GREMLIN Database
FUCM - L-fucose mutarotase
UniProt: P0AEN8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10355
Length: 140 (139)
Sequences: 583 (393)
Seq/√Len: 33.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_G42_V3.7961.00
15_K19_E3.5781.00
25_E135_K3.1951.00
25_E113_R3.1281.00
27_I117_A2.9761.00
55_Q96_Q2.8551.00
16_V119_A2.7181.00
6_S52_D2.3580.99
8_L56_A2.2260.99
45_A53_L2.0830.98
6_S59_P2.0740.98
36_H42_V2.0230.98
63_L134_L2.0180.98
55_Q95_L1.9280.97
16_V43_I1.8680.97
71_V105_I1.8520.97
78_G81_L1.8330.96
13_L121_V1.8290.96
66_Y79_D1.8280.96
109_A112_E1.8140.96
28_F57_I1.8020.96
14_L18_A1.7250.95
71_V103_I1.7160.95
28_F50_V1.6790.94
66_Y76_V1.6490.94
89_Y132_I1.6300.93
49_L52_D1.5770.92
18_A60_L1.5730.92
28_F121_V1.5520.91
14_L60_L1.5430.91
25_E133_L1.5390.91
67_A135_K1.5330.91
33_F38_M1.5300.91
50_V89_Y1.5160.90
51_S89_Y1.5130.90
54_L132_I1.5100.90
10_S46_D1.4700.89
32_H139_T1.4560.88
9_I60_L1.4360.88
97_A100_P1.4260.87
88_R127_A1.4080.87
28_F53_L1.3930.86
71_V113_R1.3920.86
106_N109_A1.3680.85
113_R135_K1.3500.84
10_S45_A1.3060.82
17_L26_I1.2830.81
3_K97_A1.2780.81
32_H62_E1.2630.80
31_A130_G1.2530.79
103_I113_R1.2240.78
90_R94_S1.2210.77
51_S88_R1.2190.77
69_P103_I1.2070.77
62_E139_T1.1910.76
108_F112_E1.1870.75
70_L93_L1.1820.75
35_A120_I1.1720.74
48_L53_L1.1630.74
72_M104_R1.1570.74
29_S35_A1.1510.73
35_A122_I1.1410.72
72_M86_E1.1300.72
91_N95_L1.1250.71
43_I121_V1.1240.71
23_G64_D1.1110.70
12_E15_K1.1080.70
86_E89_Y1.0870.69
75_A81_L1.0860.69
26_I119_A1.0580.67
107_R111_Y1.0160.63
70_L132_I1.0090.63
31_A124_G0.9910.61
35_A42_V0.9670.60
70_L102_I0.9650.59
112_E116_K0.9500.58
13_L43_I0.9360.57
68_P103_I0.9300.57
36_H39_G0.9180.56
54_L89_Y0.9110.55
8_L48_L0.8970.54
85_V125_E0.8940.54
26_I134_L0.8880.53
128_K132_I0.8830.53
18_A121_V0.8820.53
72_M131_N0.8810.52
52_D57_I0.8710.52
27_I133_L0.8670.51
114_A120_I0.8480.50
76_V79_D0.8340.49
74_A106_N0.8340.49
4_T59_P0.8330.48
88_R91_N0.8220.48
31_A50_V0.8150.47
3_K96_Q0.8030.46
73_M107_R0.7970.45
31_A128_K0.7960.45
87_R90_R0.7940.45
48_L56_A0.7930.45
112_E115_Q0.7920.45
31_A131_N0.7910.45
7_P126_R0.7820.44
9_I14_L0.7820.44
37_S115_Q0.7790.44
71_V106_N0.7770.44
66_Y131_N0.7730.43
101_D139_T0.7610.42
91_N116_K0.7520.42
105_I109_A0.7470.41
24_D111_Y0.7440.41
11_P44_R0.7390.41
11_P19_E0.7350.40
55_Q92_A0.7280.40
34_P64_D0.7260.40
26_I121_V0.7230.39
82_D87_R0.7200.39
33_F120_I0.7160.39
84_E87_R0.7130.39
6_S55_Q0.7060.38
32_H128_K0.7030.38
43_I68_P0.6980.37
38_M120_I0.6950.37
93_L97_A0.6890.37
51_S92_A0.6860.36
53_L59_P0.6750.36
46_D85_V0.6690.35
38_M41_Q0.6670.35
94_S120_I0.6650.35
25_E71_V0.6580.34
76_V129_Y0.6540.34
76_V108_F0.6520.34
6_S90_R0.6510.34
94_S99_C0.6490.34
27_I33_F0.6450.33
49_L127_A0.6440.33
75_A80_T0.6440.33
44_R122_I0.6420.33
86_E127_A0.6390.33
24_D64_D0.6350.33
36_H118_F0.6340.33
57_I134_L0.6330.32
4_T126_R0.6290.32
25_E131_N0.6270.32
72_M132_I0.6250.32
19_E130_G0.6240.32
24_D107_R0.6240.32
92_A128_K0.6150.31
44_R54_L0.6150.31
54_L134_L0.6120.31
19_E36_H0.6090.31
7_P14_L0.6060.31
113_R117_A0.6000.30
14_L17_L0.5950.30
84_E93_L0.5950.30
4_T40_P0.5940.30
57_I132_I0.5910.29
39_G114_A0.5880.29
75_A83_P0.5860.29
93_L99_C0.5800.29
95_L112_E0.5800.29
5_I59_P0.5790.29
116_K126_R0.5770.29
103_I135_K0.5760.28
74_A80_T0.5750.28
9_I59_P0.5730.28
69_P100_P0.5700.28
83_P86_E0.5680.28
6_S60_L0.5660.28
108_F135_K0.5640.28
23_G76_V0.5570.27
33_F114_A0.5520.27
16_V135_K0.5510.27
9_I61_F0.5510.27
75_A79_D0.5500.27
105_I126_R0.5480.27
59_P62_E0.5470.27
53_L114_A0.5410.26
14_L124_G0.5400.26
12_E127_A0.5390.26
48_L139_T0.5360.26
61_F91_N0.5340.26
8_L80_T0.5330.26
10_S85_V0.5330.26
62_E86_E0.5320.26
18_A39_G0.5320.26
63_L70_L0.5280.25
19_E78_G0.5280.25
28_F54_L0.5270.25
113_R133_L0.5260.25
40_P116_K0.5250.25
33_F73_M0.5250.25
94_S116_K0.5180.25
13_L26_I0.5180.25
12_E55_Q0.5180.25
77_E91_N0.5170.25
58_I62_E0.5170.25
73_M114_A0.5170.25
34_P40_P0.5160.25
113_R116_K0.5140.24
1_M83_P0.5140.24
32_H58_I0.5140.24
48_L124_G0.5080.24
56_A59_P0.5060.24
11_P46_D0.5040.24
5_I8_L0.5030.24
100_P116_K0.5020.24
5_I91_N0.5000.24
32_H138_V0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wcvA 7 1 100 0.235 Contact Map
2ob5A 2 1 100 0.241 Contact Map
2wcuA 2 1 100 0.241 Contact Map
3mvkA 5 0.9857 100 0.247 Contact Map
4a34A 5 0.9857 100 0.249 Contact Map
3e7nA 6 0.9429 100 0.341 Contact Map
3p12A 2 0.8929 100 0.354 Contact Map
1ogdA 5 0.9143 100 0.36 Contact Map
1uf9A 1 0.6714 16.6 0.954 Contact Map
1ibjA 4 0.8857 14 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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