GREMLIN Database
GLPF - Glycerol uptake facilitator protein
UniProt: P0AER0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10396
Length: 281 (221)
Sequences: 5604 (3187)
Seq/√Len: 214.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_F99_C4.1571.00
76_W83_K3.5271.00
153_M242_V3.3481.00
153_M246_V3.2391.00
72_T86_V3.0631.00
19_G103_L3.0121.00
149_F239_G2.9761.00
11_C88_P2.8831.00
76_W86_V2.8301.00
15_F95_A2.7681.00
11_C92_S2.6691.00
77_L245_I2.6541.00
49_G188_A2.5951.00
162_L186_L2.5531.00
155_I194_M2.5361.00
10_Q85_K2.5171.00
19_G100_A2.3131.00
149_F153_M2.3051.00
90_I241_I2.2631.00
25_G48_W2.0931.00
157_A247_G1.9751.00
59_T67_L1.9431.00
73_I241_I1.9141.00
201_A207_D1.8591.00
208_F237_L1.8501.00
191_G200_F1.8331.00
73_I90_I1.7741.00
139_P148_A1.7521.00
142_H229_D1.7471.00
66_H89_F1.7411.00
155_I202_M1.7301.00
55_A59_T1.6881.00
151_V197_L1.6751.00
208_F212_V1.6621.00
46_V188_A1.6381.00
53_A184_G1.6021.00
102_A213_F1.5901.00
148_A198_T1.5851.00
233_F237_L1.5651.00
23_F103_L1.5351.00
190_I202_M1.5331.00
17_G67_L1.5321.00
92_S96_G1.5321.00
157_A250_A1.5211.00
109_Y113_F1.4981.00
241_I245_I1.4941.00
112_F134_T1.4451.00
160_M244_A1.4171.00
83_K86_V1.4001.00
86_V90_I1.3971.00
71_V163_I1.3941.00
79_A252_R1.3931.00
45_S192_A1.3921.00
52_V187_I1.3901.00
87_I91_V1.3841.00
26_V104_V1.3701.00
74_A160_M1.3621.00
243_G247_G1.3611.00
94_V237_L1.3581.00
208_F233_F1.3471.00
98_F209_G1.3431.00
98_F213_F1.3411.00
56_I180_P1.3261.00
18_T97_A1.3191.00
214_A228_R1.3161.00
191_G195_G1.3091.00
234_L238_F1.3071.00
27_G104_V1.3021.00
74_A78_F1.2821.00
19_G99_C1.2761.00
75_L81_F1.2621.00
72_T93_Q1.2581.00
94_V208_F1.2301.00
72_T90_I1.2001.00
156_T244_A1.2001.00
99_C102_A1.1971.00
157_A246_V1.1931.00
102_A106_G1.1911.00
187_I202_M1.1841.00
50_L185_L1.1731.00
59_T65_A1.1721.00
69_P205_A1.1711.00
103_L154_V1.1691.00
146_V150_A1.1621.00
29_V44_I1.1511.00
101_A210_P1.1501.00
81_F86_V1.1451.00
107_L151_V1.1401.00
152_E198_T1.1391.00
149_F235_V1.1361.00
72_T81_F1.1331.00
50_L189_V1.1251.00
51_G55_A1.1221.00
29_V33_K1.1171.00
83_K87_I1.1161.00
18_T205_A1.1081.00
73_I245_I1.1051.00
82_D85_K1.1001.00
149_F238_F1.0931.00
153_M243_G1.0901.00
98_F212_V1.0731.00
163_I183_I1.0701.00
70_A204_P1.0691.00
97_A101_A1.0631.00
20_L158_I1.0601.00
131_L134_T1.0541.00
50_L188_A1.0531.00
66_H72_T1.0521.00
21_L52_V1.0501.00
20_L55_A1.0381.00
26_V101_A1.0301.00
207_D211_K1.0281.00
53_A181_L1.0121.00
57_Y180_P1.0121.00
153_M239_G1.0101.00
132_A136_S1.0081.00
28_C47_I1.0061.00
63_S89_F0.9951.00
107_L197_L0.9891.00
24_F51_G0.9841.00
151_V155_I0.9831.00
151_V198_T0.9831.00
55_A65_A0.9811.00
97_A209_G0.9761.00
230_I233_F0.9721.00
71_V160_M0.9691.00
22_I26_V0.9651.00
8_K11_C0.9631.00
77_L248_A0.9611.00
212_V215_W0.9591.00
76_W81_F0.9551.00
132_A138_Y0.9531.00
74_A248_A0.9431.00
55_A67_L0.9431.00
157_A161_G0.9431.00
13_A62_V0.9360.99
159_L187_I0.9330.99
144_N147_Q0.9160.99
56_I71_V0.9120.99
130_D133_G0.9020.99
168_D251_Y0.9020.99
206_R210_P0.8980.99
70_A244_A0.8960.99
43_E192_A0.8900.99
22_I104_V0.8820.99
161_G250_A0.8800.99
13_A63_S0.8750.99
19_G23_F0.8730.99
66_H81_F0.8700.99
98_F208_F0.8640.99
66_H93_Q0.8620.99
181_L185_L0.8580.99
53_A57_Y0.8560.99
149_F234_L0.8530.99
32_L43_E0.8520.99
101_A213_F0.8400.99
58_L162_L0.8340.99
17_G21_L0.8330.99
137_T236_P0.8280.99
78_F248_A0.8160.99
96_G100_A0.8150.99
77_L249_F0.8140.99
164_L247_G0.8130.99
166_L186_L0.8000.98
167_T183_I0.7980.98
38_S42_W0.7950.98
90_I94_V0.7910.98
27_G193_S0.7890.98
11_C15_F0.7880.98
110_N147_Q0.7860.98
166_L182_L0.7860.98
137_T207_D0.7850.98
33_K130_D0.7800.98
66_H71_V0.7770.98
137_T201_A0.7770.98
13_A64_G0.7630.98
145_F235_V0.7620.98
149_F242_V0.7590.98
94_V209_G0.7570.98
36_G114_D0.7540.98
57_Y182_L0.7520.98
244_A248_A0.7490.98
200_F236_P0.7490.98
138_Y229_D0.7470.97
190_I200_F0.7370.97
235_V240_P0.7370.97
109_Y112_F0.7330.97
54_M162_L0.7320.97
47_I192_A0.7320.97
49_G184_G0.7270.97
15_F92_S0.7260.97
73_I86_V0.7230.97
75_L80_C0.7150.97
26_V100_A0.7140.97
81_F85_K0.7130.97
23_F104_V0.7120.97
139_P142_H0.7010.96
24_F158_I0.7000.96
26_V134_T0.6970.96
82_D87_I0.6950.96
23_F158_I0.6890.96
78_F164_L0.6870.96
156_T210_P0.6870.96
75_L163_I0.6860.96
105_Y213_F0.6860.96
151_V194_M0.6820.96
105_Y109_Y0.6810.96
24_F189_V0.6790.96
57_Y177_P0.6790.96
179_A183_I0.6780.96
135_F139_P0.6750.95
164_L251_Y0.6750.95
31_A197_L0.6740.95
46_V185_L0.6740.95
20_L54_M0.6720.95
165_A251_Y0.6710.95
18_T22_I0.6700.95
194_M200_F0.6700.95
132_A135_F0.6690.95
18_T52_V0.6650.95
165_A168_D0.6640.95
29_V48_W0.6620.95
147_Q150_A0.6590.95
188_A192_A0.6570.95
31_A196_P0.6540.95
40_G43_E0.6530.95
45_S191_G0.6510.94
155_I159_L0.6490.94
133_G138_Y0.6480.94
30_A134_T0.6470.94
15_F19_G0.6460.94
33_K44_I0.6410.94
60_A63_S0.6360.94
102_A105_Y0.6310.93
20_L161_G0.6290.93
148_A235_V0.6260.93
95_A99_C0.6260.93
159_L195_G0.6250.93
189_V193_S0.6250.93
48_W191_G0.6220.93
53_A182_L0.6200.93
155_I190_I0.6190.93
204_P237_L0.6150.93
23_F107_L0.6140.93
88_P91_V0.6130.92
159_L163_I0.6070.92
238_F241_I0.6070.92
98_F102_A0.6060.92
241_I244_A0.6040.92
31_A37_A0.6030.92
14_E17_G0.6030.92
18_T21_L0.6020.92
205_A209_G0.6010.92
234_L240_P0.6000.92
207_D240_P0.6000.92
201_A236_P0.5990.92
191_G202_M0.5940.91
22_I97_A0.5930.91
32_L44_I0.5890.91
180_P184_G0.5860.91
147_Q151_V0.5850.91
46_V192_A0.5840.91
76_W87_I0.5830.91
186_L190_I0.5810.90
23_F100_A0.5790.90
101_A209_G0.5770.90
38_S142_H0.5770.90
232_Y236_P0.5760.90
145_F231_P0.5760.90
8_K12_I0.5730.90
239_G243_G0.5730.90
64_G89_F0.5720.90
55_A189_V0.5710.90
28_C44_I0.5700.90
209_G213_F0.5690.89
110_N144_N0.5670.89
250_A254_L0.5660.89
158_I194_M0.5660.89
107_L150_A0.5640.89
232_Y235_V0.5640.89
172_G175_R0.5620.89
57_Y184_G0.5620.89
158_I186_L0.5600.89
176_G182_L0.5590.89
25_G206_R0.5580.89
57_Y178_L0.5580.89
150_A153_M0.5560.88
100_A151_V0.5560.88
10_Q81_F0.5550.88
82_D86_V0.5540.88
29_V200_F0.5490.88
11_C91_V0.5460.87
31_A108_Y0.5430.87
17_G59_T0.5430.87
162_L166_L0.5430.87
33_K133_G0.5420.87
52_V56_I0.5410.87
88_P92_S0.5410.87
70_A74_A0.5400.87
29_V187_I0.5400.87
161_G165_A0.5380.87
10_Q92_S0.5370.87
12_I254_L0.5360.86
81_F88_P0.5360.86
249_F253_K0.5330.86
245_I249_F0.5320.86
32_L40_G0.5300.86
97_A205_A0.5290.86
12_I253_K0.5270.86
78_F245_I0.5270.86
78_F247_G0.5270.86
134_T139_P0.5240.85
56_I65_A0.5230.85
56_I163_I0.5190.85
215_W230_I0.5180.85
109_Y147_Q0.5170.84
21_L187_I0.5170.84
16_L250_A0.5150.84
169_D251_Y0.5140.84
27_G108_Y0.5140.84
110_N113_F0.5140.84
76_W82_D0.5080.83
10_Q88_P0.5070.83
150_A154_V0.5070.83
70_A156_T0.5050.83
249_F252_R0.5040.83
30_A104_V0.5040.83
84_R87_I0.5020.83
13_A17_G0.5010.83
59_T255_I0.5010.83
41_Q196_P0.5000.83
210_P213_F0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ldfA 3 0.9039 100 0.092 Contact Map
3c02A 3 0.8577 100 0.175 Contact Map
4oj2X 3 0.8719 100 0.206 Contact Map
1j4nA 4 0.8363 100 0.206 Contact Map
2b6oA 6 0.8185 100 0.214 Contact Map
3iyzA 3 0.79 100 0.216 Contact Map
3d9sA 3 0.8256 100 0.223 Contact Map
2zz9A 3 0.79 100 0.225 Contact Map
3cn5A 3 0.8221 100 0.229 Contact Map
4nefA 4 0.8505 100 0.236 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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