FLIY - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

FLIY - Cystine-binding periplasmic protein

UniProt:	P0AEM9	Sequences: MKLAHLGRQALMGVMAVALVAGMSVKSFADEGLLNKVKERGTLLVGLEGTYPPFSFQGDDGKLTGFEVEFAQQLAKHLGVEASLKPTKWDGMLASLDSKRIDVVINQVTISDERKKKYDFSTPYTISGIQALVKKGNEGTIKTADDLKGKKVGVGLGTNYEEWLRQNVQGVDVRTYDDDPTKYQDLRVGRIDAILVDRLAALDLVKKTNDTLAVTGEAFSRQESGVALRKGNEDLLKAVNDAIAEMQKDGTLQALSEKWFGADVTK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12680
Length:	266 (238)
Sequences:	21668 (15665)
Seq/√Len:	1015.4

ECOLI - FLIY GLTI YHDW ARGT HISJ GLNH ARTJ ARTI MLTF EVGS
BACSU - GLNH TCYK YCKB TCYJ TCYA YXEM ARTP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
46_G	101_I	3.785	1.00
153_G	191_I	3.671	1.00
42_T	83_S	3.669	1.00
77_H	245_E	2.909	1.00
161_E	175_T	2.491	1.00
176_Y	185_D	2.447	1.00
110_I	115_K	2.343	1.00
44_L	83_S	2.343	1.00
122_T	244_A	2.329	1.00
95_S	101_I	2.315	1.00
178_D	181_T	2.200	1.00
110_I	225_G	2.193	1.00
42_T	81_E	2.137	1.00
44_L	85_K	2.134	1.00
161_E	165_R	2.118	1.00
251_T	254_A	2.092	1.00
97_D	117_K	2.058	1.00
112_D	115_K	2.050	1.00
119_D	236_L	2.000	1.00
228_L	236_L	1.998	1.00
58_G	64_T	1.993	1.00
118_Y	227_A	1.993	1.00
73_Q	76_K	1.992	1.00
75_A	82_A	1.981	1.00
253_Q	257_E	1.979	1.00
151_K	174_R	1.946	1.00
244_A	248_K	1.940	1.00
236_L	240_N	1.936	1.00
77_H	242_A	1.923	1.00
182_K	194_I	1.918	1.00
143_T	146_D	1.891	1.00
196_V	201_A	1.867	1.00
122_T	240_N	1.830	1.00
45_V	71_A	1.829	1.00
228_L	239_V	1.804	1.00
151_K	172_D	1.799	1.00
185_D	190_R	1.770	1.00
142_K	146_D	1.709	1.00
132_L	201_A	1.675	1.00
73_Q	251_T	1.659	1.00
73_Q	77_H	1.624	1.00
73_Q	246_M	1.623	1.00
95_S	100_R	1.608	1.00
58_G	62_K	1.602	1.00
134_K	189_G	1.602	1.00
134_K	137_N	1.597	1.00
105_I	226_V	1.590	1.00
156_L	177_D	1.529	1.00
121_S	240_N	1.519	1.00
126_I	223_E	1.516	1.00
87_T	95_S	1.511	1.00
229_R	232_N	1.505	1.00
162_E	166_Q	1.458	1.00
233_E	237_K	1.443	1.00
92_M	104_V	1.439	1.00
237_K	241_D	1.428	1.00
77_H	249_D	1.417	1.00
69_E	258_K	1.416	1.00
35_N	39_E	1.387	1.00
238_A	241_D	1.366	1.00
93_L	118_Y	1.355	1.00
56_F	64_T	1.353	1.00
74_L	242_A	1.347	1.00
163_W	167_N	1.345	1.00
57_Q	86_P	1.340	1.00
135_K	211_T	1.327	1.00
130_Q	198_R	1.327	1.00
198_R	202_L	1.324	1.00
185_D	191_I	1.322	1.00
150_K	192_D	1.318	1.00
68_V	72_Q	1.315	1.00
49_G	86_P	1.312	1.00
119_D	231_G	1.308	1.00
45_V	103_V	1.305	1.00
72_Q	84_L	1.299	1.00
151_K	192_D	1.296	1.00
108_V	227_A	1.282	1.00
187_R	211_T	1.270	1.00
165_R	175_T	1.269	1.00
78_L	242_A	1.269	1.00
136_G	213_A	1.249	1.00
71_A	105_I	1.246	1.00
186_L	212_L	1.246	1.00
242_A	245_E	1.240	1.00
129_I	160_Y	1.231	1.00
99_K	229_R	1.224	1.00
177_D	181_T	1.208	1.00
133_V	193_A	1.197	1.00
135_K	213_A	1.192	1.00
137_N	140_T	1.186	1.00
94_A	97_D	1.184	1.00
153_G	176_Y	1.184	1.00
36_K	40_R	1.182	1.00
66_F	256_S	1.180	1.00
131_A	193_A	1.179	1.00
67_E	124_Y	1.171	1.00
152_V	193_A	1.165	1.00
184_Q	187_R	1.164	1.00
87_T	101_I	1.156	1.00
247_Q	252_L	1.152	1.00
238_A	242_A	1.147	1.00
245_E	249_D	1.145	1.00
184_Q	188_V	1.135	1.00
104_V	108_V	1.131	1.00
80_V	238_A	1.117	1.00
154_V	161_E	1.107	1.00
176_Y	182_K	1.101	1.00
113_E	116_K	1.091	1.00
242_A	246_M	1.079	1.00
88_K	91_G	1.075	1.00
32_G	234_D	1.059	1.00
66_F	255_L	1.056	1.00
119_D	230_K	1.054	1.00
41_G	80_V	1.052	1.00
71_A	84_L	1.052	1.00
94_A	98_S	1.051	1.00
35_N	38_K	1.040	1.00
130_Q	214_V	1.038	1.00
186_L	194_I	1.030	1.00
45_V	82_A	1.030	1.00
40_R	44_L	1.021	1.00
133_V	215_T	1.018	1.00
186_L	191_I	1.011	1.00
70_F	252_L	1.001	1.00
72_Q	76_K	0.992	1.00
234_D	238_A	0.992	1.00
241_D	245_E	0.990	1.00
133_V	137_N	0.989	1.00
251_T	255_L	0.988	1.00
156_L	175_T	0.987	1.00
71_A	82_A	0.984	1.00
64_T	69_E	0.983	1.00
155_G	158_T	0.981	1.00
119_D	233_E	0.981	1.00
103_V	239_V	0.972	1.00
69_E	72_Q	0.969	1.00
162_E	165_R	0.963	1.00
103_V	228_L	0.958	1.00
111_S	114_R	0.952	1.00
203_D	207_K	0.952	1.00
70_F	246_M	0.943	1.00
233_E	236_L	0.943	1.00
16_A	19_L	0.943	1.00
93_L	108_V	0.941	1.00
153_G	182_K	0.939	1.00
69_E	259_W	0.938	1.00
121_S	239_V	0.935	1.00
122_T	247_Q	0.930	1.00
77_H	251_T	0.926	1.00
63_L	68_V	0.925	1.00
97_D	118_Y	0.917	1.00
168_V	171_V	0.917	1.00
74_L	239_V	0.915	1.00
246_M	251_T	0.907	1.00
49_G	63_L	0.905	1.00
120_F	227_A	0.896	1.00
240_N	244_A	0.894	1.00
181_T	184_Q	0.891	1.00
62_K	72_Q	0.890	1.00
34_L	37_V	0.887	1.00
252_L	256_S	0.883	1.00
66_F	252_L	0.870	1.00
52_P	56_F	0.867	1.00
254_A	257_E	0.864	1.00
180_P	184_Q	0.862	1.00
37_V	80_V	0.861	1.00
163_W	166_Q	0.860	1.00
112_D	116_K	0.858	1.00
174_R	185_D	0.857	1.00
91_G	95_S	0.855	1.00
37_V	41_G	0.853	1.00
127_S	199_L	0.847	1.00
128_G	198_R	0.843	1.00
89_W	92_M	0.841	1.00
57_Q	63_L	0.838	1.00
71_A	226_V	0.835	1.00
37_V	40_R	0.834	1.00
234_D	237_K	0.830	1.00
254_A	258_K	0.828	1.00
43_L	80_V	0.828	1.00
109_T	222_Q	0.822	1.00
103_V	226_V	0.822	1.00
33_L	36_K	0.821	1.00
73_Q	242_A	0.814	1.00
240_N	243_I	0.810	1.00
22_G	25_V	0.808	1.00
43_L	103_V	0.799	1.00
115_K	230_K	0.797	1.00
57_Q	61_G	0.794	1.00
47_L	84_L	0.793	1.00
19_L	22_G	0.791	1.00
104_V	227_A	0.789	1.00
141_I	146_D	0.788	1.00
179_D	196_V	0.788	1.00
145_D	148_K	0.786	1.00
15_M	18_A	0.785	1.00
131_A	195_L	0.784	1.00
44_L	102_D	0.784	1.00
54_F	125_T	0.774	1.00
74_L	78_L	0.774	1.00
71_A	103_V	0.772	1.00
137_N	141_I	0.767	1.00
47_L	68_V	0.766	1.00
32_G	35_N	0.765	1.00
245_E	248_K	0.761	1.00
132_L	212_L	0.757	1.00
21_A	24_S	0.751	1.00
133_V	213_A	0.747	1.00
78_L	238_A	0.746	1.00
77_H	246_M	0.741	1.00
38_K	41_G	0.740	1.00
43_L	75_A	0.737	1.00
253_Q	256_S	0.736	1.00
20_V	23_M	0.732	1.00
147_L	193_A	0.731	1.00
85_K	100_R	0.731	1.00
246_M	249_D	0.730	1.00
148_K	170_G	0.730	1.00
167_N	170_G	0.724	1.00
202_L	206_K	0.722	1.00
165_R	173_V	0.720	1.00
114_R	120_F	0.718	1.00
42_T	80_V	0.715	1.00
96_L	104_V	0.713	1.00
56_F	259_W	0.711	1.00
121_S	226_V	0.711	1.00
126_I	221_R	0.704	1.00
96_L	101_I	0.699	1.00
34_L	38_K	0.699	1.00
74_L	105_I	0.697	1.00
93_L	97_D	0.696	1.00
226_V	239_V	0.691	1.00
183_Y	187_R	0.691	1.00
241_D	244_A	0.689	1.00
45_V	84_L	0.684	1.00
127_S	198_R	0.683	1.00
181_T	185_D	0.681	1.00
134_K	211_T	0.680	1.00
246_M	250_G	0.680	1.00
47_L	106_N	0.680	1.00
183_Y	212_L	0.678	1.00
72_Q	82_A	0.678	1.00
153_G	185_D	0.677	1.00
46_G	92_M	0.677	1.00
246_M	252_L	0.676	1.00
237_K	240_N	0.672	1.00
91_G	94_A	0.670	1.00
51_Y	107_Q	0.669	1.00
232_N	235_L	0.669	1.00
87_T	92_M	0.668	1.00
164_L	173_V	0.667	1.00
89_W	108_V	0.666	1.00
121_S	228_L	0.666	1.00
32_G	36_K	0.665	1.00
73_Q	255_L	0.655	1.00
64_T	259_W	0.651	1.00
109_T	114_R	0.647	1.00
176_Y	191_I	0.645	1.00
70_F	243_I	0.644	1.00
96_L	118_Y	0.644	1.00
68_V	84_L	0.643	1.00
48_E	55_S	0.642	1.00
75_A	78_L	0.635	1.00
99_K	231_G	0.634	1.00
49_G	55_S	0.632	1.00
202_L	214_V	0.627	1.00
85_K	101_I	0.626	1.00
108_V	118_Y	0.626	1.00
154_V	175_T	0.625	1.00
71_A	75_A	0.624	1.00
244_A	247_Q	0.622	1.00
75_A	79_G	0.621	1.00
110_I	123_P	0.619	1.00
140_T	213_A	0.618	1.00
96_L	229_R	0.618	1.00
75_A	80_V	0.618	1.00
174_R	191_I	0.615	1.00
14_V	18_A	0.615	1.00
119_D	232_N	0.613	1.00
121_S	243_I	0.612	1.00
97_D	229_R	0.612	1.00
159_N	222_Q	0.611	1.00
120_F	225_G	0.611	1.00
51_Y	89_W	0.610	1.00
130_Q	216_G	0.610	1.00
203_D	206_K	0.609	1.00
48_E	89_W	0.607	1.00
151_K	191_I	0.606	1.00
122_T	243_I	0.605	1.00
128_G	221_R	0.604	1.00
16_A	20_V	0.604	1.00
129_I	195_L	0.600	1.00
40_R	102_D	0.599	1.00
132_L	183_Y	0.594	1.00
201_A	205_V	0.594	1.00
196_V	200_A	0.594	1.00
205_V	208_T	0.592	1.00
128_G	218_A	0.589	1.00
123_P	126_I	0.588	1.00
110_I	120_F	0.587	1.00
52_P	207_K	0.587	1.00
128_G	220_S	0.582	1.00
18_A	21_A	0.580	1.00
47_L	63_L	0.579	1.00
55_S	106_N	0.579	1.00
36_K	39_E	0.575	1.00
130_Q	201_A	0.573	1.00
140_T	150_K	0.572	1.00
155_G	179_D	0.571	1.00
48_E	155_G	0.569	1.00
78_L	235_L	0.567	1.00
187_R	209_N	0.566	1.00
164_L	195_L	0.565	1.00
74_L	226_V	0.564	1.00
250_G	253_Q	0.561	1.00
100_R	190_R	0.560	1.00
187_R	208_T	0.555	1.00
212_L	215_T	0.553	1.00
76_K	251_T	0.551	1.00
125_T	224_S	0.551	1.00
250_G	254_A	0.550	1.00
58_G	61_G	0.549	1.00
46_G	104_V	0.549	1.00
33_L	229_R	0.548	1.00
132_L	205_V	0.545	1.00
137_N	192_D	0.544	1.00
53_P	56_F	0.542	1.00
15_M	19_L	0.541	1.00
85_K	95_S	0.532	1.00
92_M	108_V	0.531	1.00
38_K	238_A	0.530	1.00
127_S	224_S	0.530	1.00
185_D	188_V	0.530	1.00
89_W	114_R	0.528	1.00
77_H	238_A	0.525	1.00
246_M	255_L	0.522	1.00
136_G	189_G	0.520	1.00
43_L	235_L	0.518	1.00
49_G	57_Q	0.518	1.00
14_V	17_V	0.518	1.00
204_L	207_K	0.516	1.00
187_R	212_L	0.515	1.00
154_V	164_L	0.515	1.00
115_K	119_D	0.514	1.00
174_R	190_R	0.513	1.00
228_L	232_N	0.512	1.00
71_A	74_L	0.512	1.00
109_T	159_N	0.510	1.00
60_D	64_T	0.509	1.00
46_G	87_T	0.509	1.00
48_E	106_N	0.507	1.00
131_A	147_L	0.505	1.00
137_N	150_K	0.505	1.00
166_Q	169_Q	0.502	1.00
121_S	236_L	0.501	1.00
17_V	21_A	0.501	1.00
156_L	161_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1xt8A	1	0.8872	100	0.244	Contact Map
2yjpA	1	0.8759	100	0.25	Contact Map
2ylnA	1	0.8759	100	0.266	Contact Map
4ohnA	1	0.8872	100	0.275	Contact Map
4ymxA	1	0.8195	100	0.278	Contact Map
1pb7A	1	0.9248	100	0.282	Contact Map
3kbrA	4	0.8534	100	0.283	Contact Map
3hv1A	2	0.906	100	0.283	Contact Map
2vhaA	2	0.8947	100	0.286	Contact Map
4powA	1	0.8459	100	0.286	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.