GREMLIN Database
GLTS - Sodium/glutamate symport carrier protein
UniProt: P0AER8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10406
Length: 401 (385)
Sequences: 1076 (769)
Seq/√Len: 39.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_I316_F5.1991.00
334_D367_S5.1661.00
23_L27_V4.4691.00
107_M316_F4.2311.00
327_R331_K4.0951.00
28_S32_K3.9761.00
145_S158_T3.8531.00
325_T342_H3.8451.00
24_V40_A3.4431.00
112_G126_G3.4141.00
295_K298_E3.3031.00
133_T141_G3.2681.00
182_Y322_I3.1841.00
138_H169_L3.1071.00
52_L58_W2.9571.00
181_R185_K2.9331.00
47_L51_V2.8751.00
141_G161_A2.8551.00
317_M321_A2.7561.00
98_L381_F2.6981.00
182_Y186_H2.6191.00
27_V30_L2.5491.00
171_L314_T2.5351.00
128_L148_F2.4741.00
112_G116_A2.4301.00
83_N263_S2.3801.00
22_K26_S2.3711.00
227_C258_L2.3711.00
102_V385_V2.3071.00
77_T224_I2.2951.00
115_M312_V2.2661.00
317_M346_G2.2401.00
33_Y174_L2.2360.99
234_V254_V2.2270.99
94_V372_L2.1800.99
167_F310_L2.1630.99
5_D8_A2.1530.99
16_T45_V2.1230.99
119_L308_A2.1140.99
132_I148_F2.0870.99
237_L240_G2.0720.99
170_V174_L2.0580.99
25_H31_K1.9990.99
138_H349_A1.9920.99
341_G357_M1.9520.99
97_F345_F1.9420.99
28_S31_K1.9240.98
189_T336_A1.9150.98
30_L40_A1.9040.98
146_K150_E1.8780.98
100_V328_M1.8760.98
14_T285_L1.8480.98
135_S342_H1.8400.98
248_F352_T1.7860.97
129_A306_M1.7820.97
319_L323_F1.7370.97
110_A114_G1.7370.97
138_H166_T1.7290.97
141_G145_S1.7290.97
184_V336_A1.7200.97
162_M217_L1.7040.97
116_A126_G1.7020.97
29_F33_Y1.6850.96
145_S153_G1.6830.96
40_A290_A1.6670.96
105_L135_S1.6490.96
99_I103_G1.6290.96
11_V229_T1.5890.95
136_G246_P1.5640.94
83_N259_S1.5590.94
127_L132_I1.5500.94
367_S370_A1.5490.94
129_A309_I1.5280.94
182_Y185_K1.5280.94
67_R290_A1.5110.93
115_M308_A1.5110.93
136_G166_T1.5060.93
95_G99_I1.4850.93
64_M67_R1.4780.93
15_L48_A1.4720.92
259_S263_S1.4710.92
26_S31_K1.4660.92
167_F314_T1.4580.92
44_L47_L1.4480.92
308_A324_V1.4360.91
15_L19_L1.4250.91
80_L220_T1.4010.90
177_G359_A1.4010.90
300_A303_A1.3910.90
135_S325_T1.3860.90
32_K181_R1.3760.90
76_A228_L1.3630.89
224_I276_S1.3620.89
220_T274_A1.3540.89
184_V189_T1.3410.88
67_R71_M1.3370.88
249_V360_I1.3300.88
26_S29_F1.3280.88
250_C259_S1.3250.88
249_V380_F1.3200.88
152_Y394_L1.3200.88
261_G265_M1.3110.87
51_V55_S1.3010.87
235_A250_C1.3010.87
142_A161_A1.2940.87
5_D275_V1.2860.86
175_I318_A1.2850.86
23_L44_L1.2850.86
87_L381_F1.2800.86
302_L305_P1.2750.86
45_V49_L1.2710.86
256_V384_I1.2690.85
8_A229_T1.2640.85
164_C306_M1.2580.85
322_I327_R1.2540.85
236_Q240_G1.2370.84
198_E206_P1.2350.84
169_L349_A1.2330.84
69_P141_G1.2310.84
50_L54_K1.2300.84
17_L218_I1.2270.83
145_S148_F1.2200.83
287_L291_L1.2190.83
138_H165_A1.2180.83
361_T366_P1.2140.83
111_I312_V1.2040.82
376_M381_F1.2000.82
245_L387_A1.1900.81
129_A164_C1.1820.81
180_A360_I1.1750.81
249_V384_I1.1750.81
290_A350_T1.1720.80
318_A322_I1.1530.79
168_G176_G1.1390.79
24_V37_E1.1350.78
166_T246_P1.1330.78
345_F386_N1.1250.78
114_G118_L1.1210.77
183_L321_A1.1210.77
248_F255_G1.1200.77
112_G121_L1.1180.77
186_H266_G1.1170.77
7_L77_T1.1140.77
53_K297_W1.1100.77
83_N86_S1.1090.77
153_G300_A1.1090.77
98_L382_I1.1090.77
227_C367_S1.1050.76
23_L40_A1.0990.76
17_L21_R1.0970.76
26_S32_K1.0960.76
224_I278_L1.0900.75
134_L312_V1.0880.75
148_F294_L1.0870.75
26_S315_I1.0810.75
390_I393_Y1.0790.75
121_L302_L1.0730.74
217_L220_T1.0710.74
320_Y324_V1.0640.74
111_I285_L1.0600.73
16_T292_M1.0520.73
367_S375_P1.0510.73
391_K395_M1.0500.73
22_K223_L1.0490.73
142_A290_A1.0390.72
150_E155_T1.0370.72
67_R294_L1.0350.72
98_L102_V1.0290.71
179_V321_A1.0270.71
73_A282_S1.0260.71
71_M248_F1.0230.71
252_L255_G1.0140.70
69_P148_F1.0140.70
262_L388_L1.0120.70
80_L380_F1.0090.70
230_V254_V1.0070.69
296_L300_A1.0010.69
172_G352_T0.9990.69
58_W312_V0.9970.69
252_L352_T0.9930.68
388_L392_L0.9900.68
276_S279_G0.9850.68
124_L154_F0.9840.68
73_A228_L0.9810.67
118_L239_A0.9750.67
136_G169_L0.9740.67
100_V357_M0.9720.67
237_L241_T0.9720.67
332_N335_A0.9670.66
75_F248_F0.9660.66
52_L60_V0.9570.65
262_L267_F0.9530.65
220_T271_F0.9510.65
287_L297_W0.9500.65
16_T40_A0.9500.65
353_A356_N0.9480.65
134_L353_A0.9460.64
225_A285_L0.9350.64
140_T383_D0.9330.63
73_A225_A0.9330.63
128_L152_Y0.9290.63
101_V135_S0.9240.63
19_L44_L0.9230.63
34_T364_F0.9190.62
334_D341_G0.9140.62
77_T279_G0.9140.62
304_L382_I0.9130.62
240_G319_L0.9120.62
136_G140_T0.9100.61
133_T162_M0.9090.61
8_A232_K0.9070.61
311_V315_I0.9040.61
50_L160_V0.9020.61
388_L391_K0.9010.61
79_G259_S0.9000.61
367_S371_F0.9000.61
136_G283_L0.8990.61
35_I169_L0.8980.60
332_N369_M0.8960.60
138_H142_A0.8950.60
73_A224_I0.8940.60
187_S331_K0.8900.60
111_I147_L0.8890.60
329_M345_F0.8870.59
326_W335_A0.8850.59
98_L134_L0.8810.59
164_C310_L0.8800.59
48_A118_L0.8750.58
140_T148_F0.8730.58
70_L282_S0.8710.58
226_I258_L0.8690.58
289_M363_R0.8670.58
254_V257_I0.8670.58
166_T169_L0.8660.58
234_V385_V0.8650.58
128_L161_A0.8620.57
119_L309_I0.8620.57
72_L228_L0.8620.57
371_F375_P0.8610.57
293_G349_A0.8560.57
118_L206_P0.8560.57
29_F174_L0.8550.57
312_V316_F0.8530.56
70_L285_L0.8500.56
115_M309_I0.8490.56
165_A305_P0.8480.56
80_L327_R0.8460.56
172_G225_A0.8440.56
107_M312_V0.8430.56
113_I393_Y0.8430.56
380_F384_I0.8430.56
317_M343_C0.8420.55
97_F342_H0.8390.55
97_F131_S0.8380.55
186_H199_V0.8370.55
52_L57_G0.8350.55
228_L248_F0.8340.55
80_L256_V0.8320.55
21_R254_V0.8300.54
37_E252_L0.8300.54
16_T19_L0.8290.54
205_K362_E0.8290.54
95_G373_V0.8280.54
39_V157_A0.8250.54
174_L188_T0.8240.54
374_V378_G0.8200.53
288_A292_M0.8190.53
22_K261_G0.8190.53
118_L200_P0.8180.53
191_N230_V0.8170.53
158_T162_M0.8160.53
184_V364_F0.8150.53
14_T222_A0.8130.53
15_L226_I0.8080.52
253_F257_I0.8080.52
97_F329_M0.8070.52
170_V388_L0.8060.52
199_V331_K0.8040.52
88_R150_E0.8030.52
221_I285_L0.8010.52
172_G349_A0.7960.51
23_L185_K0.7960.51
279_G376_M0.7940.51
231_G242_A0.7930.51
128_L154_F0.7920.51
38_P90_G0.7900.51
263_S275_V0.7890.51
70_L73_A0.7890.51
170_V253_F0.7880.51
300_A305_P0.7840.50
4_L132_I0.7840.50
120_G390_I0.7830.50
203_F206_P0.7800.50
231_G246_P0.7800.50
229_T233_I0.7800.50
129_A313_Q0.7800.50
343_C356_N0.7790.50
227_C231_G0.7760.49
100_V382_I0.7760.49
92_R233_I0.7760.49
114_G208_V0.7630.48
236_Q308_A0.7620.48
172_G317_M0.7600.48
123_P172_G0.7590.48
52_L56_M0.7510.47
90_G94_V0.7500.47
312_V347_L0.7470.47
105_L131_S0.7450.47
128_L248_F0.7430.47
70_L382_I0.7420.46
346_G351_P0.7390.46
22_K47_L0.7390.46
254_V379_A0.7350.46
380_F383_D0.7320.46
202_A393_Y0.7320.46
252_L378_G0.7300.45
234_V261_G0.7300.45
338_L374_V0.7250.45
17_L126_G0.7230.45
33_Y381_F0.7230.45
104_L111_I0.7230.45
31_K207_D0.7230.45
209_G331_K0.7210.45
44_L53_K0.7210.45
106_V110_A0.7210.45
43_L47_L0.7200.44
104_L161_A0.7170.44
197_Q308_A0.7160.44
120_G153_G0.7150.44
142_A166_T0.7150.44
19_L261_G0.7150.44
361_T365_G0.7150.44
74_F136_G0.7150.44
13_A289_M0.7120.44
273_R311_V0.7110.44
249_V352_T0.7090.43
236_Q239_A0.7090.43
246_P283_L0.7020.43
138_H296_L0.7010.43
133_T164_C0.7010.43
325_T329_M0.6990.43
140_T386_N0.6990.43
58_W61_N0.6970.42
384_I388_L0.6960.42
133_T380_F0.6960.42
115_M118_L0.6920.42
114_G205_K0.6920.42
6_T65_S0.6910.42
180_A349_A0.6900.42
376_M383_D0.6900.42
381_F388_L0.6890.42
217_L278_L0.6890.42
105_L320_Y0.6870.42
72_L247_T0.6840.41
164_C293_G0.6820.41
19_L146_K0.6810.41
156_N298_E0.6780.41
304_L307_L0.6770.41
155_T186_H0.6760.41
314_T321_A0.6750.40
144_W259_S0.6750.40
24_V180_A0.6730.40
128_L132_I0.6720.40
353_A394_L0.6710.40
195_D307_L0.6700.40
240_G315_I0.6690.40
197_Q261_G0.6690.40
269_R294_L0.6680.40
98_L377_V0.6680.40
97_F386_N0.6670.40
60_V326_W0.6660.40
29_F236_Q0.6650.40
15_L315_I0.6640.39
218_I382_I0.6640.39
89_A195_D0.6630.39
218_I376_M0.6620.39
30_L178_P0.6590.39
64_M68_D0.6580.39
76_A227_C0.6560.39
203_F211_M0.6550.39
337_V360_I0.6540.39
179_V199_V0.6520.38
294_L357_M0.6510.38
279_G346_G0.6490.38
188_T334_D0.6490.38
33_Y212_I0.6490.38
103_G261_G0.6480.38
110_A200_P0.6480.38
303_A306_M0.6450.38
79_G283_L0.6450.38
23_L35_I0.6440.38
103_G320_Y0.6420.38
18_L64_M0.6420.38
94_V97_F0.6400.37
252_L357_M0.6390.37
142_A159_E0.6370.37
22_K265_M0.6370.37
345_F349_A0.6350.37
94_V161_A0.6320.37
377_V385_V0.6320.37
143_A246_P0.6290.37
74_F333_Y0.6290.37
30_L35_I0.6280.36
143_A353_A0.6270.36
291_L350_T0.6250.36
358_Q361_T0.6250.36
290_A341_G0.6250.36
109_N131_S0.6240.36
222_A280_N0.6230.36
25_H29_F0.6230.36
178_P333_Y0.6210.36
145_S355_A0.6200.36
71_M290_A0.6190.36
157_A238_L0.6180.36
74_F283_L0.6180.36
186_H300_A0.6160.35
244_E391_K0.6150.35
294_L329_M0.6150.35
166_T283_L0.6150.35
283_L341_G0.6140.35
228_L255_G0.6130.35
108_Q348_G0.6110.35
316_F320_Y0.6100.35
44_L155_T0.6080.35
271_F277_V0.6080.35
225_A361_T0.6060.35
43_L265_M0.6050.35
144_W387_A0.6050.35
325_T337_V0.6050.35
38_P67_R0.6040.34
160_V309_I0.6030.34
36_P42_G0.6020.34
140_T296_L0.6020.34
269_R276_S0.6000.34
62_F222_A0.6000.34
21_R25_H0.5990.34
377_V393_Y0.5990.34
44_L171_L0.5970.34
83_N228_L0.5960.34
47_L52_L0.5960.34
9_T60_V0.5930.34
271_F274_A0.5930.34
208_V220_T0.5920.33
258_L282_S0.5920.33
79_G178_P0.5910.33
29_F32_K0.5890.33
182_Y188_T0.5870.33
35_I177_G0.5840.33
136_G245_L0.5830.33
126_G353_A0.5820.33
260_N287_L0.5800.32
68_D304_L0.5790.32
28_S230_V0.5790.32
186_H322_I0.5790.32
42_G168_G0.5780.32
32_K234_V0.5760.32
44_L215_L0.5760.32
39_V291_L0.5760.32
154_F157_A0.5750.32
126_G148_F0.5750.32
148_F248_F0.5750.32
375_P378_G0.5740.32
235_A254_V0.5730.32
140_T248_F0.5730.32
101_V342_H0.5710.32
140_T246_P0.5710.32
10_L393_Y0.5710.32
104_L317_M0.5700.32
178_P370_A0.5680.32
76_A251_V0.5670.31
186_H189_T0.5670.31
221_I225_A0.5660.31
5_D114_G0.5660.31
19_L85_A0.5660.31
47_L206_P0.5650.31
291_L294_L0.5650.31
96_I198_E0.5640.31
162_M247_T0.5620.31
69_P133_T0.5620.31
47_L123_P0.5610.31
213_T216_V0.5610.31
190_P261_G0.5610.31
175_I303_A0.5590.31
7_L271_F0.5590.31
81_N112_G0.5590.31
252_L372_L0.5580.31
215_L273_R0.5570.31
15_L190_P0.5570.31
137_G168_G0.5570.31
15_L22_K0.5560.31
161_A172_G0.5560.31
31_K77_T0.5560.31
302_L310_L0.5560.31
26_S207_D0.5550.31
170_V209_G0.5540.30
93_V369_M0.5540.30
230_V307_L0.5530.30
208_V213_T0.5530.30
160_V248_F0.5530.30
132_I135_S0.5520.30
105_L382_I0.5510.30
19_L174_L0.5500.30
329_M338_L0.5500.30
82_A370_A0.5480.30
182_Y384_I0.5480.30
66_L71_M0.5470.30
169_L245_L0.5470.30
76_A173_G0.5460.30
326_W336_A0.5450.30
59_E103_G0.5450.30
10_L18_L0.5440.30
72_L91_G0.5420.30
21_R95_G0.5410.29
247_T360_I0.5400.29
356_N361_T0.5400.29
280_N362_E0.5390.29
113_I163_A0.5390.29
174_L178_P0.5390.29
382_I389_V0.5380.29
217_L277_V0.5370.29
221_I278_L0.5350.29
105_L224_I0.5340.29
184_V360_I0.5340.29
271_F299_L0.5320.29
240_G389_V0.5310.29
171_L363_R0.5310.29
296_L380_F0.5310.29
217_L253_F0.5310.29
48_A201_T0.5300.29
97_F374_V0.5290.29
356_N365_G0.5290.29
174_L200_P0.5290.29
127_L144_W0.5290.29
288_A320_Y0.5280.28
286_F364_F0.5280.28
95_G233_I0.5280.28
107_M191_N0.5280.28
347_L379_A0.5270.28
379_A383_D0.5260.28
37_E226_I0.5260.28
368_H371_F0.5250.28
208_V362_E0.5240.28
128_L162_M0.5230.28
171_L195_D0.5230.28
115_M314_T0.5220.28
257_I311_V0.5210.28
61_N195_D0.5200.28
217_L274_A0.5200.28
35_I91_G0.5200.28
205_K209_G0.5200.28
245_L274_A0.5190.28
238_L306_M0.5190.28
71_M279_G0.5180.28
48_A51_V0.5170.28
264_I315_I0.5160.28
183_L337_V0.5160.28
353_A383_D0.5140.27
256_V260_N0.5140.27
16_T128_L0.5110.27
180_A252_L0.5110.27
263_S352_T0.5100.27
223_L262_L0.5090.27
228_L283_L0.5070.27
204_E208_V0.5070.27
17_L284_S0.5070.27
215_L284_S0.5070.27
111_I309_I0.5060.27
135_S345_F0.5060.27
12_A62_F0.5060.27
74_F178_P0.5060.27
226_I267_F0.5050.27
180_A359_A0.5040.27
99_I113_I0.5040.27
372_L375_P0.5040.27
372_L384_I0.5040.27
140_T166_T0.5030.27
278_L281_V0.5030.27
88_R264_I0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4czbA 2 0.9002 98.1 0.918 Contact Map
4cz8A 2 0.8753 97.7 0.925 Contact Map
4bwzA 2 0.8703 97.3 0.931 Contact Map
4n7wA 2 0.7282 96.6 0.938 Contact Map
3zuxA 1 0.7556 94.6 0.946 Contact Map
2cfqA 1 0.8279 58.1 0.965 Contact Map
2nwlA 3 0.7132 52 0.966 Contact Map
4k0jA 3 0.3691 20.6 0.973 Contact Map
3wdoA 1 0.5835 18.4 0.974 Contact Map
1ldfA 3 0.4514 18.3 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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