GREMLIN Database
FLIY - Cystine-binding periplasmic protein
UniProt: P0AEM9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12680
Length: 266 (238)
Sequences: 21668 (15665)
Seq/√Len: 1015.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_G101_I3.7851.00
153_G191_I3.6711.00
42_T83_S3.6691.00
77_H245_E2.9091.00
161_E175_T2.4911.00
176_Y185_D2.4471.00
110_I115_K2.3431.00
44_L83_S2.3431.00
122_T244_A2.3291.00
95_S101_I2.3151.00
178_D181_T2.2001.00
110_I225_G2.1931.00
42_T81_E2.1371.00
44_L85_K2.1341.00
161_E165_R2.1181.00
251_T254_A2.0921.00
97_D117_K2.0581.00
112_D115_K2.0501.00
119_D236_L2.0001.00
228_L236_L1.9981.00
58_G64_T1.9931.00
118_Y227_A1.9931.00
73_Q76_K1.9921.00
75_A82_A1.9811.00
253_Q257_E1.9791.00
151_K174_R1.9461.00
244_A248_K1.9401.00
236_L240_N1.9361.00
77_H242_A1.9231.00
182_K194_I1.9181.00
143_T146_D1.8911.00
196_V201_A1.8671.00
122_T240_N1.8301.00
45_V71_A1.8291.00
228_L239_V1.8041.00
151_K172_D1.7991.00
185_D190_R1.7701.00
142_K146_D1.7091.00
132_L201_A1.6751.00
73_Q251_T1.6591.00
73_Q77_H1.6241.00
73_Q246_M1.6231.00
95_S100_R1.6081.00
58_G62_K1.6021.00
134_K189_G1.6021.00
134_K137_N1.5971.00
105_I226_V1.5901.00
156_L177_D1.5291.00
121_S240_N1.5191.00
126_I223_E1.5161.00
87_T95_S1.5111.00
229_R232_N1.5051.00
162_E166_Q1.4581.00
233_E237_K1.4431.00
92_M104_V1.4391.00
237_K241_D1.4281.00
77_H249_D1.4171.00
69_E258_K1.4161.00
35_N39_E1.3871.00
238_A241_D1.3661.00
93_L118_Y1.3551.00
56_F64_T1.3531.00
74_L242_A1.3471.00
163_W167_N1.3451.00
57_Q86_P1.3401.00
135_K211_T1.3271.00
130_Q198_R1.3271.00
198_R202_L1.3241.00
185_D191_I1.3221.00
150_K192_D1.3181.00
68_V72_Q1.3151.00
49_G86_P1.3121.00
119_D231_G1.3081.00
45_V103_V1.3051.00
72_Q84_L1.2991.00
151_K192_D1.2961.00
108_V227_A1.2821.00
187_R211_T1.2701.00
165_R175_T1.2691.00
78_L242_A1.2691.00
136_G213_A1.2491.00
71_A105_I1.2461.00
186_L212_L1.2461.00
242_A245_E1.2401.00
129_I160_Y1.2311.00
99_K229_R1.2241.00
177_D181_T1.2081.00
133_V193_A1.1971.00
135_K213_A1.1921.00
137_N140_T1.1861.00
94_A97_D1.1841.00
153_G176_Y1.1841.00
36_K40_R1.1821.00
66_F256_S1.1801.00
131_A193_A1.1791.00
67_E124_Y1.1711.00
152_V193_A1.1651.00
184_Q187_R1.1641.00
87_T101_I1.1561.00
247_Q252_L1.1521.00
238_A242_A1.1471.00
245_E249_D1.1451.00
184_Q188_V1.1351.00
104_V108_V1.1311.00
80_V238_A1.1171.00
154_V161_E1.1071.00
176_Y182_K1.1011.00
113_E116_K1.0911.00
242_A246_M1.0791.00
88_K91_G1.0751.00
32_G234_D1.0591.00
66_F255_L1.0561.00
119_D230_K1.0541.00
41_G80_V1.0521.00
71_A84_L1.0521.00
94_A98_S1.0511.00
35_N38_K1.0401.00
130_Q214_V1.0381.00
186_L194_I1.0301.00
45_V82_A1.0301.00
40_R44_L1.0211.00
133_V215_T1.0181.00
186_L191_I1.0111.00
70_F252_L1.0011.00
72_Q76_K0.9921.00
234_D238_A0.9921.00
241_D245_E0.9901.00
133_V137_N0.9891.00
251_T255_L0.9881.00
156_L175_T0.9871.00
71_A82_A0.9841.00
64_T69_E0.9831.00
155_G158_T0.9811.00
119_D233_E0.9811.00
103_V239_V0.9721.00
69_E72_Q0.9691.00
162_E165_R0.9631.00
103_V228_L0.9581.00
111_S114_R0.9521.00
203_D207_K0.9521.00
70_F246_M0.9431.00
233_E236_L0.9431.00
16_A19_L0.9431.00
93_L108_V0.9411.00
153_G182_K0.9391.00
69_E259_W0.9381.00
121_S239_V0.9351.00
122_T247_Q0.9301.00
77_H251_T0.9261.00
63_L68_V0.9251.00
97_D118_Y0.9171.00
168_V171_V0.9171.00
74_L239_V0.9151.00
246_M251_T0.9071.00
49_G63_L0.9051.00
120_F227_A0.8961.00
240_N244_A0.8941.00
181_T184_Q0.8911.00
62_K72_Q0.8901.00
34_L37_V0.8871.00
252_L256_S0.8831.00
66_F252_L0.8701.00
52_P56_F0.8671.00
254_A257_E0.8641.00
180_P184_Q0.8621.00
37_V80_V0.8611.00
163_W166_Q0.8601.00
112_D116_K0.8581.00
174_R185_D0.8571.00
91_G95_S0.8551.00
37_V41_G0.8531.00
127_S199_L0.8471.00
128_G198_R0.8431.00
89_W92_M0.8411.00
57_Q63_L0.8381.00
71_A226_V0.8351.00
37_V40_R0.8341.00
234_D237_K0.8301.00
254_A258_K0.8281.00
43_L80_V0.8281.00
109_T222_Q0.8221.00
103_V226_V0.8221.00
33_L36_K0.8211.00
73_Q242_A0.8141.00
240_N243_I0.8101.00
22_G25_V0.8081.00
43_L103_V0.7991.00
115_K230_K0.7971.00
57_Q61_G0.7941.00
47_L84_L0.7931.00
19_L22_G0.7911.00
104_V227_A0.7891.00
141_I146_D0.7881.00
179_D196_V0.7881.00
145_D148_K0.7861.00
15_M18_A0.7851.00
131_A195_L0.7841.00
44_L102_D0.7841.00
54_F125_T0.7741.00
74_L78_L0.7741.00
71_A103_V0.7721.00
137_N141_I0.7671.00
47_L68_V0.7661.00
32_G35_N0.7651.00
245_E248_K0.7611.00
132_L212_L0.7571.00
21_A24_S0.7511.00
133_V213_A0.7471.00
78_L238_A0.7461.00
77_H246_M0.7411.00
38_K41_G0.7401.00
43_L75_A0.7371.00
253_Q256_S0.7361.00
20_V23_M0.7321.00
147_L193_A0.7311.00
85_K100_R0.7311.00
246_M249_D0.7301.00
148_K170_G0.7301.00
167_N170_G0.7241.00
202_L206_K0.7221.00
165_R173_V0.7201.00
114_R120_F0.7181.00
42_T80_V0.7151.00
96_L104_V0.7131.00
56_F259_W0.7111.00
121_S226_V0.7111.00
126_I221_R0.7041.00
96_L101_I0.6991.00
34_L38_K0.6991.00
74_L105_I0.6971.00
93_L97_D0.6961.00
226_V239_V0.6911.00
183_Y187_R0.6911.00
241_D244_A0.6891.00
45_V84_L0.6841.00
127_S198_R0.6831.00
181_T185_D0.6811.00
134_K211_T0.6801.00
246_M250_G0.6801.00
47_L106_N0.6801.00
183_Y212_L0.6781.00
72_Q82_A0.6781.00
153_G185_D0.6771.00
46_G92_M0.6771.00
246_M252_L0.6761.00
237_K240_N0.6721.00
91_G94_A0.6701.00
51_Y107_Q0.6691.00
232_N235_L0.6691.00
87_T92_M0.6681.00
164_L173_V0.6671.00
89_W108_V0.6661.00
121_S228_L0.6661.00
32_G36_K0.6651.00
73_Q255_L0.6551.00
64_T259_W0.6511.00
109_T114_R0.6471.00
176_Y191_I0.6451.00
70_F243_I0.6441.00
96_L118_Y0.6441.00
68_V84_L0.6431.00
48_E55_S0.6421.00
75_A78_L0.6351.00
99_K231_G0.6341.00
49_G55_S0.6321.00
202_L214_V0.6271.00
85_K101_I0.6261.00
108_V118_Y0.6261.00
154_V175_T0.6251.00
71_A75_A0.6241.00
244_A247_Q0.6221.00
75_A79_G0.6211.00
110_I123_P0.6191.00
140_T213_A0.6181.00
96_L229_R0.6181.00
75_A80_V0.6181.00
174_R191_I0.6151.00
14_V18_A0.6151.00
119_D232_N0.6131.00
121_S243_I0.6121.00
97_D229_R0.6121.00
159_N222_Q0.6111.00
120_F225_G0.6111.00
51_Y89_W0.6101.00
130_Q216_G0.6101.00
203_D206_K0.6091.00
48_E89_W0.6071.00
151_K191_I0.6061.00
122_T243_I0.6051.00
128_G221_R0.6041.00
16_A20_V0.6041.00
129_I195_L0.6001.00
40_R102_D0.5991.00
132_L183_Y0.5941.00
201_A205_V0.5941.00
196_V200_A0.5941.00
205_V208_T0.5921.00
128_G218_A0.5891.00
123_P126_I0.5881.00
110_I120_F0.5871.00
52_P207_K0.5871.00
128_G220_S0.5821.00
18_A21_A0.5801.00
47_L63_L0.5791.00
55_S106_N0.5791.00
36_K39_E0.5751.00
130_Q201_A0.5731.00
140_T150_K0.5721.00
155_G179_D0.5711.00
48_E155_G0.5691.00
78_L235_L0.5671.00
187_R209_N0.5661.00
164_L195_L0.5651.00
74_L226_V0.5641.00
250_G253_Q0.5611.00
100_R190_R0.5601.00
187_R208_T0.5551.00
212_L215_T0.5531.00
76_K251_T0.5511.00
125_T224_S0.5511.00
250_G254_A0.5501.00
58_G61_G0.5491.00
46_G104_V0.5491.00
33_L229_R0.5481.00
132_L205_V0.5451.00
137_N192_D0.5441.00
53_P56_F0.5421.00
15_M19_L0.5411.00
85_K95_S0.5321.00
92_M108_V0.5311.00
38_K238_A0.5301.00
127_S224_S0.5301.00
185_D188_V0.5301.00
89_W114_R0.5281.00
77_H238_A0.5251.00
246_M255_L0.5221.00
136_G189_G0.5201.00
43_L235_L0.5181.00
49_G57_Q0.5181.00
14_V17_V0.5181.00
204_L207_K0.5161.00
187_R212_L0.5151.00
154_V164_L0.5151.00
115_K119_D0.5141.00
174_R190_R0.5131.00
228_L232_N0.5121.00
71_A74_L0.5121.00
109_T159_N0.5101.00
60_D64_T0.5091.00
46_G87_T0.5091.00
48_E106_N0.5071.00
131_A147_L0.5051.00
137_N150_K0.5051.00
166_Q169_Q0.5021.00
121_S236_L0.5011.00
17_V21_A0.5011.00
156_L161_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xt8A 1 0.8872 100 0.244 Contact Map
2yjpA 1 0.8759 100 0.25 Contact Map
2ylnA 1 0.8759 100 0.266 Contact Map
4ohnA 1 0.8872 100 0.275 Contact Map
4ymxA 1 0.8195 100 0.278 Contact Map
1pb7A 1 0.9248 100 0.282 Contact Map
3kbrA 4 0.8534 100 0.283 Contact Map
3hv1A 2 0.906 100 0.283 Contact Map
2vhaA 2 0.8947 100 0.286 Contact Map
4powA 1 0.8459 100 0.286 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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