GREMLIN Database
FDNI - Formate dehydrogenase, nitrate-inducible, cytochrome b556(Fdn) subunit
UniProt: P0AEK7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11229
Length: 217 (186)
Sequences: 2239 (1465)
Seq/√Len: 107.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_L60_F4.1181.00
8_V187_K3.8821.00
21_V67_A3.0291.00
64_I124_I2.8911.00
65_F132_V2.7781.00
20_T67_A2.6381.00
87_P90_L2.6361.00
15_R186_G2.5831.00
126_V158_A2.5821.00
92_I96_L2.5691.00
12_F16_A2.2851.00
29_A163_I2.2821.00
75_F78_H2.1711.00
6_M187_K2.1241.00
13_I74_R1.9651.00
11_K14_D1.9591.00
61_G64_I1.9231.00
87_P91_N1.8781.00
173_A180_I1.8521.00
109_Y113_Q1.8111.00
29_A166_I1.7851.00
26_F30_L1.7741.00
83_K87_P1.7701.00
94_E97_K1.7591.00
45_Q49_T1.7591.00
8_V11_K1.7431.00
153_L157_A1.7421.00
127_L158_A1.7331.00
14_D74_R1.7321.00
24_C63_A1.7291.00
65_F128_L1.7281.00
139_F143_F1.7181.00
10_T109_Y1.7101.00
46_T49_T1.7031.00
36_F156_A1.6791.00
25_F162_L1.6701.00
140_A143_F1.6591.00
139_F142_Y1.6571.00
130_T133_I1.6371.00
34_S53_G1.5781.00
85_D114_K1.5551.00
91_N94_E1.5341.00
62_I66_V1.5221.00
22_V170_M1.5151.00
134_I152_L1.5121.00
96_L99_N1.5081.00
17_C70_F1.5001.00
126_V154_I1.4751.00
124_I162_L1.4711.00
27_L56_L1.4591.00
108_K113_Q1.4531.00
86_I90_L1.4411.00
54_R58_P1.4301.00
21_V71_M1.4031.00
144_P147_V1.3901.00
95_V98_G1.3751.00
93_V97_K1.3681.00
123_M158_A1.3591.00
94_E100_E1.3511.00
62_I135_W1.3250.99
44_T48_G1.3060.99
19_W22_V1.2850.99
106_V111_A1.2830.99
94_E99_N1.2800.99
25_F29_A1.2550.99
150_Y154_I1.2500.99
181_K185_E1.2450.99
33_I159_G1.2270.99
130_T154_I1.2130.99
81_P86_I1.2110.99
89_L115_M1.2040.99
119_S165_A1.1910.99
68_L128_L1.1820.99
83_K86_I1.1770.99
170_M173_A1.1750.99
92_I97_K1.1690.99
15_R19_W1.1290.98
157_A161_I1.1250.98
20_T24_C1.1240.98
58_P61_G1.1240.98
116_M119_S1.1220.98
23_I27_L1.1210.98
55_I59_F1.1120.98
119_S123_M1.1080.98
24_C60_F1.1050.98
178_G181_K1.1000.98
68_L124_I1.0740.98
35_F54_R1.0490.97
93_V96_L1.0380.97
81_P85_D1.0330.97
149_R153_L1.0320.97
129_V133_I1.0190.97
166_I170_M1.0180.97
63_A67_A1.0030.96
80_I90_L1.0010.96
35_F38_P0.9920.96
90_L94_E0.9850.96
117_F165_A0.9800.96
178_G188_V0.9730.96
17_C67_A0.9720.96
131_G155_H0.9710.96
19_W183_M0.9560.95
89_L93_V0.9380.95
17_C68_L0.9380.95
81_P84_K0.9330.95
133_I139_F0.9320.95
6_M189_S0.9250.94
85_D88_W0.9250.94
72_F76_V0.9240.94
44_T49_T0.9090.94
92_I172_M0.9020.94
94_E98_G0.9020.94
147_V150_Y0.8970.93
49_T52_M0.8940.93
92_I95_V0.8840.93
90_L93_V0.8790.93
43_L56_L0.8780.93
9_R188_V0.8770.93
116_M165_A0.8680.92
116_M120_I0.8670.92
110_N113_Q0.8670.92
37_F156_A0.8640.92
50_P53_G0.8550.92
24_C28_V0.8540.92
60_F63_A0.8500.91
34_S44_T0.8460.91
92_I98_G0.8450.91
163_I167_L0.8410.91
39_T54_R0.8350.91
137_P140_A0.8200.90
161_I168_I0.8180.90
180_I183_M0.8130.89
122_S166_I0.8120.89
76_V121_M0.8040.89
37_F145_M0.8000.89
182_G188_V0.7920.88
150_Y153_L0.7910.88
138_Y142_Y0.7820.88
34_S38_P0.7810.87
29_A159_G0.7800.87
52_M55_I0.7800.87
158_A162_L0.7770.87
16_A24_C0.7690.87
31_S56_L0.7680.87
116_M168_I0.7680.87
89_L96_L0.7660.86
56_L59_F0.7660.86
58_P135_W0.7630.86
38_P50_P0.7600.86
73_V174_F0.7580.86
72_F121_M0.7580.86
52_M56_L0.7560.86
120_I165_A0.7540.86
116_M123_M0.7490.85
95_V99_N0.7480.85
21_V24_C0.7460.85
154_I158_A0.7380.84
31_S53_G0.7350.84
16_A82_D0.7310.84
130_T155_H0.7310.84
81_P88_W0.7310.84
50_P62_I0.7240.83
31_S136_R0.7220.83
33_I163_I0.7220.83
95_V101_H0.7050.82
179_S182_G0.7020.81
20_T63_A0.7010.81
145_M149_R0.6970.81
38_P54_R0.6960.81
120_I124_I0.6950.81
86_I187_K0.6940.81
130_T151_S0.6930.80
112_G116_M0.6910.80
152_L156_A0.6880.80
10_T181_K0.6820.79
10_T108_K0.6810.79
56_L60_F0.6810.79
82_D107_G0.6800.79
105_D109_Y0.6760.79
35_F53_G0.6760.79
166_I173_A0.6750.79
36_F111_A0.6660.78
133_I151_S0.6650.78
113_Q117_F0.6630.77
136_R151_S0.6610.77
69_M72_F0.6600.77
168_I172_M0.6600.77
148_V152_L0.6580.77
123_M161_I0.6570.77
103_V106_V0.6570.77
44_T47_F0.6560.77
89_L111_A0.6560.77
123_M127_L0.6500.76
128_L132_V0.6490.76
72_F127_L0.6480.76
101_H104_A0.6380.75
133_I184_I0.6370.75
147_V152_L0.6370.75
12_F15_R0.6350.74
8_V15_R0.6350.74
40_L43_L0.6340.74
13_I86_I0.6340.74
30_L153_L0.6290.74
136_R143_F0.6240.73
35_F50_P0.6230.73
112_G173_A0.6210.73
178_G182_G0.6210.73
53_G132_V0.6140.72
130_T175_W0.6110.72
27_L59_F0.6090.71
122_S125_F0.6080.71
68_L166_I0.6070.71
13_I16_A0.6070.71
127_L162_L0.6010.70
127_L159_G0.6000.70
14_D108_K0.5980.70
13_I157_A0.5950.70
36_F135_W0.5940.69
88_W93_V0.5880.69
156_A160_I0.5850.68
66_V129_V0.5810.68
48_G52_M0.5800.68
147_V151_S0.5790.67
61_G132_V0.5770.67
53_G174_F0.5750.67
121_M124_I0.5740.67
116_M162_L0.5720.66
9_R108_K0.5710.66
30_L166_I0.5700.66
151_S160_I0.5690.66
51_Q152_L0.5690.66
12_F77_H0.5660.66
17_C159_G0.5650.66
81_P106_V0.5630.65
10_T113_Q0.5630.65
71_M117_F0.5610.65
149_R164_H0.5600.65
9_R175_W0.5570.64
45_Q164_H0.5570.64
98_G103_V0.5550.64
94_E102_K0.5540.64
69_M86_I0.5530.64
40_L153_L0.5530.64
113_Q181_K0.5510.64
57_H169_H0.5480.63
17_C175_W0.5440.63
114_K168_I0.5440.63
27_L90_L0.5440.63
84_K162_L0.5430.63
23_I26_F0.5410.62
154_I157_A0.5390.62
76_V117_F0.5370.62
53_G129_V0.5370.62
24_C78_H0.5360.62
142_Y157_A0.5360.62
42_W49_T0.5320.61
121_M166_I0.5320.61
28_V61_G0.5250.60
42_W151_S0.5250.60
92_I99_N0.5250.60
58_P152_L0.5240.60
150_Y161_I0.5240.60
142_Y145_M0.5240.60
66_V69_M0.5210.59
118_W126_V0.5180.59
24_C128_L0.5160.59
27_L51_Q0.5150.58
134_I148_V0.5140.58
77_H136_R0.5120.58
50_P71_M0.5080.57
37_F56_L0.5070.57
11_K21_V0.5070.57
19_W182_G0.5070.57
68_L120_I0.5060.57
147_V154_I0.5060.57
119_S161_I0.5050.57
187_K190_R0.5020.57
37_F59_F0.5010.56
94_E101_H0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kqfC 3 0.9954 100 0.281 Contact Map
4gd3A 2 0.7097 100 0.498 Contact Map
4ogqA 2 0.8203 89.9 0.909 Contact Map
2qjyA 2 0.8802 89.7 0.91 Contact Map
1pp9C 2 0.9401 87.4 0.913 Contact Map
4o6yA 2 0.7005 81.5 0.919 Contact Map
3cx5C 2 0.9585 81.1 0.92 Contact Map
1q16C 2 0.7327 32.2 0.942 Contact Map
3ayfA 2 0.7373 13.9 0.951 Contact Map
3mk7A 1 0.7558 10.4 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0081 seconds.