GREMLIN Database
RSSB - Regulator of RpoS
UniProt: P0AEV1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12121
Length: 337 (272)
Sequences: 3111 (2413)
Seq/√Len: 146.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_R36_L4.4941.00
57_C69_L3.8391.00
39_D63_R3.3551.00
41_V63_R3.3291.00
35_V52_P3.2711.00
13_V43_A3.2591.00
40_G64_M3.0271.00
9_Q33_T3.0101.00
65_N68_K2.8531.00
37_A46_L2.8341.00
133_V136_E2.7751.00
38_A42_D2.6981.00
70_L82_V2.4421.00
48_G76_R2.4191.00
20_R38_A2.4181.00
14_E61_M2.3581.00
57_C82_V2.2771.00
74_R103_E2.2741.00
227_L230_Q2.2411.00
9_Q35_V2.2031.00
59_I84_V2.1621.00
54_L124_L2.1441.00
60_A88_T2.0641.00
16_E19_F2.0541.00
35_V46_L2.0261.00
39_D42_D1.9301.00
127_S131_S1.8761.00
84_V102_V1.8651.00
15_D58_D1.8431.00
149_N153_A1.8431.00
15_D61_M1.8331.00
249_N253_R1.8141.00
47_L52_P1.7831.00
137_E140_F1.7581.00
24_D36_L1.7391.00
14_E20_R1.7351.00
44_L69_L1.7201.00
55_M80_T1.7141.00
40_G69_L1.6991.00
59_I97_A1.6931.00
43_A69_L1.6901.00
68_K72_H1.6491.00
104_D119_M1.6441.00
11_L37_A1.6361.00
94_I115_R1.6261.00
43_A47_L1.5971.00
70_L84_V1.5891.00
240_E243_A1.5861.00
137_E141_R1.5701.00
147_V150_P1.5521.00
150_P153_A1.5371.00
245_L278_V1.5351.00
37_A43_A1.5341.00
160_L163_P1.5171.00
30_L117_R1.5171.00
204_D208_A1.5161.00
143_W147_V1.5161.00
35_V50_F1.5131.00
41_V45_E1.4921.00
37_A40_G1.4731.00
26_W113_L1.4671.00
247_Q250_H1.4581.00
84_V97_A1.4461.00
74_R82_V1.4251.00
226_L230_Q1.4181.00
53_D81_P1.4171.00
45_E49_G1.4101.00
64_M68_K1.4021.00
55_M73_I1.3971.00
40_G61_M1.3931.00
47_L73_I1.3801.00
39_D61_M1.3661.00
57_C70_L1.3631.00
91_M95_A1.3631.00
90_N93_D1.3571.00
103_E123_C1.3551.00
255_A258_P1.3541.00
9_Q52_P1.3521.00
166_Q170_H1.3331.00
226_L229_E1.3321.00
279_S283_N1.3271.00
163_P166_Q1.3271.00
194_S197_D1.3241.00
153_A160_L1.3141.00
61_M64_M1.2711.00
85_I110_V1.2641.00
57_C84_V1.2641.00
103_E122_A1.2631.00
9_Q50_F1.2571.00
53_D127_S1.2571.00
144_D148_D1.2531.00
98_L119_M1.2531.00
42_D45_E1.2381.00
158_Q162_P1.2021.00
98_L102_V1.1991.00
44_L64_M1.1941.00
136_E140_F1.1861.00
19_F87_A1.1811.00
70_L102_V1.1801.00
72_H75_N1.1741.00
8_K124_L1.1721.00
59_I67_L1.1581.00
97_A102_V1.1581.00
46_L52_P1.1511.00
259_G262_P1.1451.00
71_E100_L1.1410.99
204_D207_R1.1380.99
243_A246_K1.1370.99
119_M123_C1.1340.99
153_A162_P1.1230.99
176_R179_V1.1210.99
154_A158_Q1.1160.99
200_F266_G1.1110.99
244_L247_Q1.1060.99
14_E19_F1.1050.99
24_D28_S1.1020.99
58_D108_K1.0990.99
154_A157_L1.0980.99
279_S285_T1.0950.99
158_Q161_Q1.0930.99
134_E137_E1.0920.99
19_F22_L1.0870.99
140_F143_W1.0820.99
225_G230_Q1.0810.99
88_T93_D1.0790.99
150_P154_A1.0740.99
58_D61_M1.0700.99
157_L161_Q1.0650.99
14_E108_K1.0650.99
54_L120_V1.0600.99
154_A160_L1.0520.99
140_F144_D1.0490.99
155_K159_E1.0460.99
159_E163_P1.0450.99
15_D87_A1.0440.99
269_H272_L1.0320.99
208_A212_G1.0290.99
68_K71_E1.0270.99
44_L72_H1.0040.99
212_G215_A1.0000.99
64_M69_L0.9970.99
97_A103_E0.9890.99
163_P171_C0.9860.99
279_S284_A0.9840.98
275_L279_S0.9820.98
196_N271_E0.9800.98
161_Q164_V0.9680.98
115_R119_M0.9640.98
12_I23_L0.9590.98
249_N256_N0.9470.98
60_A87_A0.9400.98
23_L85_I0.9390.98
247_Q251_L0.9290.98
70_L98_L0.9240.98
32_A121_F0.9220.98
17_Q20_R0.9200.98
179_V186_L0.9180.98
10_I32_A0.9170.98
143_W146_M0.9110.98
47_L55_M0.9110.98
148_D152_A0.9100.97
58_D87_A0.9080.97
122_A125_Y0.9080.97
89_E94_I0.9050.97
31_G34_T0.9050.97
113_L117_R0.9020.97
251_L254_Q0.9000.97
144_D147_V0.8980.97
146_M149_N0.8940.97
262_P282_L0.8930.97
84_V104_D0.8920.97
139_L142_D0.8890.97
118_E122_A0.8890.97
70_L119_M0.8820.97
12_I34_T0.8820.97
157_L162_P0.8810.97
15_D86_S0.8730.97
175_Y188_L0.8700.97
40_G44_L0.8690.97
122_A126_P0.8670.97
145_A149_N0.8650.97
45_E48_G0.8620.97
110_V116_L0.8610.96
244_L258_P0.8600.96
61_M66_G0.8470.96
146_M154_A0.8340.96
73_I80_T0.8330.96
184_P207_R0.8330.96
158_Q163_P0.8300.96
98_L115_R0.8290.96
83_L120_V0.8260.96
240_E244_L0.8230.95
97_A122_A0.8210.95
197_D269_H0.8210.95
103_E126_P0.8200.95
67_L93_D0.8160.95
73_I82_V0.8120.95
261_F264_L0.8080.95
67_L96_K0.8080.95
9_Q51_T0.8080.95
126_P130_N0.8060.95
86_S108_K0.8060.95
139_L143_W0.8040.95
145_A148_D0.8040.95
70_L100_L0.8040.95
209_G213_V0.8000.95
46_L50_F0.7950.95
135_E138_R0.7950.95
93_D97_A0.7950.95
128_M131_S0.7940.95
119_M126_P0.7910.94
248_V251_L0.7900.94
13_V39_D0.7890.94
127_S130_N0.7860.94
94_I112_D0.7820.94
133_V137_E0.7810.94
83_L123_C0.7810.94
19_F61_M0.7790.94
96_K100_L0.7760.94
157_L160_L0.7740.94
69_L73_I0.7730.94
163_P170_H0.7640.93
208_A215_A0.7630.93
103_E125_Y0.7620.93
147_V151_A0.7580.93
19_F109_P0.7560.93
70_L73_I0.7560.93
95_A99_R0.7560.93
146_M150_P0.7540.93
185_G209_G0.7530.93
70_L74_R0.7510.93
264_L268_Y0.7490.93
147_V153_A0.7490.93
148_D151_A0.7480.93
162_P165_Q0.7470.93
57_C122_A0.7430.92
246_K250_H0.7420.92
13_V40_G0.7420.92
282_L285_T0.7420.92
241_L244_L0.7400.92
237_R252_L0.7400.92
249_N252_L0.7380.92
59_I70_L0.7290.92
58_D66_G0.7280.92
8_K32_A0.7270.91
84_V103_E0.7220.91
153_A163_P0.7210.91
62_P66_G0.7210.91
14_E22_L0.7200.91
136_E139_L0.7180.91
162_P166_Q0.7150.91
276_I279_S0.7140.91
104_D108_K0.7140.91
16_E87_A0.7130.91
55_M69_L0.7130.91
13_V55_M0.7110.91
81_P124_L0.7100.91
244_L255_A0.7100.91
82_V103_E0.7090.90
244_L250_H0.7080.90
40_G63_R0.7070.90
15_D66_G0.7050.90
65_N71_E0.7020.90
40_G65_N0.6980.90
94_I123_C0.6970.90
62_P102_V0.6930.89
245_L249_N0.6920.89
88_T97_A0.6890.89
269_H274_N0.6890.89
66_G108_K0.6870.89
259_G263_L0.6850.89
251_L255_A0.6850.89
84_V123_C0.6810.89
138_R142_D0.6780.88
20_R84_V0.6770.88
158_Q166_Q0.6770.88
42_D46_L0.6760.88
59_I88_T0.6740.88
262_P266_G0.6690.88
71_E75_N0.6690.88
262_P265_V0.6650.87
71_E96_K0.6650.87
210_H214_L0.6630.87
119_M122_A0.6600.87
129_F133_V0.6600.87
19_F110_V0.6590.87
66_G87_A0.6550.87
72_H76_R0.6490.86
206_T212_G0.6490.86
250_H254_Q0.6480.86
69_L88_T0.6470.86
244_L265_V0.6460.86
84_V94_I0.6460.86
251_L256_N0.6450.86
57_C73_I0.6440.86
217_L220_R0.6420.86
10_I54_L0.6350.85
21_S25_S0.6340.85
99_R121_F0.6280.84
261_F265_V0.6260.84
15_D108_K0.6200.84
275_L278_V0.6190.83
46_L49_G0.6190.83
153_A164_V0.6190.83
153_A158_Q0.6180.83
14_E60_A0.6160.83
60_A119_M0.6160.83
57_C102_V0.6140.83
126_P129_F0.6120.83
248_V252_L0.6110.83
87_A108_K0.6100.83
237_R247_Q0.6090.82
153_A159_E0.6090.82
105_V116_L0.6070.82
172_R176_R0.6070.82
13_V61_M0.6060.82
85_I106_L0.6060.82
252_L256_N0.6050.82
28_S41_V0.6040.82
237_R251_L0.6040.82
157_L183_K0.6030.82
244_L251_L0.6020.82
205_V215_A0.5980.81
41_V64_M0.5970.81
206_T209_G0.5970.81
174_N177_Q0.5970.81
62_P101_G0.5950.81
173_V177_Q0.5950.81
165_Q170_H0.5940.81
215_A219_L0.5900.80
250_H255_A0.5880.80
125_Y128_M0.5870.80
174_N178_L0.5810.79
203_L212_G0.5800.79
89_E93_D0.5780.79
254_Q258_P0.5770.79
185_G207_R0.5770.79
59_I82_V0.5760.79
27_F120_V0.5750.79
32_A117_R0.5740.79
194_S208_A0.5740.79
64_M72_H0.5730.78
13_V37_A0.5730.78
217_L221_A0.5720.78
155_K160_L0.5700.78
162_P171_C0.5660.78
92_A96_K0.5640.77
95_A98_L0.5640.77
21_S24_D0.5630.77
166_Q169_S0.5630.77
98_L126_P0.5630.77
172_R175_Y0.5620.77
261_F266_G0.5620.77
115_R118_E0.5590.77
101_G104_D0.5590.77
81_P104_D0.5580.77
40_G62_P0.5570.77
166_Q171_C0.5560.76
13_V69_L0.5540.76
160_L167_V0.5540.76
167_V171_C0.5530.76
47_L51_T0.5520.76
26_W117_R0.5500.76
56_I120_V0.5490.75
183_K186_L0.5440.75
199_A203_L0.5420.75
186_L204_D0.5420.75
152_A155_K0.5420.75
56_I104_D0.5400.74
143_W149_N0.5400.74
103_E116_L0.5380.74
264_L285_T0.5380.74
255_A260_Q0.5370.74
215_A218_L0.5370.74
66_G86_S0.5370.74
56_I116_L0.5360.74
59_I93_D0.5360.74
268_Y272_L0.5360.74
185_G208_A0.5350.74
84_V122_A0.5250.72
86_S90_N0.5250.72
264_L277_L0.5230.72
158_Q165_Q0.5210.72
98_L122_A0.5200.72
96_K99_R0.5200.72
207_R219_L0.5180.71
37_A42_D0.5180.71
207_R211_N0.5170.71
91_M94_I0.5170.71
54_L81_P0.5150.71
94_I99_R0.5130.71
56_I85_I0.5120.70
125_Y129_F0.5110.70
12_I20_R0.5100.70
98_L104_D0.5090.70
203_L261_F0.5080.70
225_G228_Q0.5080.70
27_F34_T0.5060.69
98_L103_E0.5050.69
125_Y130_N0.5040.69
150_P158_Q0.5040.69
99_R112_D0.5040.69
97_A105_V0.5010.69
109_P115_R0.5010.69
70_L106_L0.5010.69
154_A162_P0.5010.69
210_H215_A0.5000.69
120_V124_L0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eq2A 2 0.9763 100 0.209 Contact Map
3breA 4 0.9139 100 0.546 Contact Map
1w25A 2 0.8576 100 0.562 Contact Map
3n0rA 1 0.3739 100 0.586 Contact Map
4g97A 1 0.3976 100 0.586 Contact Map
2ayxA 1 0.3917 100 0.602 Contact Map
4l4uA 2 0.9733 100 0.603 Contact Map
3dzdA 2 0.9258 100 0.604 Contact Map
1s8nA 1 0.549 100 0.606 Contact Map
3lufA 2 0.3828 100 0.614 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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