GREMLIN Database
FABI - Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
UniProt: P0AEK4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11528
Length: 262 (236)
Sequences: 114386 (78369)
Seq/√Len: 5101.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_K122_Y3.3011.00
114_K118_D2.8401.00
164_A168_A2.7791.00
79_G134_M2.7281.00
67_E70_S2.6531.00
143_T170_V2.6291.00
9_I87_G2.5401.00
72_D130_A2.5081.00
118_D122_Y2.3381.00
128_A173_M2.2791.00
140_A183_R2.2251.00
22_Y26_Q2.1991.00
38_T63_C2.1711.00
188_S244_V2.1521.00
132_R177_M2.1441.00
27_A227_N2.1391.00
68_D110_R2.0891.00
75_F131_C2.0091.00
243_E246_H1.9531.00
87_G233_C1.9511.00
193_R221_T1.9441.00
27_A230_A1.9191.00
90_H143_T1.9181.00
145_S167_E1.9071.00
22_Y47_R1.9051.00
227_N236_L1.8721.00
22_Y50_E1.8441.00
27_A31_E1.8321.00
8_R34_E1.8311.00
36_A82_W1.8171.00
14_V37_F1.7951.00
228_S245_V1.7941.00
36_A78_L1.7851.00
38_T74_M1.7751.00
170_V186_A1.7591.00
61_L77_E1.7481.00
44_L60_V1.7421.00
15_A39_Y1.7291.00
63_C70_S1.6981.00
77_E81_V1.6721.00
26_Q50_E1.6681.00
34_E57_S1.6671.00
220_V239_G1.6661.00
121_S165_S1.6111.00
20_I192_I1.5751.00
48_V52_A1.5751.00
28_M233_C1.5711.00
31_E230_A1.5591.00
24_I229_A1.5581.00
110_R126_A1.5541.00
124_F166_L1.5431.00
68_D126_A1.5121.00
27_A30_R1.5071.00
120_S162_A1.4941.00
73_T77_E1.4811.00
89_V144_L1.4741.00
33_A87_G1.4711.00
140_A185_N1.4631.00
117_H121_S1.4621.00
88_F127_M1.4371.00
63_C74_M1.4271.00
68_D72_D1.4251.00
96_P115_I1.4161.00
71_I127_M1.4111.00
8_R84_K1.4101.00
150_E246_H1.4061.00
48_V60_V1.4051.00
122_Y126_A1.4021.00
9_I28_M1.3951.00
8_R36_A1.3911.00
76_A80_K1.3871.00
26_Q54_Q1.3821.00
49_E53_A1.3391.00
9_I33_A1.3351.00
109_T112_G1.3351.00
90_H128_A1.3261.00
77_E80_K1.3231.00
145_S186_A1.3191.00
70_S73_T1.2931.00
18_L195_L1.2631.00
45_K49_E1.2491.00
98_D112_G1.2451.00
23_G26_Q1.2401.00
228_S247_V1.2381.00
18_L43_K1.2341.00
72_D76_A1.2241.00
28_M33_A1.2221.00
30_R54_Q1.2151.00
128_A141_L1.2121.00
4_L33_A1.2101.00
88_F131_C1.2091.00
96_P112_G1.1811.00
193_R198_S1.1761.00
85_F131_C1.1751.00
49_E52_A1.1691.00
91_S144_L1.1631.00
39_Y44_L1.1591.00
94_F119_I1.1591.00
61_L74_M1.1521.00
25_A37_F1.1461.00
23_G223_E1.1421.00
26_Q30_R1.1381.00
6_G33_A1.1251.00
66_A115_I1.1191.00
170_V184_V1.1171.00
167_E244_V1.1141.00
36_A61_L1.1121.00
94_F115_I1.1061.00
108_V158_V1.0981.00
27_A226_G1.0981.00
117_H122_Y1.0931.00
61_L81_V1.0811.00
125_V169_N1.0751.00
7_K86_D1.0701.00
27_A223_E1.0661.00
173_M184_V1.0511.00
124_F143_T1.0501.00
186_A244_V1.0491.00
144_L229_A1.0391.00
204_R208_A1.0391.00
46_G50_E1.0351.00
69_A73_T1.0321.00
110_R122_Y1.0301.00
187_I229_A1.0281.00
45_K48_V1.0191.00
128_A169_N1.0181.00
10_L74_M1.0141.00
8_R82_W1.0131.00
24_I89_V1.0091.00
55_L58_D1.0051.00
111_E115_I0.9981.00
50_E54_Q0.9911.00
192_I220_V0.9881.00
59_I81_V0.9871.00
113_F122_Y0.9831.00
208_A212_A0.9831.00
73_T76_A0.9721.00
10_L38_T0.9601.00
47_R50_E0.9591.00
150_E188_S0.9581.00
51_F56_G0.9531.00
78_L82_W0.9441.00
10_L85_F0.9391.00
18_L41_N0.9321.00
223_E227_N0.9281.00
62_Q70_S0.9261.00
65_V123_S0.9231.00
28_M230_A0.9231.00
63_C71_I0.9141.00
110_R114_K0.9091.00
128_A143_T0.9091.00
66_A118_D0.9081.00
231_F237_S0.9061.00
46_G49_E0.9041.00
231_F240_I0.9011.00
34_E56_G0.8921.00
140_A238_A0.8901.00
130_A133_S0.8861.00
68_D129_K0.8861.00
208_A211_E0.8851.00
195_L198_S0.8831.00
112_G115_I0.8791.00
18_L22_Y0.8711.00
24_I226_G0.8641.00
110_R129_K0.8641.00
177_M180_E0.8631.00
43_K46_G0.8611.00
160_G168_A0.8611.00
20_I24_I0.8611.00
207_L211_E0.8521.00
75_F130_A0.8511.00
90_H127_M0.8491.00
120_S163_K0.8491.00
34_E82_W0.8431.00
240_I245_V0.8391.00
167_E188_S0.8241.00
135_L139_S0.8241.00
29_H56_G0.8211.00
209_H212_A0.8211.00
149_A167_E0.8211.00
52_A57_S0.8181.00
23_G222_I0.8181.00
159_M163_K0.8111.00
137_P180_E0.8091.00
31_E234_S0.8071.00
23_G27_A0.8061.00
204_R207_L0.8031.00
45_K60_V0.8021.00
68_D130_A0.7981.00
69_A72_D0.7981.00
117_H161_L0.7951.00
23_G226_G0.7871.00
150_E167_E0.7861.00
34_E58_D0.7851.00
12_T127_M0.7841.00
185_N232_L0.7841.00
88_F141_L0.7761.00
167_E186_A0.7751.00
89_V229_A0.7721.00
113_F158_V0.7671.00
14_V38_T0.7661.00
39_Y60_V0.7661.00
7_K235_D0.7661.00
221_T224_D0.7641.00
157_N176_A0.7641.00
71_I126_A0.7621.00
228_S231_F0.7591.00
22_Y46_G0.7571.00
131_C135_L0.7541.00
142_L233_C0.7471.00
121_S161_L0.7471.00
50_E53_A0.7441.00
132_R180_E0.7431.00
218_R224_D0.7391.00
39_Y62_Q0.7381.00
124_F128_A0.7381.00
11_V25_A0.7321.00
191_P197_A0.7271.00
152_A168_A0.7221.00
85_F134_M0.7221.00
122_Y125_V0.7181.00
148_G160_G0.7141.00
113_F125_V0.7121.00
84_K134_M0.7051.00
31_E236_L0.7041.00
37_F60_V0.7041.00
167_E171_R0.6991.00
94_F196_A0.6951.00
146_Y159_M0.6941.00
135_L138_G0.6861.00
155_N176_A0.6811.00
44_L48_V0.6791.00
136_N180_E0.6781.00
114_K126_A0.6751.00
76_A130_A0.6731.00
126_A130_A0.6731.00
142_L229_A0.6721.00
214_T239_G0.6711.00
79_G84_K0.6701.00
76_A79_G0.6691.00
42_D45_K0.6671.00
94_F162_A0.6651.00
26_Q51_F0.6631.00
117_H162_A0.6621.00
177_M184_V0.6621.00
84_K136_N0.6601.00
71_I130_A0.6591.00
172_Y176_A0.6581.00
193_R207_L0.6561.00
76_A134_M0.6551.00
44_L62_Q0.6541.00
29_H51_F0.6541.00
141_L184_V0.6531.00
6_G34_E0.6511.00
157_N172_Y0.6481.00
95_A196_A0.6471.00
115_I118_D0.6461.00
239_G249_G0.6441.00
8_R78_L0.6411.00
192_I225_V0.6411.00
164_A167_E0.6381.00
65_V92_I0.6371.00
205_K208_A0.6371.00
216_I241_S0.6361.00
75_F127_M0.6351.00
116_A162_A0.6341.00
7_K33_A0.6331.00
34_E59_I0.6321.00
224_D238_A0.6321.00
168_A171_R0.6301.00
68_D111_E0.6291.00
160_G164_A0.6251.00
7_K138_G0.6231.00
52_A58_D0.6191.00
143_T184_V0.6181.00
240_I247_V0.6161.00
18_L39_Y0.6151.00
27_A236_L0.6091.00
93_G120_S0.6081.00
12_T91_S0.6071.00
90_H124_F0.6051.00
78_L81_V0.6041.00
145_S188_S0.6031.00
178_G241_S0.6031.00
116_A158_V0.6021.00
66_A119_I0.6011.00
96_P116_A0.5961.00
29_H58_D0.5951.00
68_D114_K0.5901.00
19_S194_T0.5901.00
226_G230_A0.5891.00
15_A18_L0.5891.00
79_G83_P0.5851.00
12_T90_H0.5851.00
121_S166_L0.5831.00
113_F121_S0.5831.00
74_M127_M0.5821.00
124_F127_M0.5791.00
52_A59_I0.5791.00
157_N169_N0.5771.00
119_I123_S0.5761.00
231_F234_S0.5731.00
26_Q223_E0.5701.00
99_Q106_N0.5691.00
37_F59_I0.5671.00
42_D46_G0.5631.00
125_V129_K0.5621.00
164_A171_R0.5621.00
52_A55_L0.5621.00
130_A134_M0.5601.00
149_A164_A0.5561.00
28_M87_G0.5551.00
30_R223_E0.5541.00
235_D238_A0.5491.00
40_Q64_D0.5491.00
78_L83_P0.5441.00
138_G183_R0.5431.00
72_D133_S0.5421.00
29_H35_L0.5411.00
14_V25_A0.5411.00
52_A56_G0.5381.00
160_G172_Y0.5371.00
218_R238_A0.5351.00
117_H165_S0.5341.00
21_A91_S0.5331.00
87_G140_A0.5311.00
40_Q62_Q0.5311.00
140_A233_C0.5301.00
59_I82_W0.5291.00
240_I243_E0.5291.00
10_L88_F0.5281.00
37_F48_V0.5271.00
106_N177_M0.5241.00
234_S237_S0.5241.00
24_I27_A0.5231.00
55_L59_I0.5221.00
75_F79_G0.5211.00
72_D126_A0.5201.00
143_T166_L0.5201.00
39_Y43_K0.5191.00
10_L78_L0.5181.00
220_V249_G0.5181.00
38_T78_L0.5151.00
174_A242_G0.5141.00
161_L169_N0.5131.00
168_A172_Y0.5101.00
28_M229_A0.5091.00
173_M177_M0.5091.00
205_K209_H0.5071.00
177_M182_V0.5031.00
48_V58_D0.5021.00
92_I123_S0.5011.00
51_F58_D0.5011.00
36_A74_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k31A 4 0.9885 100 0.179 Contact Map
1qsgA 6 0.9771 100 0.18 Contact Map
3grkA 4 0.9656 100 0.181 Contact Map
3r3sA 4 0.9466 100 0.187 Contact Map
3uveA 4 0.9427 100 0.187 Contact Map
4rgbA 2 0.9389 100 0.188 Contact Map
3v8bA 4 0.9351 100 0.188 Contact Map
1vl8A 4 0.9427 100 0.189 Contact Map
4bmnA 4 0.9008 100 0.189 Contact Map
1geeA 4 0.9733 100 0.192 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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