GREMLIN Database
EXOX - Exodeoxyribonuclease 10
UniProt: P0AEK0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14031
Length: 220 (173)
Sequences: 3123 (2202)
Seq/√Len: 167.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_D63_W3.2191.00
79_A82_A3.1781.00
43_I58_V3.1321.00
111_K116_A2.9591.00
18_E135_R2.9531.00
38_R60_D2.8201.00
48_M54_T2.7811.00
42_P55_E2.6861.00
32_P141_Y2.6111.00
113_S116_A2.4061.00
37_V67_V2.3111.00
107_W121_R2.3051.00
80_H99_T2.2351.00
57_M61_K2.1381.00
45_P49_A2.0911.00
47_A51_H2.0521.00
15_G92_M1.9061.00
35_H62_P1.9041.00
21_S71_Y1.8641.00
15_G38_R1.8301.00
64_I68_I1.7931.00
46_Q49_A1.7541.00
19_I71_Y1.7251.00
82_A96_W1.6521.00
54_T57_M1.6361.00
20_A140_C1.6301.00
63_W66_D1.6101.00
62_P70_H1.6101.00
35_H70_H1.6021.00
24_V144_A1.5871.00
4_I143_T1.5701.00
3_R75_E1.5481.00
11_G14_G1.5181.00
14_G88_V1.4951.00
47_A50_I1.4921.00
110_I120_T1.4531.00
107_W150_I1.4351.00
103_A112_Y1.4311.00
118_Y142_I1.4291.00
3_R21_S1.4251.00
7_T16_I1.4221.00
39_P58_V1.4131.00
62_P66_D1.4101.00
36_L57_M1.4041.00
14_G41_R1.3981.00
149_D152_N1.3851.00
4_I24_V1.3761.00
80_H117_L1.3651.00
125_V142_I1.3451.00
15_G40_D1.3391.00
36_L61_K1.3361.00
43_I48_M1.3311.00
43_I55_E1.3301.00
35_H61_K1.3111.00
118_Y123_L1.3061.00
56_A59_A1.2911.00
86_R96_W1.2901.00
34_S137_L1.2861.00
35_H67_V1.2721.00
149_D153_T1.2711.00
107_W153_T1.2631.00
125_V133_H1.2341.00
100_M104_R1.2311.00
118_Y146_L1.2091.00
103_A117_L1.2011.00
9_T84_F1.1951.00
132_H138_Y1.1951.00
22_V140_C1.1901.00
64_I67_V1.1851.00
20_A34_S1.1721.00
5_I79_A1.1601.00
23_D31_N1.1521.00
133_H138_Y1.1471.00
144_A148_I1.1431.00
62_P67_V1.1371.00
4_I144_A1.1331.00
67_V71_Y1.1261.00
115_M133_H1.1201.00
20_A136_A1.1191.00
36_L135_R1.1171.00
5_I71_Y1.0991.00
140_C144_A1.0901.00
45_P48_M1.0851.00
24_V148_I1.0640.99
25_I30_V1.0550.99
3_R23_D1.0470.99
23_D75_E1.0400.99
103_A150_I1.0310.99
32_P137_L1.0270.99
44_S58_V1.0210.99
17_V43_I1.0090.99
123_L146_L1.0070.99
168_P171_M0.9960.99
43_I53_I0.9920.99
126_Q132_H0.9900.99
160_Q163_D0.9760.99
161_M164_I0.9740.99
25_I28_K0.9620.99
64_I92_M0.9590.99
53_I58_V0.9560.99
15_G41_R0.9480.99
46_Q50_I0.9430.99
18_E34_S0.9390.99
106_L150_I0.9350.99
162_A166_G0.9320.99
4_I78_V0.9300.99
141_Y145_A0.9130.98
40_D65_E0.8950.98
17_V53_I0.8940.98
44_S48_M0.8930.98
109_G112_Y0.8880.98
55_E59_A0.8880.98
33_M70_H0.8870.98
176_F179_Y0.8860.98
33_M71_Y0.8840.98
51_H135_R0.8790.98
103_A107_W0.8770.98
100_M112_Y0.8760.98
14_G44_S0.8660.98
11_G88_V0.8640.98
57_M60_D0.8630.98
125_V138_Y0.8590.98
7_T89_L0.8540.98
53_I57_M0.8540.98
137_L141_Y0.8410.97
78_V147_L0.8320.97
5_I77_Y0.8310.97
18_E137_L0.8230.97
19_I37_V0.8190.97
84_F88_V0.8100.97
162_A165_T0.8090.97
48_M55_E0.8060.97
17_V51_H0.8050.97
138_Y141_Y0.8030.96
161_M165_T0.7960.96
74_S94_G0.7940.96
165_T168_P0.7930.96
36_L53_I0.7930.96
73_G94_G0.7920.96
159_E162_A0.7900.96
174_F177_G0.7880.96
152_N155_G0.7860.96
160_Q164_I0.7830.96
42_P45_P0.7820.96
163_D167_R0.7790.96
69_P72_Y0.7770.96
9_T88_V0.7750.96
160_Q167_R0.7630.95
44_S47_A0.7600.95
79_A143_T0.7590.95
65_E69_P0.7490.95
121_R150_I0.7490.95
165_T169_S0.7440.95
43_I47_A0.7420.95
35_H71_Y0.7400.94
22_V137_L0.7390.94
87_R91_E0.7360.94
20_A137_L0.7330.94
173_T177_G0.7320.94
143_T147_L0.7260.94
173_T176_F0.7210.94
164_I168_P0.7160.93
27_G151_M0.7120.93
114_N143_T0.7110.93
9_T81_N0.7060.93
38_R59_A0.7050.93
2_L147_L0.7030.93
57_M135_R0.6940.92
117_L121_R0.6940.92
163_D166_G0.6830.92
22_V144_A0.6820.92
55_E58_V0.6810.92
145_A148_I0.6800.92
115_M118_Y0.6790.92
23_D30_V0.6680.91
38_R63_W0.6650.91
48_M57_M0.6640.91
10_C15_G0.6590.90
37_V64_I0.6580.90
99_T103_A0.6560.90
121_R126_Q0.6530.90
106_L154_S0.6520.90
160_Q165_T0.6510.90
83_S87_R0.6480.90
29_I32_P0.6450.89
81_N84_F0.6440.89
37_V61_K0.6330.88
174_F178_K0.6310.88
10_C44_S0.6290.88
175_T179_Y0.6290.88
146_L149_D0.6260.88
10_C16_I0.6230.88
79_A86_R0.6180.87
99_T147_L0.6180.87
99_T117_L0.6170.87
168_P172_T0.6150.87
175_T178_K0.6120.87
37_V63_W0.6120.87
135_R138_Y0.6060.86
164_I167_R0.6050.86
105_R164_I0.6040.86
97_I102_L0.6020.86
106_L156_W0.6010.86
161_M168_P0.5980.85
173_T178_K0.5940.85
12_L46_Q0.5940.85
68_I92_M0.5930.85
147_L151_M0.5910.85
112_Y121_R0.5870.84
160_Q170_L0.5860.84
107_W120_T0.5850.84
57_M90_P0.5850.84
150_I153_T0.5850.84
17_V44_S0.5850.84
15_G64_I0.5780.83
116_A119_K0.5780.83
114_N146_L0.5720.83
17_V47_A0.5700.83
83_S101_K0.5680.82
134_H139_D0.5670.82
14_G84_F0.5670.82
7_T88_V0.5660.82
38_R58_V0.5610.82
19_I72_Y0.5590.81
166_G171_M0.5540.81
159_E163_D0.5460.80
52_R132_H0.5450.80
118_Y125_V0.5440.80
163_D170_L0.5420.79
82_A99_T0.5370.79
63_W67_V0.5340.78
18_E36_L0.5280.78
123_L126_Q0.5280.78
81_N100_M0.5270.78
82_A143_T0.5270.78
22_V31_N0.5260.77
174_F179_Y0.5250.77
24_V29_I0.5240.77
7_T47_A0.5240.77
169_S172_T0.5220.77
121_R125_V0.5210.77
11_G84_F0.5210.77
64_I69_P0.5170.76
17_V50_I0.5160.76
165_T171_M0.5160.76
68_I72_Y0.5160.76
47_A135_R0.5150.76
22_V32_P0.5130.76
137_L140_C0.5120.76
122_K126_Q0.5080.75
124_N145_A0.5060.75
48_M52_R0.5050.75
15_G44_S0.5050.75
19_I67_V0.5050.75
66_D70_H0.5040.74
83_S86_R0.5040.74
166_G170_L0.5010.74
7_T20_A0.5000.74
79_A99_T0.5000.74
162_A170_L0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fzxC 1 0.7545 100 0.393 Contact Map
1zbuA 1 0.8455 100 0.418 Contact Map
4rg8A 1 0.9682 100 0.428 Contact Map
2xriA 1 0.7227 100 0.428 Contact Map
2qxfA 1 0.9227 100 0.428 Contact Map
4gmjB 1 0.8045 100 0.43 Contact Map
1w0hA 1 0.7227 100 0.433 Contact Map
4qozB 1 0.8364 100 0.434 Contact Map
2guiA 1 0.6682 100 0.436 Contact Map
3cg7A 2 0.9 100 0.436 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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