GALU - ECOLI - GREMLIN Contacts

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GALU - UTP--glucose-1-phosphate uridylyltransferase

UniProt:	P0AEP3	Sequences: MAAINTKVKKAVIPVAGLGTRMLPATKAIPKEMLPLVDKPLIQYVVNECIAAGITEIVLVTHSSKNSIENHFDTSFELEAMLEKRVKRQLLDEVQSICPPHVTIMQVRQGLAKGLGHAVLCAHPVVGDEPVAVILPDVILDEYESDLSQDNLAEMIRRFDETGHSQIMVEPVADVTAYGVVDCKGVELAPGESVPMVGVVEKPKADVAPSNLAIVGRYVLSADIWPLLAKTPPGAGDEIQLTDAIDMLIEKETVEAYHMKGKSHDCGNKLGYMQAFVEYGIRHNTLGTEFKAWLEEEMGIKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11319
Length:	302 (235)
Sequences:	19619 (11670)
Seq/√Len:	761.2

ECOLI - GALU GALF RMLA1 RMLA2 GLMU GLGC
BACSU - GTAB YNGB RMLA YTDA RFBF GLMU GLGC GLGD
HALSA - Q9HSV0 Q9HQQ4 Q9HSZ9 Q9HSZ8 Q9HS61 Q9HSW4
SULSO - Q97U06 Q7LXE7 Q97ZD1 Q97VX4 Q97XG0 Q7LXK9 Q980H9 Q7LXG3 Q980D4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
123_H	229_A	3.613	1.00
182_D	197_V	2.856	1.00
182_D	198_G	2.737	1.00
171_P	211_N	2.642	1.00
113_K	117_H	2.604	1.00
39_K	47_N	2.597	1.00
56_E	103_T	2.518	1.00
184_K	195_P	2.450	1.00
164_H	255_E	2.438	1.00
169_V	256_A	2.402	1.00
227_L	251_K	2.362	1.00
184_K	193_S	2.317	1.00
11_A	54_I	2.253	1.00
130_P	221_S	2.209	1.00
171_P	258_H	2.207	1.00
10_K	56_E	2.178	1.00
43_Q	71_H	2.168	1.00
246_D	250_E	2.159	1.00
159_F	166_Q	2.108	1.00
204_K	207_V	2.104	1.00
195_P	255_E	2.093	1.00
184_K	197_V	2.086	1.00
65_K	69_E	2.059	1.00
227_L	247_M	2.052	1.00
11_A	49_C	2.005	1.00
130_P	160_D	2.000	1.00
247_M	251_K	1.998	1.00
61_T	65_K	1.939	1.00
164_H	253_T	1.858	1.00
107_V	121_C	1.842	1.00
247_M	250_E	1.793	1.00
174_D	177_A	1.792	1.00
46_V	57_I	1.782	1.00
158_R	257_Y	1.760	1.00
120_L	123_H	1.760	1.00
162_T	255_E	1.743	1.00
66_N	70_N	1.734	1.00
119_V	133_V	1.724	1.00
12_V	122_A	1.719	1.00
49_C	134_I	1.716	1.00
15_V	59_L	1.704	1.00
264_H	274_Q	1.692	1.00
67_S	70_N	1.650	1.00
198_G	246_D	1.649	1.00
205_A	209_P	1.615	1.00
212_L	258_H	1.591	1.00
56_E	105_M	1.562	1.00
243_D	246_D	1.561	1.00
29_I	35_P	1.531	1.00
153_A	157_R	1.520	1.00
58_V	125_V	1.509	1.00
183_C	212_L	1.507	1.00
130_P	219_V	1.503	1.00
158_R	162_T	1.500	1.00
202_K	208_A	1.497	1.00
43_Q	47_N	1.489	1.00
196_M	254_V	1.472	1.00
196_M	256_A	1.467	1.00
57_I	102_V	1.466	1.00
151_N	154_E	1.459	1.00
117_H	121_C	1.429	1.00
29_I	67_S	1.427	1.00
155_M	219_V	1.356	1.00
126_V	131_V	1.352	1.00
227_L	244_A	1.351	1.00
223_D	226_P	1.347	1.00
169_V	181_V	1.344	1.00
155_M	168_M	1.333	1.00
33_M	67_S	1.331	1.00
207_V	210_S	1.329	1.00
226_P	230_K	1.328	1.00
23_L	27_K	1.325	1.00
165_S	220_L	1.323	1.00
157_R	161_E	1.321	1.00
131_V	222_A	1.301	1.00
200_V	209_P	1.292	1.00
181_V	196_M	1.289	1.00
272_Y	276_F	1.288	1.00
117_H	120_L	1.276	1.00
244_A	247_M	1.264	1.00
230_K	251_K	1.243	1.00
230_K	247_M	1.230	1.00
154_E	157_R	1.229	1.00
266_C	275_A	1.220	1.00
220_L	245_I	1.219	1.00
226_P	229_A	1.218	1.00
120_L	229_A	1.218	1.00
40_P	43_Q	1.203	1.00
185_G	193_S	1.198	1.00
195_P	253_T	1.195	1.00
10_K	129_E	1.187	1.00
179_G	201_E	1.183	1.00
273_M	277_V	1.179	1.00
69_E	108_R	1.169	1.00
50_I	102_V	1.168	1.00
65_K	108_R	1.166	1.00
58_V	107_V	1.160	1.00
132_A	219_V	1.155	1.00
183_C	194_V	1.146	1.00
268_N	271_G	1.141	1.00
18_L	112_A	1.137	1.00
105_M	125_V	1.135	1.00
264_H	278_E	1.125	1.00
262_K	278_E	1.123	1.00
123_H	225_W	1.120	1.00
156_I	160_D	1.113	1.00
242_T	246_D	1.100	1.00
182_D	200_V	1.084	1.00
129_E	222_A	1.081	1.00
176_T	202_K	1.080	1.00
141_D	282_R	1.080	1.00
227_L	230_K	1.077	1.00
169_V	212_L	1.075	1.00
277_V	280_G	1.068	1.00
58_V	122_A	1.068	1.00
12_V	131_V	1.064	1.00
41_L	266_C	1.062	1.00
154_E	158_R	1.058	1.00
158_R	255_E	1.044	1.00
194_V	258_H	1.039	1.00
61_T	106_Q	1.036	1.00
66_N	69_E	1.035	1.00
120_L	228_L	1.032	1.00
43_Q	75_S	1.030	1.00
54_I	132_A	1.025	1.00
33_M	71_H	1.023	1.00
73_D	106_Q	1.017	1.00
130_P	222_A	1.016	1.00
182_D	210_S	1.010	1.00
22_M	34_L	1.008	1.00
233_P	236_G	1.006	1.00
133_V	220_L	1.006	1.00
9_K	129_E	1.000	1.00
135_L	216_G	0.993	1.00
142_E	262_K	0.988	1.00
185_G	194_V	0.971	1.00
47_N	50_I	0.966	1.00
128_D	223_D	0.961	1.00
39_K	44_Y	0.956	1.00
271_G	274_Q	0.955	1.00
42_I	72_F	0.955	1.00
58_V	105_M	0.954	1.00
223_D	227_L	0.930	1.00
183_C	256_A	0.916	1.00
194_V	197_V	0.908	1.00
22_M	26_T	0.896	1.00
180_V	213_A	0.894	1.00
157_R	160_D	0.889	1.00
42_I	59_L	0.885	1.00
152_L	155_M	0.885	1.00
141_D	262_K	0.882	1.00
274_Q	277_V	0.880	1.00
273_M	276_F	0.874	1.00
64_S	67_S	0.873	1.00
35_P	40_P	0.869	1.00
9_K	160_D	0.869	1.00
198_G	207_V	0.868	1.00
16_A	60_V	0.867	1.00
278_E	281_I	0.862	1.00
177_A	271_G	0.858	1.00
158_R	161_E	0.849	1.00
40_P	71_H	0.843	1.00
270_L	274_Q	0.827	1.00
61_T	108_R	0.826	1.00
208_A	211_N	0.825	1.00
155_M	166_Q	0.822	1.00
176_T	204_K	0.818	1.00
52_A	153_A	0.817	1.00
277_V	281_I	0.815	1.00
61_T	68_I	0.805	1.00
14_P	135_L	0.805	1.00
181_V	256_A	0.804	1.00
61_T	69_E	0.803	1.00
245_I	254_V	0.802	1.00
274_Q	278_E	0.801	1.00
223_D	251_K	0.801	1.00
159_F	221_S	0.801	1.00
10_K	58_V	0.797	1.00
132_A	156_I	0.795	1.00
126_V	225_W	0.794	1.00
54_I	156_I	0.792	1.00
119_V	224_I	0.791	1.00
41_L	45_V	0.790	1.00
69_E	106_Q	0.789	1.00
37_V	276_F	0.785	1.00
177_A	202_K	0.785	1.00
164_H	195_P	0.784	1.00
71_H	74_T	0.783	1.00
37_V	44_Y	0.779	1.00
255_E	258_H	0.778	1.00
138_V	263_S	0.775	1.00
248_L	252_E	0.766	1.00
25_A	269_K	0.765	1.00
42_I	68_I	0.765	1.00
19_G	31_K	0.763	1.00
73_D	76_F	0.763	1.00
50_I	55_T	0.759	1.00
10_K	126_V	0.754	1.00
13_I	136_P	0.753	1.00
123_H	127_G	0.753	1.00
156_I	159_F	0.752	1.00
231_T	247_M	0.749	1.00
26_T	34_L	0.749	1.00
165_S	254_V	0.745	1.00
264_H	275_A	0.741	1.00
246_D	249_I	0.737	1.00
69_E	73_D	0.737	1.00
115_L	135_L	0.736	1.00
165_S	248_L	0.732	1.00
276_F	280_G	0.730	1.00
73_D	77_E	0.729	1.00
154_E	257_Y	0.725	1.00
12_V	60_V	0.725	1.00
223_D	253_T	0.720	1.00
32_E	136_P	0.716	1.00
38_D	44_Y	0.709	1.00
114_G	242_T	0.707	1.00
199_V	214_I	0.707	1.00
156_I	219_V	0.707	1.00
10_K	127_G	0.704	1.00
107_V	125_V	0.703	1.00
236_G	240_Q	0.701	1.00
159_F	219_V	0.701	1.00
212_L	256_A	0.700	1.00
123_H	131_V	0.700	1.00
120_L	239_I	0.699	1.00
162_T	166_Q	0.699	1.00
273_M	280_G	0.697	1.00
50_I	57_I	0.696	1.00
107_V	122_A	0.694	1.00
30_P	67_S	0.693	1.00
50_I	75_S	0.691	1.00
158_R	166_Q	0.690	1.00
163_G	221_S	0.690	1.00
70_N	73_D	0.688	1.00
117_H	239_I	0.685	1.00
46_V	104_I	0.680	1.00
248_L	251_K	0.679	1.00
177_A	268_N	0.678	1.00
60_V	122_A	0.676	1.00
127_G	222_A	0.667	1.00
170_E	213_A	0.663	1.00
175_V	180_V	0.663	1.00
151_N	262_K	0.662	1.00
171_P	212_L	0.662	1.00
200_V	211_N	0.655	1.00
9_K	156_I	0.654	1.00
72_F	104_I	0.653	1.00
44_Y	47_N	0.651	1.00
232_P	239_I	0.648	1.00
25_A	29_I	0.647	1.00
245_I	249_I	0.645	1.00
207_V	211_N	0.645	1.00
48_E	217_R	0.642	1.00
46_V	72_F	0.642	1.00
227_L	248_L	0.641	1.00
175_V	178_Y	0.638	1.00
128_D	222_A	0.637	1.00
222_A	225_W	0.637	1.00
55_T	103_T	0.634	1.00
40_P	44_Y	0.630	1.00
155_M	257_Y	0.629	1.00
55_T	101_H	0.628	1.00
43_Q	72_F	0.627	1.00
231_T	239_I	0.627	1.00
172_V	175_V	0.621	1.00
203_P	235_A	0.617	1.00
111_L	117_H	0.617	1.00
39_K	43_Q	0.616	1.00
223_D	252_E	0.615	1.00
62_H	65_K	0.613	1.00
172_V	213_A	0.613	1.00
169_V	196_M	0.609	1.00
11_A	57_I	0.607	1.00
197_V	200_V	0.607	1.00
21_R	31_K	0.607	1.00
243_D	247_M	0.606	1.00
14_P	115_L	0.606	1.00
59_L	72_F	0.605	1.00
214_I	218_Y	0.605	1.00
151_N	155_M	0.603	1.00
153_A	156_I	0.599	1.00
48_E	52_A	0.599	1.00
169_V	258_H	0.596	1.00
12_V	58_V	0.595	1.00
47_N	51_A	0.593	1.00
200_V	203_P	0.591	1.00
200_V	207_V	0.588	1.00
46_V	59_L	0.587	1.00
132_A	152_L	0.587	1.00
231_T	244_A	0.584	1.00
112_A	117_H	0.580	1.00
182_D	209_P	0.580	1.00
129_E	221_S	0.579	1.00
278_E	282_R	0.576	1.00
36_L	276_F	0.576	1.00
50_I	101_H	0.568	1.00
9_K	55_T	0.567	1.00
48_E	152_L	0.567	1.00
14_P	118_A	0.566	1.00
60_V	118_A	0.564	1.00
226_P	251_K	0.563	1.00
124_P	127_G	0.561	1.00
269_K	273_M	0.560	1.00
234_G	237_D	0.557	1.00
59_L	104_I	0.557	1.00
67_S	71_H	0.555	1.00
232_P	235_A	0.555	1.00
34_L	272_Y	0.555	1.00
140_L	215_V	0.554	1.00
151_N	159_F	0.553	1.00
12_V	119_V	0.552	1.00
178_Y	265_D	0.550	1.00
185_G	195_P	0.550	1.00
25_A	28_A	0.547	1.00
44_Y	279_Y	0.545	1.00
199_V	246_D	0.545	1.00
215_V	263_S	0.541	1.00
37_V	279_Y	0.541	1.00
68_I	72_F	0.537	1.00
129_E	223_D	0.532	1.00
31_K	137_D	0.532	1.00
173_A	212_L	0.531	1.00
30_P	64_S	0.530	1.00
135_L	138_V	0.529	1.00
123_H	126_V	0.529	1.00
134_I	152_L	0.529	1.00
174_D	178_Y	0.527	1.00
9_K	130_P	0.526	1.00
49_C	132_A	0.523	1.00
155_M	159_F	0.521	1.00
234_G	238_E	0.521	1.00
10_K	131_V	0.519	1.00
233_P	239_I	0.516	1.00
115_L	214_I	0.516	1.00
75_S	106_Q	0.514	1.00
166_Q	257_Y	0.514	1.00
159_F	164_H	0.514	1.00
123_H	226_P	0.514	1.00
142_E	260_K	0.513	1.00
227_L	231_T	0.512	1.00
220_L	244_A	0.511	1.00
47_N	75_S	0.511	1.00
110_G	117_H	0.511	1.00
205_A	208_A	0.509	1.00
36_L	272_Y	0.508	1.00
178_Y	201_E	0.507	1.00
184_K	194_V	0.507	1.00
166_Q	255_E	0.506	1.00
72_F	75_S	0.503	1.00
130_P	159_F	0.503	1.00
109_Q	118_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2e3dA	3	0.9702	100	0.304	Contact Map
2ux8A	4	0.9503	100	0.346	Contact Map
3jukA	3	0.8642	100	0.348	Contact Map
2pa4A	3	0.957	100	0.357	Contact Map
1iimA	3	0.8543	100	0.383	Contact Map
4ho4A	3	0.8477	100	0.383	Contact Map
1lvwA	3	0.8543	100	0.386	Contact Map
1mc3A	3	0.8477	100	0.39	Contact Map
4ecmA	3	0.8013	100	0.405	Contact Map
3brkX	2	0.8444	100	0.413	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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