GREMLIN Database
GLTK - Glutamate/aspartate transport system permease protein GltK
UniProt: P0AER5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12662
Length: 224 (205)
Sequences: 17817 (10791)
Seq/√Len: 753.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_L216_V3.1951.00
193_T196_E3.1691.00
33_I105_S3.1111.00
100_A172_V3.0461.00
184_A201_A2.8461.00
131_A141_S2.7701.00
137_T140_Q2.7361.00
21_V25_K2.5731.00
44_M56_A2.4731.00
127_Q149_Q2.4701.00
66_I71_V2.3361.00
41_L113_S2.3251.00
128_S141_S2.2221.00
41_L109_A2.1061.00
51_P55_F2.0551.00
139_W143_K2.0481.00
214_L218_Y1.9761.00
132_L141_S1.9461.00
51_P54_W1.9411.00
45_R57_K1.8481.00
42_A116_I1.8291.00
182_R186_T1.8071.00
119_G154_M1.7921.00
128_S132_L1.7741.00
60_V113_S1.7711.00
122_S153_A1.7701.00
95_I98_I1.7571.00
37_W109_A1.7501.00
27_T166_F1.7301.00
188_G194_Q1.7251.00
206_F210_L1.7001.00
20_L208_I1.6971.00
22_I25_K1.6891.00
29_T101_M1.6711.00
50_A54_W1.6671.00
17_L21_V1.6621.00
26_I172_V1.6571.00
184_A197_M1.6441.00
210_L214_L1.6401.00
25_K97_L1.6191.00
137_T141_S1.6071.00
75_F103_A1.6071.00
46_L121_Q1.5781.00
112_Y158_L1.5401.00
34_G108_E1.5211.00
114_E117_R1.5201.00
214_L217_S1.4811.00
18_D21_V1.4541.00
31_V162_G1.4541.00
218_Y221_R1.4501.00
138_H142_M1.4351.00
41_L56_A1.4331.00
215_L218_Y1.4121.00
22_I177_L1.4111.00
27_T169_T1.3991.00
39_T116_I1.3791.00
140_Q143_K1.3641.00
50_A53_A1.3611.00
71_V107_F1.3511.00
97_L101_M1.3451.00
49_F54_W1.3371.00
15_Y18_D1.3181.00
140_Q144_L1.3181.00
63_F106_M1.3111.00
40_M44_M1.2931.00
116_I154_M1.2841.00
132_L138_H1.2681.00
66_I107_F1.2451.00
112_Y161_Q1.2221.00
136_M140_Q1.2101.00
128_S146_I1.1981.00
29_T105_S1.1961.00
45_R114_E1.1861.00
96_R176_S1.1781.00
44_M47_S1.1761.00
46_L120_I1.1761.00
54_W58_A1.1641.00
188_G198_I1.1581.00
72_L103_A1.1561.00
13_L17_L1.1331.00
183_T186_T1.1291.00
131_A145_I1.1291.00
36_L40_M1.1271.00
172_V179_D1.1191.00
182_R185_S1.1071.00
115_I161_Q1.0921.00
53_A57_K1.0861.00
178_A182_R1.0841.00
55_F59_Y1.0771.00
49_F52_V1.0731.00
55_F58_A1.0691.00
33_I101_M1.0651.00
120_I146_I1.0631.00
61_N210_L1.0601.00
72_L172_V1.0591.00
25_K29_T1.0581.00
142_M147_L1.0561.00
101_M105_S1.0541.00
15_Y183_T1.0541.00
166_F208_I1.0511.00
115_I157_L1.0421.00
117_R121_Q1.0371.00
97_L177_L1.0281.00
18_D22_I1.0161.00
56_A113_S1.0081.00
38_G112_Y1.0061.00
75_F99_S1.0051.00
215_L219_L0.9931.00
98_I101_M0.9901.00
58_A61_N0.9851.00
30_A105_S0.9831.00
123_I153_A0.9791.00
217_S220_K0.9791.00
123_I150_A0.9761.00
61_N206_F0.9761.00
170_S205_Y0.9761.00
218_Y222_R0.9701.00
187_I197_M0.9671.00
71_V75_F0.9651.00
164_V168_D0.9601.00
217_S221_R0.9571.00
23_T166_F0.9561.00
196_E199_L0.9351.00
72_L171_L0.9311.00
27_T162_G0.9221.00
166_F212_A0.9151.00
126_G130_A0.9151.00
185_S188_G0.9141.00
63_F110_A0.9131.00
186_T190_R0.9131.00
136_M144_L0.9091.00
31_V165_L0.9081.00
20_L204_V0.8921.00
44_M52_V0.8881.00
42_A46_L0.8871.00
138_H141_S0.8801.00
78_I82_F0.8721.00
211_S215_L0.8721.00
14_P18_D0.8651.00
32_V36_L0.8621.00
98_I102_V0.8611.00
74_W78_I0.8611.00
47_S138_H0.8581.00
153_A157_L0.8561.00
142_M146_I0.8561.00
73_L77_L0.8521.00
45_R60_V0.8511.00
166_F209_S0.8511.00
104_F169_T0.8431.00
29_T33_I0.8401.00
19_G183_T0.8401.00
191_D194_Q0.8371.00
108_E161_Q0.8351.00
28_V32_V0.8331.00
35_I158_L0.8321.00
68_L107_F0.8301.00
24_L28_V0.8271.00
96_R177_L0.8191.00
59_Y63_F0.8121.00
48_S53_A0.7951.00
100_A175_L0.7941.00
59_Y110_A0.7901.00
125_R129_S0.7901.00
54_W57_K0.7831.00
184_A188_G0.7801.00
126_G129_S0.7801.00
207_V211_S0.7751.00
49_F55_F0.7731.00
59_Y109_A0.7731.00
68_L168_D0.7731.00
20_L180_F0.7711.00
23_T205_Y0.7701.00
108_E168_D0.7691.00
47_S56_A0.7661.00
128_S138_H0.7561.00
174_V178_A0.7511.00
76_Y99_S0.7491.00
49_F53_A0.7471.00
181_F205_Y0.7441.00
43_V142_M0.7421.00
181_F198_I0.7331.00
23_T27_T0.7301.00
76_Y175_L0.7271.00
188_G197_M0.7261.00
112_Y116_I0.7261.00
29_T97_L0.7241.00
71_V103_A0.7231.00
120_I150_A0.7221.00
180_F204_V0.7201.00
172_V177_L0.7191.00
57_K61_N0.7161.00
119_G153_A0.7161.00
203_F207_V0.7121.00
198_I201_A0.7121.00
72_L175_L0.7091.00
42_A120_I0.7081.00
22_I179_D0.7071.00
96_R175_L0.7051.00
26_I169_T0.7021.00
170_S181_F0.7011.00
206_F209_S0.6971.00
200_F204_V0.6941.00
74_W199_L0.6941.00
39_T147_L0.6921.00
199_L203_F0.6911.00
104_F165_L0.6911.00
45_R53_A0.6901.00
37_W41_L0.6901.00
213_S217_S0.6891.00
173_Y182_R0.6891.00
123_I146_I0.6851.00
170_S173_Y0.6831.00
37_W105_S0.6811.00
29_T32_V0.6811.00
212_A216_V0.6731.00
107_F168_D0.6681.00
173_Y176_S0.6671.00
181_F201_A0.6661.00
155_V219_L0.6661.00
105_S109_A0.6651.00
26_I177_L0.6651.00
34_G112_Y0.6611.00
178_A183_T0.6611.00
197_M201_A0.6601.00
26_I100_A0.6561.00
116_I120_I0.6551.00
120_I142_M0.6511.00
108_E112_Y0.6481.00
108_E165_L0.6461.00
69_V174_V0.6431.00
125_R128_S0.6391.00
52_V55_F0.6311.00
33_I36_L0.6291.00
107_F161_Q0.6261.00
48_S138_H0.6241.00
26_I30_A0.6231.00
22_I97_L0.6231.00
161_Q164_V0.6221.00
36_L105_S0.6201.00
14_P17_L0.6191.00
78_I81_G0.6161.00
25_K98_I0.6131.00
12_S187_I0.6101.00
163_I212_A0.6091.00
129_S144_L0.6091.00
33_I37_W0.6071.00
76_Y96_R0.6071.00
125_R132_L0.6061.00
44_M55_F0.6051.00
57_K60_V0.6041.00
39_T151_F0.6021.00
128_S142_M0.6021.00
35_I116_I0.6011.00
21_V24_L0.6011.00
79_V89_L0.5981.00
41_L44_M0.5981.00
137_T144_L0.5961.00
190_R193_T0.5961.00
30_A165_L0.5961.00
75_F78_I0.5961.00
211_S218_Y0.5901.00
65_S167_Q0.5861.00
162_G212_A0.5851.00
91_P98_I0.5841.00
19_G22_I0.5831.00
15_Y19_G0.5811.00
16_L204_V0.5791.00
48_S51_P0.5781.00
104_F172_V0.5751.00
146_I149_Q0.5711.00
131_A136_M0.5711.00
30_A104_F0.5711.00
63_F71_V0.5661.00
58_A62_V0.5661.00
69_V171_L0.5631.00
90_S95_I0.5581.00
198_I202_G0.5571.00
156_P220_K0.5561.00
44_M49_F0.5531.00
52_V56_A0.5501.00
195_V199_L0.5501.00
16_L184_A0.5491.00
211_S214_L0.5491.00
27_T31_V0.5471.00
41_L59_Y0.5471.00
201_A204_V0.5451.00
45_R113_S0.5431.00
17_L20_L0.5401.00
119_G157_L0.5391.00
219_L223_T0.5351.00
118_A157_L0.5341.00
37_W40_M0.5341.00
16_L187_I0.5331.00
136_M141_S0.5281.00
141_S146_I0.5281.00
187_I191_D0.5261.00
56_A60_V0.5241.00
206_F213_S0.5231.00
62_V66_I0.5211.00
36_L39_T0.5201.00
155_V223_T0.5191.00
121_Q156_P0.5181.00
69_V73_L0.5161.00
160_T167_Q0.5141.00
157_L160_T0.5121.00
111_Y168_D0.5121.00
15_Y186_T0.5081.00
30_A101_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ymuD 2 0.9598 100 0.538 Contact Map
3tuiA 2 0.9286 99.9 0.605 Contact Map
3rlfF 1 0.9554 99.9 0.627 Contact Map
2onkC 2 0.9777 99.9 0.632 Contact Map
3d31C 2 0.9598 99.9 0.64 Contact Map
3rlfG 1 0.9732 99.8 0.657 Contact Map
4tquM 1 0.9911 99.8 0.658 Contact Map
4tquN 1 0.942 99.8 0.684 Contact Map
5a63B 1 0.2812 10.8 0.956 Contact Map
4uisB 1 0.1875 7.1 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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