GREMLIN Database
GLNH - Glutamine-binding periplasmic protein
UniProt: P0AEQ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10386
Length: 248 (228)
Sequences: 21574 (15520)
Seq/√Len: 1027.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_A84_V3.6721.00
135_A173_A3.5441.00
26_K66_E3.5411.00
60_E228_T2.8181.00
158_F167_E2.4021.00
143_V157_Q2.3971.00
93_I98_K2.3641.00
105_D227_K2.2901.00
42_Q47_V2.2751.00
78_A84_V2.2461.00
28_V66_E2.2401.00
160_N163_N2.1321.00
93_I208_G2.0761.00
28_V68_K2.0711.00
80_Q100_A2.0601.00
58_A65_Y2.0561.00
143_V147_K2.0441.00
26_K64_D2.0121.00
234_T237_E2.0051.00
95_D98_K1.9911.00
236_N240_K1.9811.00
102_D219_R1.9761.00
211_F219_R1.9651.00
56_A59_K1.9501.00
60_E225_A1.9361.00
133_V156_R1.9331.00
164_A176_V1.9321.00
101_I210_A1.8971.00
227_K231_E1.8921.00
178_H183_I1.8781.00
219_R223_N1.8431.00
125_S128_D1.8421.00
167_E172_R1.8021.00
29_V54_W1.7621.00
211_F222_V1.7511.00
56_A234_T1.7171.00
105_D223_N1.7111.00
133_V154_D1.7111.00
78_A83_N1.6641.00
115_M183_I1.6561.00
88_L209_I1.6531.00
124_K128_D1.5891.00
117_K171_N1.5801.00
56_A60_E1.5411.00
56_A229_L1.5321.00
104_S223_N1.5181.00
109_K206_Q1.5091.00
138_S159_P1.4881.00
52_D241_K1.4361.00
220_D224_G1.4351.00
75_I87_A1.4291.00
60_E232_N1.4031.00
113_L180_T1.4011.00
212_P215_S1.3971.00
42_Q45_K1.3911.00
180_T184_L1.3901.00
145_Y149_N1.3791.00
221_K224_G1.3671.00
61_L225_A1.3591.00
40_F47_V1.3571.00
144_D148_A1.3521.00
19_S23_A1.3491.00
51_V55_A1.3421.00
29_V86_L1.3411.00
216_D220_D1.3311.00
57_I225_A1.3311.00
169_G194_Q1.3231.00
133_V174_D1.3221.00
76_I101_I1.3211.00
54_W88_L1.3031.00
167_E173_A1.2931.00
33_T69_P1.2921.00
70_M78_A1.2901.00
14_L17_A1.2811.00
55_A67_L1.2781.00
225_A228_T1.2671.00
116_V175_A1.2561.00
147_K157_Q1.2421.00
50_D107_Y1.2361.00
91_I210_A1.2251.00
112_L142_S1.2231.00
82_K212_P1.2101.00
20_S24_D1.1961.00
135_A158_F1.1941.00
102_D214_G1.1921.00
77_P80_Q1.1881.00
230_R235_Y1.1841.00
132_K174_D1.1761.00
168_L195_F1.1751.00
41_K69_P1.1701.00
166_M170_T1.1691.00
134_V175_A1.1651.00
221_K225_A1.1651.00
228_T232_N1.1631.00
225_A229_L1.1601.00
19_S22_A1.1571.00
159_P163_N1.1491.00
114_V175_A1.1321.00
63_L221_K1.1231.00
166_M169_G1.1181.00
25_K63_L1.1171.00
150_I153_K1.0991.00
113_L197_A1.0931.00
77_P81_T1.0871.00
158_F164_A1.0871.00
87_A91_I1.0791.00
136_V143_V1.0781.00
118_A196_K1.0751.00
118_A194_Q1.0521.00
54_W67_L1.0491.00
49_F239_Y1.0451.00
96_E99_K1.0441.00
185_Y189_T1.0381.00
119_N196_K1.0361.00
49_F238_I1.0361.00
70_M84_V1.0301.00
234_T238_I1.0291.00
102_D213_K1.0251.00
138_S157_Q1.0241.00
217_E221_K1.0231.00
52_D242_W1.0191.00
71_D74_G1.0151.00
47_V52_D1.0111.00
224_G228_T1.0011.00
55_A59_K1.0011.00
137_K140_T0.9981.00
102_D216_D0.9861.00
29_V65_Y0.9861.00
116_V198_V0.9691.00
54_W65_Y0.9691.00
21_H24_D0.9671.00
76_I91_I0.9671.00
53_L235_Y0.9591.00
49_F243_F0.9581.00
21_H63_L0.9571.00
168_L173_A0.9531.00
46_Y51_V0.9521.00
168_L176_V0.9511.00
45_K55_A0.9501.00
144_D147_K0.9451.00
21_H25_K0.9421.00
60_E234_T0.9411.00
33_T46_Y0.9331.00
216_D219_R0.9331.00
15_A18_V0.9331.00
41_K44_D0.9291.00
135_A164_A0.9281.00
163_N166_M0.9271.00
162_D166_M0.9221.00
24_D28_V0.9211.00
223_N227_K0.9191.00
105_D230_R0.9171.00
52_D55_A0.9131.00
57_I222_V0.9111.00
86_L222_V0.9091.00
103_F210_A0.9041.00
86_L211_F0.8981.00
94_T97_R0.8931.00
36_V40_F0.8871.00
127_K130_D0.8871.00
53_L229_L0.8871.00
229_L234_T0.8841.00
235_Y239_Y0.8751.00
104_S222_V0.8721.00
98_K213_K0.8661.00
239_Y243_F0.8611.00
49_F235_Y0.8601.00
14_L18_V0.8571.00
111_G180_T0.8561.00
95_D99_K0.8531.00
80_Q101_I0.8511.00
74_G78_A0.8501.00
92_T205_Q0.8481.00
161_I178_H0.8431.00
156_R167_E0.8371.00
54_W209_I0.8331.00
237_E241_K0.8301.00
237_E240_K0.8281.00
223_N226_L0.8251.00
217_E220_D0.8251.00
145_Y148_A0.8241.00
87_A210_A0.8161.00
27_L86_L0.8161.00
116_V196_K0.8151.00
110_S181_P0.8141.00
86_L209_I0.8141.00
72_F75_I0.8121.00
56_A225_A0.8081.00
13_T16_F0.8081.00
61_L221_K0.8031.00
28_V85_D0.8021.00
41_K46_Y0.8001.00
27_L63_L0.8001.00
31_T67_L0.7901.00
236_N239_Y0.7891.00
54_W86_L0.7871.00
228_T231_E0.7781.00
57_I61_L0.7721.00
38_F108_Y0.7711.00
26_K63_L0.7661.00
31_T51_V0.7481.00
109_K204_A0.7461.00
184_L188_K0.7441.00
115_M195_F0.7441.00
229_L232_N0.7401.00
22_A25_K0.7321.00
129_L175_A0.7321.00
57_I88_L0.7291.00
27_L58_A0.7201.00
40_F242_W0.7191.00
149_N153_K0.7161.00
29_V67_L0.7151.00
114_V177_L0.7111.00
79_L101_I0.7091.00
229_L233_G0.7081.00
123_V128_D0.7011.00
68_K83_N0.6951.00
110_S180_T0.6881.00
163_N167_E0.6881.00
60_E229_L0.6861.00
229_L235_Y0.6861.00
165_Y169_G0.6851.00
158_F173_A0.6851.00
113_L199_G0.6821.00
55_A65_Y0.6811.00
74_G77_P0.6801.00
79_L84_V0.6781.00
135_A167_E0.6781.00
215_S218_L0.6721.00
227_K230_R0.6681.00
224_G227_K0.6661.00
104_S209_I0.6621.00
209_I222_V0.6601.00
93_I106_G0.6591.00
76_I80_Q0.6561.00
56_A238_I0.6541.00
103_F208_G0.6521.00
82_K214_G0.6501.00
220_D223_N0.6501.00
70_M75_I0.6491.00
130_D152_T0.6491.00
79_L87_A0.6471.00
32_D72_F0.6451.00
97_R103_F0.6451.00
104_S211_F0.6431.00
32_D39_E0.6431.00
111_G204_A0.6421.00
31_T89_A0.6391.00
47_V242_W0.6391.00
156_R173_A0.6391.00
133_V173_A0.6381.00
185_Y188_K0.6371.00
106_G109_K0.6371.00
122_D196_K0.6361.00
147_K155_L0.6351.00
111_G201_S0.6341.00
93_I103_F0.6331.00
53_L226_L0.6321.00
30_A75_I0.6301.00
68_K84_V0.6291.00
54_W58_A0.6251.00
113_L183_I0.6251.00
13_T17_A0.6231.00
51_V67_L0.6231.00
169_G192_N0.6211.00
141_G205_Q0.6201.00
146_A155_L0.6201.00
58_A61_L0.6171.00
115_M165_Y0.6161.00
35_F90_G0.6121.00
92_T97_R0.6061.00
136_V157_Q0.6061.00
50_D90_G0.6041.00
72_F91_I0.6031.00
165_Y195_F0.6021.00
111_G203_E0.6011.00
80_Q212_P0.5981.00
43_G47_V0.5951.00
20_S23_A0.5941.00
184_L197_A0.5941.00
35_F72_F0.5931.00
192_N195_F0.5911.00
36_V189_T0.5901.00
117_K194_Q0.5861.00
104_S226_L0.5841.00
31_T46_Y0.5841.00
58_A63_L0.5811.00
91_I101_I0.5791.00
178_H182_N0.5791.00
195_F198_V0.5761.00
39_E89_A0.5751.00
24_D85_D0.5751.00
72_F97_R0.5731.00
229_L238_I0.5721.00
102_D215_S0.5701.00
104_S219_R0.5691.00
13_T18_V0.5671.00
112_L177_L0.5671.00
233_G236_N0.5651.00
27_L218_L0.5621.00
108_Y207_Y0.5611.00
33_T39_E0.5591.00
61_L218_L0.5571.00
183_I187_I0.5551.00
79_L212_P0.5541.00
169_G195_F0.5501.00
137_K161_I0.5461.00
60_E221_K0.5461.00
30_A87_A0.5441.00
186_F189_T0.5421.00
167_E170_T0.5421.00
146_A177_L0.5411.00
54_W57_I0.5381.00
32_D89_A0.5381.00
32_D137_K0.5361.00
114_V129_L0.5351.00
233_G237_E0.5331.00
36_V185_Y0.5281.00
22_A221_K0.5261.00
33_T41_K0.5261.00
37_P40_F0.5261.00
68_K78_A0.5251.00
156_R172_R0.5241.00
25_K221_K0.5221.00
52_D238_I0.5211.00
83_N172_R0.5201.00
115_M187_I0.5201.00
59_K234_T0.5181.00
92_T141_G0.5181.00
136_V155_L0.5171.00
146_A150_I0.5131.00
148_A151_K0.5121.00
98_K102_D0.5121.00
105_D226_L0.5101.00
110_S207_Y0.5101.00
30_A78_A0.5101.00
58_A62_K0.5071.00
57_I209_I0.5061.00
70_M74_G0.5051.00
134_V146_A0.5031.00
138_S143_V0.5011.00
180_T201_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4powA 1 0.9032 100 0.239 Contact Map
3hv1A 2 0.9677 100 0.244 Contact Map
3kbrA 4 0.9073 100 0.245 Contact Map
3k4uA 5 0.9153 100 0.247 Contact Map
1pb7A 1 0.9435 100 0.248 Contact Map
1wdnA 1 0.8992 100 0.249 Contact Map
2vhaA 2 0.9556 100 0.251 Contact Map
4ohnA 1 0.9476 100 0.252 Contact Map
1xt8A 1 0.9153 100 0.252 Contact Map
2ylnA 1 0.9194 100 0.254 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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