FABI - ECOLI - GREMLIN Contacts

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FABI - Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

UniProt:	P0AEK4	Sequences: MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNELELK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11528
Length:	262 (236)
Sequences:	114386 (78369)
Seq/√Len:	5101.4

ECOLI - FABI UCPA YGHA IDNO YGCW KDUD HCAB HDHA YOHF FABG ENTA SRLD FOLM BDCA YGFF YBBO YCIK YDFG
BACSU - FABI GS39 YHXD YXBG UXUB YHXC YHDF YJDA KDUD YXJF YKVO DHG DHG2 YWFH DHBA FABL YVRD YTKK FADH BACC FABG YVAG YOXD YMFI YQJQ YUXG BZRD YUSZ DLTE YXNA
HALSA - Q9HNC5 Q9HQ41 Q9HRV8 Q9HSR4 Q9HMA5 Q9HPP2 Q9HRZ2 Q9HS80 Q9HP93
SULSO - Q97VV6 Q97WF0 Q97UK6 Q97ZE4 Q97WD7 Q97UA4 Q97WL1 Q97Y09 Q97VG2 Q97ZA0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
114_K	122_Y	3.301	1.00
114_K	118_D	2.840	1.00
164_A	168_A	2.779	1.00
79_G	134_M	2.728	1.00
67_E	70_S	2.653	1.00
143_T	170_V	2.629	1.00
9_I	87_G	2.540	1.00
72_D	130_A	2.508	1.00
118_D	122_Y	2.338	1.00
128_A	173_M	2.279	1.00
140_A	183_R	2.225	1.00
22_Y	26_Q	2.199	1.00
38_T	63_C	2.171	1.00
188_S	244_V	2.152	1.00
132_R	177_M	2.144	1.00
27_A	227_N	2.139	1.00
68_D	110_R	2.089	1.00
75_F	131_C	2.009	1.00
243_E	246_H	1.953	1.00
87_G	233_C	1.951	1.00
193_R	221_T	1.944	1.00
27_A	230_A	1.919	1.00
90_H	143_T	1.918	1.00
145_S	167_E	1.907	1.00
22_Y	47_R	1.905	1.00
227_N	236_L	1.872	1.00
22_Y	50_E	1.844	1.00
27_A	31_E	1.832	1.00
8_R	34_E	1.831	1.00
36_A	82_W	1.817	1.00
14_V	37_F	1.795	1.00
228_S	245_V	1.794	1.00
36_A	78_L	1.785	1.00
38_T	74_M	1.775	1.00
170_V	186_A	1.759	1.00
61_L	77_E	1.748	1.00
44_L	60_V	1.742	1.00
15_A	39_Y	1.729	1.00
63_C	70_S	1.698	1.00
77_E	81_V	1.672	1.00
26_Q	50_E	1.668	1.00
34_E	57_S	1.667	1.00
220_V	239_G	1.666	1.00
121_S	165_S	1.611	1.00
20_I	192_I	1.575	1.00
48_V	52_A	1.575	1.00
28_M	233_C	1.571	1.00
31_E	230_A	1.559	1.00
24_I	229_A	1.558	1.00
110_R	126_A	1.554	1.00
124_F	166_L	1.543	1.00
68_D	126_A	1.512	1.00
27_A	30_R	1.507	1.00
120_S	162_A	1.494	1.00
73_T	77_E	1.481	1.00
89_V	144_L	1.474	1.00
33_A	87_G	1.471	1.00
140_A	185_N	1.463	1.00
117_H	121_S	1.462	1.00
88_F	127_M	1.437	1.00
63_C	74_M	1.427	1.00
68_D	72_D	1.425	1.00
96_P	115_I	1.416	1.00
71_I	127_M	1.411	1.00
8_R	84_K	1.410	1.00
150_E	246_H	1.406	1.00
48_V	60_V	1.405	1.00
122_Y	126_A	1.402	1.00
9_I	28_M	1.395	1.00
8_R	36_A	1.391	1.00
76_A	80_K	1.387	1.00
26_Q	54_Q	1.382	1.00
49_E	53_A	1.339	1.00
9_I	33_A	1.335	1.00
109_T	112_G	1.335	1.00
90_H	128_A	1.326	1.00
77_E	80_K	1.323	1.00
145_S	186_A	1.319	1.00
70_S	73_T	1.293	1.00
18_L	195_L	1.263	1.00
45_K	49_E	1.249	1.00
98_D	112_G	1.245	1.00
23_G	26_Q	1.240	1.00
228_S	247_V	1.238	1.00
18_L	43_K	1.234	1.00
72_D	76_A	1.224	1.00
28_M	33_A	1.222	1.00
30_R	54_Q	1.215	1.00
128_A	141_L	1.212	1.00
4_L	33_A	1.210	1.00
88_F	131_C	1.209	1.00
96_P	112_G	1.181	1.00
193_R	198_S	1.176	1.00
85_F	131_C	1.175	1.00
49_E	52_A	1.169	1.00
91_S	144_L	1.163	1.00
39_Y	44_L	1.159	1.00
94_F	119_I	1.159	1.00
61_L	74_M	1.152	1.00
25_A	37_F	1.146	1.00
23_G	223_E	1.142	1.00
26_Q	30_R	1.138	1.00
6_G	33_A	1.125	1.00
66_A	115_I	1.119	1.00
170_V	184_V	1.117	1.00
167_E	244_V	1.114	1.00
36_A	61_L	1.112	1.00
94_F	115_I	1.106	1.00
108_V	158_V	1.098	1.00
27_A	226_G	1.098	1.00
117_H	122_Y	1.093	1.00
61_L	81_V	1.081	1.00
125_V	169_N	1.075	1.00
7_K	86_D	1.070	1.00
27_A	223_E	1.066	1.00
173_M	184_V	1.051	1.00
124_F	143_T	1.050	1.00
186_A	244_V	1.049	1.00
144_L	229_A	1.039	1.00
204_R	208_A	1.039	1.00
46_G	50_E	1.035	1.00
69_A	73_T	1.032	1.00
110_R	122_Y	1.030	1.00
187_I	229_A	1.028	1.00
45_K	48_V	1.019	1.00
128_A	169_N	1.018	1.00
10_L	74_M	1.014	1.00
8_R	82_W	1.013	1.00
24_I	89_V	1.009	1.00
55_L	58_D	1.005	1.00
111_E	115_I	0.998	1.00
50_E	54_Q	0.991	1.00
192_I	220_V	0.988	1.00
59_I	81_V	0.987	1.00
113_F	122_Y	0.983	1.00
208_A	212_A	0.983	1.00
73_T	76_A	0.972	1.00
10_L	38_T	0.960	1.00
47_R	50_E	0.959	1.00
150_E	188_S	0.958	1.00
51_F	56_G	0.953	1.00
78_L	82_W	0.944	1.00
10_L	85_F	0.939	1.00
18_L	41_N	0.932	1.00
223_E	227_N	0.928	1.00
62_Q	70_S	0.926	1.00
65_V	123_S	0.923	1.00
28_M	230_A	0.923	1.00
63_C	71_I	0.914	1.00
110_R	114_K	0.909	1.00
128_A	143_T	0.909	1.00
66_A	118_D	0.908	1.00
231_F	237_S	0.906	1.00
46_G	49_E	0.904	1.00
231_F	240_I	0.901	1.00
34_E	56_G	0.892	1.00
140_A	238_A	0.890	1.00
130_A	133_S	0.886	1.00
68_D	129_K	0.886	1.00
208_A	211_E	0.885	1.00
195_L	198_S	0.883	1.00
112_G	115_I	0.879	1.00
18_L	22_Y	0.871	1.00
24_I	226_G	0.864	1.00
110_R	129_K	0.864	1.00
177_M	180_E	0.863	1.00
43_K	46_G	0.861	1.00
160_G	168_A	0.861	1.00
20_I	24_I	0.861	1.00
207_L	211_E	0.852	1.00
75_F	130_A	0.851	1.00
90_H	127_M	0.849	1.00
120_S	163_K	0.849	1.00
34_E	82_W	0.843	1.00
240_I	245_V	0.839	1.00
167_E	188_S	0.824	1.00
135_L	139_S	0.824	1.00
29_H	56_G	0.821	1.00
209_H	212_A	0.821	1.00
149_A	167_E	0.821	1.00
52_A	57_S	0.818	1.00
23_G	222_I	0.818	1.00
159_M	163_K	0.811	1.00
137_P	180_E	0.809	1.00
31_E	234_S	0.807	1.00
23_G	27_A	0.806	1.00
204_R	207_L	0.803	1.00
45_K	60_V	0.802	1.00
68_D	130_A	0.798	1.00
69_A	72_D	0.798	1.00
117_H	161_L	0.795	1.00
23_G	226_G	0.787	1.00
150_E	167_E	0.786	1.00
34_E	58_D	0.785	1.00
12_T	127_M	0.784	1.00
185_N	232_L	0.784	1.00
88_F	141_L	0.776	1.00
167_E	186_A	0.775	1.00
89_V	229_A	0.772	1.00
113_F	158_V	0.767	1.00
14_V	38_T	0.766	1.00
39_Y	60_V	0.766	1.00
7_K	235_D	0.766	1.00
221_T	224_D	0.764	1.00
157_N	176_A	0.764	1.00
71_I	126_A	0.762	1.00
228_S	231_F	0.759	1.00
22_Y	46_G	0.757	1.00
131_C	135_L	0.754	1.00
142_L	233_C	0.747	1.00
121_S	161_L	0.747	1.00
50_E	53_A	0.744	1.00
132_R	180_E	0.743	1.00
218_R	224_D	0.739	1.00
39_Y	62_Q	0.738	1.00
124_F	128_A	0.738	1.00
11_V	25_A	0.732	1.00
191_P	197_A	0.727	1.00
152_A	168_A	0.722	1.00
85_F	134_M	0.722	1.00
122_Y	125_V	0.718	1.00
148_G	160_G	0.714	1.00
113_F	125_V	0.712	1.00
84_K	134_M	0.705	1.00
31_E	236_L	0.704	1.00
37_F	60_V	0.704	1.00
167_E	171_R	0.699	1.00
94_F	196_A	0.695	1.00
146_Y	159_M	0.694	1.00
135_L	138_G	0.686	1.00
155_N	176_A	0.681	1.00
44_L	48_V	0.679	1.00
136_N	180_E	0.678	1.00
114_K	126_A	0.675	1.00
76_A	130_A	0.673	1.00
126_A	130_A	0.673	1.00
142_L	229_A	0.672	1.00
214_T	239_G	0.671	1.00
79_G	84_K	0.670	1.00
76_A	79_G	0.669	1.00
42_D	45_K	0.667	1.00
94_F	162_A	0.665	1.00
26_Q	51_F	0.663	1.00
117_H	162_A	0.662	1.00
177_M	184_V	0.662	1.00
84_K	136_N	0.660	1.00
71_I	130_A	0.659	1.00
172_Y	176_A	0.658	1.00
193_R	207_L	0.656	1.00
76_A	134_M	0.655	1.00
44_L	62_Q	0.654	1.00
29_H	51_F	0.654	1.00
141_L	184_V	0.653	1.00
6_G	34_E	0.651	1.00
157_N	172_Y	0.648	1.00
95_A	196_A	0.647	1.00
115_I	118_D	0.646	1.00
239_G	249_G	0.644	1.00
8_R	78_L	0.641	1.00
192_I	225_V	0.641	1.00
164_A	167_E	0.638	1.00
65_V	92_I	0.637	1.00
205_K	208_A	0.637	1.00
216_I	241_S	0.636	1.00
75_F	127_M	0.635	1.00
116_A	162_A	0.634	1.00
7_K	33_A	0.633	1.00
34_E	59_I	0.632	1.00
224_D	238_A	0.632	1.00
168_A	171_R	0.630	1.00
68_D	111_E	0.629	1.00
160_G	164_A	0.625	1.00
7_K	138_G	0.623	1.00
52_A	58_D	0.619	1.00
143_T	184_V	0.618	1.00
240_I	247_V	0.616	1.00
18_L	39_Y	0.615	1.00
27_A	236_L	0.609	1.00
93_G	120_S	0.608	1.00
12_T	91_S	0.607	1.00
90_H	124_F	0.605	1.00
78_L	81_V	0.604	1.00
145_S	188_S	0.603	1.00
178_G	241_S	0.603	1.00
116_A	158_V	0.602	1.00
66_A	119_I	0.601	1.00
96_P	116_A	0.596	1.00
29_H	58_D	0.595	1.00
68_D	114_K	0.590	1.00
19_S	194_T	0.590	1.00
226_G	230_A	0.589	1.00
15_A	18_L	0.589	1.00
79_G	83_P	0.585	1.00
12_T	90_H	0.585	1.00
121_S	166_L	0.583	1.00
113_F	121_S	0.583	1.00
74_M	127_M	0.582	1.00
124_F	127_M	0.579	1.00
52_A	59_I	0.579	1.00
157_N	169_N	0.577	1.00
119_I	123_S	0.576	1.00
231_F	234_S	0.573	1.00
26_Q	223_E	0.570	1.00
99_Q	106_N	0.569	1.00
37_F	59_I	0.567	1.00
42_D	46_G	0.563	1.00
125_V	129_K	0.562	1.00
164_A	171_R	0.562	1.00
52_A	55_L	0.562	1.00
130_A	134_M	0.560	1.00
149_A	164_A	0.556	1.00
28_M	87_G	0.555	1.00
30_R	223_E	0.554	1.00
235_D	238_A	0.549	1.00
40_Q	64_D	0.549	1.00
78_L	83_P	0.544	1.00
138_G	183_R	0.543	1.00
72_D	133_S	0.542	1.00
29_H	35_L	0.541	1.00
14_V	25_A	0.541	1.00
52_A	56_G	0.538	1.00
160_G	172_Y	0.537	1.00
218_R	238_A	0.535	1.00
117_H	165_S	0.534	1.00
21_A	91_S	0.533	1.00
87_G	140_A	0.531	1.00
40_Q	62_Q	0.531	1.00
140_A	233_C	0.530	1.00
59_I	82_W	0.529	1.00
240_I	243_E	0.529	1.00
10_L	88_F	0.528	1.00
37_F	48_V	0.527	1.00
106_N	177_M	0.524	1.00
234_S	237_S	0.524	1.00
24_I	27_A	0.523	1.00
55_L	59_I	0.522	1.00
75_F	79_G	0.521	1.00
72_D	126_A	0.520	1.00
143_T	166_L	0.520	1.00
39_Y	43_K	0.519	1.00
10_L	78_L	0.518	1.00
220_V	249_G	0.518	1.00
38_T	78_L	0.515	1.00
174_A	242_G	0.514	1.00
161_L	169_N	0.513	1.00
168_A	172_Y	0.510	1.00
28_M	229_A	0.509	1.00
173_M	177_M	0.509	1.00
205_K	209_H	0.507	1.00
177_M	182_V	0.503	1.00
48_V	58_D	0.502	1.00
92_I	123_S	0.501	1.00
51_F	58_D	0.501	1.00
36_A	74_M	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3k31A	4	0.9885	100	0.179	Contact Map
1qsgA	6	0.9771	100	0.18	Contact Map
3grkA	4	0.9656	100	0.181	Contact Map
3r3sA	4	0.9466	100	0.187	Contact Map
3uveA	4	0.9427	100	0.187	Contact Map
4rgbA	2	0.9389	100	0.188	Contact Map
3v8bA	4	0.9351	100	0.188	Contact Map
1vl8A	4	0.9427	100	0.189	Contact Map
4bmnA	4	0.9008	100	0.189	Contact Map
1geeA	4	0.9733	100	0.192	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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