GREMLIN Database
ENVZ - Osmolarity sensor protein EnvZ
UniProt: P0AEJ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10269
Length: 450 (421)
Sequences: 50580 (43902)
Seq/√Len: 2139.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
373_D377_G4.1411.00
372_E431_S4.1101.00
410_Q414_D3.8191.00
366_R435_W3.7031.00
299_A332_M3.4191.00
421_E433_R3.4021.00
256_T270_I3.2351.00
370_Q431_S3.1301.00
383_R424_T3.0071.00
352_G374_D2.9981.00
359_S370_Q2.8351.00
368_W435_W2.7971.00
370_Q433_R2.7781.00
355_W374_D2.7121.00
332_M416_H2.7121.00
422_L432_I2.7061.00
357_K372_E2.6271.00
260_S271_N2.6091.00
361_G368_W2.6081.00
379_A382_Q2.6041.00
322_A357_K2.6011.00
425_S428_G2.5861.00
298_M331_K2.5491.00
368_W433_R2.5491.00
253_R275_E2.5441.00
409_V420_L2.5291.00
260_S268_E2.5011.00
423_G433_R2.4911.00
340_A413_V2.4691.00
423_G431_S2.4561.00
211_S214_R2.4431.00
387_F420_L2.3991.00
361_G370_Q2.3941.00
359_S372_E2.3891.00
378_I386_L2.3491.00
383_R422_L2.3131.00
320_E355_W2.3051.00
413_V418_G2.3011.00
300_D303_A2.2781.00
424_T430_L2.2521.00
382_Q385_H2.2231.00
298_M329_E2.2161.00
362_T438_V2.2111.00
363_E368_W2.1751.00
307_E338_K2.1321.00
419_M435_W2.1141.00
297_E334_P2.0511.00
413_V434_A2.0401.00
253_R274_I1.9931.00
332_M337_I1.9661.00
340_A412_I1.9641.00
385_H388_Q1.9541.00
312_E342_A1.9071.00
414_D419_M1.8741.00
253_R278_N1.8671.00
209_G214_R1.8631.00
412_I416_H1.8611.00
354_G374_D1.8491.00
278_N282_E1.8381.00
322_A355_W1.8301.00
380_P383_R1.8211.00
340_A409_V1.8111.00
195_Q200_I1.8051.00
232_D236_L1.7861.00
296_M331_K1.7781.00
378_I382_Q1.7741.00
236_L240_G1.7731.00
421_E435_W1.7571.00
382_Q391_V1.7541.00
378_I430_L1.7331.00
223_M227_V1.7331.00
385_H391_V1.7061.00
346_V350_R1.7061.00
256_T271_N1.6791.00
341_V369_F1.6781.00
210_A214_R1.6711.00
32_L36_N1.6651.00
260_S264_G1.6431.00
343_N409_V1.6141.00
90_S94_A1.6081.00
224_A228_K1.6021.00
302_N306_G1.5971.00
234_R238_M1.5801.00
352_G356_I1.5791.00
369_F434_A1.5771.00
257_E271_N1.5771.00
333_H336_S1.5501.00
224_A227_V1.5401.00
302_N360_S1.5161.00
231_A234_R1.5121.00
196_V224_A1.5071.00
255_A266_L1.5001.00
357_K374_D1.5001.00
217_T221_N1.5001.00
387_F422_L1.4851.00
373_D429_G1.4841.00
252_I274_I1.4751.00
336_S339_R1.4671.00
424_T427_R1.4571.00
382_Q393_G1.4541.00
190_E194_L1.4451.00
175_A179_I1.4441.00
424_T428_G1.4391.00
221_N224_A1.4331.00
204_P225_A1.4271.00
413_V420_L1.4251.00
351_Y392_R1.4241.00
340_A434_A1.4221.00
259_M263_D1.4091.00
213_V217_T1.4061.00
383_R387_F1.3891.00
259_M267_A1.3831.00
379_A426_E1.3801.00
190_E215_S1.3791.00
294_M333_H1.3761.00
244_D339_R1.3691.00
252_I270_I1.3651.00
367_A438_V1.3611.00
388_Q391_V1.3581.00
307_E334_P1.3491.00
300_D327_S1.3461.00
251_R255_A1.3371.00
271_N275_E1.3351.00
226_G229_Q1.3321.00
336_S415_N1.3241.00
220_F223_M1.3221.00
334_P338_K1.3181.00
256_T274_I1.3121.00
311_A338_K1.2981.00
336_S412_I1.2871.00
300_D329_E1.2701.00
251_R273_D1.2701.00
366_R419_M1.2691.00
200_I203_P1.2541.00
193_A196_V1.2501.00
411_R414_D1.2451.00
387_F432_I1.2361.00
195_Q203_P1.2331.00
253_R271_N1.2271.00
304_V308_V1.2251.00
418_G436_L1.2241.00
240_G389_P1.2221.00
237_L241_V1.2171.00
230_L234_R1.1991.00
386_L422_L1.1891.00
392_R399_I1.1871.00
131_P136_K1.1851.00
268_E272_K1.1811.00
372_E425_S1.1801.00
202_P228_K1.1751.00
256_T260_S1.1751.00
193_A197_G1.1741.00
33_V37_F1.1671.00
179_I183_N1.1561.00
158_S162_R1.1521.00
317_R321_T1.1471.00
387_F410_Q1.1421.00
422_L430_L1.1381.00
279_A335_L1.1271.00
231_A235_T1.1191.00
305_L360_S1.1161.00
255_A269_S1.1081.00
251_R254_L1.1031.00
363_E435_W1.0981.00
373_D430_L1.0841.00
282_E286_D1.0751.00
39_I43_L1.0661.00
308_V342_A1.0631.00
348_A356_I1.0571.00
180_R184_R1.0561.00
380_P424_T1.0491.00
209_G217_T1.0451.00
89_Y95_E1.0401.00
343_N346_V1.0361.00
344_M432_I1.0321.00
296_M416_H1.0321.00
253_R257_E1.0321.00
14_R211_S1.0311.00
337_I416_H1.0281.00
187_V190_E1.0231.00
254_L258_M1.0231.00
285_I288_L1.0231.00
246_R282_E1.0211.00
302_N327_S1.0191.00
219_A222_H1.0181.00
256_T267_A1.0151.00
244_D343_N1.0071.00
149_L153_H0.9981.00
265_Y269_S0.9901.00
204_P221_N0.9891.00
306_G323_L0.9891.00
344_M420_L0.9861.00
294_M336_S0.9861.00
192_A205_L0.9851.00
31_Y35_L0.9821.00
273_D276_E0.9811.00
264_G268_E0.9811.00
213_V216_V0.9781.00
189_L193_A0.9761.00
269_S273_D0.9741.00
308_V312_E0.9721.00
363_E366_R0.9701.00
365_N438_V0.9691.00
328_I367_A0.9661.00
210_A213_V0.9611.00
236_L389_P0.9611.00
216_V220_F0.9601.00
299_A304_V0.9581.00
283_Q336_S0.9521.00
341_V345_V0.9511.00
172_I176_W0.9501.00
204_P228_K0.9471.00
389_P411_R0.9451.00
193_A220_F0.9431.00
308_V338_K0.9421.00
182_Q185_P0.9411.00
303_A307_E0.9401.00
404_L408_I0.9401.00
344_M409_V0.9381.00
222_H226_G0.9361.00
12_F180_R0.9361.00
148_P151_E0.9311.00
304_V332_M0.9301.00
386_L432_I0.9291.00
35_L157_F0.9291.00
47_N51_A0.9281.00
193_A219_A0.9281.00
194_L215_S0.9281.00
206_R221_N0.9271.00
220_F224_A0.9251.00
243_H343_N0.9241.00
51_A55_R0.9231.00
190_E219_A0.9201.00
177_L181_I0.9201.00
378_I422_L0.9191.00
58_M62_L0.9181.00
127_N131_P0.9181.00
314_G317_R0.9161.00
378_I383_R0.9161.00
250_T254_L0.9081.00
173_G177_L0.9081.00
209_G213_V0.9071.00
340_A416_H0.9041.00
341_V371_V0.9031.00
185_P189_L0.9021.00
378_I384_K0.8971.00
207_E218_R0.8961.00
85_G98_G0.8951.00
413_V436_L0.8931.00
53_E56_M0.8931.00
377_G430_L0.8921.00
342_A346_V0.8921.00
54_V58_M0.8901.00
309_I323_L0.8891.00
320_E357_K0.8871.00
232_D235_T0.8791.00
108_L112_M0.8791.00
274_I278_N0.8771.00
344_M434_A0.8751.00
43_L47_N0.8741.00
190_E193_A0.8731.00
312_E345_V0.8711.00
308_V345_V0.8691.00
351_Y376_P0.8621.00
311_A342_A0.8611.00
245_L277_C0.8581.00
204_P224_A0.8511.00
244_D248_P0.8511.00
272_K307_E0.8491.00
295_P333_H0.8481.00
309_I313_S0.8481.00
306_G310_A0.8421.00
95_E98_G0.8411.00
179_I182_Q0.8401.00
196_V223_M0.8391.00
301_L369_F0.8371.00
410_Q419_M0.8361.00
305_L341_V0.8311.00
157_F161_F0.8241.00
36_N39_I0.8221.00
217_T220_F0.8201.00
312_E346_V0.8181.00
247_T251_R0.8181.00
358_V371_V0.8181.00
87_S95_E0.8151.00
265_Y268_E0.8121.00
345_V358_V0.8111.00
215_S218_R0.8091.00
379_A393_G0.8071.00
158_S161_F0.8061.00
338_K342_A0.8061.00
216_V221_N0.8051.00
411_R415_N0.8041.00
135_L138_W0.8041.00
95_E99_L0.8031.00
127_N130_S0.8001.00
197_G222_H0.7991.00
49_V52_Y0.7991.00
335_L338_K0.7981.00
376_P399_I0.7981.00
228_K232_D0.7971.00
45_Q49_V0.7961.00
50_L54_V0.7951.00
225_A229_Q0.7941.00
300_D328_I0.7911.00
238_M241_V0.7901.00
22_L26_S0.7901.00
36_N40_L0.7851.00
270_I274_I0.7851.00
263_D266_L0.7841.00
366_R437_P0.7841.00
46_F49_V0.7811.00
130_S134_W0.7801.00
90_S93_A0.7781.00
79_E83_E0.7781.00
214_R217_T0.7781.00
380_P384_K0.7761.00
115_Q119_P0.7731.00
392_R401_G0.7711.00
277_C281_I0.7701.00
275_E278_N0.7701.00
54_V57_L0.7701.00
214_R218_R0.7691.00
255_A273_D0.7671.00
279_A283_Q0.7641.00
205_L217_T0.7621.00
48_K51_A0.7621.00
28_V32_L0.7621.00
45_Q48_K0.7601.00
317_R349_A0.7601.00
268_E271_N0.7591.00
366_R438_V0.7571.00
296_M332_M0.7551.00
260_S267_A0.7531.00
216_V219_A0.7531.00
176_W180_R0.7521.00
286_D339_R0.7511.00
187_V191_H0.7501.00
230_L233_D0.7501.00
233_D236_L0.7501.00
203_P207_E0.7491.00
301_L367_A0.7471.00
192_A203_P0.7451.00
191_H195_Q0.7441.00
246_R278_N0.7431.00
314_G349_A0.7421.00
317_R322_A0.7391.00
249_L281_I0.7371.00
418_G434_A0.7371.00
96_E99_L0.7361.00
409_V413_V0.7351.00
380_P425_S0.7341.00
287_Y407_A0.7311.00
188_D191_H0.7311.00
378_I424_T0.7301.00
215_S219_A0.7301.00
181_I184_R0.7291.00
296_M417_N0.7271.00
339_R412_I0.7261.00
319_I323_L0.7251.00
194_L219_A0.7241.00
310_A313_S0.7241.00
286_D336_S0.7241.00
383_R423_G0.7221.00
350_R399_I0.7191.00
90_S96_E0.7181.00
131_P135_L0.7171.00
255_A270_I0.7161.00
152_I156_D0.7161.00
373_D376_P0.7151.00
139_L142_N0.7151.00
131_P139_L0.7151.00
241_V284_F0.7141.00
55_R58_M0.7131.00
244_D408_I0.7121.00
112_M116_L0.7111.00
306_G309_I0.7101.00
186_L189_L0.7091.00
269_S272_K0.7081.00
421_E434_A0.7081.00
193_A216_V0.7071.00
138_W141_P0.7061.00
276_E338_K0.7051.00
133_V137_T0.7051.00
44_Q47_N0.7041.00
283_Q339_R0.7041.00
109_S113_A0.7011.00
328_I331_K0.7001.00
41_P45_Q0.6991.00
42_S45_Q0.6981.00
307_E311_A0.6971.00
294_M415_N0.6951.00
372_E427_R0.6951.00
285_I289_R0.6941.00
243_H247_T0.6931.00
74_P78_R0.6921.00
336_S340_A0.6921.00
350_R401_G0.6911.00
46_F50_L0.6851.00
324_Y361_G0.6841.00
327_S330_V0.6841.00
43_L46_F0.6831.00
59_T63_Q0.6831.00
185_P211_S0.6831.00
383_R432_I0.6821.00
205_L221_N0.6811.00
378_I432_I0.6811.00
161_F165_L0.6771.00
171_A175_A0.6761.00
299_A334_P0.6751.00
111_Q115_Q0.6751.00
382_Q395_S0.6741.00
299_A331_K0.6741.00
223_M226_G0.6721.00
60_D63_Q0.6711.00
308_V311_A0.6711.00
129_S132_V0.6711.00
408_I412_I0.6711.00
370_Q423_G0.6691.00
203_P206_R0.6671.00
344_M413_V0.6651.00
250_T253_R0.6651.00
251_R269_S0.6621.00
320_E323_L0.6621.00
318_E353_N0.6611.00
73_P77_R0.6601.00
317_R352_G0.6601.00
237_L244_D0.6601.00
235_T291_G0.6591.00
192_A195_Q0.6581.00
55_R59_T0.6571.00
204_P209_G0.6551.00
418_G437_P0.6551.00
193_A223_M0.6541.00
159_P163_Y0.6531.00
360_S369_F0.6511.00
207_E217_T0.6501.00
291_G389_P0.6491.00
184_R188_D0.6491.00
49_V53_E0.6471.00
194_L198_K0.6451.00
328_I362_T0.6441.00
218_R222_H0.6441.00
115_Q118_G0.6431.00
409_V412_I0.6431.00
322_A359_S0.6431.00
305_L358_V0.6431.00
73_P76_F0.6431.00
116_L120_T0.6421.00
328_I360_S0.6421.00
185_P190_E0.6401.00
324_Y359_S0.6391.00
386_L407_A0.6371.00
255_A259_M0.6371.00
258_M266_L0.6371.00
130_S136_K0.6351.00
219_A223_M0.6351.00
262_Q266_L0.6341.00
61_K65_E0.6331.00
360_S367_A0.6281.00
37_F40_L0.6261.00
240_G244_D0.6251.00
40_L44_Q0.6231.00
330_V367_A0.6221.00
345_V356_I0.6221.00
44_Q48_K0.6211.00
348_A371_V0.6201.00
131_P134_W0.6191.00
130_S133_V0.6191.00
77_R81_Y0.6171.00
386_L391_V0.6161.00
273_D311_A0.6161.00
266_L270_I0.6161.00
210_A217_T0.6161.00
217_T224_A0.6151.00
238_M242_S0.6131.00
136_K139_L0.6121.00
188_D192_A0.6121.00
13_A17_L0.6111.00
52_Y55_R0.6101.00
301_L330_V0.6101.00
206_R209_G0.6101.00
162_R166_A0.6091.00
221_N225_A0.6081.00
35_L39_I0.6071.00
191_H194_L0.6071.00
302_N325_P0.6061.00
216_V223_M0.6041.00
185_P188_D0.6031.00
312_E349_A0.6031.00
309_I321_T0.6031.00
336_S416_H0.6031.00
197_G226_G0.6031.00
136_K140_S0.6021.00
40_L43_L0.6011.00
303_A306_G0.6011.00
131_P137_T0.6011.00
185_P193_A0.6011.00
255_A274_I0.6001.00
32_L35_L0.6001.00
218_R221_N0.6001.00
116_L119_P0.5981.00
74_P77_R0.5961.00
76_F80_I0.5961.00
356_I371_V0.5941.00
59_T62_L0.5931.00
78_R81_Y0.5921.00
62_L66_D0.5911.00
47_N50_L0.5891.00
165_L169_L0.5891.00
324_Y327_S0.5881.00
317_R323_L0.5881.00
420_L432_I0.5871.00
277_C285_I0.5871.00
368_W421_E0.5871.00
384_K388_Q0.5871.00
159_P162_R0.5871.00
107_F111_Q0.5851.00
284_F288_L0.5851.00
357_K360_S0.5851.00
21_T24_F0.5841.00
383_R430_L0.5841.00
271_N274_I0.5841.00
267_A271_N0.5821.00
60_D64_L0.5811.00
50_L53_E0.5811.00
245_L248_P0.5801.00
309_I358_V0.5791.00
194_L197_G0.5781.00
275_E279_A0.5781.00
244_D280_I0.5731.00
318_E355_W0.5721.00
110_H114_Q0.5701.00
18_L22_L0.5701.00
388_Q410_Q0.5701.00
149_L152_I0.5701.00
78_R82_R0.5661.00
201_I224_A0.5651.00
57_L61_K0.5641.00
72_V75_A0.5631.00
93_A99_L0.5621.00
392_R400_S0.5611.00
12_F187_V0.5611.00
87_S90_S0.5611.00
188_D206_R0.5601.00
259_M266_L0.5591.00
21_T28_V0.5581.00
81_Y84_L0.5581.00
304_V337_I0.5581.00
57_L60_D0.5571.00
14_R181_I0.5561.00
111_Q114_Q0.5561.00
345_V349_A0.5561.00
212_E216_V0.5561.00
75_A79_E0.5551.00
238_M284_F0.5541.00
48_K52_Y0.5531.00
77_R80_I0.5521.00
63_Q66_D0.5511.00
247_T254_L0.5511.00
302_N328_I0.5511.00
229_Q233_D0.5501.00
29_T33_V0.5481.00
337_I436_L0.5461.00
186_L190_E0.5451.00
244_D247_T0.5451.00
105_Y109_S0.5441.00
189_L220_F0.5441.00
183_N187_V0.5431.00
254_L274_I0.5431.00
287_Y411_R0.5431.00
379_A383_R0.5421.00
407_A411_R0.5421.00
246_R277_C0.5411.00
121_E125_E0.5401.00
137_T140_S0.5391.00
37_F41_P0.5391.00
287_Y389_P0.5371.00
239_A242_S0.5371.00
307_E310_A0.5371.00
184_R187_V0.5371.00
186_L216_V0.5361.00
302_N323_L0.5351.00
427_R430_L0.5341.00
38_A41_P0.5341.00
339_R342_A0.5331.00
293_E296_M0.5321.00
413_V419_M0.5321.00
160_L163_Y0.5311.00
185_P209_G0.5301.00
119_P123_R0.5251.00
348_A352_G0.5241.00
134_W137_T0.5241.00
189_L217_T0.5231.00
396_A400_S0.5231.00
132_V136_K0.5221.00
72_V77_R0.5221.00
222_H225_A0.5211.00
104_H107_F0.5211.00
225_A228_K0.5201.00
304_V311_A0.5181.00
189_L192_A0.5171.00
294_M416_H0.5171.00
57_L65_E0.5161.00
283_Q335_L0.5141.00
75_A78_R0.5131.00
52_Y56_M0.5131.00
249_L274_I0.5121.00
377_G429_G0.5121.00
195_Q199_G0.5121.00
235_T240_G0.5111.00
242_S248_P0.5101.00
128_K132_V0.5091.00
390_F407_A0.5091.00
303_A334_P0.5091.00
262_Q265_Y0.5081.00
106_E110_H0.5081.00
362_T367_A0.5081.00
19_I175_A0.5071.00
143_I146_R0.5061.00
20_V23_L0.5051.00
186_L213_V0.5041.00
12_F16_L0.5041.00
207_E214_R0.5031.00
236_L411_R0.5031.00
131_P142_N0.5031.00
237_L390_F0.5021.00
257_E260_S0.5011.00
376_P430_L0.5011.00
33_V36_N0.5011.00
211_S215_S0.5001.00
319_I352_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ctiA 2 0.5067 100 0.364 Contact Map
4i5sA 2 0.58 100 0.368 Contact Map
4bixA 2 0.4911 100 0.391 Contact Map
4q20A 2 0.4844 100 0.486 Contact Map
4gczA 2 0.7778 100 0.496 Contact Map
4mpcA 2 0.6489 100 0.504 Contact Map
3d36A 2 0.4689 100 0.505 Contact Map
3a0rA 2 0.7111 100 0.505 Contact Map
2q8gA 2 0.6556 100 0.507 Contact Map
3jz3A 2 0.3289 100 0.51 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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