GREMLIN Database
GLCG - Protein GlcG
UniProt: P0AEQ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12952
Length: 134 (126)
Sequences: 2379 (1555)
Seq/√Len: 138.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_E25_K3.6601.00
16_I43_A3.4701.00
13_S45_S2.8221.00
33_A58_S2.8021.00
31_S44_L2.2041.00
73_K122_A2.1951.00
126_K130_A2.1561.00
22_E26_N2.1041.00
33_A41_L2.0241.00
33_A44_L1.9691.00
22_E123_Q1.9451.00
41_L44_L1.9161.00
30_V124_V1.9111.00
116_L120_Q1.8991.00
101_V129_A1.8811.00
63_R91_L1.8111.00
71_E100_P1.7751.00
13_S20_Q1.7381.00
15_I128_A1.7341.00
102_V107_I1.6701.00
35_A110_A1.6141.00
7_L42_L1.5951.00
60_E91_L1.5651.00
33_A59_Q1.5631.00
96_E122_A1.5451.00
19_G128_A1.4731.00
57_I114_S1.4441.00
113_V125_A1.4371.00
12_A43_A1.4301.00
24_Q47_M1.4141.00
15_I101_V1.3631.00
20_Q45_S1.3411.00
31_S54_A1.3391.00
99_V122_A1.3131.00
9_Q45_S1.2791.00
44_L55_A1.2451.00
95_L118_G1.2391.00
63_R67_L1.2281.00
56_Y59_Q1.2221.00
53_I68_G1.2211.00
13_S17_A1.2161.00
18_A131_V1.2141.00
19_G32_I1.2101.00
20_Q32_I1.2071.00
68_G75_Y1.1991.00
72_T98_G1.1991.00
19_G111_V1.1791.00
23_A30_V1.1730.99
8_S11_M1.1700.99
26_N123_Q1.1570.99
15_I111_V1.1550.99
21_E25_K1.1540.99
28_W116_L1.1360.99
73_K96_E1.1340.99
101_V109_G1.1240.99
117_T120_Q1.0850.99
122_A126_K1.0820.99
29_S49_D1.0810.99
23_A124_V1.0720.99
17_A21_E1.0450.99
11_M103_V1.0380.99
9_Q12_A1.0370.99
16_I34_V1.0330.99
60_E93_T1.0300.99
74_G77_E1.0270.99
20_Q24_Q1.0180.99
36_D46_R1.0120.98
6_I37_D1.0060.98
50_C54_A1.0010.98
19_G113_V0.9910.98
81_N86_F0.9890.98
53_I67_L0.9870.98
31_S50_C0.9850.98
30_V116_L0.9840.98
49_D106_Q0.9720.98
9_Q13_S0.9670.98
42_L48_D0.9590.98
38_G46_R0.9530.98
30_V113_V0.9530.98
16_I45_S0.9490.98
103_V108_I0.9460.98
17_A45_S0.9320.97
41_L59_Q0.9310.97
79_V86_F0.9280.97
23_A47_M0.9250.97
19_G124_V0.9190.97
22_E127_A0.9180.97
40_H52_P0.9110.97
76_E79_V0.9100.97
44_L59_Q0.9060.97
18_A21_E0.9060.97
127_A130_A0.9040.97
56_Y60_E0.8770.96
12_A34_V0.8720.96
102_V105_G0.8650.96
99_V126_K0.8600.96
30_V115_G0.8480.96
57_I93_T0.8340.95
26_N120_Q0.8270.95
120_Q123_Q0.8160.94
18_A128_A0.7980.94
96_E118_G0.7940.94
73_K77_E0.7820.93
34_V43_A0.7760.93
35_A62_A0.7720.93
14_A17_A0.7700.93
99_V129_A0.7600.92
28_W120_Q0.7570.92
60_E89_A0.7560.92
65_A72_T0.7560.92
66_A110_A0.7510.92
31_S55_A0.7500.92
10_Q24_Q0.7430.91
35_A66_A0.7360.91
77_E81_N0.7330.91
111_V129_A0.7270.90
10_Q14_A0.7250.90
66_A69_R0.7240.90
51_A54_A0.7230.90
21_E24_Q0.7200.90
14_A18_A0.7150.90
41_L55_A0.7140.89
71_E99_V0.7120.89
15_I129_A0.7120.89
55_A59_Q0.7070.89
20_Q47_M0.7050.89
56_Y89_A0.7040.89
52_P67_L0.7000.89
7_L101_V0.6970.88
127_A131_V0.6940.88
75_Y79_V0.6890.88
18_A127_A0.6870.88
119_A123_Q0.6770.87
12_A42_L0.6750.87
72_T94_S0.6740.87
111_V128_A0.6730.87
110_A129_A0.6630.86
11_M14_A0.6580.85
68_G92_L0.6580.85
77_E80_N0.6480.84
76_E80_N0.6470.84
69_R107_I0.6440.84
32_I124_V0.6430.84
14_A131_V0.6420.84
32_I111_V0.6400.84
10_Q17_A0.6340.83
7_L37_D0.6310.83
85_A118_G0.6250.82
88_T94_S0.6240.82
29_S116_L0.6220.82
64_T72_T0.6140.81
50_C91_L0.6080.81
44_L58_S0.6080.81
99_V125_A0.6070.80
26_N124_V0.6030.80
15_I18_A0.6000.80
8_S42_L0.5930.79
53_I57_I0.5930.79
100_P107_I0.5870.78
71_E126_K0.5860.78
64_T92_L0.5800.77
38_G66_A0.5770.77
7_L11_M0.5750.77
67_L88_T0.5740.77
79_V82_G0.5680.76
56_Y91_L0.5660.76
81_N94_S0.5600.75
98_G125_A0.5550.74
13_S43_A0.5520.74
42_L46_R0.5500.74
82_G86_F0.5480.73
53_I88_T0.5450.73
9_Q48_D0.5440.73
51_A118_G0.5410.72
96_E116_L0.5330.71
60_E88_T0.5290.71
113_V128_A0.5280.71
70_R74_G0.5200.69
16_I32_I0.5190.69
68_G89_A0.5170.69
124_V127_A0.5160.69
76_E92_L0.5150.69
31_S115_G0.5140.69
79_V90_P0.5130.68
81_N118_G0.5100.68
26_N116_L0.5080.68
55_A58_S0.5040.67
24_Q37_D0.5040.67
75_Y94_S0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nkpA 5 1 100 0.164 Contact Map
2a2lA 5 1 100 0.17 Contact Map
3fpwA 5 0.9776 100 0.175 Contact Map
4clcA 5 0.9925 100 0.217 Contact Map
3mq0A 2 0.9478 88.4 0.878 Contact Map
2ia2A 4 0.9552 86.8 0.881 Contact Map
2o0yA 4 0.9552 86.4 0.882 Contact Map
1yspA 1 0.8806 85.9 0.883 Contact Map
1mkmA 4 0.9552 83.7 0.886 Contact Map
2o99A 2 0.9254 83.3 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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