GREMLIN Database
GLCD - Glycolate oxidase subunit GlcD
UniProt: P0AEP9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12997
Length: 499 (439)
Sequences: 17824 (13249)
Seq/√Len: 632.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_M183_E4.0581.00
183_E222_E4.0421.00
76_H463_D3.8971.00
160_V223_V3.5411.00
111_E125_Q3.4231.00
79_R463_D3.1841.00
180_L226_K3.1791.00
116_N119_G3.1061.00
110_K132_A3.0351.00
183_E193_T2.9751.00
136_A139_P2.9291.00
123_R222_E2.9121.00
243_S246_K2.9071.00
60_V71_I2.8771.00
123_R224_T2.8511.00
184_V210_F2.7321.00
362_A365_G2.6451.00
142_L227_L2.6411.00
68_V221_T2.6221.00
69_T191_A2.5831.00
125_Q222_E2.5771.00
128_V133_I2.5301.00
72_L82_V2.4701.00
186_T190_E2.4081.00
63_K108_R2.4061.00
181_K193_T2.3771.00
187_L466_L2.3321.00
131_L135_Q2.2591.00
117_P140_H2.2401.00
181_K224_T2.2381.00
112_I128_V2.1911.00
74_V78_L2.0961.00
65_M191_A2.0851.00
245_E368_E2.0761.00
369_G422_E2.0681.00
66_E69_T2.0521.00
138_A230_K2.0471.00
183_E191_A2.0191.00
129_R132_A2.0151.00
65_M221_T2.0081.00
186_T192_L1.9991.00
61_L108_R1.9951.00
65_M69_T1.9841.00
104_L219_V1.9811.00
307_E311_D1.9801.00
418_E422_E1.9751.00
114_D123_R1.9541.00
184_V218_G1.9521.00
181_K195_G1.9461.00
122_A133_I1.9421.00
66_E70_A1.9141.00
419_L422_E1.9101.00
68_V219_V1.9061.00
109_F125_Q1.9021.00
63_K67_Q1.8981.00
161_A213_S1.8911.00
182_I210_F1.8671.00
120_R142_L1.8611.00
69_T73_A1.8471.00
72_L466_L1.8331.00
137_V227_L1.8221.00
121_R180_L1.7991.00
407_A411_E1.7951.00
106_M219_V1.7871.00
121_R224_T1.7871.00
70_A73_A1.7771.00
122_A225_V1.7631.00
132_A135_Q1.7611.00
124_V156_I1.7601.00
372_R376_Q1.7601.00
115_I136_A1.7551.00
64_Q67_Q1.7341.00
84_T219_V1.7341.00
455_A459_A1.7151.00
376_Q415_K1.7141.00
85_R88_G1.7131.00
209_L456_V1.6921.00
26_R31_G1.6671.00
120_R229_P1.6611.00
75_C102_V1.6421.00
183_E221_T1.6391.00
160_V179_L1.6391.00
33_E67_Q1.6341.00
411_E415_K1.6101.00
136_A140_H1.5831.00
458_A464_G1.5781.00
451_T454_H1.5711.00
161_A220_T1.5701.00
112_I136_A1.5691.00
160_V225_V1.5661.00
451_T455_A1.5601.00
369_G372_R1.5591.00
418_E443_A1.5531.00
178_N228_L1.5451.00
303_Q307_E1.5391.00
106_M109_F1.5371.00
73_A76_H1.5321.00
68_V185_Q1.5161.00
60_V102_V1.5161.00
195_G202_P1.5151.00
246_K249_L1.5111.00
369_G419_L1.5041.00
72_L76_H1.4921.00
371_A375_Q1.4811.00
159_N175_T1.4731.00
124_V225_V1.4711.00
187_L460_F1.4651.00
68_V104_L1.4581.00
33_E63_K1.4541.00
28_H70_A1.4541.00
194_L203_G1.4481.00
210_F218_G1.4461.00
245_E249_L1.4431.00
253_D257_N1.4411.00
116_N121_R1.4411.00
74_V80_V1.4391.00
30_P33_E1.4381.00
454_H458_A1.4371.00
72_L185_Q1.4341.00
72_L219_V1.4211.00
369_G423_V1.4131.00
435_R470_K1.4071.00
179_L182_I1.4041.00
299_E303_Q1.4041.00
125_Q128_V1.3921.00
111_E128_V1.3791.00
191_A221_T1.3791.00
37_T40_E1.3751.00
194_L207_L1.3691.00
452_T455_A1.3651.00
377_Y415_K1.3621.00
185_Q221_T1.3501.00
373_L376_Q1.3491.00
35_L40_E1.3371.00
327_E331_V1.3271.00
372_R375_Q1.3261.00
145_A178_N1.3241.00
135_Q139_P1.3191.00
335_A339_N1.3061.00
124_V133_I1.3031.00
73_A77_R1.2991.00
69_T185_Q1.2871.00
28_H74_V1.2841.00
365_G369_G1.2821.00
249_L253_D1.2801.00
75_C82_V1.2781.00
38_D41_I1.2761.00
154_C159_N1.2741.00
457_K464_G1.2731.00
29_V33_E1.2691.00
62_P67_Q1.2681.00
122_A227_L1.2621.00
67_Q70_A1.2601.00
314_L317_G1.2591.00
446_N449_E1.2571.00
62_P71_I1.2551.00
71_I104_L1.2531.00
450_I454_H1.2361.00
115_I122_A1.2361.00
414_G418_E1.2321.00
29_V60_V1.2251.00
110_K125_Q1.2151.00
61_L105_V1.2141.00
405_E408_R1.2111.00
404_G407_A1.2001.00
408_R411_E1.2001.00
410_E414_G1.1921.00
71_I102_V1.1891.00
192_L203_G1.1801.00
185_Q191_A1.1701.00
122_A137_V1.1691.00
242_D246_K1.1601.00
134_S148_P1.1541.00
326_D329_E1.1401.00
76_H465_L1.1391.00
265_E268_D1.1391.00
455_A458_A1.1391.00
368_E372_R1.1381.00
205_D208_A1.1331.00
58_L102_V1.1291.00
173_G177_H1.1281.00
373_L419_L1.1281.00
334_W337_R1.1171.00
428_S431_H1.1151.00
310_N314_L1.1141.00
449_E452_T1.1071.00
82_V104_L1.1021.00
86_G155_S1.0991.00
307_E310_N1.0971.00
385_F388_G1.0951.00
179_L211_T1.0941.00
328_A332_R1.0901.00
29_V71_I1.0891.00
160_V175_T1.0861.00
210_F220_T1.0821.00
402_E405_E1.0811.00
186_T460_F1.0791.00
184_V192_L1.0731.00
208_A452_T1.0731.00
132_A136_A1.0651.00
115_I142_L1.0631.00
253_D256_A1.0561.00
30_P64_Q1.0551.00
366_V423_V1.0531.00
157_G223_V1.0481.00
182_I207_L1.0431.00
359_P362_A1.0421.00
430_E434_G1.0391.00
411_E414_G1.0381.00
253_D316_A1.0341.00
301_D304_E1.0291.00
308_R311_D1.0211.00
36_H41_I1.0181.00
428_S433_I1.0181.00
79_R465_L1.0171.00
337_R340_A1.0141.00
156_I225_V1.0131.00
85_R103_L1.0101.00
41_I45_E1.0081.00
82_V465_L1.0071.00
44_Y61_L1.0021.00
49_L52_Y0.9971.00
35_L61_L0.9951.00
318_A321_V0.9941.00
237_L240_S0.9941.00
237_L241_F0.9921.00
182_I223_V0.9921.00
81_P101_G0.9921.00
427_I430_E0.9871.00
73_A190_E0.9831.00
106_M126_P0.9781.00
298_V301_D0.9761.00
65_M185_Q0.9751.00
65_M125_Q0.9721.00
334_W338_K0.9711.00
61_L107_A0.9671.00
269_N273_R0.9621.00
41_I55_R0.9511.00
130_N148_P0.9481.00
304_E307_E0.9441.00
86_G106_M0.9391.00
178_N226_K0.9321.00
213_S217_L0.9311.00
431_H434_G0.9281.00
364_P368_E0.9251.00
329_E332_R0.9251.00
57_L100_K0.9231.00
68_V109_F0.9231.00
193_T222_E0.9231.00
209_L217_L0.9191.00
194_L210_F0.9161.00
331_V335_A0.9131.00
193_T224_T0.9101.00
98_L101_G0.9051.00
131_L152_I0.9041.00
80_V102_V0.9031.00
194_L197_D0.9011.00
40_E43_P0.8991.00
42_I45_E0.8991.00
156_I223_V0.8991.00
250_A253_D0.8991.00
26_R36_H0.8971.00
116_N123_R0.8951.00
85_R105_V0.8941.00
42_I55_R0.8931.00
37_T41_I0.8921.00
188_D192_L0.8881.00
336_G341_F0.8861.00
87_A155_S0.8861.00
267_M270_L0.8851.00
70_A74_V0.8831.00
68_V106_M0.8791.00
415_K418_E0.8731.00
263_G268_D0.8721.00
429_G432_G0.8681.00
41_I44_Y0.8641.00
268_D271_S0.8631.00
365_G368_E0.8621.00
252_G256_A0.8611.00
86_G126_P0.8601.00
373_L415_K0.8581.00
126_P223_V0.8581.00
333_F337_R0.8521.00
131_L153_A0.8521.00
90_G94_G0.8491.00
365_G423_V0.8481.00
130_N159_N0.8471.00
128_V132_A0.8431.00
357_T426_S0.8431.00
327_E330_R0.8421.00
403_P407_A0.8361.00
110_K128_V0.8361.00
65_M109_F0.8361.00
81_P467_N0.8361.00
204_F216_M0.8351.00
62_P106_M0.8351.00
107_A155_S0.8331.00
160_V220_T0.8321.00
338_K341_F0.8301.00
301_D305_D0.8301.00
269_N288_E0.8251.00
318_A323_L0.8251.00
122_A136_A0.8201.00
377_Y411_E0.8191.00
442_C450_I0.8181.00
373_L377_Y0.8181.00
427_I431_H0.8181.00
419_L423_V0.8121.00
133_I156_I0.8121.00
403_P406_F0.8091.00
355_D360_R0.8061.00
380_R383_N0.8061.00
441_M445_F0.8011.00
36_H58_L0.8001.00
306_C310_N0.7941.00
386_H389_D0.7931.00
44_Y59_V0.7921.00
362_A423_V0.7901.00
141_N230_K0.7881.00
293_C296_D0.7871.00
220_T223_V0.7821.00
300_S303_Q0.7801.00
262_G296_D0.7761.00
179_L223_V0.7761.00
273_R277_D0.7751.00
382_A385_F0.7741.00
62_P108_R0.7731.00
130_N133_I0.7711.00
406_F410_E0.7711.00
329_E334_W0.7711.00
418_E421_V0.7701.00
366_V370_I0.7701.00
241_F250_A0.7691.00
59_V103_L0.7681.00
66_E191_A0.7681.00
65_M68_V0.7671.00
333_F336_G0.7651.00
451_T458_A0.7641.00
187_L465_L0.7631.00
430_E433_I0.7631.00
369_G373_L0.7621.00
30_P34_I0.7621.00
145_A228_L0.7561.00
407_A410_E0.7561.00
337_R341_F0.7561.00
333_F338_K0.7531.00
205_D459_A0.7511.00
180_L224_T0.7511.00
305_D308_R0.7501.00
258_G261_P0.7501.00
300_S304_E0.7491.00
311_D314_L0.7471.00
109_F221_T0.7471.00
203_G460_F0.7471.00
205_D456_V0.7461.00
261_P268_D0.7461.00
353_C356_G0.7461.00
421_V443_A0.7461.00
142_L229_P0.7451.00
121_R226_K0.7431.00
265_E269_N0.7421.00
174_L177_H0.7401.00
325_Q329_E0.7391.00
310_N313_L0.7371.00
181_K222_E0.7361.00
249_L252_G0.7341.00
456_V460_F0.7321.00
355_D359_P0.7321.00
26_R34_I0.7321.00
354_M357_T0.7301.00
135_Q138_A0.7291.00
31_G67_Q0.7281.00
292_L296_D0.7281.00
441_M450_I0.7271.00
330_R333_F0.7261.00
265_E271_S0.7221.00
90_G95_A0.7211.00
251_V255_I0.7211.00
344_V347_I0.7201.00
265_E270_L0.7191.00
261_P264_L0.7181.00
295_L309_V0.7181.00
35_L41_I0.7181.00
84_T106_M0.7151.00
337_R343_A0.7141.00
468_P471_N0.7121.00
330_R334_W0.7121.00
245_E365_G0.7111.00
320_D323_L0.7111.00
413_G417_L0.7101.00
76_H188_D0.7081.00
439_N442_C0.7081.00
342_P345_G0.7071.00
279_I282_G0.7061.00
190_E448_D0.7061.00
404_G408_R0.7061.00
268_D272_I0.7051.00
72_L187_L0.7051.00
182_I220_T0.7041.00
428_S432_G0.7041.00
351_Y355_D0.7031.00
271_S340_A0.7021.00
270_L273_R0.7011.00
329_E333_F0.7011.00
332_R335_A0.7001.00
341_F344_V0.7001.00
400_A406_F0.6991.00
428_S434_G0.6981.00
336_G339_N0.6941.00
33_E108_R0.6931.00
130_N154_C0.6911.00
57_L101_G0.6901.00
303_Q310_N0.6891.00
457_K467_N0.6881.00
56_P103_L0.6881.00
343_A347_I0.6871.00
464_G467_N0.6851.00
112_I125_Q0.6851.00
254_I309_V0.6811.00
274_A277_D0.6811.00
46_C53_R0.6791.00
263_G270_L0.6761.00
263_G267_M0.6751.00
38_D42_I0.6741.00
50_S53_R0.6721.00
248_G252_G0.6721.00
383_N388_G0.6721.00
331_V338_K0.6711.00
383_N387_A0.6681.00
328_A331_V0.6671.00
119_G361_R0.6671.00
344_V348_S0.6661.00
318_A322_R0.6661.00
207_L211_T0.6661.00
184_V194_L0.6661.00
163_N174_L0.6611.00
143_Y230_K0.6601.00
107_A129_R0.6601.00
374_S377_Y0.6591.00
442_C451_T0.6591.00
157_G161_A0.6591.00
183_E224_T0.6581.00
311_D315_K0.6581.00
117_P120_R0.6571.00
45_E53_R0.6551.00
245_E364_P0.6511.00
62_P68_V0.6501.00
253_D315_K0.6491.00
395_L400_A0.6491.00
137_V140_H0.6471.00
208_A211_T0.6471.00
115_I140_H0.6451.00
39_E43_P0.6451.00
273_R276_E0.6451.00
146_P178_N0.6431.00
112_I124_V0.6421.00
114_D121_R0.6411.00
74_V102_V0.6411.00
115_I227_L0.6401.00
373_L412_L0.6401.00
309_V313_L0.6401.00
394_P398_F0.6391.00
385_F389_D0.6371.00
134_S143_Y0.6351.00
28_H33_E0.6331.00
341_F345_G0.6321.00
346_R349_P0.6301.00
266_M271_S0.6301.00
65_M222_E0.6301.00
193_T202_P0.6281.00
294_E297_G0.6271.00
381_V385_F0.6231.00
391_N395_L0.6221.00
237_L293_C0.6221.00
83_V101_G0.6211.00
345_G349_P0.6191.00
261_P267_M0.6191.00
370_I374_S0.6191.00
454_H472_I0.6191.00
130_N156_I0.6191.00
111_E114_D0.6181.00
194_L202_P0.6141.00
337_R342_P0.6131.00
247_A251_V0.6131.00
324_A329_E0.6121.00
312_I316_A0.6101.00
331_V337_R0.6101.00
339_N342_P0.6101.00
120_R226_K0.6091.00
171_K296_D0.6091.00
427_I433_I0.6081.00
291_L294_E0.6071.00
287_A290_I0.6071.00
384_V387_A0.6071.00
35_L44_Y0.6051.00
67_Q71_I0.6041.00
332_R336_G0.6041.00
69_T72_L0.6031.00
252_G255_I0.6011.00
182_I194_L0.6011.00
371_A374_S0.5991.00
235_R303_Q0.5981.00
310_N321_V0.5981.00
417_L421_V0.5971.00
440_Q443_A0.5971.00
365_G372_R0.5961.00
304_E308_R0.5961.00
343_A348_S0.5941.00
379_L383_N0.5941.00
261_P270_L0.5941.00
333_F340_A0.5941.00
114_D117_P0.5921.00
192_L452_T0.5911.00
276_E280_H0.5911.00
81_P468_P0.5911.00
409_A413_G0.5901.00
423_V426_S0.5891.00
151_Q154_C0.5891.00
338_K343_A0.5881.00
217_L456_V0.5861.00
429_G434_G0.5851.00
131_L151_Q0.5831.00
33_E36_H0.5831.00
250_A313_L0.5821.00
182_I211_T0.5821.00
34_I40_E0.5811.00
129_R155_S0.5811.00
291_L296_D0.5811.00
260_I263_G0.5801.00
340_A343_A0.5801.00
329_E336_G0.5781.00
448_D451_T0.5761.00
124_V128_V0.5761.00
393_H399_D0.5751.00
262_G265_E0.5751.00
435_R438_I0.5751.00
414_G417_L0.5741.00
445_F449_E0.5731.00
429_G433_I0.5731.00
427_I432_G0.5721.00
267_M271_S0.5711.00
187_L463_D0.5701.00
26_R30_P0.5701.00
62_P109_F0.5701.00
166_G169_C0.5701.00
338_K342_P0.5701.00
266_M270_L0.5701.00
386_H390_G0.5691.00
345_G348_S0.5691.00
330_R338_K0.5671.00
393_H398_F0.5671.00
232_P299_E0.5661.00
34_I60_V0.5651.00
203_G459_A0.5651.00
28_H67_Q0.5651.00
116_N120_R0.5631.00
276_E279_I0.5631.00
278_F282_G0.5631.00
324_A327_E0.5621.00
64_Q109_F0.5621.00
62_P104_L0.5601.00
379_L385_F0.5601.00
29_V70_A0.5601.00
134_S230_K0.5591.00
292_L333_F0.5591.00
441_M444_Q0.5571.00
235_R306_C0.5571.00
69_T186_T0.5561.00
169_C174_L0.5561.00
180_L196_S0.5551.00
385_F390_G0.5531.00
262_G268_D0.5531.00
181_K196_S0.5521.00
341_F347_I0.5511.00
275_A278_F0.5491.00
310_N316_A0.5481.00
35_L38_D0.5481.00
353_C359_P0.5481.00
149_S159_N0.5461.00
273_R287_A0.5461.00
134_S137_V0.5451.00
433_I441_M0.5441.00
338_K345_G0.5431.00
336_G340_A0.5431.00
302_V306_C0.5431.00
352_Y355_D0.5410.99
382_A389_D0.5400.99
336_G342_P0.5380.99
40_E44_Y0.5380.99
267_M272_I0.5370.99
387_A390_G0.5370.99
179_L225_V0.5360.99
58_L80_V0.5350.99
28_H71_I0.5340.99
368_E371_A0.5340.99
46_C50_S0.5340.99
395_L399_D0.5340.99
30_P63_K0.5330.99
344_V349_P0.5330.99
345_G350_D0.5330.99
412_L416_I0.5310.99
289_A296_D0.5310.99
80_V465_L0.5310.99
42_I46_C0.5300.99
269_N272_I0.5280.99
382_A387_A0.5280.99
343_A349_P0.5280.99
195_G204_F0.5280.99
313_L316_A0.5270.99
450_I453_F0.5270.99
337_R345_G0.5250.99
310_N317_G0.5250.99
438_I442_C0.5250.99
206_L460_F0.5250.99
54_T99_E0.5250.99
375_Q378_D0.5220.99
275_A279_I0.5220.99
196_S211_T0.5220.99
276_E282_G0.5210.99
263_G269_N0.5200.99
69_T221_T0.5190.99
264_L267_M0.5180.99
331_V336_G0.5180.99
325_Q330_R0.5170.99
336_G343_A0.5160.99
353_C395_L0.5150.99
133_I225_V0.5150.99
56_P59_V0.5150.99
327_E334_W0.5150.99
270_L380_R0.5150.99
204_F208_A0.5140.99
334_W341_F0.5140.99
456_V459_A0.5140.99
330_R336_G0.5130.99
75_C465_L0.5100.99
415_K419_L0.5100.99
340_A344_V0.5100.99
319_T322_R0.5100.99
123_R126_P0.5100.99
71_I219_V0.5100.99
41_I47_D0.5090.99
119_G224_T0.5080.99
395_L398_F0.5080.99
38_D55_R0.5080.99
326_D333_F0.5080.99
81_P465_L0.5070.99
383_N386_H0.5070.99
338_K346_R0.5070.99
295_L302_V0.5050.99
331_V334_W0.5050.99
261_P266_M0.5050.99
394_P397_L0.5030.99
343_A346_R0.5030.99
276_E281_A0.5020.99
324_A328_A0.5020.99
334_W339_N0.5010.99
322_R329_E0.5010.99
112_I122_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pm9A 5 0.9138 100 0.301 Contact Map
2uuuA 2 0.8898 100 0.35 Contact Map
1wvfA 2 0.9319 100 0.37 Contact Map
4xloA 2 0.8918 100 0.375 Contact Map
4o95A 1 0.8236 100 0.379 Contact Map
1w1oA 1 0.8417 100 0.38 Contact Map
1f0xA 1 0.8677 100 0.381 Contact Map
2bvfA 1 0.8457 100 0.398 Contact Map
4bbyA 2 0.9319 100 0.4 Contact Map
2exrA 1 0.8497 100 0.404 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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