430_S0.6390.08
195_Y294_G0.6390.08
100_H228_G0.6360.08
210_M315_E0.6360.08
19_D28_E0.6360.08
20_P425_D0.6350.08
196_L203_E0.6320.08
137_T234_A0.6310.08
103_S268_L0.6300.08
36_V61_S0.6270.08
21_L29_N0.6250.08
20_P202_G0.6220.08
375_R394_L0.6220.08
112_L160_G0.6210.08
43_L46_I0.6200.08
2_K32_S0.6200.08
21_L412_H0.6170.08
8_K79_E0.6140.08
139_L160_G0.6140.08
94_T395_A0.6140.08
258_A295_F0.6120.08
351_M410_N0.6110.08
151_R361_L0.6100.08
25_F385_K0.6100.08
80_L160_G0.6090.08
275_L302_R0.6070.08
30_E425_D0.6050.08
179_I232_V0.6040.08
104_V278_V0.6040.08
197_V204_P0.6040.08
56_E146_D0.6030.08
252_A339_H0.6020.08
94_T112_L0.6020.08
23_Q170_H0.6000.08
117_C149_I0.6000.08
401_A433_D0.6000.08
62_A73_A0.5980.08
30_E433_D0.5970.08
37_V53_E0.5970.08
41_Q44_V0.5960.08
220_N329_D0.5950.08
33_A39_I0.5950.08
94_T162_R0.5930.08
21_L283_C0.5930.08
76_L128_R0.5900.08
21_L25_F0.5860.08
208_A263_G0.5860.08
152_C293_A0.5850.08
149_I423_R0.5850.08
227_L354_N0.5840.08
249_S388_W0.5840.08
29_N33_A0.5830.08
148_P156_I0.5820.08
109_R119_N0.5810.08
72_V179_I0.5800.08
32_S385_K0.5790.08
184_I203_E0.5780.08
26_Q33_A0.5780.08
93_G108_D0.5770.08
6_K197_V0.5760.08
196_L413_S0.5760.08
318_Q423_R0.5750.08
344_M348_E0.5740.08
94_T394_L0.5740.08
155_L294_G0.5730.08
22_L385_K0.5730.08
25_F182_D0.5730.08
40_D194_S0.5700.08
9_S410_N0.5660.08
75_A191_V0.5650.08
9_S47_E0.5650.08
32_S376_S0.5640.08
6_K29_N0.5590.08
138_D433_D0.5560.08
17_A82_Q0.5520.08
271_S283_C0.5510.08
111_V184_I0.5500.08
19_D412_H0.5490.08
286_G289_G0.5480.08
66_L328_K0.5480.08
173_Q217_K0.5480.08
370_A405_S0.5460.08
117_C417_T0.5460.08
18_R249_S0.5430.08
165_A236_N0.5430.08
162_R227_L0.5430.08
228_G253_M0.5410.08
91_A426_S0.5390.08
43_L58_Y0.5380.08
43_L336_V0.5370.08
116_M149_I0.5360.08
81_K295_F0.5340.08
113_L184_I0.5340.08
129_Y157_G0.5330.08
179_I426_S0.5310.08
6_K28_E0.5300.08
113_L187_A0.5290.08
22_L66_L0.5290.08
42_T57_R0.5290.08
168_P232_V0.5270.08
98_T229_T0.5260.08
171_M252_A0.5260.08
42_T434_R0.5260.08
9_S306_H0.5260.08
9_S17_A0.5260.08
318_Q324_A0.5260.08
68_I237_P0.5260.08
55_I136_R0.5250.08
24_Q246_D0.5250.08
87_T106_A0.5240.08
220_N299_E0.5240.08
23_Q32_S0.5230.08
100_H229_T0.5220.08
94_T150_G0.5210.08
26_Q433_D0.5210.08
23_Q117_C0.5210.08
84_N202_G0.5200.08
218_K314_A0.5200.08
6_K410_N0.5200.08
338_S398_C0.5190.08
18_R29_N0.5190.08
261_L429_E0.5190.08
26_Q52_D0.5180.08
116_M422_E0.5170.07
46_I144_G0.5170.07
67_V209_T0.5160.07
51_D134_S0.5150.07
192_L195_Y0.5140.07
286_G355_G0.5140.07
40_D426_S0.5110.07
33_A430_S0.5110.07
198_R228_G0.5110.07
214_E376_S0.5110.07
240_W283_C0.5100.07
20_P112_L0.5090.07
329_D375_R0.5080.07
344_M349_K0.5070.07
29_N246_D0.5060.07
122_I283_C0.5060.07
205_M273_K0.5060.07
92_G358_D0.5060.07
375_R430_S0.5050.07
74_E117_C0.5030.07
60_L293_A0.5030.07
76_L173_Q0.5030.07
360_A366_H0.5020.07
273_K372_S0.5010.07
25_F61_S0.5010.07
227_L258_A0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vasA 1 0.7488 100 0.71 Contact Map
4k8kA 2 0.7627 100 0.715 Contact Map
3otxA 1 0.7396 100 0.719 Contact Map
3looA 1 0.7419 100 0.72 Contact Map
1bx4A 1 0.7419 100 0.721 Contact Map
2absA 1 0.735 100 0.727 Contact Map
2rbcA 2 0.7005 100 0.745 Contact Map
2fv7A 2 0.6866 100 0.749 Contact Map
4xdaA 2 0.6866 100 0.752 Contact Map
3iq0A 2 0.7005 100 0.753 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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