GREMLIN Database
CPDA - 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
UniProt: P0AEW4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12187
Length: 275 (235)
Sequences: 8611 (6520)
Seq/√Len: 425.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_R247_E3.6001.00
148_E192_K3.4861.00
17_I58_L3.3921.00
91_L126_L3.3901.00
123_Q150_K3.2231.00
19_Q62_T3.0281.00
116_V150_K3.0211.00
163_L199_L2.7991.00
129_S163_L2.7081.00
129_S165_H2.4851.00
118_I123_Q2.3481.00
150_K153_D2.2161.00
148_E193_F2.0791.00
23_T61_A2.0591.00
148_E152_A2.0481.00
123_Q154_A2.0401.00
125_L147_L1.9791.00
160_L198_Y1.9791.00
60_V162_L1.9611.00
18_L49_I1.9291.00
17_I246_L1.9161.00
14_R249_H1.9111.00
108_A111_S1.8911.00
125_L150_K1.8621.00
154_A159_T1.8541.00
126_L162_L1.8291.00
116_V123_Q1.7931.00
163_L201_C1.7731.00
151_L193_F1.7581.00
21_T62_T1.7321.00
130_Q165_H1.7201.00
209_D216_R1.7101.00
145_E149_R1.6781.00
59_I86_A1.6751.00
121_Q157_R1.6731.00
71_S75_Q1.6361.00
118_I150_K1.6351.00
78_A82_A1.6281.00
149_R153_D1.6181.00
50_R85_R1.6021.00
141_E145_E1.5951.00
146_W150_K1.5911.00
124_I160_L1.5871.00
162_L200_L1.5861.00
102_Y105_L1.5771.00
200_L246_L1.5561.00
147_L161_L1.5491.00
158_H197_K1.5311.00
58_L89_V1.5191.00
70_S73_A1.5061.00
61_A65_L1.4911.00
62_T162_L1.4901.00
189_V193_F1.4401.00
118_I157_R1.4301.00
18_L56_F1.4221.00
127_L147_L1.4141.00
114_K143_Q1.4091.00
148_E189_V1.4051.00
122_W160_L1.4041.00
152_A193_F1.3961.00
117_F124_I1.3881.00
43_Q47_E1.3741.00
15_V124_I1.3671.00
141_E185_E1.3631.00
19_Q200_L1.3601.00
113_A128_D1.3541.00
161_L190_L1.3131.00
247_E257_E1.2901.00
77_F81_I1.2871.00
18_L245_T1.2861.00
127_L161_L1.2741.00
201_C219_A1.2691.00
145_E148_E1.2641.00
147_L151_L1.2501.00
14_R247_E1.2501.00
39_W43_Q1.2491.00
75_Q79_E1.2391.00
21_T24_H1.2331.00
115_R126_L1.2311.00
16_R245_T1.2291.00
58_L119_G1.2181.00
43_Q83_S1.2131.00
48_A243_W1.2081.00
48_A51_P1.2021.00
249_H255_T1.2001.00
186_L190_L1.1991.00
187_D191_A1.1971.00
144_L185_E1.1811.00
24_H67_Q1.1781.00
46_L50_R1.1741.00
61_A90_W1.1691.00
66_A73_A1.1631.00
182_N185_E1.1571.00
47_E51_P1.1471.00
65_L77_F1.1431.00
160_L200_L1.1411.00
170_A208_L1.1401.00
124_I162_L1.1311.00
116_V125_L1.1171.00
220_T223_T1.1161.00
122_W248_L1.1131.00
80_G83_S1.1041.00
19_Q246_L1.1001.00
234_F237_D1.0981.00
17_I248_L1.0971.00
144_L189_V1.0901.00
43_Q80_G1.0851.00
60_V126_L1.0811.00
125_L159_T1.0781.00
191_A215_R1.0751.00
199_L217_L1.0521.00
250_A253_T1.0461.00
38_T41_S1.0341.00
185_E188_T1.0171.00
167_P217_L1.0141.00
140_S143_Q1.0111.00
21_T220_T1.0081.00
97_F101_M1.0041.00
188_T192_K1.0011.00
16_R57_D0.9941.00
161_L199_L0.9841.00
249_H253_T0.9781.00
123_Q157_R0.9761.00
101_M105_L0.9731.00
81_I84_F0.9711.00
102_Y106_Q0.9631.00
103_S107_D0.9611.00
163_L167_P0.9591.00
76_H79_E0.9591.00
89_V117_F0.9481.00
189_V192_K0.9451.00
244_R256_T0.9351.00
74_Y78_A0.9331.00
149_R152_A0.9331.00
220_T244_R0.9291.00
222_S225_V0.9291.00
97_F100_A0.9291.00
56_F86_A0.9251.00
150_K154_A0.9231.00
133_G136_H0.9231.00
198_Y218_L0.9201.00
144_L148_E0.9181.00
69_Q72_A0.9161.00
131_V136_H0.9121.00
190_L196_V0.9111.00
247_E255_T0.9061.00
122_W158_H0.9061.00
161_L196_V0.9021.00
92_P126_L0.9011.00
15_V58_L0.8961.00
137_G165_H0.8931.00
188_T191_A0.8911.00
17_I124_I0.8901.00
123_Q159_T0.8891.00
19_Q220_T0.8891.00
175_L178_H0.8881.00
98_Q105_L0.8851.00
191_A213_N0.8851.00
180_L183_A0.8781.00
225_V229_P0.8751.00
114_K146_W0.8731.00
21_T202_G0.8721.00
46_L84_F0.8721.00
224_C228_K0.8711.00
190_L215_R0.8671.00
104_A107_D0.8661.00
108_A112_P0.8611.00
16_R54_H0.8591.00
151_L189_V0.8531.00
138_E181_R0.8511.00
44_A48_A0.8511.00
16_R55_E0.8501.00
42_Y46_L0.8471.00
20_I59_I0.8471.00
64_D203_H0.8461.00
77_F80_G0.8451.00
89_V115_R0.8441.00
79_E82_A0.8361.00
159_T195_H0.8331.00
127_L143_Q0.8311.00
41_S44_A0.8301.00
45_V223_T0.8231.00
125_L151_L0.8181.00
222_S227_F0.8151.00
15_V119_G0.8121.00
94_N203_H0.8091.00
80_G84_F0.8061.00
99_P102_Y0.8061.00
64_D205_H0.8031.00
242_G258_V0.8001.00
156_E159_T0.8001.00
22_D205_H0.7971.00
167_P199_L0.7961.00
245_T257_E0.7961.00
74_Y77_F0.7951.00
62_T91_L0.7941.00
151_L159_T0.7931.00
223_T226_Q0.7901.00
201_C217_L0.7891.00
115_R146_W0.7861.00
224_C227_F0.7801.00
179_S183_A0.7791.00
180_L185_E0.7771.00
95_H205_H0.7761.00
127_L163_L0.7751.00
98_Q104_A0.7711.00
160_L254_L0.7701.00
144_L186_L0.7661.00
47_E83_S0.7581.00
123_Q156_E0.7571.00
147_L186_L0.7561.00
187_D190_L0.7511.00
147_L189_V0.7461.00
89_V126_L0.7451.00
117_F126_L0.7451.00
183_A186_L0.7411.00
61_A77_F0.7311.00
211_D216_R0.7261.00
73_A77_F0.7241.00
186_L189_V0.7211.00
154_A157_R0.7181.00
91_L162_L0.7161.00
233_N236_L0.7161.00
187_D217_L0.7121.00
248_L254_L0.7101.00
140_S182_N0.7081.00
221_P227_F0.7051.00
55_E86_A0.7001.00
183_A187_D0.6991.00
127_L146_W0.6981.00
98_Q101_M0.6971.00
15_V248_L0.6961.00
121_Q158_H0.6961.00
61_A88_C0.6901.00
151_L196_V0.6891.00
204_I208_L0.6861.00
45_V49_I0.6861.00
97_F104_A0.6851.00
166_H201_C0.6841.00
233_N237_D0.6811.00
41_S45_V0.6801.00
221_P224_C0.6761.00
100_A107_D0.6761.00
119_G122_W0.6751.00
160_L248_L0.6741.00
72_A76_H0.6701.00
117_F120_E0.6691.00
62_T200_L0.6671.00
115_R118_I0.6661.00
100_A103_S0.6661.00
179_S182_N0.6641.00
79_E83_S0.6641.00
94_N205_H0.6610.99
71_S74_Y0.6590.99
222_S226_Q0.6550.99
190_L199_L0.6530.99
169_P208_L0.6460.99
227_F230_H0.6440.99
44_A47_E0.6430.99
109_G112_P0.6410.99
57_D120_E0.6400.99
221_P242_G0.6380.99
62_T202_G0.6360.99
101_M107_D0.6350.99
204_I219_A0.6340.99
245_T259_H0.6340.99
103_S106_Q0.6330.99
167_P201_C0.6300.99
183_A189_V0.6270.99
116_V146_W0.6250.99
219_A222_S0.6250.99
64_D94_N0.6230.99
169_P204_I0.6200.99
97_F106_Q0.6190.99
15_V57_D0.6160.99
199_L215_R0.6150.99
76_H80_G0.6140.99
141_E144_L0.6130.99
40_E44_A0.6110.99
16_R56_F0.6060.99
207_E221_P0.6040.99
211_D214_G0.6040.99
73_A76_H0.6000.99
184_G188_T0.5990.99
208_L221_P0.5970.99
99_P103_S0.5970.99
42_Y45_V0.5960.99
217_L223_T0.5950.99
163_L186_L0.5940.99
39_W76_H0.5920.99
60_V124_I0.5910.99
148_E185_E0.5910.99
20_I49_I0.5900.99
98_Q102_Y0.5900.99
17_I160_L0.5890.99
182_N188_T0.5870.99
181_R185_E0.5870.99
202_G205_H0.5870.99
182_N186_L0.5860.99
101_M106_Q0.5860.99
74_Y84_F0.5840.99
221_P226_Q0.5830.99
101_M104_A0.5830.99
42_Y50_R0.5820.99
24_H66_A0.5820.99
69_Q74_Y0.5810.99
70_S75_Q0.5790.99
56_F245_T0.5790.99
225_V228_K0.5780.99
102_Y112_P0.5770.99
217_L221_P0.5760.99
218_L224_C0.5690.98
166_H169_P0.5650.98
139_L144_L0.5620.98
132_F135_P0.5590.98
49_I56_F0.5590.98
87_P90_W0.5580.98
72_A75_Q0.5580.98
100_A105_L0.5580.98
114_K117_F0.5580.98
104_A108_A0.5560.98
23_T42_Y0.5530.98
64_D164_H0.5530.98
180_L184_G0.5500.98
75_Q82_A0.5490.98
26_F67_Q0.5470.98
92_P101_M0.5470.98
123_Q153_D0.5460.98
23_T96_D0.5450.98
92_P113_A0.5450.98
143_Q146_W0.5390.98
101_M108_A0.5390.98
244_R258_V0.5350.98
21_T61_A0.5350.98
75_Q104_A0.5310.98
255_T258_V0.5260.97
102_Y107_D0.5260.97
218_L221_P0.5230.97
122_W197_K0.5230.97
105_L108_A0.5220.97
47_E50_R0.5190.97
70_S74_Y0.5180.97
168_L217_L0.5160.97
131_V138_E0.5160.97
73_A81_I0.5140.97
58_L87_P0.5110.97
14_R250_A0.5090.97
98_Q106_Q0.5080.97
98_Q128_D0.5050.97
222_S242_G0.5030.97
69_Q73_A0.5030.97
168_L210_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d03A 5 0.9382 100 0.364 Contact Map
3zk4A 5 0.9782 100 0.365 Contact Map
3ib7A 2 0.9782 100 0.366 Contact Map
1uteA 1 0.9273 100 0.366 Contact Map
1xzwA 2 0.9309 100 0.368 Contact Map
2qfpA 2 0.9309 100 0.37 Contact Map
2nxfA 1 0.8873 100 0.381 Contact Map
3tghA 1 0.8945 100 0.388 Contact Map
2yeqA 2 0.9382 100 0.45 Contact Map
2xmoA 1 0.9127 100 0.473 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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