GREMLIN Database
GLTJ - Glutamate/aspartate transport system permease protein GltJ
UniProt: P0AER3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12661
Length: 246 (207)
Sequences: 15805 (9324)
Seq/√Len: 648.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_I119_G3.3171.00
173_T230_M3.2121.00
145_A155_A3.0851.00
207_H210_E2.8911.00
114_S186_A2.8671.00
30_Q34_A2.8181.00
198_A215_I2.7081.00
53_L65_G2.5781.00
151_T154_Q2.5421.00
50_F127_C2.4981.00
141_Q163_N2.2171.00
146_L155_A2.1741.00
142_K155_A2.1321.00
228_L232_L2.1261.00
54_R66_T2.0841.00
142_K146_L2.0381.00
75_V80_Q2.0191.00
153_P157_R1.9711.00
50_F123_A1.9621.00
60_F64_L1.9561.00
31_V34_A1.9461.00
109_Q112_L1.9351.00
60_F63_G1.9331.00
202_L208_A1.8151.00
133_A168_I1.8061.00
38_C115_M1.7651.00
34_A111_F1.7511.00
55_T135_Q1.7471.00
59_R63_G1.7311.00
46_V123_A1.7181.00
136_S167_V1.7131.00
69_V127_C1.6931.00
29_F222_I1.6921.00
26_W30_Q1.6911.00
198_A211_S1.6681.00
228_L231_T1.6591.00
51_G130_V1.6511.00
27_S30_Q1.6491.00
224_A228_L1.6471.00
35_L186_A1.6451.00
50_F65_G1.6211.00
84_W117_C1.5981.00
31_V191_L1.5851.00
151_T155_A1.5801.00
36_S180_V1.5491.00
128_E131_R1.5331.00
154_Q158_Y1.5291.00
232_L235_R1.5291.00
152_L156_Y1.4921.00
220_V224_A1.4851.00
48_S130_V1.4701.00
196_A200_K1.4561.00
24_W27_S1.4161.00
43_A122_T1.4111.00
126_V172_M1.3471.00
197_Q200_K1.3081.00
40_W176_M1.3001.00
150_L154_Q1.2741.00
146_L152_L1.2721.00
154_Q157_R1.2651.00
58_N63_G1.2651.00
63_G67_L1.2641.00
131_R135_Q1.2641.00
22_L26_W1.2601.00
49_F53_L1.2401.00
229_V232_L1.2381.00
34_A38_C1.2291.00
81_F117_C1.2221.00
192_V196_A1.2141.00
24_W197_Q1.2131.00
64_L67_L1.2101.00
72_F120_L1.2091.00
142_K160_L1.2091.00
54_R128_E1.2091.00
36_S183_S1.1911.00
196_A199_G1.1801.00
180_V222_I1.1771.00
80_Q121_F1.1761.00
130_V168_I1.1751.00
134_I160_L1.1741.00
111_F115_M1.1731.00
59_R62_S1.1661.00
38_C119_G1.1621.00
110_F190_G1.1611.00
55_T134_I1.1581.00
236_K239_L1.1501.00
62_S66_T1.1491.00
202_L212_F1.1441.00
67_L70_E1.1321.00
47_G126_V1.1311.00
145_A159_V1.1111.00
186_A193_D1.1011.00
23_G27_S1.0971.00
199_G202_L1.0961.00
42_I115_M1.0911.00
115_M119_G1.0881.00
152_L155_A1.0791.00
58_N61_L1.0731.00
84_W113_S1.0661.00
53_L61_L1.0631.00
44_F172_M1.0611.00
64_L68_Y1.0601.00
68_Y123_A1.0581.00
65_G127_C1.0501.00
210_E213_T1.0491.00
27_S31_V1.0341.00
201_L211_S1.0301.00
29_F218_A1.0231.00
57_P62_S1.0131.00
70_E224_A1.0101.00
36_S176_M1.0081.00
150_L158_Y1.0061.00
142_K152_L0.9991.00
129_Q175_E0.9981.00
232_L236_K0.9941.00
231_T235_R0.9731.00
75_V121_F0.9681.00
53_L56_V0.9671.00
137_L164_A0.9641.00
126_V175_E0.9571.00
80_Q84_W0.9551.00
112_L115_M0.9551.00
156_Y161_L0.9511.00
68_Y72_F0.9481.00
51_G55_T0.9431.00
85_Y189_I0.9361.00
178_N182_N0.9351.00
85_Y113_S0.9351.00
200_K204_Y0.9321.00
72_F124_A0.9291.00
188_T192_V0.9271.00
180_V226_I0.9221.00
81_F185_I0.9171.00
70_E220_V0.9061.00
81_F186_A0.8881.00
41_I45_L0.8871.00
63_G66_T0.8871.00
77_L121_F0.8791.00
156_Y160_L0.8751.00
192_V197_Q0.8751.00
32_T180_V0.8701.00
184_A219_Y0.8671.00
54_R69_V0.8661.00
39_A119_G0.8601.00
122_T175_E0.8601.00
77_L182_N0.8561.00
45_L49_F0.8521.00
112_L116_L0.8461.00
111_F191_L0.8401.00
231_T234_E0.8351.00
83_T87_V0.8321.00
229_V233_V0.8281.00
129_Q171_P0.8251.00
110_F191_L0.8121.00
140_G144_A0.8081.00
221_L225_F0.8061.00
194_M218_A0.8041.00
108_I112_L0.8031.00
80_Q117_C0.8021.00
225_F229_V0.7991.00
32_T219_Y0.7961.00
46_V119_G0.7961.00
68_Y124_A0.7941.00
114_S189_I0.7841.00
205_S208_A0.7811.00
51_G134_I0.7781.00
122_T182_N0.7781.00
66_T70_E0.7771.00
54_R62_S0.7771.00
139_R143_N0.7761.00
32_T36_S0.7761.00
58_N64_L0.7751.00
186_A191_L0.7731.00
137_L167_V0.7711.00
139_R142_K0.7701.00
167_V171_P0.7691.00
40_W179_L0.7661.00
180_V223_N0.7631.00
126_V130_V0.7621.00
35_L191_L0.7621.00
38_C42_I0.7611.00
118_L183_S0.7601.00
29_F194_M0.7581.00
37_I41_I0.7541.00
56_V65_G0.7471.00
58_N62_S0.7461.00
61_L64_L0.7371.00
87_V91_L0.7371.00
31_V193_D0.7351.00
39_A179_L0.7341.00
134_I156_Y0.7311.00
195_A212_F0.7301.00
195_A219_Y0.7281.00
187_S196_A0.7271.00
52_I156_Y0.7261.00
46_V50_F0.7111.00
82_F86_L0.7061.00
85_Y110_F0.7061.00
23_G26_W0.7051.00
198_A202_L0.7011.00
213_T217_L0.6991.00
50_F53_L0.6991.00
33_I37_I0.6981.00
78_I188_T0.6971.00
134_I164_A0.6961.00
35_L114_S0.6881.00
227_M231_T0.6841.00
43_A126_V0.6811.00
38_C111_F0.6791.00
48_S161_L0.6791.00
72_F80_Q0.6781.00
122_T126_V0.6771.00
71_L75_V0.6761.00
137_L160_L0.6741.00
83_T213_T0.6731.00
217_L221_L0.6671.00
56_V152_L0.6651.00
202_L211_S0.6651.00
21_Y201_L0.6621.00
214_A218_A0.6561.00
118_L179_L0.6561.00
81_F189_I0.6521.00
28_G197_Q0.6521.00
21_Y24_W0.6511.00
54_R127_C0.6491.00
35_L183_S0.6481.00
27_S197_Q0.6461.00
56_V59_R0.6451.00
122_T179_L0.6411.00
187_S190_G0.6361.00
184_A195_A0.6351.00
226_I230_M0.6341.00
184_A187_S0.6341.00
110_F189_I0.6321.00
225_F232_L0.6291.00
31_V111_F0.6281.00
48_S165_Y0.6271.00
195_A215_I0.6261.00
50_F68_Y0.6211.00
215_I218_A0.6181.00
45_L119_G0.6171.00
211_S215_I0.6141.00
44_F130_V0.6121.00
175_E178_N0.6061.00
65_G69_V0.6041.00
233_V237_V0.6021.00
53_L58_N0.6001.00
177_M226_I0.6001.00
78_I82_F0.5991.00
53_L64_L0.5971.00
177_M223_N0.5951.00
35_L39_A0.5931.00
143_N158_Y0.5881.00
160_L163_N0.5871.00
45_L48_S0.5821.00
209_W213_T0.5791.00
204_Y207_H0.5771.00
220_V223_N0.5761.00
151_T158_Y0.5751.00
27_S34_A0.5731.00
26_W218_A0.5731.00
39_A118_L0.5721.00
42_I45_L0.5711.00
44_F176_M0.5711.00
212_F215_I0.5671.00
57_P60_F0.5631.00
50_F54_R0.5621.00
129_Q168_I0.5591.00
225_F228_L0.5591.00
26_W29_F0.5581.00
25_I198_A0.5571.00
150_L155_A0.5551.00
56_V62_S0.5541.00
110_F113_S0.5541.00
142_K145_A0.5491.00
118_L186_A0.5471.00
67_L71_L0.5451.00
155_A160_L0.5441.00
30_Q33_I0.5401.00
171_P174_S0.5391.00
201_L205_S0.5361.00
166_R237_V0.5310.99
197_Q201_L0.5280.99
228_L235_R0.5270.99
213_T216_T0.5250.99
54_R65_G0.5240.99
66_T69_V0.5220.99
190_G196_A0.5210.99
179_L182_N0.5200.99
88_I106_P0.5180.99
35_L111_F0.5170.99
33_I222_I0.5170.99
61_L65_G0.5160.99
132_A171_P0.5140.99
202_L205_S0.5130.99
39_A115_M0.5130.99
169_V237_V0.5120.99
47_G51_G0.5110.99
36_S40_W0.5110.99
81_F114_S0.5080.99
25_I218_A0.5080.99
145_A148_M0.5060.99
84_W87_V0.5060.99
34_A115_M0.5040.99
212_F216_T0.5040.99
25_I201_L0.5030.99
121_F182_N0.5020.99
121_F175_E0.5010.99
194_M219_Y0.5000.99
137_L163_N0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ymuD 2 0.874 100 0.595 Contact Map
3tuiA 2 0.8496 99.9 0.659 Contact Map
2onkC 2 0.9065 99.9 0.676 Contact Map
3rlfF 1 0.9065 99.9 0.678 Contact Map
3d31C 2 0.9065 99.9 0.684 Contact Map
4tquM 1 0.9146 99.8 0.705 Contact Map
3rlfG 1 0.9553 99.8 0.708 Contact Map
4tquN 1 0.8902 99.7 0.742 Contact Map
2m8gX 1 0.252 5.5 0.967 Contact Map
4b0tA 2 0.1707 5.2 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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