GREMLIN Database
GUDD - Glucarate dehydratase
UniProt: P0AES2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13167
Length: 446 (358)
Sequences: 6739 (4141)
Seq/√Len: 218.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_E389_L4.0691.00
279_R308_D3.5991.00
49_H123_L3.3931.00
75_K86_L3.2581.00
14_Q42_I2.7551.00
276_A280_R2.7491.00
193_E226_R2.6791.00
42_I404_M2.6461.00
241_S244_E2.6391.00
302_L334_L2.6121.00
125_G132_V2.5811.00
45_D123_L2.5111.00
44_K50_T2.4421.00
249_G259_A2.4211.00
380_K401_E2.4071.00
249_G282_T2.3581.00
250_K253_K2.3551.00
14_Q44_K2.3451.00
52_V402_I2.3391.00
12_E44_K2.3301.00
193_E197_E2.2931.00
246_I281_A2.2911.00
271_G274_V2.2681.00
295_W321_G2.2481.00
277_E280_R2.2321.00
45_D49_H2.2301.00
253_K283_G2.2181.00
117_E320_Q2.2171.00
317_W325_V2.1891.00
185_P189_V2.1881.00
49_H127_H2.1871.00
273_E304_L2.1241.00
9_V46_N2.1131.00
42_I50_T2.0641.00
146_E202_N2.0521.00
299_G303_S2.0411.00
13_M43_I1.9961.00
189_V226_R1.9691.00
126_Q401_E1.9541.00
196_Y230_A1.9331.00
79_E82_N1.8741.00
242_L278_F1.8711.00
184_T187_A1.8531.00
277_E281_A1.8481.00
303_S332_F1.8461.00
221_V225_Q1.8461.00
248_I252_L1.8421.00
263_C278_F1.8231.00
276_A304_L1.7971.00
386_K391_Q1.7951.00
140_Q143_S1.7791.00
217_A251_Y1.7601.00
16_I42_I1.7551.00
144_E391_Q1.7451.00
251_Y254_G1.7251.00
253_K284_L1.7141.00
300_H304_L1.6851.00
75_K82_N1.6711.00
222_A225_Q1.6661.00
298_M325_V1.6531.00
132_V398_L1.6421.00
130_V134_S1.6401.00
19_A35_F1.6371.00
43_I120_M1.6361.00
11_T46_N1.6151.00
227_F232_I1.5881.00
301_T307_V1.5831.00
11_T44_K1.5731.00
49_H126_Q1.5631.00
187_A190_R1.5461.00
242_L277_E1.5361.00
221_V254_G1.5281.00
356_A392_V1.5191.00
204_F230_A1.5111.00
45_D127_H1.5091.00
302_L328_M1.5061.00
324_R330_H1.4931.00
16_I411_H1.4841.00
75_K83_V1.4751.00
322_S354_V1.4751.00
190_R193_E1.4741.00
380_K403_D1.4701.00
78_G127_H1.4671.00
83_V87_V1.4661.00
124_L128_L1.4611.00
327_Q330_H1.4471.00
212_A215_E1.4341.00
125_G135_L1.4241.00
321_G324_R1.4221.00
246_I278_F1.4221.00
55_I115_G1.4121.00
13_M69_I1.4111.00
81_K324_R1.4081.00
207_K237_N1.4031.00
218_E221_V1.4031.00
117_E121_L1.3881.00
298_M310_P1.3841.00
404_M408_M1.3671.00
76_T79_E1.3581.00
381_E395_K1.3551.00
41_V115_G1.3541.00
132_V319_M1.3541.00
323_V327_Q1.3461.00
192_A227_F1.3341.00
206_L223_L1.3271.00
40_I407_V1.3261.00
406_Q409_K1.3231.00
47_S127_H1.3161.00
220_I234_L1.3011.00
263_C274_V1.3001.00
40_I346_I1.3001.00
300_H303_S1.2961.00
78_G124_L1.2931.00
287_A311_L1.2871.00
12_E69_I1.2781.00
231_R257_A1.2721.00
27_N32_H1.2711.00
192_A204_F1.2671.00
196_Y204_F1.2661.00
233_T257_A1.2631.00
87_V113_V1.2621.00
186_D190_R1.2581.00
75_K79_E1.2561.00
194_A199_Y1.2551.00
288_T301_T1.2501.00
81_K323_V1.2421.00
402_I407_V1.2371.00
253_K282_T1.2371.00
83_V86_L1.2331.00
234_L256_L1.2281.00
293_T297_Q1.2221.00
273_E300_H1.2221.00
146_E389_L1.2201.00
193_E196_Y1.2171.00
46_N77_L1.2151.00
131_N134_S1.2111.00
406_Q410_A1.2101.00
313_D339_H1.1971.00
250_K281_A1.1941.00
218_E222_A1.1901.00
224_A232_I1.1851.00
63_K66_E1.1801.00
302_L332_F1.1761.00
250_K283_G1.1681.00
13_M72_V1.1671.00
227_F230_A1.1601.00
121_L320_Q1.1601.00
69_I73_V1.1521.00
350_M398_L1.1491.00
256_L284_L1.1461.00
215_E218_E1.1421.00
224_A229_Q1.1351.00
189_V227_F1.1351.00
43_I72_V1.1251.00
247_K251_Y1.1221.00
326_A358_A1.1201.00
82_N86_L1.1131.00
223_L227_F1.1121.00
312_A322_S1.1081.00
217_A221_V1.1071.00
403_D406_Q1.1041.00
144_E387_G1.1011.00
307_V310_P1.0971.00
261_D311_L1.0971.00
78_G128_L1.0931.00
130_V135_L1.0881.00
134_S394_E1.0821.00
279_R305_Q1.0791.00
118_A350_M1.0771.00
275_M288_T1.0771.00
42_I52_V1.0751.00
330_H359_P1.0691.00
208_G236_P1.0651.00
190_R194_A1.0611.00
194_A197_E1.0511.00
278_F286_T1.0361.00
317_W322_S1.0341.00
126_Q395_K1.0321.00
314_P322_S1.0301.00
189_V193_E1.0291.00
206_L220_I1.0261.00
352_T392_V1.0251.00
80_Y124_L1.0211.00
192_A223_L1.0211.00
68_A116_I1.0211.00
203_D233_T1.0191.00
272_R301_T1.0181.00
294_D297_Q1.0171.00
68_A87_V1.0161.00
128_L135_L1.0101.00
302_L310_P1.0061.00
222_A226_R1.0031.00
213_G248_I1.0021.00
405_D408_M1.0001.00
236_P259_A0.9981.00
204_F227_F0.9931.00
323_V357_A0.9921.00
185_P222_A0.9881.00
287_A309_I0.9831.00
220_I252_L0.9821.00
195_A199_Y0.9821.00
217_A254_G0.9821.00
129_G396_P0.9801.00
189_V225_Q0.9721.00
133_A392_V0.9711.00
65_L70_P0.9691.00
40_I52_V0.9561.00
299_G332_F0.9531.00
240_W248_I0.9531.00
149_G201_F0.9501.00
228_P255_S0.9471.00
214_E251_Y0.9471.00
295_W328_M0.9331.00
292_A298_M0.9331.00
324_R327_Q0.9321.00
297_Q300_H0.9260.99
242_L263_C0.9250.99
136_L319_M0.9240.99
65_L69_I0.9230.99
246_I282_T0.9220.99
263_C275_M0.9210.99
15_V62_R0.9200.99
189_V222_A0.9130.99
349_A400_V0.9120.99
39_N62_R0.9040.99
282_T286_T0.9000.99
185_P218_E0.8980.99
242_L274_V0.8960.99
277_E305_Q0.8910.99
76_T134_S0.8900.99
240_W259_A0.8880.99
144_E386_K0.8840.99
319_M354_V0.8820.99
120_M124_L0.8820.99
246_I277_E0.8810.99
44_K47_S0.8790.99
77_L120_M0.8780.99
193_E227_F0.8760.99
408_M411_H0.8760.99
65_L116_I0.8750.99
272_R306_S0.8740.99
233_T258_Y0.8640.99
346_I400_V0.8620.99
209_G216_E0.8610.99
328_M332_F0.8600.99
124_L135_L0.8580.99
404_M407_V0.8580.99
299_G328_M0.8530.99
79_E134_S0.8510.99
385_I390_V0.8490.99
356_A393_P0.8490.99
83_V120_M0.8470.99
190_R226_R0.8470.99
71_L86_L0.8470.99
214_E218_E0.8460.99
72_V116_I0.8400.99
84_L320_Q0.8390.99
319_M323_V0.8380.99
381_E401_E0.8380.99
279_R286_T0.8380.99
15_V65_L0.8350.99
189_V192_A0.8340.99
224_A228_P0.8320.99
310_P329_C0.8300.99
189_V223_L0.8290.99
386_K389_L0.8260.99
133_A394_E0.8250.99
192_A226_R0.8230.99
395_K401_E0.8220.99
149_G195_A0.8220.99
289_N313_D0.8210.99
196_Y226_R0.8190.99
16_I408_M0.8150.99
140_Q394_E0.8130.99
376_Q406_Q0.8130.99
203_D231_R0.8100.99
246_I250_K0.8090.99
125_G128_L0.8090.99
236_P240_W0.8070.99
10_V43_I0.8050.99
84_L117_E0.8040.99
72_V83_V0.8030.99
50_T401_E0.7990.98
19_A37_T0.7970.98
67_D70_P0.7950.98
44_K52_V0.7950.98
88_R321_G0.7940.98
280_R305_Q0.7910.98
123_L127_H0.7910.98
87_V116_I0.7880.98
314_P351_F0.7870.98
261_D289_N0.7860.98
122_D126_Q0.7860.98
64_T112_V0.7860.98
196_Y227_F0.7850.98
243_N247_K0.7800.98
367_T370_I0.7800.98
84_L87_V0.7730.98
272_R300_H0.7690.98
314_P354_V0.7690.98
292_A297_Q0.7670.98
262_P286_T0.7670.98
202_N229_Q0.7660.98
9_V76_T0.7640.98
125_G130_V0.7630.98
311_L339_H0.7630.98
17_P37_T0.7620.98
288_T307_V0.7590.98
292_A301_T0.7580.98
125_G396_P0.7570.98
391_Q394_E0.7550.98
66_E69_I0.7540.98
11_T45_D0.7540.98
330_H360_G0.7540.98
143_S394_E0.7530.98
305_Q334_L0.7530.98
202_N387_G0.7490.98
188_V219_S0.7470.98
134_S140_Q0.7450.98
312_A336_W0.7430.98
349_A352_T0.7430.98
242_L246_I0.7410.98
62_R65_L0.7400.97
124_L127_H0.7390.97
77_L123_L0.7360.97
276_A306_S0.7330.97
216_E240_W0.7320.97
224_A255_S0.7280.97
214_E247_K0.7200.97
192_A222_A0.7190.97
50_T126_Q0.7190.97
147_M390_V0.7190.97
234_L252_L0.7190.97
63_K67_D0.7150.97
319_M350_M0.7140.97
88_R113_V0.7130.97
69_I116_I0.7120.97
68_A91_F0.7110.97
53_G115_G0.7060.97
84_L88_R0.7020.97
352_T390_V0.7000.96
47_S77_L0.6960.96
383_F390_V0.6950.96
154_V187_A0.6950.96
384_E391_Q0.6920.96
225_Q228_P0.6900.96
62_R66_E0.6820.96
46_N49_H0.6800.96
208_G234_L0.6720.96
323_V358_A0.6710.96
366_D370_I0.6710.96
133_A353_H0.6700.95
80_Y87_V0.6690.95
191_L194_A0.6690.95
146_E231_R0.6690.95
133_A140_Q0.6640.95
251_Y255_S0.6610.95
55_I111_H0.6600.95
275_M286_T0.6590.95
273_E303_S0.6580.95
272_R304_L0.6550.95
121_L132_V0.6550.95
368_H372_Q0.6510.95
345_D379_T0.6490.95
17_P62_R0.6480.95
77_L80_Y0.6470.95
213_G217_A0.6470.95
66_E70_P0.6430.94
257_A285_P0.6420.94
366_D369_W0.6420.94
214_E228_P0.6410.94
249_G284_L0.6390.94
370_I373_E0.6380.94
128_L131_N0.6370.94
11_T47_S0.6370.94
196_Y229_Q0.6360.94
214_E221_V0.6350.94
256_L259_A0.6340.94
244_E247_K0.6310.94
247_K250_K0.6290.94
83_V116_I0.6280.94
405_D409_K0.6260.94
238_G265_A0.6260.94
273_E276_A0.6250.94
52_V346_I0.6240.93
52_V404_M0.6210.93
340_S348_L0.6200.93
298_M312_A0.6190.93
150_Y207_K0.6180.93
224_A230_A0.6180.93
223_L226_R0.6160.93
276_A305_Q0.6150.93
132_V323_V0.6140.93
77_L127_H0.6130.93
215_E219_S0.6120.93
118_A346_I0.6120.93
369_W372_Q0.6120.93
72_V120_M0.6120.93
335_T362_I0.6100.93
131_N353_H0.6090.93
126_Q398_L0.6080.93
318_T321_G0.6080.93
80_Y83_V0.6070.93
68_A113_V0.6050.92
311_L338_S0.6050.92
186_D189_V0.6040.92
217_A252_L0.6030.92
118_A315_H0.6020.92
253_K256_L0.6020.92
346_I402_I0.6020.92
65_L112_V0.5990.92
352_T393_P0.5990.92
247_K255_S0.5990.92
186_D222_A0.5970.92
326_A360_G0.5950.92
56_P315_H0.5920.92
289_N311_L0.5920.92
258_Y337_G0.5910.92
151_L195_A0.5910.92
245_A263_C0.5900.91
28_L33_A0.5900.91
217_A220_I0.5890.91
296_R300_H0.5890.91
24_M191_L0.5880.91
275_M278_F0.5870.91
121_L125_G0.5860.91
16_I52_V0.5850.91
93_D109_T0.5830.91
310_P334_L0.5810.91
302_L329_C0.5810.91
57_G111_H0.5800.91
271_G333_G0.5800.91
202_N389_L0.5790.91
381_E384_E0.5770.91
61_I65_L0.5770.91
261_D290_M0.5760.90
131_N135_L0.5760.90
64_T108_T0.5750.90
278_F281_A0.5750.90
298_M329_C0.5720.90
349_A398_L0.5700.90
132_V136_L0.5700.90
365_I368_H0.5690.90
12_E46_N0.5680.90
245_A249_G0.5680.90
13_M116_I0.5670.90
28_L31_A0.5670.90
322_S338_S0.5670.90
289_N339_H0.5660.90
78_G82_N0.5640.90
71_L90_T0.5630.89
124_L134_S0.5600.89
202_N388_G0.5600.89
85_T141_Q0.5600.89
311_L337_G0.5590.89
214_E229_Q0.5590.89
41_V116_I0.5590.89
85_T89_N0.5590.89
329_C334_L0.5580.89
279_R306_S0.5580.89
261_D291_I0.5570.89
245_A259_A0.5550.89
46_N127_H0.5540.89
292_A310_P0.5530.89
25_L33_A0.5530.89
295_W299_G0.5520.89
208_G240_W0.5500.88
328_M331_E0.5500.88
191_L195_A0.5500.88
379_T382_P0.5490.88
266_E296_R0.5480.88
118_A132_V0.5480.88
153_F219_S0.5470.88
15_V39_N0.5460.88
118_A398_L0.5460.88
329_C336_W0.5450.88
25_L32_H0.5450.88
39_N55_I0.5430.88
22_D36_F0.5420.88
315_H341_N0.5410.88
39_N61_I0.5390.87
148_L311_L0.5370.87
123_L126_Q0.5370.87
51_G119_A0.5360.87
52_V126_Q0.5350.87
71_L75_K0.5340.87
376_Q380_K0.5340.87
213_G244_E0.5320.87
241_S335_T0.5310.87
121_L319_M0.5300.86
349_A353_H0.5280.86
289_N338_S0.5270.86
114_T118_A0.5270.86
131_N395_K0.5270.86
347_S351_F0.5270.86
295_W324_R0.5270.86
336_W358_A0.5260.86
58_G341_N0.5260.86
125_G398_L0.5250.86
220_I256_L0.5240.86
250_K254_G0.5240.86
207_K235_D0.5230.86
148_L339_H0.5220.86
263_C288_T0.5210.86
148_L233_T0.5210.86
111_H316_F0.5190.85
54_E344_F0.5190.85
275_M307_V0.5190.85
296_R299_G0.5160.85
327_Q331_E0.5160.85
20_G344_F0.5160.85
242_L273_E0.5150.85
64_T91_F0.5150.85
355_A361_K0.5150.85
285_P309_I0.5140.85
353_H398_L0.5140.85
320_Q323_V0.5140.85
131_N392_V0.5130.85
206_L219_S0.5120.85
43_I123_L0.5120.85
57_G316_F0.5110.84
357_A360_G0.5110.84
259_A282_T0.5100.84
78_G130_V0.5100.84
217_A248_I0.5100.84
10_V13_M0.5090.84
85_T359_P0.5070.84
85_T324_R0.5060.84
254_G283_G0.5050.84
80_Y120_M0.5050.84
21_H410_A0.5040.84
258_Y289_N0.5040.84
258_Y339_H0.5010.83
149_G152_F0.5010.83
259_A284_L0.5010.83
154_V191_L0.5000.83
221_V251_Y0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mznA 2 0.9776 100 0.243 Contact Map
3p0wA 2 0.9372 100 0.249 Contact Map
3pfrA 2 0.9372 100 0.251 Contact Map
4hyrA 4 0.9596 100 0.257 Contact Map
4g8tA 3 0.9798 100 0.269 Contact Map
3vdgA 2 0.9327 100 0.296 Contact Map
3vc5A 2 0.917 100 0.302 Contact Map
4it1A 3 0.9395 100 0.308 Contact Map
3va8A 2 0.9283 100 0.31 Contact Map
3s5sA 2 0.7937 100 0.329 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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