GREMLIN Database
GYRB - DNA gyrase subunit B
UniProt: P0AES6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10424
Length: 804 (793)
Sequences: 1408 (733)
Seq/√Len: 26.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_K74_D11.5941.00
171_P182_F6.0421.00
152_A155_A5.7261.00
139_K159_E5.5531.00
129_K170_W5.3291.00
146_E151_Q5.1731.00
141_H156_V5.0321.00
206_R213_E4.8371.00
44_V191_L4.8231.00
131_E144_I4.6021.00
488_L526_H4.4381.00
139_K156_V4.2941.00
147_H175_T4.1491.00
101_G104_F4.1161.00
91_A132_L4.0781.00
535_Y549_D4.0731.00
485_P524_R3.9721.00
72_Q166_M3.9401.00
346_K350_E3.4471.00
486_D524_R3.4081.00
356_L359_E3.3251.00
538_K543_E3.3101.00
202_S215_H3.2861.00
447_K466_E3.1731.00
627_T631_N3.1521.00
81_G137_E3.0971.00
327_V345_V3.0891.00
43_V120_V3.0191.00
250_I348_A2.9661.00
756_D759_S2.8701.00
293_L361_L2.8561.00
61_V191_L2.8321.00
400_L468_A2.8251.00
128_Q170_W2.8101.00
450_I466_E2.8071.00
184_Y214_D2.7971.00
133_V166_M2.7851.00
414_D417_L2.7801.00
11_K105_D2.7380.99
131_E142_R2.7130.99
276_R338_D2.7020.99
13_L21_K2.6730.99
437_N440_N2.5870.99
412_E417_L2.5780.99
790_A794_E2.5760.99
145_Y150_P2.5730.99
223_K227_E2.5050.99
82_I88_V2.4780.99
394_R397_A2.4740.99
254_V323_V2.4340.99
63_I67_N2.3530.98
795_N798_K2.3490.98
459_D463_S2.3490.98
58_E74_D2.3400.98
242_Y253_E2.3310.98
143_Q150_P2.3230.98
129_K144_I2.3050.98
64_H168_R2.2880.98
431_S747_P2.2780.98
293_L375_I2.2660.98
718_S721_Q2.2590.98
92_E153_P2.2490.98
86_E93_V2.2400.98
63_I205_L2.2000.97
447_K450_I2.1920.97
14_K85_E2.1750.97
521_I527_V2.1630.97
109_Y328_P2.1560.97
83_H93_V2.1480.97
144_I151_Q2.1460.97
494_I762_M2.1340.97
422_L437_N2.1290.97
64_H70_S2.1200.97
772_A775_Q2.1200.97
83_H86_E2.1100.97
48_I201_V2.0990.97
58_E204_R2.0870.96
69_V168_R2.0560.96
761_R770_A2.0450.96
522_V527_V2.0370.96
552_M556_Q2.0370.96
202_S217_H2.0360.96
285_F323_V2.0360.96
113_G273_I2.0350.96
128_Q173_L2.0300.96
91_A134_I2.0120.96
277_D342_S1.9980.95
331_K342_S1.9920.95
654_N657_Q1.9700.95
183_E768_K1.9560.95
224_A227_E1.9530.95
60_I72_Q1.9520.95
422_L470_L1.9500.95
287_A350_E1.9500.95
135_Q140_I1.9370.95
27_I35_G1.9370.95
334_S341_V1.9350.95
105_D108_S1.9340.95
333_S338_D1.9210.94
172_S175_T1.9190.94
708_E713_R1.9080.94
277_D338_D1.8900.94
492_S528_Y1.8800.94
422_L466_E1.8640.93
135_Q162_K1.8530.93
41_F186_I1.8520.93
292_T354_N1.8360.93
44_V71_V1.8350.93
297_M303_S1.8320.93
731_R736_I1.8290.93
129_K146_E1.8230.93
706_F713_R1.8030.92
408_A433_K1.8010.92
245_T352_Q1.8000.92
355_E359_E1.7920.92
12_V86_E1.7300.90
450_I465_Q1.7220.90
447_K465_Q1.7210.90
421_Y755_M1.7150.90
246_E327_V1.7110.90
7_S81_G1.6980.90
63_I69_V1.6890.89
80_T141_H1.6860.89
268_C275_Q1.6850.89
230_N320_I1.6740.89
275_Q341_V1.6710.89
648_K651_V1.6700.89
283_A287_A1.6700.89
222_I515_Y1.6690.89
586_E696_K1.6630.89
295_A299_K1.6530.88
15_G19_V1.6490.88
122_V172_S1.6410.88
270_T275_Q1.6350.88
7_S90_A1.6270.87
254_V353_M1.6110.87
303_S306_A1.6080.87
728_K731_R1.5990.87
654_N660_F1.5890.86
783_D787_P1.5820.86
493_I514_F1.5740.86
88_V92_E1.5720.86
270_T334_S1.5700.85
546_I551_A1.5670.85
189_K274_P1.5640.85
135_Q163_T1.5640.85
447_K731_R1.5630.85
11_K17_D1.5600.85
615_L618_A1.5440.85
557_I584_V1.5360.84
204_R213_E1.5350.84
268_C282_L1.5310.84
752_E756_D1.5290.84
246_E249_G1.5280.84
567_H574_A1.5250.84
575_L703_E1.5170.83
275_Q333_S1.5170.83
608_E611_Y1.5110.83
277_D341_V1.5050.83
133_V168_R1.5040.83
70_S166_M1.5000.83
331_K334_S1.4860.82
275_Q334_S1.4850.82
331_K341_V1.4840.82
256_L767_V1.4700.81
260_D756_D1.4670.81
334_S338_D1.4660.81
11_K14_K1.4660.81
88_V97_V1.4600.81
411_Q438_R1.4550.81
89_S152_A1.4440.80
58_E202_S1.4360.80
418_S526_H1.4230.79
613_P616_T1.4220.79
458_F517_Q1.4200.79
14_K39_M1.4190.79
467_V476_C1.4180.79
297_M375_I1.4150.79
565_T574_A1.4150.79
712_R732_R1.4110.79
133_V140_I1.4110.79
82_I85_E1.4100.79
716_V722_A1.4090.79
364_N367_D1.4080.78
147_H172_S1.4060.78
577_G580_L1.4030.78
128_Q174_E1.4020.78
204_R215_H1.3970.78
285_F321_A1.3960.78
606_L610_I1.3960.78
268_C334_S1.3950.78
520_E524_R1.3940.78
334_S342_S1.3900.78
128_Q147_H1.3820.77
270_T342_S1.3790.77
87_G94_I1.3730.77
275_Q331_K1.3700.77
256_L323_V1.3700.77
391_M471_I1.3690.76
724_D728_K1.3560.76
310_A375_I1.3540.76
231_K775_Q1.3470.75
44_V61_V1.3430.75
71_V167_V1.3410.75
64_H208_K1.3380.75
460_K463_S1.3380.75
552_M736_I1.3360.75
471_I478_I1.3350.75
8_S84_P1.3280.74
15_G18_A1.3230.74
466_E504_S1.3220.74
256_L539_K1.3210.74
86_E97_V1.3130.73
40_V187_L1.3130.73
477_G480_R1.3070.73
135_Q166_M1.3060.73
13_L19_V1.3040.73
318_G378_A1.3040.73
268_C341_V1.3030.73
72_Q162_K1.3030.73
60_I204_R1.3010.73
747_P779_T1.3000.73
56_C294_N1.2980.72
394_R409_D1.2950.72
305_K375_I1.2940.72
570_A573_P1.2940.72
140_I160_T1.2920.72
270_T341_V1.2890.72
277_D333_S1.2850.72
333_S341_V1.2770.71
260_D456_A1.2750.71
24_G342_S1.2690.71
737_Q749_Q1.2650.70
701_L705_A1.2580.70
609_L612_Q1.2530.70
422_L514_F1.2510.70
647_W651_V1.2490.69
419_E494_I1.2450.69
681_F687_Y1.2420.69
466_E747_P1.2420.69
422_L692_T1.2410.69
725_W729_E1.2410.69
285_F353_M1.2400.69
232_N778_T1.2400.69
134_I165_T1.2270.68
270_T331_K1.2140.67
676_P690_I1.2130.67
544_Q558_S1.2110.67
83_H87_G1.2090.67
85_E93_V1.2090.67
510_L514_F1.2060.67
434_Q747_P1.2060.67
43_V273_I1.1970.66
14_K18_A1.1940.66
488_L521_I1.1920.66
10_I15_G1.1910.66
131_E166_M1.1840.65
147_H174_E1.1800.65
62_T70_S1.1770.65
521_I644_G1.1740.65
17_D172_S1.1730.65
287_A346_K1.1700.64
226_V255_A1.1690.64
654_N658_N1.1630.64
717_A721_Q1.1630.64
730_S734_L1.1610.64
643_H646_Q1.1590.64
771_I784_A1.1570.63
39_M172_S1.1540.63
199_S253_E1.1520.63
455_K460_K1.1520.63
133_V142_R1.1510.63
293_L315_A1.1420.62
645_S648_K1.1350.62
67_N181_E1.1350.62
651_V654_N1.1340.62
693_L697_L1.1320.62
396_G399_D1.1310.62
233_K536_K1.1270.61
567_H706_F1.1250.61
623_E627_T1.1220.61
39_M47_A1.1190.61
167_V355_E1.1190.61
11_K21_K1.1190.61
80_T156_V1.1160.61
394_R399_D1.1130.60
172_S275_Q1.1030.60
402_G472_T1.1020.60
156_V159_E1.1010.60
67_N182_F1.1010.60
584_V723_L1.0990.59
12_V93_V1.0970.59
411_Q751_W1.0940.59
243_F254_V1.0920.59
93_V97_V1.0890.59
128_Q146_E1.0880.59
33_G270_T1.0850.58
71_V526_H1.0840.58
643_H648_K1.0800.58
667_R672_D1.0800.58
106_D327_V1.0790.58
485_P521_I1.0790.58
413_R417_L1.0790.58
18_A21_K1.0780.58
681_F684_G1.0750.58
710_G722_A1.0740.58
418_S440_N1.0730.58
17_D224_A1.0690.57
315_A375_I1.0640.57
263_Q266_I1.0600.57
766_T776_L1.0590.56
732_R755_M1.0580.56
402_G793_E1.0550.56
33_G275_Q1.0550.56
222_I322_V1.0530.56
700_L703_E1.0530.56
24_G29_D1.0530.56
24_G334_S1.0520.56
661_E664_V1.0510.56
564_A726_L1.0500.56
366_T369_K1.0500.56
739_Y749_Q1.0490.56
544_Q551_A1.0490.56
272_N540_G1.0480.56
653_T660_F1.0470.56
100_A104_F1.0450.55
142_R155_A1.0430.55
687_Y755_M1.0390.55
687_Y730_S1.0360.55
169_F182_F1.0350.55
719_F722_A1.0330.55
140_I159_E1.0320.55
303_S309_S1.0320.55
394_R414_D1.0320.55
231_K254_V1.0310.54
29_D258_W1.0300.54
468_A483_Y1.0280.54
619_D625_T1.0250.54
308_V526_H1.0220.54
83_H94_I1.0190.54
538_K801_N1.0150.53
230_N257_Q1.0080.53
295_A354_N1.0080.53
195_S470_L1.0070.53
277_D339_K1.0050.53
202_S209_R1.0030.52
546_I552_M1.0030.52
531_Q763_L1.0020.52
784_A790_A1.0010.52
266_I323_V1.0010.52
338_D341_V1.0000.52
222_I229_L0.9980.52
641_E645_S0.9950.52
660_F664_V0.9930.52
228_Y775_Q0.9900.51
97_V143_Q0.9890.51
159_E537_V0.9870.51
447_K586_E0.9860.51
92_E141_H0.9860.51
590_T594_I0.9840.51
18_A24_G0.9820.51
24_G258_W0.9790.51
274_P334_S0.9780.51
30_T331_K0.9740.50
775_Q779_T0.9740.50
422_L563_G0.9700.50
292_T447_K0.9700.50
774_D778_T0.9690.50
60_I206_R0.9690.50
378_A381_A0.9680.50
145_Y152_A0.9670.50
573_P579_A0.9670.50
666_V669_H0.9670.50
412_E447_K0.9660.50
654_N661_E0.9650.50
609_L677_L0.9650.50
418_S422_L0.9620.49
568_T571_S0.9620.49
56_C59_I0.9550.49
747_P751_W0.9540.49
19_V164_G0.9510.49
325_V340_L0.9500.48
560_A726_L0.9480.48
333_S342_S0.9470.48
485_P488_L0.9470.48
50_E102_G0.9440.48
392_T397_A0.9410.48
229_L320_I0.9370.48
383_E387_R0.9370.48
338_D342_S0.9370.48
701_L719_F0.9350.47
82_I87_G0.9340.47
39_M275_Q0.9320.47
39_M334_S0.9320.47
539_K739_Y0.9320.47
170_W173_L0.9310.47
394_R404_P0.9280.47
59_I194_L0.9250.47
451_L461_M0.9240.47
579_A582_K0.9220.46
401_A468_A0.9190.46
31_D334_S0.9190.46
292_T295_A0.9180.46
128_Q292_T0.9180.46
684_G687_Y0.9170.46
110_K273_I0.9160.46
408_A434_Q0.9150.46
768_K772_A0.9140.46
85_E94_I0.9130.46
267_Y771_I0.9110.46
485_P526_H0.9100.46
250_I345_V0.9100.46
270_T333_S0.9090.45
622_D625_T0.9080.45
7_S13_L0.9080.45
133_V157_T0.9080.45
258_W331_K0.9080.45
122_V143_Q0.9070.45
12_V97_V0.9070.45
633_L756_D0.9060.45
684_G723_L0.9040.45
268_C331_K0.9030.45
13_L447_K0.9020.45
18_A99_H0.9010.45
61_V721_Q0.9010.45
297_M310_A0.9000.45
536_K737_Q0.8990.45
74_D162_K0.8970.45
120_V363_E0.8960.44
320_I484_N0.8960.44
686_E693_L0.8960.44
187_L377_D0.8940.44
552_M728_K0.8940.44
666_V762_M0.8940.44
716_V721_Q0.8920.44
50_E54_G0.8920.44
575_L767_V0.8920.44
404_P472_T0.8920.44
681_F693_L0.8920.44
120_V130_L0.8910.44
651_V660_F0.8900.44
12_V83_H0.8900.44
10_I18_A0.8890.44
63_I212_K0.8890.44
24_G277_D0.8870.44
602_P675_Y0.8860.44
294_N315_A0.8850.44
565_T708_E0.8850.44
517_Q520_E0.8840.44
351_Q515_Y0.8840.44
642_Q723_L0.8830.44
504_S779_T0.8820.43
66_D317_E0.8810.43
515_Y537_V0.8810.43
67_N173_L0.8800.43
284_G349_V0.8790.43
504_S538_K0.8760.43
322_V357_L0.8750.43
9_S81_G0.8740.43
239_N364_N0.8740.43
568_T572_A0.8740.43
56_C411_Q0.8710.43
422_L447_K0.8710.43
220_G363_E0.8700.43
359_E363_E0.8700.43
48_I361_L0.8700.43
686_E764_R0.8640.42
722_A726_L0.8640.42
779_T801_N0.8630.42
778_T784_A0.8620.42
703_E727_V0.8600.42
254_V799_A0.8580.42
599_R680_E0.8580.42
458_F462_L0.8550.42
367_D736_I0.8550.42
726_L730_S0.8540.41
12_V122_V0.8530.41
546_I763_L0.8510.41
277_D334_S0.8490.41
52_L326_K0.8480.41
284_G288_A0.8470.41
266_I346_K0.8470.41
720_E724_D0.8460.41
417_L439_K0.8450.41
290_T374_K0.8440.41
322_V762_M0.8440.41
770_A773_A0.8420.41
160_T163_T0.8410.41
121_S130_L0.8410.41
21_K783_D0.8410.41
11_K122_V0.8400.40
81_G470_L0.8390.40
34_T338_D0.8390.40
80_T163_T0.8360.40
234_T260_D0.8340.40
63_I718_S0.8340.40
277_D331_K0.8340.40
399_D412_E0.8310.40
89_S153_P0.8300.40
411_Q797_L0.8280.40
16_L22_R0.8220.39
570_A702_E0.8200.39
228_Y249_G0.8200.39
377_D393_R0.8190.39
290_T312_G0.8180.39
29_D275_Q0.8180.39
391_M478_I0.8160.39
80_T355_E0.8160.39
227_E790_A0.8160.39
24_G338_D0.8160.39
392_T399_D0.8140.39
722_A725_W0.8130.39
652_H655_A0.8120.38
17_D137_E0.8110.38
515_Y602_P0.8110.38
74_D110_K0.8110.38
633_L637_L0.8110.38
422_L446_L0.8100.38
94_I132_L0.8100.38
77_G165_T0.8090.38
290_T381_A0.8080.38
714_Q721_Q0.8080.38
704_D715_P0.8070.38
94_I333_S0.8060.38
39_M341_V0.8060.38
39_M331_K0.8060.38
762_M766_T0.8050.38
438_R538_K0.8040.38
222_I292_T0.8040.38
267_Y778_T0.8000.38
101_G255_A0.8000.38
546_I730_S0.8000.38
485_P518_M0.7990.38
727_V761_R0.7990.38
145_Y292_T0.7970.37
567_H702_E0.7970.37
711_E732_R0.7960.37
606_L613_P0.7960.37
470_L612_Q0.7950.37
420_L720_E0.7950.37
653_T799_A0.7950.37
47_A247_K0.7940.37
27_I430_G0.7930.37
224_A229_L0.7930.37
412_E749_Q0.7930.37
707_I726_L0.7930.37
732_R772_A0.7910.37
557_I794_E0.7900.37
21_K139_K0.7890.37
476_C778_T0.7870.37
735_S799_A0.7870.37
243_F323_V0.7860.37
275_Q342_S0.7850.37
647_W726_L0.7830.36
266_I282_L0.7820.36
721_Q799_A0.7820.36
421_Y494_I0.7820.36
291_R346_K0.7820.36
145_Y321_A0.7820.36
254_V493_I0.7810.36
596_R602_P0.7800.36
284_G327_V0.7800.36
97_V150_P0.7790.36
484_N487_K0.7770.36
619_D622_D0.7760.36
626_V637_L0.7750.36
657_Q664_V0.7740.36
183_E186_I0.7740.36
136_R340_L0.7740.36
247_K352_Q0.7730.36
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626_V631_N0.5130.21
94_I97_V0.5120.20
80_T492_S0.5120.20
157_T588_N0.5120.20
755_M793_E0.5110.20
461_M524_R0.5110.20
493_I570_A0.5110.20
201_V408_A0.5100.20
568_T575_L0.5100.20
224_A584_V0.5100.20
17_D21_K0.5100.20
88_V238_P0.5090.20
728_K748_E0.5090.20
665_R670_G0.5090.20
91_A727_V0.5090.20
137_E526_H0.5090.20
88_V492_S0.5090.20
361_L401_A0.5090.20
83_H401_A0.5090.20
31_D331_K0.5080.20
222_I242_Y0.5080.20
40_V225_F0.5070.20
120_V280_T0.5070.20
714_Q728_K0.5070.20
669_H710_G0.5060.20
37_H112_S0.5060.20
374_K381_A0.5060.20
716_V764_R0.5060.20
262_F313_D0.5050.20
313_D396_G0.5040.20
205_L214_D0.5040.20
167_V222_I0.5040.20
242_Y715_P0.5030.20
439_K759_S0.5030.20
43_V775_Q0.5030.20
172_S333_S0.5030.20
164_G525_G0.5020.20
486_D758_E0.5020.20
630_V634_V0.5020.20
303_S776_L0.5010.20
654_N662_P0.5010.20
218_Y614_T0.5000.20
467_V772_A0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i3hA 2 0.7002 100 0.292 Contact Map
4gfhA 2 0.9142 100 0.33 Contact Map
3nuhB 1 0.4403 100 0.597 Contact Map
3zkbA 5 0.4801 100 0.63 Contact Map
4wubA 2 0.4776 100 0.648 Contact Map
4urlA 1 0.449 100 0.65 Contact Map
3lnuA 1 0.4241 100 0.657 Contact Map
1zxmA 2 0.4341 100 0.661 Contact Map
1pvgA 2 0.4328 100 0.661 Contact Map
1s16A 2 0.4689 100 0.666 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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