GLTJ - ECOLI - GREMLIN Contacts

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GLTJ - Glutamate/aspartate transport system permease protein GltJ

UniProt:	P0AER3	Sequences: MSIDWNWGIFLQQAPFGNTTYLGWIWSGFQVTIALSICAWIIAFLVGSFFGILRTVPNRFLSGLGTLYVELFRNVPLIVQFFTWYLVIPELLPEKIGMWFKAELDPNIQFFLSSMLCLGLFTAARVCEQVRAAIQSLPRGQKNAALAMGLTLPQAYRYVLLPNAYRVIVPPMTSEMMNLVKNSAIASTIGLVDMAAQAGKLLDYSAHAWESFTAITLAYVLINAFIMLVMTLVERKVRLPGNMGGK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12661
Length:	246 (207)
Sequences:	15805 (9324)
Seq/√Len:	648.0

ECOLI - GLTJ ARTQ HISQ GLTK HISM ARTM YHDY YHDX GLNP YECS
BACSU - TCYM GLNM YCKA GLNP ARTQ YXEN

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
42_I	119_G	3.317	1.00
173_T	230_M	3.212	1.00
145_A	155_A	3.085	1.00
207_H	210_E	2.891	1.00
114_S	186_A	2.867	1.00
30_Q	34_A	2.818	1.00
198_A	215_I	2.708	1.00
53_L	65_G	2.578	1.00
151_T	154_Q	2.542	1.00
50_F	127_C	2.498	1.00
141_Q	163_N	2.217	1.00
146_L	155_A	2.174	1.00
142_K	155_A	2.132	1.00
228_L	232_L	2.126	1.00
54_R	66_T	2.084	1.00
142_K	146_L	2.038	1.00
75_V	80_Q	2.019	1.00
153_P	157_R	1.971	1.00
50_F	123_A	1.962	1.00
60_F	64_L	1.956	1.00
31_V	34_A	1.946	1.00
109_Q	112_L	1.935	1.00
60_F	63_G	1.933	1.00
202_L	208_A	1.815	1.00
133_A	168_I	1.806	1.00
38_C	115_M	1.765	1.00
34_A	111_F	1.751	1.00
55_T	135_Q	1.747	1.00
59_R	63_G	1.731	1.00
46_V	123_A	1.718	1.00
136_S	167_V	1.713	1.00
69_V	127_C	1.693	1.00
29_F	222_I	1.692	1.00
26_W	30_Q	1.691	1.00
198_A	211_S	1.668	1.00
228_L	231_T	1.659	1.00
51_G	130_V	1.651	1.00
27_S	30_Q	1.649	1.00
224_A	228_L	1.647	1.00
35_L	186_A	1.645	1.00
50_F	65_G	1.621	1.00
84_W	117_C	1.598	1.00
31_V	191_L	1.585	1.00
151_T	155_A	1.580	1.00
36_S	180_V	1.549	1.00
128_E	131_R	1.533	1.00
154_Q	158_Y	1.529	1.00
232_L	235_R	1.529	1.00
152_L	156_Y	1.492	1.00
220_V	224_A	1.485	1.00
48_S	130_V	1.470	1.00
196_A	200_K	1.456	1.00
24_W	27_S	1.416	1.00
43_A	122_T	1.411	1.00
126_V	172_M	1.347	1.00
197_Q	200_K	1.308	1.00
40_W	176_M	1.300	1.00
150_L	154_Q	1.274	1.00
146_L	152_L	1.272	1.00
154_Q	157_R	1.265	1.00
58_N	63_G	1.265	1.00
63_G	67_L	1.264	1.00
131_R	135_Q	1.264	1.00
22_L	26_W	1.260	1.00
49_F	53_L	1.240	1.00
229_V	232_L	1.238	1.00
34_A	38_C	1.229	1.00
81_F	117_C	1.222	1.00
192_V	196_A	1.214	1.00
24_W	197_Q	1.213	1.00
64_L	67_L	1.210	1.00
72_F	120_L	1.209	1.00
142_K	160_L	1.209	1.00
54_R	128_E	1.209	1.00
36_S	183_S	1.191	1.00
196_A	199_G	1.180	1.00
180_V	222_I	1.177	1.00
80_Q	121_F	1.176	1.00
130_V	168_I	1.175	1.00
134_I	160_L	1.174	1.00
111_F	115_M	1.173	1.00
59_R	62_S	1.166	1.00
38_C	119_G	1.162	1.00
110_F	190_G	1.161	1.00
55_T	134_I	1.158	1.00
236_K	239_L	1.150	1.00
62_S	66_T	1.149	1.00
202_L	212_F	1.144	1.00
67_L	70_E	1.132	1.00
47_G	126_V	1.131	1.00
145_A	159_V	1.111	1.00
186_A	193_D	1.101	1.00
23_G	27_S	1.097	1.00
199_G	202_L	1.096	1.00
42_I	115_M	1.091	1.00
115_M	119_G	1.088	1.00
152_L	155_A	1.079	1.00
58_N	61_L	1.073	1.00
84_W	113_S	1.066	1.00
53_L	61_L	1.063	1.00
44_F	172_M	1.061	1.00
64_L	68_Y	1.060	1.00
68_Y	123_A	1.058	1.00
65_G	127_C	1.050	1.00
210_E	213_T	1.049	1.00
27_S	31_V	1.034	1.00
201_L	211_S	1.030	1.00
29_F	218_A	1.023	1.00
57_P	62_S	1.013	1.00
70_E	224_A	1.010	1.00
36_S	176_M	1.008	1.00
150_L	158_Y	1.006	1.00
142_K	152_L	0.999	1.00
129_Q	175_E	0.998	1.00
232_L	236_K	0.994	1.00
231_T	235_R	0.973	1.00
75_V	121_F	0.968	1.00
53_L	56_V	0.967	1.00
137_L	164_A	0.964	1.00
126_V	175_E	0.957	1.00
80_Q	84_W	0.955	1.00
112_L	115_M	0.955	1.00
156_Y	161_L	0.951	1.00
68_Y	72_F	0.948	1.00
51_G	55_T	0.943	1.00
85_Y	189_I	0.936	1.00
178_N	182_N	0.935	1.00
85_Y	113_S	0.935	1.00
200_K	204_Y	0.932	1.00
72_F	124_A	0.929	1.00
188_T	192_V	0.927	1.00
180_V	226_I	0.922	1.00
81_F	185_I	0.917	1.00
70_E	220_V	0.906	1.00
81_F	186_A	0.888	1.00
41_I	45_L	0.887	1.00
63_G	66_T	0.887	1.00
77_L	121_F	0.879	1.00
156_Y	160_L	0.875	1.00
192_V	197_Q	0.875	1.00
32_T	180_V	0.870	1.00
184_A	219_Y	0.867	1.00
54_R	69_V	0.866	1.00
39_A	119_G	0.860	1.00
122_T	175_E	0.860	1.00
77_L	182_N	0.856	1.00
45_L	49_F	0.852	1.00
112_L	116_L	0.846	1.00
111_F	191_L	0.840	1.00
231_T	234_E	0.835	1.00
83_T	87_V	0.832	1.00
229_V	233_V	0.828	1.00
129_Q	171_P	0.825	1.00
110_F	191_L	0.812	1.00
140_G	144_A	0.808	1.00
221_L	225_F	0.806	1.00
194_M	218_A	0.804	1.00
108_I	112_L	0.803	1.00
80_Q	117_C	0.802	1.00
225_F	229_V	0.799	1.00
32_T	219_Y	0.796	1.00
46_V	119_G	0.796	1.00
68_Y	124_A	0.794	1.00
114_S	189_I	0.784	1.00
205_S	208_A	0.781	1.00
51_G	134_I	0.778	1.00
122_T	182_N	0.778	1.00
66_T	70_E	0.777	1.00
54_R	62_S	0.777	1.00
139_R	143_N	0.776	1.00
32_T	36_S	0.776	1.00
58_N	64_L	0.775	1.00
186_A	191_L	0.773	1.00
137_L	167_V	0.771	1.00
139_R	142_K	0.770	1.00
167_V	171_P	0.769	1.00
40_W	179_L	0.766	1.00
180_V	223_N	0.763	1.00
126_V	130_V	0.762	1.00
35_L	191_L	0.762	1.00
38_C	42_I	0.761	1.00
118_L	183_S	0.760	1.00
29_F	194_M	0.758	1.00
37_I	41_I	0.754	1.00
56_V	65_G	0.747	1.00
58_N	62_S	0.746	1.00
61_L	64_L	0.737	1.00
87_V	91_L	0.737	1.00
31_V	193_D	0.735	1.00
39_A	179_L	0.734	1.00
134_I	156_Y	0.731	1.00
195_A	212_F	0.730	1.00
195_A	219_Y	0.728	1.00
187_S	196_A	0.727	1.00
52_I	156_Y	0.726	1.00
46_V	50_F	0.711	1.00
82_F	86_L	0.706	1.00
85_Y	110_F	0.706	1.00
23_G	26_W	0.705	1.00
198_A	202_L	0.701	1.00
213_T	217_L	0.699	1.00
50_F	53_L	0.699	1.00
33_I	37_I	0.698	1.00
78_I	188_T	0.697	1.00
134_I	164_A	0.696	1.00
35_L	114_S	0.688	1.00
227_M	231_T	0.684	1.00
43_A	126_V	0.681	1.00
38_C	111_F	0.679	1.00
48_S	161_L	0.679	1.00
72_F	80_Q	0.678	1.00
122_T	126_V	0.677	1.00
71_L	75_V	0.676	1.00
137_L	160_L	0.674	1.00
83_T	213_T	0.673	1.00
217_L	221_L	0.667	1.00
56_V	152_L	0.665	1.00
202_L	211_S	0.665	1.00
21_Y	201_L	0.662	1.00
214_A	218_A	0.656	1.00
118_L	179_L	0.656	1.00
81_F	189_I	0.652	1.00
28_G	197_Q	0.652	1.00
21_Y	24_W	0.651	1.00
54_R	127_C	0.649	1.00
35_L	183_S	0.648	1.00
27_S	197_Q	0.646	1.00
56_V	59_R	0.645	1.00
122_T	179_L	0.641	1.00
187_S	190_G	0.636	1.00
184_A	195_A	0.635	1.00
226_I	230_M	0.634	1.00
184_A	187_S	0.634	1.00
110_F	189_I	0.632	1.00
225_F	232_L	0.629	1.00
31_V	111_F	0.628	1.00
48_S	165_Y	0.627	1.00
195_A	215_I	0.626	1.00
50_F	68_Y	0.621	1.00
215_I	218_A	0.618	1.00
45_L	119_G	0.617	1.00
211_S	215_I	0.614	1.00
44_F	130_V	0.612	1.00
175_E	178_N	0.606	1.00
65_G	69_V	0.604	1.00
233_V	237_V	0.602	1.00
53_L	58_N	0.600	1.00
177_M	226_I	0.600	1.00
78_I	82_F	0.599	1.00
53_L	64_L	0.597	1.00
177_M	223_N	0.595	1.00
35_L	39_A	0.593	1.00
143_N	158_Y	0.588	1.00
160_L	163_N	0.587	1.00
45_L	48_S	0.582	1.00
209_W	213_T	0.579	1.00
204_Y	207_H	0.577	1.00
220_V	223_N	0.576	1.00
151_T	158_Y	0.575	1.00
27_S	34_A	0.573	1.00
26_W	218_A	0.573	1.00
39_A	118_L	0.572	1.00
42_I	45_L	0.571	1.00
44_F	176_M	0.571	1.00
212_F	215_I	0.567	1.00
57_P	60_F	0.563	1.00
50_F	54_R	0.562	1.00
129_Q	168_I	0.559	1.00
225_F	228_L	0.559	1.00
26_W	29_F	0.558	1.00
25_I	198_A	0.557	1.00
150_L	155_A	0.555	1.00
56_V	62_S	0.554	1.00
110_F	113_S	0.554	1.00
142_K	145_A	0.549	1.00
118_L	186_A	0.547	1.00
67_L	71_L	0.545	1.00
155_A	160_L	0.544	1.00
30_Q	33_I	0.540	1.00
171_P	174_S	0.539	1.00
201_L	205_S	0.536	1.00
166_R	237_V	0.531	0.99
197_Q	201_L	0.528	0.99
228_L	235_R	0.527	0.99
213_T	216_T	0.525	0.99
54_R	65_G	0.524	0.99
66_T	69_V	0.522	0.99
190_G	196_A	0.521	0.99
179_L	182_N	0.520	0.99
88_I	106_P	0.518	0.99
35_L	111_F	0.517	0.99
33_I	222_I	0.517	0.99
61_L	65_G	0.516	0.99
132_A	171_P	0.514	0.99
202_L	205_S	0.513	0.99
39_A	115_M	0.513	0.99
169_V	237_V	0.512	0.99
47_G	51_G	0.511	0.99
36_S	40_W	0.511	0.99
81_F	114_S	0.508	0.99
25_I	218_A	0.508	0.99
145_A	148_M	0.506	0.99
84_W	87_V	0.506	0.99
34_A	115_M	0.504	0.99
212_F	216_T	0.504	0.99
25_I	201_L	0.503	0.99
121_F	182_N	0.502	0.99
121_F	175_E	0.501	0.99
194_M	219_Y	0.500	0.99
137_L	163_N	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ymuD	2	0.874	100	0.595	Contact Map
3tuiA	2	0.8496	99.9	0.659	Contact Map
2onkC	2	0.9065	99.9	0.676	Contact Map
3rlfF	1	0.9065	99.9	0.678	Contact Map
3d31C	2	0.9065	99.9	0.684	Contact Map
4tquM	1	0.9146	99.8	0.705	Contact Map
3rlfG	1	0.9553	99.8	0.708	Contact Map
4tquN	1	0.8902	99.7	0.742	Contact Map
2m8gX	1	0.252	5.5	0.967	Contact Map
4b0tA	2	0.1707	5.2	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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