GREMLIN Database
HYCI - Hydrogenase 3 maturation protease
UniProt: P0AEV9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13396
Length: 156 (141)
Sequences: 1466 (1128)
Seq/√Len: 95.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_D127_P5.8361.00
23_A36_V3.8491.00
75_I142_W2.9341.00
18_A113_I2.8041.00
65_D114_Q2.8031.00
21_L24_E2.7011.00
61_V139_L2.5541.00
57_R107_E2.5141.00
75_I111_L2.2681.00
29_A140_E2.2181.00
22_L61_V2.1291.00
14_G117_I2.1011.00
115_P118_V2.0911.00
68_L72_E2.0401.00
69_N72_E1.9911.00
56_T106_G1.9731.00
7_C23_A1.9571.00
67_G114_Q1.9401.00
75_I109_I1.9371.00
35_V53_L1.9291.00
25_K133_E1.8331.00
64_T112_G1.6791.00
126_Q130_D1.6601.00
25_K29_A1.6571.00
25_K28_A1.6441.00
128_I131_A1.6271.00
22_L132_V1.6261.00
111_L135_V1.6171.00
138_R141_G1.6161.00
74_R114_Q1.6011.00
113_I128_I1.5941.00
111_L139_L1.5191.00
68_L74_R1.5081.00
25_K136_Y1.5061.00
126_Q129_K1.4941.00
66_M74_R1.4771.00
142_W145_N1.4751.00
18_A135_V1.4341.00
11_S16_D1.3950.99
59_L139_L1.3920.99
77_D107_E1.3540.99
4_V53_L1.3440.99
11_S20_P1.3390.99
66_M114_Q1.3330.99
60_I108_V1.3240.99
93_P96_Y1.3150.99
61_V135_V1.2940.99
134_T138_R1.2370.99
5_L143_E1.2340.99
20_P38_D1.2180.98
22_L136_Y1.2170.98
133_E137_Q1.1810.98
68_L114_Q1.1770.98
57_R109_I1.1760.98
24_E38_D1.1750.98
131_A135_V1.1640.98
113_I135_V1.1540.98
59_L142_W1.0850.97
21_L123_P1.0820.97
64_T74_R1.0810.97
11_S24_E1.0750.96
58_L108_V1.0720.96
16_D103_E1.0560.96
141_G144_G1.0550.96
77_D80_D1.0510.96
131_A134_T1.0420.96
23_A61_V1.0330.96
60_I94_L1.0310.96
18_A128_I1.0300.96
59_L111_L1.0180.95
44_E100_Q0.9900.94
75_I138_R0.9900.94
13_M16_D0.9840.94
6_L39_G0.9840.94
7_C19_G0.9810.94
109_I142_W0.9800.94
133_E136_Y0.9770.94
4_V58_L0.9680.94
10_N17_G0.9590.93
43_P93_P0.9420.93
3_D57_R0.9410.93
134_T137_Q0.9360.93
4_V37_I0.9100.92
123_P129_K0.8810.90
73_I135_V0.8800.90
17_G21_L0.8750.90
89_T92_M0.8680.90
18_A132_V0.8680.90
113_I131_A0.8600.89
47_I101_L0.8580.89
30_P140_E0.8550.89
14_G121_Y0.8440.88
112_G115_P0.8430.88
17_G20_P0.8370.88
111_L142_W0.8280.87
137_Q141_G0.8270.87
20_P23_A0.8260.87
39_G46_D0.8090.86
74_R112_G0.8030.86
101_L111_L0.7950.85
77_D109_I0.7930.85
26_C30_P0.7830.84
18_A63_A0.7800.84
47_I100_Q0.7760.84
23_A38_D0.7750.83
73_I134_T0.7720.83
35_V49_A0.7640.83
3_D143_E0.7620.82
26_C140_E0.7620.82
70_P114_Q0.7460.81
78_P110_F0.7410.81
51_R104_D0.7410.81
130_D134_T0.7350.80
88_T113_I0.7350.80
66_M115_P0.7340.80
24_E27_A0.7340.80
26_C61_V0.7290.80
17_G38_D0.7210.79
78_P102_K0.7030.77
22_L139_L0.7030.77
132_V135_V0.6910.76
39_G49_A0.6900.76
70_P130_D0.6830.75
44_E93_P0.6820.75
11_S38_D0.6800.75
20_P115_P0.6750.74
8_V48_V0.6740.74
14_G122_Y0.6730.74
14_G119_G0.6680.73
37_I49_A0.6670.73
29_A133_E0.6650.73
64_T81_I0.6610.73
86_M91_N0.6600.72
14_G123_P0.6590.72
14_G125_T0.6580.72
66_M72_E0.6560.72
89_T120_F0.6480.71
127_P130_D0.6420.70
12_M122_Y0.6300.69
127_P131_A0.6290.69
31_K64_T0.6290.69
11_S40_G0.6240.68
18_A138_R0.6160.67
73_I138_R0.6150.67
16_D115_P0.6150.67
58_L106_G0.6140.67
73_I111_L0.6120.67
73_I113_I0.6050.66
5_L26_C0.6020.65
17_G124_M0.5980.65
107_E144_G0.5970.65
13_M45_N0.5930.64
116_D126_Q0.5920.64
20_P74_R0.5910.64
38_D41_S0.5890.64
97_L114_Q0.5890.64
64_T76_I0.5880.64
45_N88_T0.5880.64
43_P46_D0.5870.64
21_L124_M0.5840.63
3_D34_W0.5820.63
130_D133_E0.5810.63
94_L112_G0.5790.62
62_D90_H0.5790.62
16_D39_G0.5780.62
127_P145_N0.5770.62
22_L102_K0.5760.62
126_Q134_T0.5720.62
117_I125_T0.5720.62
5_L34_W0.5710.61
50_I81_I0.5670.61
50_I108_V0.5620.60
72_E134_T0.5590.60
28_A143_E0.5580.60
13_M20_P0.5530.59
28_A83_E0.5500.59
16_D20_P0.5480.58
134_T141_G0.5470.58
86_M112_G0.5450.58
3_D33_N0.5430.58
25_K129_K0.5430.58
75_I135_V0.5420.57
7_C13_M0.5370.57
13_M89_T0.5360.57
18_A22_L0.5360.57
129_K132_V0.5350.57
69_N127_P0.5350.57
71_G131_A0.5330.56
87_M96_Y0.5320.56
61_V128_I0.5300.56
23_A27_A0.5290.56
95_N110_F0.5230.55
12_M92_M0.5190.54
111_L115_P0.5190.54
57_R108_V0.5190.54
137_Q145_N0.5170.54
27_A129_K0.5170.54
50_I58_L0.5160.54
14_G17_G0.5150.54
74_R110_F0.5130.53
130_D137_Q0.5130.53
46_D105_I0.5120.53
27_A36_V0.5120.53
32_G130_D0.5110.53
93_P100_Q0.5100.53
8_V92_M0.5070.53
20_P97_L0.5050.52
14_G115_P0.5030.52
41_S45_N0.5030.52
16_D90_H0.5020.52
16_D38_D0.5010.52
5_L36_V0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1cfzA 1 0.9872 100 0.156 Contact Map
2e85A 2 0.9872 100 0.172 Contact Map
3pu6A 1 0.8654 100 0.218 Contact Map
1c8bA 3 0.8013 98 0.797 Contact Map
3b1fA 2 0.891 84.5 0.892 Contact Map
4wjiA 2 0.9167 81.1 0.896 Contact Map
3l9wA 2 0.8974 77.1 0.9 Contact Map
3hp4A 1 0.8333 76.6 0.9 Contact Map
3k1yA 4 0.9103 73.6 0.903 Contact Map
2q9uA 3 0.9103 69.7 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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