GREMLIN Database
FTSL - Cell division protein FtsL
UniProt: P0AEN4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11086
Length: 121 (99)
Sequences: 197 (128)
Seq/√Len: 12.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_V88_E2.9190.96
47_I101_A2.3660.88
25_P86_L2.2570.85
68_E97_V2.2090.84
57_A60_T2.1780.83
27_V46_I2.1390.82
108_Q117_I2.0710.80
28_I54_V2.0500.79
60_T88_E1.8980.73
20_E83_N1.8890.73
51_V54_V1.7800.68
53_V81_W1.7620.68
84_L105_L1.7510.67
43_F57_A1.7300.66
73_E76_A1.6930.64
49_T102_T1.6380.62
46_I102_T1.5490.57
72_L93_D1.5340.56
58_H98_E1.4430.52
53_V78_D1.4330.51
96_R100_I1.4220.51
41_C108_Q1.4110.50
68_E71_V1.3980.49
81_W91_L1.3790.48
28_I57_A1.3770.48
19_H69_Q1.3740.48
57_A83_N1.3550.47
78_D92_G1.3550.47
64_T97_V1.3330.46
53_V82_R1.3220.45
58_H83_N1.2740.43
74_R82_R1.2730.43
50_A63_L1.2510.42
46_I115_E1.2380.41
32_L66_Q1.2200.40
44_I50_A1.2200.40
66_Q100_I1.2140.40
22_H90_A1.2020.39
68_E118_V1.1930.39
93_D110_V1.1780.38
40_L74_R1.1750.38
44_I106_Q1.1380.36
83_N86_L1.1230.36
62_L108_Q1.1210.35
70_L98_E1.1100.35
47_I98_E1.0980.34
23_A30_D1.0690.33
58_H66_Q1.0620.33
52_T56_T1.0610.33
30_D51_V1.0340.31
21_R66_Q1.0270.31
113_S116_N1.0140.30
55_T113_S1.0120.30
58_H116_N1.0090.30
107_M118_V0.9930.30
83_N93_D0.9890.29
111_D114_Q0.9800.29
111_D117_I0.9680.29
109_H116_N0.9630.28
29_G35_F0.9580.28
45_C48_L0.9560.28
94_H110_V0.9540.28
33_L85_I0.9510.28
30_D46_I0.9430.27
81_W95_S0.9250.27
74_R101_A0.9140.26
41_C65_A0.9070.26
66_Q106_Q0.9040.26
31_D83_N0.8970.26
82_R109_H0.8950.26
32_L90_A0.8910.25
48_L73_E0.8900.25
21_R60_T0.8780.25
38_L73_E0.8690.25
65_A98_E0.8620.24
62_L99_R0.8520.24
64_T83_N0.8460.24
40_L59_H0.8370.23
54_V65_A0.8350.23
54_V74_R0.8300.23
83_N111_D0.8200.23
75_D110_V0.8150.22
74_R109_H0.8120.22
29_G54_V0.8110.22
32_L46_I0.8060.22
27_V84_L0.8020.22
32_L56_T0.7970.22
51_V117_I0.7930.22
40_L101_A0.7900.22
76_A93_D0.7830.21
75_D82_R0.7770.21
48_L51_V0.7730.21
62_L110_V0.7710.21
65_A86_L0.7560.20
44_I97_V0.7420.20
55_T116_N0.7390.20
47_I57_A0.7390.20
19_H118_V0.7290.20
25_P51_V0.7280.19
86_L104_K0.7220.19
27_V57_A0.7130.19
72_L84_L0.7090.19
80_E107_M0.7070.19
74_R118_V0.7050.19
40_L45_C0.7040.19
44_I52_T0.6940.18
31_D114_Q0.6880.18
44_I103_E0.6860.18
65_A115_E0.6850.18
90_A116_N0.6840.18
90_A97_V0.6840.18
37_K41_C0.6830.18
63_L70_L0.6760.18
41_C50_A0.6740.18
60_T92_G0.6730.18
49_T98_E0.6720.18
32_L44_I0.6710.18
82_R94_H0.6690.18
38_L103_E0.6620.17
37_K43_F0.6560.17
29_G70_L0.6430.17
48_L56_T0.6380.17
24_L42_L0.6370.17
52_T79_I0.6280.16
39_P90_A0.6120.16
70_L97_V0.6010.16
37_K57_A0.6000.16
79_I95_S0.5910.15
28_I91_L0.5850.15
94_H105_L0.5810.15
76_A92_G0.5770.15
55_T59_H0.5690.15
49_T91_L0.5610.15
86_L117_I0.5540.14
75_D94_H0.5500.14
41_C69_Q0.5470.14
48_L69_Q0.5400.14
97_V103_E0.5400.14
21_R92_G0.5390.14
47_I70_L0.5390.14
87_E91_L0.5350.14
19_H41_C0.5340.14
102_T112_P0.5270.14
20_E101_A0.5260.14
49_T118_V0.5140.13
75_D81_W0.5120.13
58_H105_L0.5050.13
47_I50_A0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mcbA 1 0.1736 8.1 0.948 Contact Map
3mceA 2 0.2231 4.3 0.954 Contact Map
2fswA 2 0.4959 3.7 0.955 Contact Map
4p6vC 1 0.719 3.6 0.956 Contact Map
2ju0B 1 0.3471 2.6 0.959 Contact Map
4v3iA 2 0.1488 1.7 0.963 Contact Map
1r1uA 2 0.4959 1.6 0.963 Contact Map
1biaA 1 0.3554 1.5 0.964 Contact Map
4pzjA 2 0.3388 1.5 0.964 Contact Map
5ajoA 1 0.1488 1.5 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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