GREMLIN Database
SKP - Chaperone protein Skp
UniProt: P0AEU7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10455
Length: 161 (157)
Sequences: 2205 (1736)
Seq/√Len: 138.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_Q155_D3.1951.00
130_S159_Q2.7621.00
67_K90_Q2.7271.00
128_A136_V2.6831.00
51_K55_S2.5021.00
49_E108_R2.5001.00
65_Q69_K2.4331.00
108_R111_E2.3141.00
47_E51_K2.2111.00
31_S35_Q2.1981.00
79_D82_K2.1231.00
118_T122_T2.0411.00
38_Q119_R2.0131.00
126_S159_Q2.0051.00
58_Q62_T1.9351.00
83_L86_D1.8761.00
66_A70_K1.8661.00
64_L87_V1.8501.00
77_G81_T1.7801.00
154_A158_K1.7761.00
28_N139_A1.7581.00
44_N47_E1.7561.00
54_A58_Q1.7561.00
81_T85_K1.7341.00
127_V156_V1.6901.00
41_G45_T1.6891.00
62_T66_A1.6881.00
125_K129_N1.6711.00
40_T44_N1.6411.00
146_S149_V1.5071.00
89_A93_T1.4951.00
63_D90_Q1.4851.00
92_Q96_Q1.4771.00
103_Q107_R1.4751.00
85_K89_A1.4721.00
96_Q100_A1.4671.00
82_K86_D1.4621.00
42_V116_L1.4471.00
107_R111_E1.4131.00
114_G118_T1.4061.00
134_D146_S1.3721.00
63_D67_K1.3691.00
60_M97_K1.3651.00
61_E98_A1.3641.00
77_G80_R1.3621.00
53_R104_D1.3341.00
70_K83_L1.3221.00
26_I135_L1.3071.00
71_L84_E1.2941.00
75_K83_L1.2931.00
80_R84_E1.2911.00
112_E115_K1.2831.00
62_T65_Q1.2761.00
55_S59_R1.2671.00
123_A159_Q1.2641.00
61_E65_Q1.2481.00
64_L94_F1.2481.00
137_V142_V1.2381.00
68_M91_R1.2351.00
24_I137_V1.2341.00
67_K86_D1.2211.00
91_R95_A1.2201.00
155_D158_K1.2181.00
60_M93_T1.2111.00
27_V156_V1.2051.00
71_L80_R1.1911.00
81_T84_E1.1911.00
84_E88_M1.1841.00
123_A127_V1.1841.00
32_L157_L1.1821.00
87_V91_R1.1761.00
25_A133_I1.1740.99
31_S154_A1.1570.99
56_E97_K1.1540.99
31_S157_L1.1240.99
31_S153_T1.1110.99
108_R112_E1.0870.99
133_I152_I1.0830.99
60_M90_Q1.0780.99
25_A152_I1.0710.99
133_I136_V1.0650.99
56_E59_R1.0640.99
61_E94_F1.0510.99
122_T125_K1.0470.99
68_M72_Q1.0430.99
32_L120_I1.0330.99
117_V121_Q1.0240.99
43_S47_E1.0190.99
97_K101_F1.0130.99
51_K54_A0.9970.98
64_L68_M0.9870.98
99_Q103_Q0.9710.98
135_L150_K0.9670.98
48_N51_K0.9630.98
109_S113_R0.9570.98
129_N146_S0.9540.98
128_A144_Y0.9450.98
55_S58_Q0.9380.98
136_V152_I0.9310.97
86_D90_Q0.9240.97
69_K72_Q0.9200.97
126_S130_S0.9200.97
68_M71_L0.9170.97
106_A109_S0.9030.97
44_N48_N0.8960.97
57_L94_F0.8890.97
146_S150_K0.8750.96
45_T112_E0.8620.96
60_M63_D0.8490.96
122_T126_S0.8490.96
6_L14_L0.8480.96
57_L98_A0.8380.95
36_V120_I0.8320.95
79_D83_L0.8310.95
100_A104_D0.8170.95
42_V112_E0.8160.94
101_F104_D0.8150.94
94_F98_A0.8150.94
4_W7_A0.8130.94
26_I145_N0.8110.94
48_N52_G0.8080.94
66_A69_K0.8070.94
75_K80_R0.8060.94
60_M94_F0.8050.94
29_M138_D0.7990.94
126_S129_N0.7980.94
19_Q22_D0.7980.94
127_V131_Q0.7970.94
23_K133_I0.7950.94
28_N31_S0.7870.93
36_V39_K0.7860.93
75_K79_D0.7860.93
98_A102_E0.7820.93
25_A136_V0.7790.93
32_L153_T0.7770.93
50_F105_R0.7750.93
121_Q125_K0.7740.93
37_A40_T0.7660.92
53_R101_F0.7630.92
35_Q157_L0.7430.91
6_L10_L0.7410.91
10_L13_A0.7400.91
27_V121_Q0.7370.91
49_E53_R0.7320.91
110_N114_G0.7300.90
57_L97_K0.7280.90
27_V124_V0.7250.90
148_D151_D0.7250.90
77_G84_E0.7170.90
113_R117_V0.7170.90
41_G44_N0.7140.90
11_G14_L0.7130.89
4_W11_G0.7100.89
89_A92_Q0.7090.89
45_T108_R0.7010.89
47_E50_F0.6920.88
24_I149_V0.6820.87
12_L18_A0.6810.87
9_G12_L0.6810.87
27_V153_T0.6750.87
26_I137_V0.6730.87
154_A157_L0.6680.86
102_E106_A0.6650.86
57_L101_F0.6610.86
35_Q40_T0.6610.86
143_A148_D0.6540.85
53_R56_E0.6540.85
93_T96_Q0.6470.84
88_M91_R0.6460.84
127_V152_I0.6400.84
85_K88_M0.6380.84
7_A11_G0.6370.83
29_M124_V0.6340.83
26_I151_D0.6340.83
30_G34_Q0.6330.83
64_L91_R0.6240.82
78_S82_K0.6240.82
11_G16_T0.6200.82
3_K6_L0.6130.81
23_K134_D0.6090.81
13_A16_T0.6090.81
5_L10_L0.6060.80
6_L11_G0.6050.80
142_V145_N0.6010.80
36_V123_A0.5990.80
74_M78_S0.5930.79
115_K119_R0.5910.79
11_G17_S0.5890.78
42_V109_S0.5860.78
71_L87_V0.5850.78
138_D141_A0.5840.78
43_S109_S0.5840.78
46_L105_R0.5790.77
5_L13_A0.5770.77
10_L14_L0.5700.76
25_A127_V0.5690.76
59_R63_D0.5690.76
129_N144_Y0.5680.76
95_A98_A0.5670.76
96_Q99_Q0.5650.76
71_L75_K0.5620.75
60_M64_L0.5610.75
9_G13_A0.5570.74
103_Q106_A0.5510.74
7_A13_A0.5490.73
71_L83_L0.5460.73
6_L13_A0.5450.73
45_T48_N0.5440.73
27_V143_A0.5430.73
56_E60_M0.5420.72
68_M87_V0.5390.72
13_A17_S0.5380.72
88_M92_Q0.5340.71
139_A142_V0.5330.71
28_N151_D0.5320.71
36_V153_T0.5290.71
131_Q152_I0.5280.71
46_L109_S0.5280.71
64_L71_L0.5270.70
58_Q61_E0.5260.70
26_I36_V0.5230.70
93_T97_K0.5210.70
78_S81_T0.5190.69
38_Q42_V0.5180.69
25_A150_K0.5180.69
64_L67_K0.5170.69
132_D146_S0.5160.69
61_E64_L0.5160.69
65_Q72_Q0.5130.68
11_G15_A0.5110.68
120_I153_T0.5090.68
6_L51_K0.5080.68
9_G17_S0.5070.67
65_Q68_M0.5040.67
152_I155_D0.5020.67
36_V157_L0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u2mA 3 0.882 100 0.208 Contact Map
4kqtA 1 0.9317 100 0.248 Contact Map
4cgkA 3 0.6398 94.5 0.832 Contact Map
4q4gX 1 0 91.7 0.849 Contact Map
2dfsA 2 0.7081 25 0.912 Contact Map
1dj7A 1 0.236 24.5 0.913 Contact Map
3a6mA 2 0.6708 23.9 0.913 Contact Map
3layA 5 0.472 21.5 0.915 Contact Map
3zbiC 1 0.1677 17.5 0.918 Contact Map
3zg1A 2 0.6025 15.4 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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