GREMLIN Database
FDOI - Formate dehydrogenase, cytochrome b556(fdo) subunit
UniProt: P0AEL0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11856
Length: 211 (183)
Sequences: 2230 (1512)
Seq/√Len: 111.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_V185_W3.9621.00
27_L60_V3.9171.00
87_F90_K3.0931.00
21_T67_S2.9531.00
65_F130_V2.8061.00
20_I67_S2.6261.00
15_R184_G2.4401.00
94_K97_V2.4211.00
124_L156_A2.4061.00
29_A161_I2.2401.00
64_M122_L2.1801.00
12_A16_I2.1151.00
46_I49_T2.0771.00
6_T185_W2.0631.00
47_M50_P2.0461.00
93_R97_V2.0281.00
45_Q50_P2.0061.00
11_T14_E1.9741.00
61_G64_M1.9501.00
107_Y111_Q1.8971.00
118_A159_A1.8191.00
29_A164_I1.7941.00
86_I90_K1.7761.00
26_I30_V1.7681.00
8_V11_T1.7531.00
87_F91_N1.7311.00
125_L156_A1.7161.00
34_G53_A1.7101.00
25_F160_L1.7081.00
65_F126_L1.7021.00
88_W91_N1.6681.00
24_C63_V1.6671.00
92_I95_I1.6641.00
171_A178_I1.6311.00
36_L154_S1.6241.00
10_Y107_Y1.5831.00
117_A121_F1.5491.00
106_R111_Q1.5271.00
21_T71_M1.5141.00
45_Q49_T1.5011.00
151_M155_F1.4941.00
128_S152_L1.4841.00
22_A168_I1.4691.00
128_S131_I1.4651.00
17_N70_I1.4591.00
85_D112_K1.4581.00
68_F126_L1.4141.00
132_I150_L1.4131.00
62_V66_A1.4041.00
92_I96_V1.4031.00
168_I171_A1.3821.00
83_R87_F1.3751.00
118_A122_L1.3611.00
25_F29_A1.3501.00
54_R58_P1.3341.00
124_L152_L1.2980.99
142_S145_V1.2720.99
19_W22_A1.2600.99
44_M47_M1.2520.99
94_K101_V1.2510.99
120_I123_V1.2360.99
43_L46_I1.2330.99
45_Q48_G1.2310.99
90_K93_R1.2190.99
115_F163_V1.2190.99
33_L157_A1.2150.99
62_V133_W1.2140.99
44_M49_T1.2130.99
118_A163_V1.1960.99
152_L156_A1.1960.99
55_I59_F1.1950.99
46_I50_P1.1600.99
44_M50_P1.1590.99
27_L56_L1.1570.99
147_R151_M1.1560.99
83_R86_I1.1490.99
15_R19_W1.1400.99
72_F76_W1.1130.98
42_W45_Q1.1130.98
104_T109_F1.1090.98
58_P61_G1.1090.98
114_V117_A1.0770.98
91_N94_K1.0760.98
81_I86_I1.0740.98
17_N67_S1.0690.98
155_F159_A1.0680.98
75_Y78_H1.0660.98
23_F27_L1.0660.98
108_N111_Q1.0630.98
24_C60_V1.0560.98
81_I85_D1.0460.98
52_L56_L1.0460.98
176_G179_T1.0340.97
38_P54_R1.0260.97
85_D88_W1.0180.97
180_A186_V1.0160.97
35_F54_R1.0020.97
19_W181_M1.0010.97
9_R186_V0.9940.97
74_R79_N0.9940.97
178_I181_M0.9930.97
76_W80_L0.9900.97
17_N68_F0.9870.96
179_T183_E0.9770.96
74_R78_H0.9640.96
20_I24_C0.9630.96
31_S134_R0.9610.96
63_V67_S0.9610.96
143_I147_R0.9530.96
148_F152_L0.9340.95
117_A163_V0.9320.95
42_W48_G0.9250.95
156_A160_L0.9220.95
43_L49_T0.9140.95
84_D87_F0.9030.94
176_G186_V0.9020.94
127_V131_I0.8990.94
24_C28_A0.8850.94
92_I97_V0.8790.93
114_V163_V0.8610.93
129_G153_H0.8540.92
20_I63_V0.8510.92
119_I123_V0.8490.92
128_S141_F0.8430.92
31_S56_L0.8430.92
6_T187_T0.8420.92
101_V104_T0.8400.92
99_E102_G0.8340.91
114_V118_A0.8330.91
122_L156_A0.8240.91
164_I168_I0.8210.91
94_K102_G0.8160.91
44_M48_G0.8100.90
98_N102_G0.8080.90
10_Y179_T0.8060.90
58_P133_W0.8060.90
16_I24_C0.8010.90
110_G114_V0.7940.89
164_I171_A0.7920.89
75_Y79_N0.7910.89
37_F59_F0.7890.89
9_R106_R0.7760.88
40_F151_M0.7750.88
31_S53_A0.7730.88
80_L90_K0.7730.88
68_F164_I0.7630.87
118_A123_V0.7610.87
10_Y106_R0.7610.87
170_A177_T0.7590.87
29_A157_A0.7570.87
56_L60_V0.7560.87
25_F122_L0.7560.87
72_F120_I0.7540.87
136_Y139_P0.7540.87
91_N95_I0.7530.87
134_R149_A0.7510.86
51_Q150_L0.7500.86
158_V162_V0.7480.86
70_I73_F0.7450.86
21_T24_C0.7420.86
148_F151_M0.7380.86
177_T180_A0.7360.85
176_G180_A0.7330.85
33_L161_I0.7290.85
24_C126_L0.7240.84
159_A166_V0.7230.84
16_I82_N0.7210.84
52_L55_I0.7150.84
101_V170_A0.7150.84
36_L133_W0.7140.84
60_V63_V0.7120.83
145_V148_F0.7090.83
12_A15_R0.7080.83
161_I165_M0.7070.83
162_V166_V0.7050.83
89_A113_C0.7010.82
42_W47_M0.6990.82
14_E106_R0.6980.82
56_L59_F0.6930.82
62_V130_V0.6880.81
150_L154_S0.6870.81
125_L160_L0.6830.81
34_G39_S0.6830.81
89_A109_F0.6740.80
111_Q115_F0.6710.80
111_Q179_T0.6700.80
145_V150_L0.6680.79
117_A159_A0.6670.79
104_T174_V0.6660.79
154_S158_V0.6630.79
8_V15_R0.6630.79
103_D107_Y0.6590.78
22_A26_I0.6560.78
82_N85_D0.6530.78
128_S153_H0.6500.77
175_K179_T0.6490.77
37_F165_M0.6470.77
11_T21_T0.6460.77
128_S149_A0.6450.77
114_V160_L0.6430.77
93_R98_N0.6410.77
10_Y111_Q0.6370.76
146_I150_L0.6320.76
34_G44_M0.6310.75
9_R85_D0.6230.74
131_I149_A0.6220.74
56_L117_A0.6220.74
35_F53_A0.6210.74
72_F119_I0.6210.74
119_I164_I0.6180.74
42_W49_T0.6180.74
20_I66_A0.6130.73
166_V170_A0.6070.73
36_L109_F0.6060.72
145_V152_L0.6050.72
12_A140_A0.6040.72
103_D168_I0.6020.72
27_L51_Q0.6000.72
37_F154_S0.5950.71
69_I72_F0.5940.71
79_N119_I0.5910.71
23_F26_I0.5870.70
38_P58_P0.5830.70
145_V149_A0.5820.69
38_P132_I0.5780.69
81_I84_D0.5770.69
57_H167_H0.5720.68
26_I164_I0.5690.68
111_Q143_I0.5690.68
17_N124_L0.5690.68
16_I74_R0.5690.68
110_G171_A0.5670.67
71_M115_F0.5630.67
166_V180_A0.5630.67
35_F150_L0.5570.66
43_L50_P0.5550.66
66_A127_V0.5510.65
58_P150_L0.5510.65
81_I104_T0.5510.65
37_F40_F0.5490.65
54_R169_Y0.5480.65
13_P155_F0.5470.65
37_F56_L0.5450.64
53_A71_M0.5440.64
91_N117_A0.5430.64
53_A130_V0.5410.64
76_W115_F0.5400.64
154_S157_A0.5350.63
31_S58_P0.5340.63
53_A127_V0.5300.62
94_K98_N0.5290.62
87_F96_V0.5280.62
10_Y177_T0.5270.62
176_G187_T0.5250.62
148_F159_A0.5220.61
21_T119_I0.5210.61
28_A62_V0.5190.61
115_F173_W0.5180.61
148_F164_I0.5170.60
17_N157_A0.5160.60
81_I109_F0.5160.60
90_K113_C0.5150.60
161_I183_E0.5140.60
30_V151_M0.5140.60
71_M119_I0.5110.59
66_A189_A0.5100.59
93_R96_V0.5090.59
76_W82_N0.5030.58
60_V64_M0.5030.58
8_V14_E0.5030.58
38_P52_L0.5020.58
26_I60_V0.5020.58
141_F144_P0.5010.58
80_L139_P0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kqfC 3 0.9953 100 0.28 Contact Map
4gd3A 2 0.7109 100 0.515 Contact Map
4ogqA 2 0.8199 91.7 0.903 Contact Map
2qjyA 2 0.9194 91.4 0.904 Contact Map
1pp9C 2 0.9526 90 0.907 Contact Map
3cx5C 2 0.981 86.1 0.913 Contact Map
4o6yA 2 0.7156 80.6 0.919 Contact Map
1q16C 2 0.7536 47.9 0.935 Contact Map
4ytpC 1 0.5261 23.5 0.945 Contact Map
3s8fA 1 0.6919 15.9 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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