GREMLIN Database
FEOA - Ferrous iron transport protein A
UniProt: P0AEL3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12101
Length: 75 (66)
Sequences: 334 (248)
Seq/√Len: 30.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_A36_S2.7431.00
55_R65_L2.1570.98
31_M38_N2.1070.98
47_D61_R1.8550.96
32_L54_R1.8050.95
48_P61_R1.8050.95
43_A61_R1.7010.93
4_T7_T1.6400.92
44_P47_D1.6400.92
9_W65_L1.6250.91
4_T70_V1.6220.91
10_K36_S1.6090.91
22_Y28_S1.5210.88
52_E57_S1.5120.88
55_R59_V1.5030.88
10_K71_E1.4180.84
5_P66_A1.3320.80
20_P24_Q1.3090.79
14_F49_I1.2780.78
35_S70_V1.2760.77
44_P54_R1.2570.76
54_R61_R1.2530.76
27_L33_P1.2330.75
40_V57_S1.2260.75
44_P61_R1.2230.74
9_W37_F1.2180.74
37_F51_I1.2160.74
22_Y68_L1.2070.73
23_R41_R1.1900.72
34_G53_T1.1750.71
4_T71_E1.1750.71
43_A47_D1.1600.70
22_Y37_F1.1290.68
27_L46_G1.1290.68
28_S68_L1.1160.67
42_V49_I1.0800.65
21_A33_P1.0370.61
60_L69_E1.0120.60
26_L64_D0.9980.58
35_S39_V0.9820.57
12_T66_A0.9640.56
44_P48_P0.9270.53
9_W64_D0.9250.53
10_K17_E0.9160.52
13_G22_Y0.9100.51
45_L61_R0.9080.51
45_L48_P0.9010.51
41_R57_S0.9000.51
25_K28_S0.8860.50
36_S66_A0.8770.49
15_S63_K0.8770.49
4_T37_F0.8760.49
43_A48_P0.8750.49
25_K45_L0.8640.48
5_P40_V0.8630.48
47_D64_D0.8490.47
46_G64_D0.8310.45
46_G61_R0.8220.44
14_F25_K0.8170.44
38_N52_E0.8170.44
31_M59_V0.8150.44
48_P64_D0.7950.42
25_K59_V0.7890.42
24_Q32_L0.7720.41
47_D54_R0.7470.39
9_W59_V0.7430.38
5_P42_V0.7390.38
29_L65_L0.7390.38
25_K31_M0.7350.38
22_Y66_A0.7280.37
8_A66_A0.7100.36
14_F28_S0.7080.36
16_R37_F0.7000.35
20_P40_V0.6920.35
45_L64_D0.6900.34
9_W26_L0.6750.33
16_R69_E0.6670.33
13_G68_L0.6640.33
11_I29_L0.6310.30
9_W70_V0.6250.30
12_T71_E0.6240.30
13_G69_E0.6130.29
7_T10_K0.6020.28
38_N57_S0.6010.28
10_K34_G0.5730.26
17_E39_V0.5700.26
32_L59_V0.5690.26
5_P33_P0.5680.26
9_W39_V0.5630.26
7_T49_I0.5590.26
12_T17_E0.5560.25
14_F67_L0.5550.25
11_I67_L0.5540.25
49_I69_E0.5180.23
4_T63_K0.5160.23
17_E60_L0.5150.23
25_K56_V0.5020.22
46_G54_R0.5000.22
59_V64_D0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lx9A 1 1 99.5 0.371 Contact Map
2k4yA 1 0.9733 99.5 0.377 Contact Map
2k5iA 1 0.9733 99.5 0.382 Contact Map
2k5fA 1 0.9733 99.5 0.383 Contact Map
2gcxA 1 1 99.4 0.391 Contact Map
2k5lA 1 0.9733 99.4 0.394 Contact Map
3hrsA 2 0.9467 99.4 0.395 Contact Map
2h3jA 1 0.9867 99.4 0.408 Contact Map
3mhxA 1 0.9733 99.4 0.415 Contact Map
3e19A 5 0.9333 99.3 0.423 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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