GREMLIN Database
GALU - UTP--glucose-1-phosphate uridylyltransferase
UniProt: P0AEP3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11319
Length: 302 (235)
Sequences: 19619 (11670)
Seq/√Len: 761.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_H229_A3.6131.00
182_D197_V2.8561.00
182_D198_G2.7371.00
171_P211_N2.6421.00
113_K117_H2.6041.00
39_K47_N2.5971.00
56_E103_T2.5181.00
184_K195_P2.4501.00
164_H255_E2.4381.00
169_V256_A2.4021.00
227_L251_K2.3621.00
184_K193_S2.3171.00
11_A54_I2.2531.00
130_P221_S2.2091.00
171_P258_H2.2071.00
10_K56_E2.1781.00
43_Q71_H2.1681.00
246_D250_E2.1591.00
159_F166_Q2.1081.00
204_K207_V2.1041.00
195_P255_E2.0931.00
184_K197_V2.0861.00
65_K69_E2.0591.00
227_L247_M2.0521.00
11_A49_C2.0051.00
130_P160_D2.0001.00
247_M251_K1.9981.00
61_T65_K1.9391.00
164_H253_T1.8581.00
107_V121_C1.8421.00
247_M250_E1.7931.00
174_D177_A1.7921.00
46_V57_I1.7821.00
158_R257_Y1.7601.00
120_L123_H1.7601.00
162_T255_E1.7431.00
66_N70_N1.7341.00
119_V133_V1.7241.00
12_V122_A1.7191.00
49_C134_I1.7161.00
15_V59_L1.7041.00
264_H274_Q1.6921.00
67_S70_N1.6501.00
198_G246_D1.6491.00
205_A209_P1.6151.00
212_L258_H1.5911.00
56_E105_M1.5621.00
243_D246_D1.5611.00
29_I35_P1.5311.00
153_A157_R1.5201.00
58_V125_V1.5091.00
183_C212_L1.5071.00
130_P219_V1.5031.00
158_R162_T1.5001.00
202_K208_A1.4971.00
43_Q47_N1.4891.00
196_M254_V1.4721.00
196_M256_A1.4671.00
57_I102_V1.4661.00
151_N154_E1.4591.00
117_H121_C1.4291.00
29_I67_S1.4271.00
155_M219_V1.3561.00
126_V131_V1.3521.00
227_L244_A1.3511.00
223_D226_P1.3471.00
169_V181_V1.3441.00
155_M168_M1.3331.00
33_M67_S1.3311.00
207_V210_S1.3291.00
226_P230_K1.3281.00
23_L27_K1.3251.00
165_S220_L1.3231.00
157_R161_E1.3211.00
131_V222_A1.3011.00
200_V209_P1.2921.00
181_V196_M1.2891.00
272_Y276_F1.2881.00
117_H120_L1.2761.00
244_A247_M1.2641.00
230_K251_K1.2431.00
230_K247_M1.2301.00
154_E157_R1.2291.00
266_C275_A1.2201.00
220_L245_I1.2191.00
226_P229_A1.2181.00
120_L229_A1.2181.00
40_P43_Q1.2031.00
185_G193_S1.1981.00
195_P253_T1.1951.00
10_K129_E1.1871.00
179_G201_E1.1831.00
273_M277_V1.1791.00
69_E108_R1.1691.00
50_I102_V1.1681.00
65_K108_R1.1661.00
58_V107_V1.1601.00
132_A219_V1.1551.00
183_C194_V1.1461.00
268_N271_G1.1411.00
18_L112_A1.1371.00
105_M125_V1.1351.00
264_H278_E1.1251.00
262_K278_E1.1231.00
123_H225_W1.1201.00
156_I160_D1.1131.00
242_T246_D1.1001.00
182_D200_V1.0841.00
129_E222_A1.0811.00
176_T202_K1.0801.00
141_D282_R1.0801.00
227_L230_K1.0771.00
169_V212_L1.0751.00
277_V280_G1.0681.00
58_V122_A1.0681.00
12_V131_V1.0641.00
41_L266_C1.0621.00
154_E158_R1.0581.00
158_R255_E1.0441.00
194_V258_H1.0391.00
61_T106_Q1.0361.00
66_N69_E1.0351.00
120_L228_L1.0321.00
43_Q75_S1.0301.00
54_I132_A1.0251.00
33_M71_H1.0231.00
73_D106_Q1.0171.00
130_P222_A1.0161.00
182_D210_S1.0101.00
22_M34_L1.0081.00
233_P236_G1.0061.00
133_V220_L1.0061.00
9_K129_E1.0001.00
135_L216_G0.9931.00
142_E262_K0.9881.00
185_G194_V0.9711.00
47_N50_I0.9661.00
128_D223_D0.9611.00
39_K44_Y0.9561.00
271_G274_Q0.9551.00
42_I72_F0.9551.00
58_V105_M0.9541.00
223_D227_L0.9301.00
183_C256_A0.9161.00
194_V197_V0.9081.00
22_M26_T0.8961.00
180_V213_A0.8941.00
157_R160_D0.8891.00
42_I59_L0.8851.00
152_L155_M0.8851.00
141_D262_K0.8821.00
274_Q277_V0.8801.00
273_M276_F0.8741.00
64_S67_S0.8731.00
35_P40_P0.8691.00
9_K160_D0.8691.00
198_G207_V0.8681.00
16_A60_V0.8671.00
278_E281_I0.8621.00
177_A271_G0.8581.00
158_R161_E0.8491.00
40_P71_H0.8431.00
270_L274_Q0.8271.00
61_T108_R0.8261.00
208_A211_N0.8251.00
155_M166_Q0.8221.00
176_T204_K0.8181.00
52_A153_A0.8171.00
277_V281_I0.8151.00
61_T68_I0.8051.00
14_P135_L0.8051.00
181_V256_A0.8041.00
61_T69_E0.8031.00
245_I254_V0.8021.00
274_Q278_E0.8011.00
223_D251_K0.8011.00
159_F221_S0.8011.00
10_K58_V0.7971.00
132_A156_I0.7951.00
126_V225_W0.7941.00
54_I156_I0.7921.00
119_V224_I0.7911.00
41_L45_V0.7901.00
69_E106_Q0.7891.00
37_V276_F0.7851.00
177_A202_K0.7851.00
164_H195_P0.7841.00
71_H74_T0.7831.00
37_V44_Y0.7791.00
255_E258_H0.7781.00
138_V263_S0.7751.00
248_L252_E0.7661.00
25_A269_K0.7651.00
42_I68_I0.7651.00
19_G31_K0.7631.00
73_D76_F0.7631.00
50_I55_T0.7591.00
10_K126_V0.7541.00
13_I136_P0.7531.00
123_H127_G0.7531.00
156_I159_F0.7521.00
231_T247_M0.7491.00
26_T34_L0.7491.00
165_S254_V0.7451.00
264_H275_A0.7411.00
246_D249_I0.7371.00
69_E73_D0.7371.00
115_L135_L0.7361.00
165_S248_L0.7321.00
276_F280_G0.7301.00
73_D77_E0.7291.00
154_E257_Y0.7251.00
12_V60_V0.7251.00
223_D253_T0.7201.00
32_E136_P0.7161.00
38_D44_Y0.7091.00
114_G242_T0.7071.00
199_V214_I0.7071.00
156_I219_V0.7071.00
10_K127_G0.7041.00
107_V125_V0.7031.00
236_G240_Q0.7011.00
159_F219_V0.7011.00
212_L256_A0.7001.00
123_H131_V0.7001.00
120_L239_I0.6991.00
162_T166_Q0.6991.00
273_M280_G0.6971.00
50_I57_I0.6961.00
107_V122_A0.6941.00
30_P67_S0.6931.00
50_I75_S0.6911.00
158_R166_Q0.6901.00
163_G221_S0.6901.00
70_N73_D0.6881.00
117_H239_I0.6851.00
46_V104_I0.6801.00
248_L251_K0.6791.00
177_A268_N0.6781.00
60_V122_A0.6761.00
127_G222_A0.6671.00
170_E213_A0.6631.00
175_V180_V0.6631.00
151_N262_K0.6621.00
171_P212_L0.6621.00
200_V211_N0.6551.00
9_K156_I0.6541.00
72_F104_I0.6531.00
44_Y47_N0.6511.00
232_P239_I0.6481.00
25_A29_I0.6471.00
245_I249_I0.6451.00
207_V211_N0.6451.00
48_E217_R0.6421.00
46_V72_F0.6421.00
227_L248_L0.6411.00
175_V178_Y0.6381.00
128_D222_A0.6371.00
222_A225_W0.6371.00
55_T103_T0.6341.00
40_P44_Y0.6301.00
155_M257_Y0.6291.00
55_T101_H0.6281.00
43_Q72_F0.6271.00
231_T239_I0.6271.00
172_V175_V0.6211.00
203_P235_A0.6171.00
111_L117_H0.6171.00
39_K43_Q0.6161.00
223_D252_E0.6151.00
62_H65_K0.6131.00
172_V213_A0.6131.00
169_V196_M0.6091.00
11_A57_I0.6071.00
197_V200_V0.6071.00
21_R31_K0.6071.00
243_D247_M0.6061.00
14_P115_L0.6061.00
59_L72_F0.6051.00
214_I218_Y0.6051.00
151_N155_M0.6031.00
153_A156_I0.5991.00
48_E52_A0.5991.00
169_V258_H0.5961.00
12_V58_V0.5951.00
47_N51_A0.5931.00
200_V203_P0.5911.00
200_V207_V0.5881.00
46_V59_L0.5871.00
132_A152_L0.5871.00
231_T244_A0.5841.00
112_A117_H0.5801.00
182_D209_P0.5801.00
129_E221_S0.5791.00
278_E282_R0.5761.00
36_L276_F0.5761.00
50_I101_H0.5681.00
9_K55_T0.5671.00
48_E152_L0.5671.00
14_P118_A0.5661.00
60_V118_A0.5641.00
226_P251_K0.5631.00
124_P127_G0.5611.00
269_K273_M0.5601.00
234_G237_D0.5571.00
59_L104_I0.5571.00
67_S71_H0.5551.00
232_P235_A0.5551.00
34_L272_Y0.5551.00
140_L215_V0.5541.00
151_N159_F0.5531.00
12_V119_V0.5521.00
178_Y265_D0.5501.00
185_G195_P0.5501.00
25_A28_A0.5471.00
44_Y279_Y0.5451.00
199_V246_D0.5451.00
215_V263_S0.5411.00
37_V279_Y0.5411.00
68_I72_F0.5371.00
129_E223_D0.5321.00
31_K137_D0.5321.00
173_A212_L0.5311.00
30_P64_S0.5301.00
135_L138_V0.5291.00
123_H126_V0.5291.00
134_I152_L0.5291.00
174_D178_Y0.5271.00
9_K130_P0.5261.00
49_C132_A0.5231.00
155_M159_F0.5211.00
234_G238_E0.5211.00
10_K131_V0.5191.00
233_P239_I0.5161.00
115_L214_I0.5161.00
75_S106_Q0.5141.00
166_Q257_Y0.5141.00
159_F164_H0.5141.00
123_H226_P0.5141.00
142_E260_K0.5131.00
227_L231_T0.5121.00
220_L244_A0.5111.00
47_N75_S0.5111.00
110_G117_H0.5111.00
205_A208_A0.5091.00
36_L272_Y0.5081.00
178_Y201_E0.5071.00
184_K194_V0.5071.00
166_Q255_E0.5061.00
72_F75_S0.5031.00
130_P159_F0.5031.00
109_Q118_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e3dA 3 0.9702 100 0.304 Contact Map
2ux8A 4 0.9503 100 0.346 Contact Map
3jukA 3 0.8642 100 0.348 Contact Map
2pa4A 3 0.957 100 0.357 Contact Map
1iimA 3 0.8543 100 0.383 Contact Map
4ho4A 3 0.8477 100 0.383 Contact Map
1lvwA 3 0.8543 100 0.386 Contact Map
1mc3A 3 0.8477 100 0.39 Contact Map
4ecmA 3 0.8013 100 0.405 Contact Map
3brkX 2 0.8444 100 0.413 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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