GREMLIN Database
FEPB - Ferrienterobactin-binding periplasmic protein
UniProt: P0AEL6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10294
Length: 318 (275)
Sequences: 12975 (10501)
Seq/√Len: 633.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_T170_A4.0471.00
258_N285_P3.9841.00
160_G169_A3.9051.00
153_Q177_D3.7751.00
165_H168_Q3.3341.00
161_E166_E3.0921.00
285_P289_N3.0491.00
34_T39_T3.0061.00
51_S57_T2.7931.00
157_T173_I2.6851.00
32_Q39_T2.6821.00
168_Q171_E2.6661.00
181_A185_E2.6521.00
170_A174_A2.5711.00
174_A178_K2.5321.00
110_A113_A2.5211.00
179_Q312_D2.4741.00
50_V111_V2.3251.00
219_L224_F2.3201.00
179_Q308_M2.2061.00
35_D40_H2.1731.00
252_N256_G2.1401.00
177_D181_A2.0871.00
48_R68_I2.0641.00
49_I163_T2.0421.00
60_L163_T2.0321.00
178_K182_A2.0311.00
276_Y290_K2.0151.00
260_E285_P1.9741.00
182_A186_Q1.9541.00
273_D277_A1.9081.00
135_Q138_T1.8711.00
216_G220_E1.8391.00
195_T225_T1.8331.00
65_A163_T1.8201.00
261_S291_Q1.8091.00
32_Q41_T1.8011.00
171_E175_Q1.8001.00
261_S293_Y1.7961.00
167_K171_E1.7941.00
59_S156_L1.7921.00
284_L287_V1.7721.00
151_S154_S1.7651.00
30_P41_T1.7571.00
133_Y137_S1.7401.00
65_A165_H1.7271.00
120_L159_L1.6941.00
283_H288_Q1.6701.00
272_A276_Y1.6611.00
69_A114_Q1.6601.00
285_P288_Q1.6481.00
181_A184_K1.6321.00
175_Q179_Q1.6041.00
154_S157_T1.5891.00
31_R161_E1.5641.00
134_D138_T1.5341.00
99_Q110_A1.5231.00
106_P111_V1.5051.00
273_D276_Y1.5051.00
262_L286_A1.4951.00
50_V114_Q1.4851.00
168_Q172_R1.4771.00
250_G278_N1.4711.00
281_L287_V1.4341.00
154_S158_Q1.4311.00
112_A139_I1.4291.00
50_V69_A1.4161.00
130_L134_D1.3921.00
107_S110_A1.3751.00
109_E251_E1.3321.00
68_I114_Q1.3291.00
185_E188_K1.3181.00
182_A185_E1.3151.00
167_K170_A1.3111.00
179_Q182_A1.3081.00
60_L65_A1.3061.00
178_K181_A1.3051.00
8_R11_L1.3041.00
143_L162_I1.2961.00
153_Q173_I1.2921.00
205_S247_Q1.2921.00
63_I165_H1.2911.00
134_D137_S1.2881.00
143_L158_Q1.2851.00
166_E170_A1.2781.00
71_G74_T1.2671.00
305_Y309_Q1.2631.00
158_Q161_E1.2561.00
48_R115_M1.2461.00
121_I144_I1.2421.00
174_A177_D1.2411.00
42_L45_Q1.2411.00
172_R175_Q1.2291.00
9_N12_L1.2251.00
118_L143_L1.2221.00
252_N257_L1.2141.00
35_D38_G1.2051.00
175_Q178_K1.2011.00
108_A135_Q1.2001.00
51_S60_L1.1921.00
157_T177_D1.1911.00
46_P117_D1.1861.00
269_Q273_D1.1831.00
129_A132_L1.1731.00
156_L169_A1.1651.00
119_I140_A1.1631.00
196_A224_F1.1601.00
47_Q117_D1.1561.00
173_I177_D1.1501.00
194_V261_S1.1401.00
35_D133_Y1.1351.00
49_I118_L1.1251.00
184_K188_K1.1231.00
94_K98_L1.1221.00
30_P45_Q1.1221.00
308_M312_D1.1131.00
211_P220_E1.1001.00
84_G87_R1.0991.00
194_V291_Q1.0861.00
62_A172_R1.0811.00
199_Y278_N1.0671.00
228_K257_L1.0661.00
35_D39_T1.0601.00
227_A257_L1.0581.00
281_L284_L1.0531.00
95_E98_L1.0521.00
184_K221_Q1.0361.00
99_Q102_Y1.0281.00
30_P44_S1.0241.00
176_F221_Q1.0221.00
132_L135_Q1.0081.00
47_Q66_P1.0071.00
197_I208_L1.0031.00
37_R144_I0.9991.00
157_T161_E0.9991.00
225_T229_L0.9971.00
274_A277_A0.9901.00
195_T260_E0.9871.00
29_W164_G0.9851.00
44_S47_Q0.9801.00
112_A140_A0.9771.00
180_L184_K0.9751.00
95_E99_Q0.9731.00
49_I60_L0.9661.00
279_P282_A0.9641.00
264_L294_A0.9631.00
309_Q312_D0.9511.00
67_V98_L0.9451.00
42_L141_P0.9431.00
70_S98_L0.9431.00
58_G303_D0.9411.00
287_V292_V0.9381.00
60_L120_L0.9371.00
296_G299_T0.9371.00
160_G173_I0.9331.00
145_I158_Q0.9331.00
285_P291_Q0.9281.00
195_T199_Y0.9251.00
192_Q195_T0.9191.00
159_L163_T0.9181.00
253_L284_L0.9121.00
7_Y11_L0.9121.00
198_V219_L0.9121.00
187_I190_P0.9111.00
254_A284_L0.9101.00
37_R137_S0.9071.00
179_Q183_A0.8941.00
169_A173_I0.8901.00
137_S142_T0.8861.00
120_L162_I0.8751.00
193_P225_T0.8751.00
276_Y292_V0.8751.00
282_A287_V0.8721.00
42_L46_P0.8671.00
230_P257_L0.8621.00
9_N13_L0.8611.00
176_F180_L0.8601.00
63_I172_R0.8561.00
228_K252_N0.8521.00
61_L67_V0.8481.00
72_A100_R0.8471.00
46_P118_L0.8461.00
29_W45_Q0.8451.00
153_Q157_T0.8441.00
228_K231_A0.8431.00
11_L14_T0.8401.00
171_E174_A0.8401.00
53_S122_S0.8391.00
270_K273_D0.8361.00
116_P119_I0.8361.00
45_Q165_H0.8361.00
66_P165_H0.8351.00
157_T160_G0.8341.00
29_W44_S0.8321.00
170_A173_I0.8291.00
263_F293_Y0.8291.00
10_A14_T0.8291.00
30_P43_E0.8251.00
52_T119_I0.8211.00
33_I143_L0.8191.00
58_G305_Y0.8181.00
45_Q164_G0.8181.00
118_L162_I0.8181.00
159_L162_I0.8171.00
158_Q162_I0.8141.00
123_A146_N0.8111.00
150_K154_S0.8071.00
298_E302_L0.8051.00
60_L67_V0.8041.00
62_A156_L0.8021.00
217_Q221_Q0.7971.00
59_S159_L0.7961.00
217_Q220_E0.7911.00
31_R42_L0.7861.00
62_A305_Y0.7851.00
199_Y202_A0.7801.00
63_I160_G0.7691.00
306_S309_Q0.7671.00
61_L95_E0.7651.00
194_V224_F0.7621.00
16_L19_S0.7621.00
153_Q180_L0.7601.00
135_Q139_I0.7591.00
196_A219_L0.7571.00
56_L120_L0.7561.00
94_K97_K0.7551.00
197_I259_G0.7541.00
63_I168_Q0.7521.00
10_A13_L0.7501.00
248_L257_L0.7501.00
156_L172_R0.7451.00
51_S67_V0.7441.00
270_K274_A0.7391.00
213_S216_G0.7351.00
272_A294_A0.7331.00
63_I163_T0.7301.00
278_N282_A0.7241.00
172_R176_F0.7241.00
267_G297_T0.7191.00
299_T302_L0.7191.00
209_W245_I0.7151.00
227_A230_P0.7081.00
254_A283_H0.7061.00
197_I253_L0.7061.00
40_H143_L0.7041.00
69_A101_L0.7031.00
211_P231_A0.7031.00
155_L158_Q0.7021.00
180_L221_Q0.7021.00
111_V136_L0.6981.00
152_W176_F0.6941.00
193_P197_I0.6941.00
264_L292_V0.6921.00
48_R117_D0.6891.00
70_S100_R0.6871.00
14_T17_L0.6851.00
211_P229_L0.6831.00
56_L145_I0.6831.00
7_Y10_A0.6801.00
186_Q189_L0.6801.00
42_L118_L0.6801.00
176_F179_Q0.6791.00
226_L230_P0.6781.00
29_W43_E0.6781.00
156_L173_I0.6781.00
214_A217_Q0.6761.00
198_V265_F0.6721.00
183_A222_L0.6721.00
153_Q221_Q0.6711.00
254_A259_G0.6711.00
183_A187_I0.6691.00
136_L139_I0.6681.00
16_L20_G0.6631.00
64_D168_Q0.6611.00
50_V101_L0.6601.00
60_L159_L0.6581.00
195_T227_A0.6561.00
304_Y308_M0.6561.00
63_I169_A0.6551.00
36_S158_Q0.6541.00
64_D165_H0.6521.00
163_T166_E0.6491.00
109_E249_G0.6481.00
266_A294_A0.6471.00
42_L162_I0.6461.00
173_I176_F0.6431.00
109_E112_A0.6411.00
261_S265_F0.6391.00
305_Y308_M0.6391.00
131_A134_D0.6311.00
184_K222_L0.6301.00
29_W46_P0.6301.00
96_R99_Q0.6291.00
56_L159_L0.6281.00
195_T200_T0.6231.00
249_G252_N0.6211.00
50_V116_P0.6211.00
208_L228_K0.6211.00
157_T166_E0.6181.00
12_L15_G0.6181.00
101_L114_Q0.6161.00
46_P163_T0.6161.00
108_A139_I0.6161.00
33_I42_L0.6151.00
150_K153_Q0.6151.00
61_L98_L0.6101.00
37_R40_H0.6101.00
59_S62_A0.6101.00
19_S22_A0.6071.00
303_D306_S0.6071.00
190_P193_P0.6071.00
224_F261_S0.6051.00
53_S56_L0.6041.00
63_I156_L0.6031.00
278_N281_L0.6011.00
133_Y142_T0.5981.00
250_G281_L0.5961.00
43_E141_P0.5961.00
281_L292_V0.5941.00
16_L21_I0.5921.00
108_A111_V0.5921.00
145_I159_L0.5911.00
108_A132_L0.5911.00
119_I139_I0.5901.00
50_V68_I0.5891.00
248_L253_L0.5871.00
145_I155_L0.5871.00
197_I200_T0.5861.00
51_S56_L0.5851.00
262_L281_L0.5851.00
183_A186_Q0.5821.00
102_Y106_P0.5811.00
228_K248_L0.5801.00
284_L288_Q0.5801.00
172_R304_Y0.5801.00
191_P194_V0.5791.00
194_V198_V0.5771.00
99_Q114_Q0.5761.00
112_A251_E0.5741.00
51_S70_S0.5731.00
177_D180_L0.5721.00
110_A114_Q0.5701.00
137_S141_P0.5681.00
31_R44_S0.5671.00
8_R12_L0.5671.00
136_L142_T0.5661.00
207_N247_Q0.5651.00
295_L300_F0.5641.00
199_Y262_L0.5631.00
259_G262_L0.5621.00
70_S74_T0.5611.00
147_Y155_L0.5611.00
37_R133_Y0.5601.00
196_A200_T0.5591.00
119_I142_T0.5581.00
133_Y144_I0.5581.00
57_T70_S0.5581.00
33_I158_Q0.5561.00
46_P49_I0.5541.00
31_R45_Q0.5541.00
196_A199_Y0.5541.00
133_Y136_L0.5541.00
216_G229_L0.5531.00
42_L143_L0.5511.00
180_L183_A0.5501.00
56_L59_S0.5501.00
212_E216_G0.5491.00
18_L21_I0.5481.00
40_H141_P0.5451.00
254_A280_L0.5441.00
185_E189_L0.5431.00
8_R14_T0.5431.00
153_Q176_F0.5390.99
69_A102_Y0.5390.99
130_L133_Y0.5370.99
35_D137_S0.5360.99
50_V119_I0.5350.99
207_N245_I0.5350.99
26_A29_W0.5330.99
52_T121_I0.5330.99
52_T101_L0.5320.99
206_A209_W0.5290.99
258_N262_L0.5290.99
57_T74_T0.5260.99
48_R116_P0.5260.99
265_F295_L0.5250.99
61_L94_K0.5240.99
186_Q190_P0.5220.99
67_V70_S0.5200.99
184_K187_I0.5200.99
141_P144_I0.5200.99
275_I278_N0.5200.99
198_V215_Q0.5190.99
25_Q29_W0.5180.99
119_I136_L0.5170.99
219_L226_L0.5170.99
213_S244_D0.5160.99
297_T301_R0.5150.99
27_A31_R0.5140.99
269_Q272_A0.5140.99
7_Y12_L0.5120.99
216_G226_L0.5120.99
33_I162_I0.5110.99
37_R130_L0.5090.99
57_T61_L0.5070.99
210_T216_G0.5070.99
29_W32_Q0.5040.99
103_I121_I0.5030.99
194_V199_Y0.5030.99
95_E100_R0.5020.99
75_P84_G0.5010.99
30_P42_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tlkA 1 0.9182 100 0.215 Contact Map
4mlzA 1 0.8491 100 0.249 Contact Map
4n01A 1 0.8459 100 0.25 Contact Map
3tnyA 1 0.8428 100 0.253 Contact Map
3r5tA 1 0.8868 100 0.262 Contact Map
3lhsA 1 0.8711 100 0.267 Contact Map
2x4lA 1 0.8648 100 0.273 Contact Map
3tefA 1 0.8302 100 0.276 Contact Map
4mx8A 1 0.8491 100 0.278 Contact Map
4hn9A 1 0.8491 100 0.279 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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