GREMLIN Database
HISM - Histidine transport system permease protein HisM
UniProt: P0AEU3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10007
Length: 238 (206)
Sequences: 18004 (10543)
Seq/√Len: 734.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_S221_F3.3241.00
198_Q201_T3.2111.00
36_I110_T3.1991.00
105_T177_A2.9541.00
136_A146_M2.9271.00
189_A206_A2.8321.00
142_S145_K2.7131.00
24_A28_W2.6841.00
47_G59_I2.5291.00
44_L118_T2.3871.00
132_E154_S2.3791.00
133_I146_M2.2221.00
69_T74_Q2.2131.00
144_F148_R2.1261.00
54_Y58_P2.0961.00
219_S223_R2.0811.00
137_R146_M2.0611.00
44_L114_C2.0051.00
54_Y57_F1.9491.00
187_K191_D1.9121.00
48_R60_W1.8811.00
133_I137_R1.8781.00
40_L114_C1.8101.00
124_A159_A1.7691.00
25_I28_W1.7561.00
20_F24_A1.7471.00
193_N199_P1.7421.00
127_S158_I1.7371.00
32_L106_V1.7261.00
53_K57_F1.7221.00
23_V213_I1.7171.00
100_S103_N1.7131.00
45_A121_F1.7071.00
30_L171_L1.7041.00
28_W102_L1.6991.00
29_L177_A1.6741.00
211_L215_Y1.6661.00
215_Y219_S1.6631.00
189_A202_A1.6631.00
78_F108_A1.6491.00
223_R226_K1.6381.00
142_S146_M1.6361.00
63_T118_T1.6351.00
49_V126_R1.5901.00
21_T24_A1.5691.00
219_S222_R1.5541.00
37_G113_T1.5361.00
119_E122_A1.5101.00
117_T163_Y1.4971.00
34_V167_V1.4921.00
25_I182_V1.4711.00
44_L59_I1.4511.00
143_T147_Y1.4401.00
145_K149_C1.4191.00
18_Y21_T1.4131.00
220_L223_R1.4001.00
30_L174_T1.3801.00
145_K148_R1.3731.00
42_L121_F1.3551.00
52_N57_F1.3341.00
137_R143_T1.3161.00
53_K56_Q1.3011.00
74_Q112_N1.2851.00
43_F47_G1.2801.00
102_L106_V1.2601.00
121_F159_A1.2571.00
141_F145_K1.2531.00
32_L110_T1.2271.00
16_D20_F1.2231.00
66_F111_L1.2221.00
57_F61_L1.2121.00
117_T166_E1.2121.00
69_T112_N1.1891.00
133_I151_I1.1861.00
188_I191_D1.1821.00
39_V43_F1.1811.00
48_R119_E1.1651.00
56_Q60_W1.1591.00
58_P61_L1.1581.00
52_N55_I1.1561.00
193_N203_F1.1541.00
75_L108_A1.1431.00
136_A150_I1.1421.00
28_W32_L1.1291.00
125_I151_I1.1261.00
183_P187_K1.1221.00
120_I166_E1.1051.00
18_Y188_I1.1031.00
187_K190_R1.1031.00
47_G50_S1.0981.00
122_A126_R1.0961.00
21_T25_I1.0921.00
36_I106_V1.0811.00
64_Y215_Y1.0801.00
223_R227_R1.0801.00
106_V110_T1.0751.00
41_A117_T1.0751.00
171_L213_I1.0711.00
49_V125_I1.0601.00
58_P62_F1.0601.00
103_N106_V1.0561.00
120_I162_A1.0451.00
101_G181_T1.0321.00
147_Y152_L1.0161.00
102_L182_V1.0121.00
78_F104_C1.0071.00
59_I118_T1.0061.00
75_L177_A1.0021.00
177_A184_D0.9781.00
128_V155_A0.9751.00
64_Y211_L0.9661.00
61_L64_Y0.9641.00
74_Q78_F0.9591.00
222_R226_K0.9571.00
26_T171_L0.9531.00
190_R193_N0.9501.00
220_L224_A0.9491.00
171_L217_L0.9481.00
143_T146_M0.9451.00
17_G21_T0.9391.00
191_D195_A0.9341.00
192_I202_A0.9321.00
66_F115_A0.9221.00
201_T204_G0.9211.00
30_L167_V0.9161.00
33_S110_T0.9071.00
81_G85_L0.9031.00
34_V170_M0.9031.00
128_V158_I0.9001.00
141_F149_C0.9001.00
169_L173_S0.8981.00
131_G135_A0.8961.00
175_A210_Y0.8891.00
75_L176_L0.8881.00
62_F114_C0.8861.00
222_R225_E0.8671.00
51_S56_Q0.8661.00
171_L214_S0.8641.00
38_G163_Y0.8641.00
147_Y151_I0.8611.00
23_V209_L0.8601.00
45_A49_V0.8581.00
103_N107_L0.8411.00
57_F60_W0.8411.00
47_G55_I0.8401.00
32_L36_I0.8381.00
71_L112_N0.8351.00
71_L173_S0.8261.00
35_V39_V0.8261.00
52_N58_P0.8261.00
113_T166_E0.8261.00
216_V220_L0.8241.00
77_V81_G0.8241.00
101_G182_V0.8211.00
22_G188_I0.8181.00
109_L174_T0.8131.00
76_L80_S0.8091.00
62_F66_F0.8051.00
212_I216_V0.8031.00
133_I143_T0.8001.00
105_T180_A0.7991.00
130_H134_E0.7991.00
196_T199_P0.7981.00
50_S59_I0.7971.00
179_T183_P0.7921.00
48_R63_T0.7881.00
50_S143_T0.7851.00
45_A125_I0.7851.00
79_Y180_A0.7851.00
31_I35_V0.7831.00
158_I162_A0.7821.00
79_Y104_C0.7781.00
204_G208_V0.7761.00
62_F115_A0.7611.00
27_L31_I0.7601.00
23_V185_L0.7551.00
74_Q108_A0.7491.00
177_A182_V0.7431.00
46_I147_Y0.7401.00
26_T30_L0.7391.00
26_T210_Y0.7371.00
113_T173_S0.7371.00
75_L180_A0.7361.00
48_R56_Q0.7351.00
60_W64_Y0.7351.00
185_L209_L0.7351.00
32_L102_L0.7331.00
189_A193_N0.7321.00
125_I155_A0.7301.00
186_L203_F0.7291.00
52_N56_Q0.7231.00
183_P188_I0.7201.00
117_T121_F0.7161.00
72_Y179_T0.7141.00
33_S170_M0.7101.00
25_I184_D0.7051.00
77_V204_G0.7001.00
17_G20_F0.6971.00
208_V212_I0.6951.00
42_L152_L0.6951.00
37_G117_T0.6941.00
193_N202_A0.6921.00
109_L170_M0.6901.00
99_R103_N0.6871.00
161_P225_E0.6851.00
40_L110_T0.6831.00
130_H133_I0.6821.00
40_L44_L0.6821.00
205_I209_L0.6811.00
29_L182_V0.6791.00
186_L206_A0.6741.00
178_F187_K0.6721.00
195_A198_Q0.6661.00
29_L33_S0.6641.00
55_I58_P0.6621.00
186_L210_Y0.6621.00
29_L105_T0.6621.00
124_A158_I0.6611.00
175_A178_F0.6611.00
82_M86_E0.6601.00
175_A186_L0.6571.00
32_L35_V0.6571.00
44_L47_G0.6561.00
121_F125_I0.6531.00
224_A228_W0.6481.00
110_T114_C0.6451.00
25_I102_L0.6441.00
82_M87_I0.6411.00
131_G134_E0.6361.00
29_L174_T0.6291.00
113_T170_M0.6271.00
79_Y99_R0.6241.00
101_G180_A0.6211.00
160_L224_A0.6211.00
125_I147_Y0.6201.00
48_R51_S0.6181.00
33_S109_L0.6181.00
66_F74_Q0.6171.00
113_T117_T0.6141.00
15_T192_I0.6141.00
112_N173_S0.6111.00
218_I222_R0.6101.00
36_I40_L0.6091.00
19_R209_L0.6091.00
160_L228_W0.6061.00
60_W63_T0.6051.00
42_L156_L0.5971.00
200_F204_G0.5961.00
136_A141_F0.5931.00
48_R118_T0.5931.00
81_G84_T0.5911.00
130_H137_R0.5871.00
203_F206_A0.5871.00
36_I39_V0.5851.00
109_L177_A0.5831.00
166_E169_L0.5811.00
79_Y101_G0.5801.00
206_A209_L0.5761.00
38_G121_F0.5751.00
178_F181_T0.5741.00
47_G58_P0.5711.00
44_L62_F0.5701.00
216_V223_R0.5691.00
39_V110_T0.5691.00
39_V42_L0.5681.00
162_A165_N0.5681.00
51_S54_Y0.5681.00
134_E149_C0.5671.00
128_V151_I0.5641.00
151_I154_S0.5631.00
124_A162_A0.5631.00
18_Y22_G0.5611.00
142_S149_C0.5601.00
168_I217_L0.5591.00
30_L34_V0.5591.00
112_N166_E0.5581.00
157_R228_W0.5571.00
105_T182_V0.5571.00
24_A27_L0.5571.00
167_V217_L0.5541.00
217_L221_F0.5531.00
20_F23_V0.5481.00
83_Y99_R0.5451.00
28_W103_N0.5441.00
22_G25_I0.5441.00
72_Y76_L0.5391.00
51_S143_T0.5381.00
211_L214_S0.5351.00
19_R189_A0.5331.00
72_Y176_L0.5321.00
216_V219_S0.5311.00
59_I63_T0.5281.00
18_Y191_D0.5231.00
19_R192_I0.5221.00
78_F81_G0.5201.00
133_I147_Y0.5201.00
168_I214_S0.5201.00
40_L43_F0.5201.00
141_F146_M0.5171.00
65_I69_T0.5131.00
146_M151_I0.5111.00
61_L65_I0.5091.00
50_S56_Q0.5091.00
123_G162_A0.5081.00
59_I62_F0.5071.00
55_I59_I0.5061.00
156_L228_W0.5041.00
50_S53_K0.5010.99
202_A206_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ymuD 2 0.9034 100 0.533 Contact Map
3tuiA 2 0.8782 99.9 0.6 Contact Map
2onkC 2 0.9412 99.9 0.614 Contact Map
3d31C 2 0.9244 99.9 0.628 Contact Map
3rlfF 1 0.9202 99.9 0.631 Contact Map
4tquM 1 0.9496 99.9 0.651 Contact Map
3rlfG 1 0.9622 99.9 0.655 Contact Map
4tquN 1 0.895 99.8 0.692 Contact Map
2kv5A 1 0.1387 7.8 0.961 Contact Map
4gxbB 1 0.0042 7.4 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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