GREMLIN Database
EUTB - Ethanolamine ammonia-lyase heavy chain
UniProt: P0AEJ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG50006
Length: 453 (439)
Sequences: 620 (279)
Seq/√Len: 13.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_L122_V5.5871.00
249_C254_G5.5321.00
21_L64_V5.3231.00
251_S307_M5.2721.00
252_E256_K4.9241.00
102_S105_T4.3581.00
20_V50_V4.2761.00
266_D318_Y3.9971.00
392_M407_T3.5550.99
422_R428_E3.4020.99
394_M406_T3.3690.99
269_R273_A3.2990.98
233_E236_R3.2590.98
67_Y78_D3.2520.98
244_I272_G3.2430.98
88_I113_T3.2070.98
266_D317_H3.1820.98
142_P154_P3.1720.98
226_A230_T3.0930.97
156_T428_E2.9860.97
256_K261_E2.9580.97
20_V54_M2.9040.96
67_Y73_T2.8990.96
71_C261_E2.8960.96
397_G406_T2.8810.96
16_D19_E2.8630.96
273_A283_C2.8010.95
27_L32_V2.7180.94
57_A89_K2.6110.93
19_E23_K2.5630.92
165_D172_S2.5160.92
199_V234_A2.4850.91
381_I414_T2.4200.90
131_N378_N2.4070.90
393_G407_T2.3780.89
56_V121_V2.3670.89
159_A412_T2.2450.86
177_I209_I2.2310.86
56_V93_I2.2310.86
262_L314_L2.2300.86
202_L230_T2.2270.86
363_C391_I2.2200.85
384_A419_L2.2000.85
139_K421_L2.1600.84
93_I121_V2.1370.83
423_P437_M2.1020.82
113_T117_L2.0720.81
385_T418_L2.0650.81
87_Q112_F2.0500.80
270_A274_E2.0450.80
151_I158_S1.9700.77
73_T78_D1.9590.77
151_I321_F1.8580.73
79_D317_H1.8570.73
203_S234_A1.8540.73
170_V201_N1.8280.72
149_T213_I1.8240.72
159_A185_V1.8210.72
135_I382_L1.8110.71
146_K279_A1.8050.71
90_N95_E1.8040.71
202_L226_A1.7870.70
384_A418_L1.7850.70
71_C252_E1.7840.70
64_V302_A1.7790.70
341_I369_A1.7730.69
95_E98_E1.7720.69
380_M391_I1.7280.67
309_A350_F1.7260.67
142_P421_L1.7150.67
235_I244_I1.7080.66
107_V141_M1.7080.66
345_G379_L1.7020.66
217_N433_S1.7000.66
203_S239_A1.6930.66
88_I117_L1.6800.65
103_D417_Q1.6780.65
266_D270_A1.6630.64
234_A239_A1.6460.63
183_F436_I1.6460.63
6_T11_V1.6280.63
129_C137_G1.6180.62
21_L25_N1.6080.62
4_K11_V1.5980.61
122_V355_S1.5510.59
394_M397_G1.5390.58
91_W95_E1.5380.58
105_T113_T1.5230.57
128_I415_V1.5210.57
10_N42_Q1.5140.57
202_L231_Q1.5110.57
228_V268_A1.5080.56
272_G283_C1.4720.55
281_E319_D1.4590.54
75_L262_L1.4520.54
177_I212_V1.4350.53
23_K43_E1.4290.52
390_Y407_T1.4260.52
210_Y214_D1.4240.52
88_I91_W1.4060.51
136_Y139_K1.4050.51
106_S109_D1.3910.50
257_E296_A1.3870.50
231_Q234_A1.3840.50
71_C263_A1.3800.50
414_T418_L1.3780.50
359_M423_P1.3720.49
233_E237_R1.3650.49
190_I220_T1.3510.48
157_F415_V1.3460.48
192_V205_V1.3420.48
293_A311_N1.3410.48
253_K300_F1.3370.47
231_Q417_Q1.3240.47
157_F384_A1.3120.46
213_I222_G1.2980.45
199_V203_S1.2890.45
296_A311_N1.2860.45
207_D211_G1.2810.44
74_R78_D1.2790.44
228_V244_I1.2780.44
178_Y212_V1.2750.44
316_R355_S1.2730.44
408_A411_D1.2710.44
266_D269_R1.2630.44
209_I213_I1.2510.43
36_V212_V1.2480.43
204_R207_D1.2360.42
232_I268_A1.2330.42
71_C264_M1.2320.42
378_N381_I1.2310.42
202_L388_C1.2290.42
100_V137_G1.2170.41
14_F46_A1.2130.41
286_F318_Y1.2060.41
174_A212_V1.1870.40
307_M435_G1.1860.40
241_G244_I1.1860.40
325_T361_C1.1780.39
176_Q392_M1.1750.39
302_A307_M1.1720.39
269_R283_C1.1670.39
50_V54_M1.1610.38
269_R319_D1.1580.38
282_N319_D1.1560.38
53_E95_E1.1500.38
393_G412_T1.1430.37
231_Q241_G1.1380.37
185_V415_V1.1310.37
199_V230_T1.1270.37
159_A393_G1.1240.37
384_A391_I1.1210.36
61_N90_N1.1170.36
254_G293_A1.1070.36
135_I381_I1.1050.36
161_L180_G1.1020.35
88_I116_G1.0970.35
88_I105_T1.0940.35
380_M415_V1.0840.35
176_Q436_I1.0830.35
200_E237_R1.0740.34
122_V309_A1.0730.34
21_L128_I1.0720.34
48_K131_N1.0690.34
391_I407_T1.0630.34
183_F400_I1.0530.33
32_V340_Q1.0520.33
17_V64_V1.0500.33
156_T422_R1.0460.33
253_K256_K1.0400.33
235_I271_V1.0370.32
23_K230_T1.0280.32
376_N397_G1.0190.32
391_I412_T1.0180.31
407_T412_T1.0130.31
185_V202_L1.0130.31
203_S207_D1.0110.31
166_T400_I1.0090.31
323_V357_I1.0080.31
235_I274_E1.0080.31
18_K36_V1.0080.31
91_W113_T1.0070.31
363_C376_N1.0030.31
334_Y362_D0.9970.31
106_S140_K0.9950.30
4_K211_G0.9930.30
249_C293_A0.9880.30
327_V362_D0.9870.30
54_M58_D0.9860.30
230_T435_G0.9830.30
327_V334_Y0.9830.30
105_T115_K0.9820.30
189_V321_F0.9810.30
105_T109_D0.9800.30
140_K403_N0.9770.30
157_F423_P0.9730.29
60_R77_Q0.9700.29
20_V363_C0.9680.29
232_I271_V0.9650.29
126_A305_V0.9650.29
294_L334_Y0.9650.29
170_V204_R0.9560.29
119_S355_S0.9550.29
63_P77_Q0.9550.29
138_A349_H0.9500.28
18_K140_K0.9470.28
349_H353_K0.9420.28
380_M412_T0.9420.28
36_V213_I0.9400.28
378_N389_N0.9390.28
36_V140_K0.9390.28
145_K358_S0.9380.28
65_I363_C0.9370.28
60_R80_V0.9360.28
112_F115_K0.9350.28
248_I315_A0.9340.28
99_Y138_A0.9300.28
235_I272_G0.9240.27
226_A232_I0.9230.27
327_V379_L0.9230.27
261_E357_I0.9210.27
175_A391_I0.9210.27
363_C388_C0.9150.27
231_Q235_I0.9100.27
159_A397_G0.9080.27
158_S392_M0.9080.27
36_V300_F0.9050.27
201_N249_C0.9030.26
334_Y379_L0.9030.26
15_K19_E0.9030.26
147_A242_G0.9010.26
203_S237_R0.8990.26
131_N159_A0.8990.26
102_S113_T0.8970.26
316_R357_I0.8960.26
380_M407_T0.8940.26
91_W199_V0.8930.26
159_A381_I0.8920.26
159_A407_T0.8890.26
25_N305_V0.8880.26
60_R82_E0.8880.26
199_V202_L0.8880.26
153_I156_T0.8800.26
213_I359_M0.8780.25
151_I389_N0.8760.25
65_I307_M0.8730.25
167_R394_M0.8700.25
48_K423_P0.8680.25
45_V248_I0.8670.25
177_I190_I0.8670.25
5_T18_K0.8660.25
362_D379_L0.8650.25
23_K48_K0.8630.25
199_V204_R0.8620.25
202_L359_M0.8580.25
144_I389_N0.8570.25
12_Y43_E0.8550.25
15_K233_E0.8540.25
381_I385_T0.8510.24
339_R374_N0.8500.24
208_T352_G0.8500.24
192_V222_G0.8480.24
88_I114_R0.8440.24
67_Y74_R0.8420.24
99_Y113_T0.8420.24
170_V231_Q0.8390.24
58_D158_S0.8390.24
384_A415_V0.8380.24
103_D140_K0.8370.24
110_I141_M0.8360.24
253_K408_A0.8320.24
17_V145_K0.8320.24
57_A217_N0.8290.24
122_V394_M0.8290.24
27_L208_T0.8280.24
206_L359_M0.8280.24
428_E437_M0.8270.23
96_L117_L0.8240.23
3_L58_D0.8240.23
19_E50_V0.8220.23
384_A393_G0.8200.23
201_N224_V0.8200.23
342_I378_N0.8180.23
325_T362_D0.8140.23
131_N337_N0.8140.23
166_T254_G0.8140.23
325_T334_Y0.8110.23
363_C406_T0.8100.23
261_E264_M0.8080.23
261_E317_H0.8070.23
254_G260_V0.8060.23
86_N113_T0.8030.23
190_I419_L0.8000.22
44_R423_P0.7990.22
260_V264_M0.7980.22
209_I222_G0.7900.22
210_Y213_I0.7900.22
256_K357_I0.7890.22
182_S234_A0.7890.22
305_V396_L0.7880.22
269_R318_Y0.7870.22
202_L206_L0.7860.22
192_V424_S0.7850.22
294_L327_V0.7840.22
159_A406_T0.7840.22
192_V209_I0.7840.22
180_G284_L0.7820.22
36_V390_Y0.7810.22
305_V351_M0.7800.22
132_A414_T0.7800.22
226_A390_Y0.7790.22
68_E74_R0.7790.22
19_E233_E0.7770.22
57_A95_E0.7770.22
337_N370_D0.7760.22
139_K417_Q0.7690.21
231_Q244_I0.7680.21
107_V117_L0.7650.21
128_I374_N0.7640.21
29_S340_Q0.7590.21
159_A414_T0.7580.21
64_V422_R0.7570.21
15_K248_I0.7540.21
100_V354_L0.7530.21
103_D213_I0.7480.21
136_Y407_T0.7480.21
388_C436_I0.7430.20
67_Y77_Q0.7420.20
205_V307_M0.7400.20
170_V208_T0.7380.20
385_T419_L0.7370.20
65_I78_D0.7360.20
257_E392_M0.7330.20
195_V305_V0.7320.20
236_R271_V0.7320.20
128_I139_K0.7320.20
68_E78_D0.7310.20
53_E90_N0.7310.20
7_L297_G0.7310.20
265_L314_L0.7310.20
55_T313_G0.7300.20
48_K202_L0.7270.20
104_E441_R0.7250.20
429_R433_S0.7230.20
294_L379_L0.7220.20
18_K300_F0.7220.20
362_D406_T0.7220.20
167_R272_G0.7200.20
94_S396_L0.7200.20
374_N413_A0.7190.20
327_V345_G0.7190.20
345_G362_D0.7170.20
229_T371_A0.7160.20
111_A143_V0.7160.20
276_N297_G0.7140.19
102_S202_L0.7140.19
81_N112_F0.7130.19
25_N128_I0.7110.19
377_E397_G0.7090.19
200_E203_S0.7090.19
422_R437_M0.7090.19
334_Y345_G0.7080.19
228_V272_G0.7070.19
128_I419_L0.7070.19
202_L340_Q0.7050.19
149_T220_T0.7050.19
299_N361_C0.7040.19
110_I316_R0.7020.19
17_V20_V0.7010.19
79_D318_Y0.7010.19
63_P109_D0.7010.19
158_S363_C0.7000.19
198_D201_N0.6980.19
270_A273_A0.6970.19
4_K13_Q0.6950.19
249_C260_V0.6940.19
39_A43_E0.6940.19
122_V137_G0.6920.19
58_D62_N0.6920.19
21_L406_T0.6910.19
151_I435_G0.6910.19
36_V50_V0.6910.19
83_T440_G0.6910.19
11_V260_V0.6910.19
158_S419_L0.6890.19
200_E204_R0.6890.19
45_V171_Q0.6880.19
392_M406_T0.6860.19
23_K232_I0.6840.18
174_A400_I0.6840.18
230_T260_V0.6840.18
316_R425_P0.6830.18
361_C388_C0.6830.18
119_S369_A0.6820.18
231_Q249_C0.6820.18
6_T10_N0.6820.18
139_K418_L0.6800.18
201_N231_Q0.6790.18
304_Q327_V0.6770.18
91_W403_N0.6760.18
176_Q403_N0.6760.18
307_M361_C0.6750.18
136_Y213_I0.6750.18
105_T135_I0.6750.18
16_D21_L0.6750.18
12_Y230_T0.6730.18
226_A231_Q0.6730.18
199_V233_E0.6720.18
204_R252_E0.6700.18
58_D141_M0.6690.18
146_K435_G0.6670.18
363_C380_M0.6660.18
5_T50_V0.6650.18
201_N359_M0.6640.18
196_T231_Q0.6640.18
19_E43_E0.6630.18
16_D260_V0.6630.18
6_T50_V0.6620.18
304_Q334_Y0.6620.18
71_C173_I0.6610.18
213_I220_T0.6600.18
119_S351_M0.6600.18
230_T434_M0.6580.18
149_T170_V0.6570.18
323_V359_M0.6570.18
214_D217_N0.6570.18
25_N126_A0.6550.18
177_I192_V0.6530.18
88_I122_V0.6530.18
58_D89_K0.6530.18
175_A384_A0.6530.18
294_L362_D0.6520.17
103_D177_I0.6520.17
226_A264_M0.6520.17
388_C407_T0.6510.17
140_K300_F0.6510.17
135_I307_M0.6510.17
391_I415_V0.6500.17
114_R316_R0.6490.17
216_F232_I0.6490.17
58_D61_N0.6480.17
210_Y222_G0.6460.17
216_F437_M0.6450.17
117_L121_V0.6420.17
17_V302_A0.6400.17
45_V206_L0.6380.17
102_S140_K0.6370.17
173_I205_V0.6360.17
376_N406_T0.6360.17
48_K137_G0.6350.17
21_L359_M0.6330.17
304_Q325_T0.6330.17
273_A319_D0.6320.17
334_Y406_T0.6310.17
173_I391_I0.6310.17
83_T441_R0.6300.17
136_Y392_M0.6280.17
88_I236_R0.6270.17
141_M183_F0.6270.17
198_D235_I0.6270.17
242_G358_S0.6270.17
59_I354_L0.6260.17
139_K154_P0.6240.17
159_A216_F0.6240.17
131_N216_F0.6230.17
37_A167_R0.6220.17
11_V237_R0.6220.17
3_L50_V0.6210.17
322_I363_C0.6210.17
175_A292_S0.6210.17
10_N388_C0.6200.17
52_S397_G0.6200.17
146_K232_I0.6190.17
42_Q151_I0.6190.17
256_K317_H0.6190.17
107_V111_A0.6180.16
232_I357_I0.6180.16
201_N251_S0.6170.16
42_Q117_L0.6170.16
394_M417_Q0.6160.16
296_A334_Y0.6140.16
199_V239_A0.6140.16
63_P89_K0.6130.16
45_V202_L0.6130.16
352_G390_Y0.6080.16
156_T177_I0.6080.16
25_N374_N0.6070.16
234_A389_N0.6050.16
63_P105_T0.6050.16
174_A178_Y0.6040.16
292_S392_M0.6040.16
325_T379_L0.6040.16
165_D176_Q0.6040.16
37_A436_I0.6040.16
253_K307_M0.6030.16
161_L409_F0.6030.16
39_A297_G0.6020.16
263_A309_A0.6020.16
234_A238_G0.6010.16
158_S300_F0.5980.16
57_A61_N0.5970.16
207_D237_R0.5930.16
272_G403_N0.5930.16
304_Q362_D0.5930.16
48_K185_V0.5930.16
71_C255_L0.5920.16
52_S92_S0.5910.16
228_V235_I0.5880.16
87_Q113_T0.5870.16
362_D376_N0.5860.16
205_V224_V0.5860.16
41_S292_S0.5860.16
21_L59_I0.5850.16
182_S415_V0.5850.16
44_R359_M0.5850.16
41_S61_N0.5840.16
110_I408_A0.5840.16
12_Y15_K0.5840.16
18_K302_A0.5830.15
171_Q208_T0.5830.15
407_T418_L0.5830.15
99_Y130_S0.5820.15
345_G385_T0.5800.15
136_Y418_L0.5800.15
149_T154_P0.5790.15
103_D409_F0.5780.15
18_K88_I0.5780.15
107_V110_I0.5780.15
381_I418_L0.5780.15
196_T201_N0.5750.15
12_Y261_E0.5750.15
156_T385_T0.5750.15
269_R281_E0.5740.15
192_V224_V0.5720.15
3_L226_A0.5720.15
96_L207_D0.5710.15
49_Q140_K0.5710.15
192_V216_F0.5680.15
6_T264_M0.5680.15
26_E147_A0.5680.15
338_D375_L0.5680.15
107_V142_P0.5660.15
42_Q263_A0.5650.15
185_V423_P0.5650.15
9_G42_Q0.5650.15
21_L378_N0.5650.15
39_A273_A0.5650.15
134_L346_L0.5620.15
339_R375_L0.5620.15
125_V252_E0.5620.15
230_T390_Y0.5610.15
95_E207_D0.5610.15
26_E48_K0.5600.15
146_K429_R0.5600.15
36_V307_M0.5600.15
195_V351_M0.5590.15
27_L151_I0.5590.15
89_K139_K0.5590.15
257_E407_T0.5590.15
304_Q379_L0.5580.15
369_A424_S0.5580.15
103_D407_T0.5570.15
98_E173_I0.5570.15
185_V394_M0.5560.15
235_I264_M0.5560.15
270_A434_M0.5560.15
39_A432_E0.5550.15
159_A359_M0.5530.15
107_V113_T0.5520.15
45_V48_K0.5510.15
61_N89_K0.5500.15
174_A208_T0.5500.15
65_I302_A0.5500.15
9_G392_M0.5500.15
256_K260_V0.5490.15
144_I153_I0.5480.15
432_E438_A0.5480.15
20_V48_K0.5440.14
63_P202_L0.5440.14
109_D113_T0.5430.14
114_R252_E0.5430.14
141_M436_I0.5420.14
5_T317_H0.5420.14
80_V314_L0.5410.14
86_N263_A0.5410.14
19_E36_V0.5410.14
48_K359_M0.5380.14
88_I115_K0.5380.14
192_V309_A0.5370.14
7_L18_K0.5370.14
226_A251_S0.5360.14
251_S408_A0.5350.14
131_N135_I0.5340.14
138_A353_K0.5330.14
261_E342_I0.5330.14
107_V154_P0.5330.14
21_L357_I0.5320.14
151_I249_C0.5320.14
226_A271_V0.5310.14
171_Q436_I0.5300.14
198_D234_A0.5290.14
279_A390_Y0.5270.14
84_A87_Q0.5270.14
44_R157_F0.5270.14
157_F272_G0.5260.14
135_I237_R0.5250.14
106_S433_S0.5240.14
45_V54_M0.5230.14
150_T325_T0.5230.14
177_I256_K0.5230.14
161_L224_V0.5220.14
48_K159_A0.5220.14
208_T391_I0.5210.14
338_D396_L0.5210.14
149_T279_A0.5210.14
230_T415_V0.5200.14
147_A277_R0.5200.14
226_A423_P0.5200.14
83_T86_N0.5200.14
261_E390_Y0.5190.14
105_T117_L0.5190.14
159_A202_L0.5190.14
57_A317_H0.5190.14
119_S313_G0.5190.14
72_V363_C0.5190.14
69_D388_C0.5180.14
306_T376_N0.5180.14
234_A434_M0.5170.14
48_K128_I0.5170.14
49_Q212_V0.5170.14
252_E264_M0.5170.14
171_Q215_K0.5170.14
18_K176_Q0.5150.14
296_A327_V0.5150.14
140_K234_A0.5150.14
96_L111_A0.5140.14
89_K98_E0.5120.14
220_T321_F0.5110.14
183_F434_M0.5110.14
207_D390_Y0.5110.14
196_T434_M0.5110.14
207_D397_G0.5100.14
251_S409_F0.5080.14
18_K21_L0.5080.14
232_I274_E0.5080.14
65_I73_T0.5070.13
391_I414_T0.5060.13
15_K237_R0.5060.13
59_I63_P0.5060.13
36_V86_N0.5050.13
20_V180_G0.5050.13
257_E281_E0.5040.13
380_M392_M0.5030.13
171_Q397_G0.5020.13
13_Q69_D0.5020.13
12_Y202_L0.5010.13
94_S132_A0.5000.13
10_N96_L0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3abqA 3 1 100 0.004 Contact Map
2qezA 3 0.9868 100 0.009 Contact Map
2h9aA 1 0.5673 89 0.979 Contact Map
1eexA 2 0.8742 71.8 0.982 Contact Map
3plvC 1 0.0464 48.7 0.985 Contact Map
3ff4A 1 0.2472 42.6 0.985 Contact Map
3kb4A 2 0.404 19.4 0.988 Contact Map
3t7vA 1 0.6865 18.4 0.988 Contact Map
2kjpA 1 0.1987 16.6 0.988 Contact Map
4uirA 2 0.1744 15.6 0.988 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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