GREMLIN Database
FKBX - FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase
UniProt: P0AEM0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11080
Length: 149 (137)
Sequences: 2507 (1724)
Seq/√Len: 147.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_P133_T3.7561.00
60_K139_E3.4381.00
62_T137_D3.0341.00
68_D73_V2.8681.00
50_Q69_A2.7471.00
17_L25_A2.5391.00
55_L61_T2.5001.00
12_L142_E2.2291.00
66_E133_T2.1861.00
66_E69_A2.1511.00
12_L36_L2.1361.00
51_H63_F2.1071.00
81_Y120_S2.0951.00
57_V142_E2.0821.00
56_K59_D2.0091.00
111_G125_F1.8201.00
14_H28_T1.7531.00
5_V140_V1.7381.00
57_V143_I1.7341.00
20_D135_H1.6801.00
65_L70_A1.6641.00
60_K137_D1.6501.00
64_S133_T1.6301.00
19_L23_T1.6081.00
6_Q9_S1.6041.00
74_P79_I1.5841.00
7_S53_L1.5601.00
5_V39_L1.5531.00
14_H139_E1.5461.00
20_D133_T1.5441.00
81_Y122_T1.5221.00
55_L59_D1.5101.00
27_S30_N1.5031.00
16_T29_R1.4881.00
16_T137_D1.4751.00
18_K135_H1.4681.00
16_T27_S1.4611.00
44_L48_L1.4511.00
10_A38_R1.4211.00
39_L53_L1.4081.00
37_F52_L1.4051.00
14_H141_L1.4021.00
100_L110_P1.3971.00
13_V48_L1.3851.00
115_E122_T1.3551.00
18_K24_T1.3381.00
45_S65_L1.2681.00
75_S78_L1.2671.00
62_T135_H1.2291.00
101_F111_G1.2271.00
19_L25_A1.1951.00
19_L132_Q1.1671.00
111_G123_V1.1461.00
8_N41_D1.1421.00
16_T24_T1.1421.00
95_I116_I1.1300.99
46_E50_Q1.1280.99
64_S135_H1.1210.99
9_S143_I1.1080.99
84_R121_I1.0980.99
24_T30_N1.0910.99
100_L108_E1.0860.99
94_E97_A1.0800.99
87_F121_I1.0780.99
18_K137_D1.0610.99
14_H27_S1.0510.99
61_T138_I1.0320.99
117_N122_T1.0150.99
41_D49_E1.0120.99
48_L63_F1.0070.99
39_L49_E1.0040.99
14_H29_R1.0030.99
71_F134_V0.9960.99
13_V140_V0.9920.99
98_I110_P0.9840.99
47_G50_Q0.9800.98
84_R119_D0.9780.98
45_S71_F0.9540.98
102_T108_E0.9500.98
30_N33_K0.9300.98
99_M111_G0.9280.98
50_Q53_L0.9280.98
55_L140_V0.9060.97
18_K62_T0.8840.97
67_P70_A0.8780.97
93_P97_A0.8780.97
5_V54_G0.8770.97
93_P116_I0.8680.97
81_Y117_N0.8540.96
101_F125_F0.8520.96
38_R41_D0.8510.96
29_R139_E0.8510.96
103_A109_M0.8470.96
48_L71_F0.8460.96
9_S39_L0.8410.96
95_I115_E0.8320.96
20_D64_S0.8240.96
98_I112_V0.8230.96
47_G69_A0.8210.95
11_V143_I0.8170.95
10_A36_L0.8090.95
5_V52_L0.8040.95
87_F93_P0.8010.95
45_S70_A0.8010.95
117_N120_S0.7970.95
101_F104_M0.7950.95
48_L138_I0.7910.94
87_F123_V0.7900.94
84_R116_I0.7890.94
115_E119_D0.7730.94
6_Q53_L0.7630.93
47_G51_H0.7600.93
83_S120_S0.7530.93
101_F123_V0.7450.93
17_L26_E0.7420.92
29_R60_K0.7410.92
68_D133_T0.7290.92
46_E49_E0.7240.91
46_E69_A0.7200.91
114_R122_T0.7130.91
20_D132_Q0.7070.90
13_V52_L0.7050.90
79_I114_R0.7050.90
21_D132_Q0.7040.90
93_P99_M0.7010.90
79_I122_T0.6960.90
55_L63_F0.6930.90
13_V37_F0.6900.89
78_L125_F0.6860.89
48_L52_L0.6820.89
88_M91_G0.6760.88
43_S48_L0.6760.88
29_R32_G0.6740.88
35_A71_F0.6680.88
124_D131_G0.6670.88
85_R118_G0.6620.87
105_D108_E0.6550.87
15_F71_F0.6550.87
5_V11_V0.6550.87
87_F99_M0.6540.87
80_Q83_S0.6510.86
103_A108_E0.6490.86
8_N38_R0.6480.86
38_R43_S0.6420.86
51_H59_D0.6400.86
101_F109_M0.6340.85
39_L140_V0.6330.85
28_T32_G0.6310.85
86_E109_M0.6310.85
11_V45_S0.6290.85
70_A134_V0.6270.84
15_F45_S0.6180.84
24_T29_R0.6170.83
52_L138_I0.6160.83
37_F44_L0.6150.83
19_L125_F0.6090.83
73_V131_G0.6080.83
47_G71_F0.6080.83
48_L103_A0.6080.83
51_H61_T0.6070.82
96_G99_M0.6040.82
91_G99_M0.6030.82
84_R92_E0.6030.82
18_K22_G0.5960.81
80_Q101_F0.5900.81
17_L134_V0.5900.81
27_S33_K0.5890.81
52_L61_T0.5880.80
42_A49_E0.5860.80
9_S38_R0.5830.80
25_A129_L0.5820.80
64_S67_P0.5780.79
47_G65_L0.5710.78
84_R117_N0.5690.78
114_R124_D0.5680.78
19_L129_L0.5610.77
35_A134_V0.5580.77
83_S103_A0.5530.76
85_R119_D0.5470.75
83_S86_E0.5460.75
91_G94_E0.5460.75
5_V143_I0.5430.75
90_A93_P0.5420.75
84_R94_E0.5420.75
27_S32_G0.5380.74
24_T27_S0.5380.74
89_D93_P0.5350.74
100_L125_F0.5340.74
103_A106_G0.5320.73
74_P132_Q0.5300.73
113_I121_I0.5290.73
84_R93_P0.5210.72
33_K36_L0.5200.72
74_P114_R0.5190.72
40_G49_E0.5160.71
102_T106_G0.5160.71
44_L65_L0.5160.71
115_E118_G0.5130.71
36_L105_D0.5120.71
45_S48_L0.5060.70
80_Q123_V0.5050.70
98_I128_P0.5050.70
110_P138_I0.5040.69
67_P73_V0.5010.69
82_F86_E0.5010.69
15_F44_L0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dt4A 1 1 100 0.106 Contact Map
2kfwA 1 0.9732 100 0.114 Contact Map
2k8iA 1 0.9732 100 0.117 Contact Map
2kr7A 1 0.9799 100 0.137 Contact Map
4odkA 1 0.9262 100 0.142 Contact Map
1ix5A 1 0.9195 100 0.163 Contact Map
3prbA 2 0.9396 100 0.179 Contact Map
3pr9A 1 0.9128 100 0.187 Contact Map
3jxvA 1 0.3557 99.9 0.42 Contact Map
2lknA 1 0.9195 99.9 0.449 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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