ENVZ - ECOLI - GREMLIN Contacts

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ENVZ - Osmolarity sensor protein EnvZ

UniProt:	P0AEJ4	Sequences: MRRLRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIETALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTISGTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGTTKEG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10269
Length:	450 (421)
Sequences:	50580 (43902)
Seq/√Len:	2139.6

ECOLI - ENVZ BARA GLRK PHOQ BAES CUSS CPXA RSTB CREC YEDV QSEC TORS ATOS ZRAS RCSD NARX DCUS DPIB RCSC BASS NARQ KDPD EVGS ARCB PHOR YPDA UHPB
BACSU - CSSS YKOH YCLK YYCG RESE PHOR YVRG KINB DCTS CITS KIND MALK YRKQ YVCQ KINE YXDK BCES YCBM YESM KINA LIAS GLNK LYTS KINC YWPD YBDK COMP YFIJ NATK YDFH
HALSA - Q9HQ15 Q9HQG5 Q9HQE9 Q9HQ16 Q9HR10 Q9HRE4 O51970 Q9HRG1 Q9HNM2 Q9HNA6 BAT Q9HQB9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
373_D	377_G	4.141	1.00
372_E	431_S	4.110	1.00
410_Q	414_D	3.819	1.00
366_R	435_W	3.703	1.00
299_A	332_M	3.419	1.00
421_E	433_R	3.402	1.00
256_T	270_I	3.235	1.00
370_Q	431_S	3.130	1.00
383_R	424_T	3.007	1.00
352_G	374_D	2.998	1.00
359_S	370_Q	2.835	1.00
368_W	435_W	2.797	1.00
370_Q	433_R	2.778	1.00
355_W	374_D	2.712	1.00
332_M	416_H	2.712	1.00
422_L	432_I	2.706	1.00
357_K	372_E	2.627	1.00
260_S	271_N	2.609	1.00
361_G	368_W	2.608	1.00
379_A	382_Q	2.604	1.00
322_A	357_K	2.601	1.00
425_S	428_G	2.586	1.00
298_M	331_K	2.549	1.00
368_W	433_R	2.549	1.00
253_R	275_E	2.544	1.00
409_V	420_L	2.529	1.00
260_S	268_E	2.501	1.00
423_G	433_R	2.491	1.00
340_A	413_V	2.469	1.00
423_G	431_S	2.456	1.00
211_S	214_R	2.443	1.00
387_F	420_L	2.399	1.00
361_G	370_Q	2.394	1.00
359_S	372_E	2.389	1.00
378_I	386_L	2.349	1.00
383_R	422_L	2.313	1.00
320_E	355_W	2.305	1.00
413_V	418_G	2.301	1.00
300_D	303_A	2.278	1.00
424_T	430_L	2.252	1.00
382_Q	385_H	2.223	1.00
298_M	329_E	2.216	1.00
362_T	438_V	2.211	1.00
363_E	368_W	2.175	1.00
307_E	338_K	2.132	1.00
419_M	435_W	2.114	1.00
297_E	334_P	2.051	1.00
413_V	434_A	2.040	1.00
253_R	274_I	1.993	1.00
332_M	337_I	1.966	1.00
340_A	412_I	1.964	1.00
385_H	388_Q	1.954	1.00
312_E	342_A	1.907	1.00
414_D	419_M	1.874	1.00
253_R	278_N	1.867	1.00
209_G	214_R	1.863	1.00
412_I	416_H	1.861	1.00
354_G	374_D	1.849	1.00
278_N	282_E	1.838	1.00
322_A	355_W	1.830	1.00
380_P	383_R	1.821	1.00
340_A	409_V	1.811	1.00
195_Q	200_I	1.805	1.00
232_D	236_L	1.786	1.00
296_M	331_K	1.778	1.00
378_I	382_Q	1.774	1.00
236_L	240_G	1.773	1.00
421_E	435_W	1.757	1.00
382_Q	391_V	1.754	1.00
378_I	430_L	1.733	1.00
223_M	227_V	1.733	1.00
385_H	391_V	1.706	1.00
346_V	350_R	1.706	1.00
256_T	271_N	1.679	1.00
341_V	369_F	1.678	1.00
210_A	214_R	1.671	1.00
32_L	36_N	1.665	1.00
260_S	264_G	1.643	1.00
343_N	409_V	1.614	1.00
90_S	94_A	1.608	1.00
224_A	228_K	1.602	1.00
302_N	306_G	1.597	1.00
234_R	238_M	1.580	1.00
352_G	356_I	1.579	1.00
369_F	434_A	1.577	1.00
257_E	271_N	1.577	1.00
333_H	336_S	1.550	1.00
224_A	227_V	1.540	1.00
302_N	360_S	1.516	1.00
231_A	234_R	1.512	1.00
196_V	224_A	1.507	1.00
255_A	266_L	1.500	1.00
357_K	374_D	1.500	1.00
217_T	221_N	1.500	1.00
387_F	422_L	1.485	1.00
373_D	429_G	1.484	1.00
252_I	274_I	1.475	1.00
336_S	339_R	1.467	1.00
424_T	427_R	1.457	1.00
382_Q	393_G	1.454	1.00
190_E	194_L	1.445	1.00
175_A	179_I	1.444	1.00
424_T	428_G	1.439	1.00
221_N	224_A	1.433	1.00
204_P	225_A	1.427	1.00
413_V	420_L	1.425	1.00
351_Y	392_R	1.424	1.00
340_A	434_A	1.422	1.00
259_M	263_D	1.409	1.00
213_V	217_T	1.406	1.00
383_R	387_F	1.389	1.00
259_M	267_A	1.383	1.00
379_A	426_E	1.380	1.00
190_E	215_S	1.379	1.00
294_M	333_H	1.376	1.00
244_D	339_R	1.369	1.00
252_I	270_I	1.365	1.00
367_A	438_V	1.361	1.00
388_Q	391_V	1.358	1.00
307_E	334_P	1.349	1.00
300_D	327_S	1.346	1.00
251_R	255_A	1.337	1.00
271_N	275_E	1.335	1.00
226_G	229_Q	1.332	1.00
336_S	415_N	1.324	1.00
220_F	223_M	1.322	1.00
334_P	338_K	1.318	1.00
256_T	274_I	1.312	1.00
311_A	338_K	1.298	1.00
336_S	412_I	1.287	1.00
300_D	329_E	1.270	1.00
251_R	273_D	1.270	1.00
366_R	419_M	1.269	1.00
200_I	203_P	1.254	1.00
193_A	196_V	1.250	1.00
411_R	414_D	1.245	1.00
387_F	432_I	1.236	1.00
195_Q	203_P	1.233	1.00
253_R	271_N	1.227	1.00
304_V	308_V	1.225	1.00
418_G	436_L	1.224	1.00
240_G	389_P	1.222	1.00
237_L	241_V	1.217	1.00
230_L	234_R	1.199	1.00
386_L	422_L	1.189	1.00
392_R	399_I	1.187	1.00
131_P	136_K	1.185	1.00
268_E	272_K	1.181	1.00
372_E	425_S	1.180	1.00
202_P	228_K	1.175	1.00
256_T	260_S	1.175	1.00
193_A	197_G	1.174	1.00
33_V	37_F	1.167	1.00
179_I	183_N	1.156	1.00
158_S	162_R	1.152	1.00
317_R	321_T	1.147	1.00
387_F	410_Q	1.142	1.00
422_L	430_L	1.138	1.00
279_A	335_L	1.127	1.00
231_A	235_T	1.119	1.00
305_L	360_S	1.116	1.00
255_A	269_S	1.108	1.00
251_R	254_L	1.103	1.00
363_E	435_W	1.098	1.00
373_D	430_L	1.084	1.00
282_E	286_D	1.075	1.00
39_I	43_L	1.066	1.00
308_V	342_A	1.063	1.00
348_A	356_I	1.057	1.00
180_R	184_R	1.056	1.00
380_P	424_T	1.049	1.00
209_G	217_T	1.045	1.00
89_Y	95_E	1.040	1.00
343_N	346_V	1.036	1.00
344_M	432_I	1.032	1.00
296_M	416_H	1.032	1.00
253_R	257_E	1.032	1.00
14_R	211_S	1.031	1.00
337_I	416_H	1.028	1.00
187_V	190_E	1.023	1.00
254_L	258_M	1.023	1.00
285_I	288_L	1.023	1.00
246_R	282_E	1.021	1.00
302_N	327_S	1.019	1.00
219_A	222_H	1.018	1.00
256_T	267_A	1.015	1.00
244_D	343_N	1.007	1.00
149_L	153_H	0.998	1.00
265_Y	269_S	0.990	1.00
204_P	221_N	0.989	1.00
306_G	323_L	0.989	1.00
344_M	420_L	0.986	1.00
294_M	336_S	0.986	1.00
192_A	205_L	0.985	1.00
31_Y	35_L	0.982	1.00
273_D	276_E	0.981	1.00
264_G	268_E	0.981	1.00
213_V	216_V	0.978	1.00
189_L	193_A	0.976	1.00
269_S	273_D	0.974	1.00
308_V	312_E	0.972	1.00
363_E	366_R	0.970	1.00
365_N	438_V	0.969	1.00
328_I	367_A	0.966	1.00
210_A	213_V	0.961	1.00
236_L	389_P	0.961	1.00
216_V	220_F	0.960	1.00
299_A	304_V	0.958	1.00
283_Q	336_S	0.952	1.00
341_V	345_V	0.951	1.00
172_I	176_W	0.950	1.00
204_P	228_K	0.947	1.00
389_P	411_R	0.945	1.00
193_A	220_F	0.943	1.00
308_V	338_K	0.942	1.00
182_Q	185_P	0.941	1.00
303_A	307_E	0.940	1.00
404_L	408_I	0.940	1.00
344_M	409_V	0.938	1.00
222_H	226_G	0.936	1.00
12_F	180_R	0.936	1.00
148_P	151_E	0.931	1.00
304_V	332_M	0.930	1.00
386_L	432_I	0.929	1.00
35_L	157_F	0.929	1.00
47_N	51_A	0.928	1.00
193_A	219_A	0.928	1.00
194_L	215_S	0.928	1.00
206_R	221_N	0.927	1.00
220_F	224_A	0.925	1.00
243_H	343_N	0.924	1.00
51_A	55_R	0.923	1.00
190_E	219_A	0.920	1.00
177_L	181_I	0.920	1.00
378_I	422_L	0.919	1.00
58_M	62_L	0.918	1.00
127_N	131_P	0.918	1.00
314_G	317_R	0.916	1.00
378_I	383_R	0.916	1.00
250_T	254_L	0.908	1.00
173_G	177_L	0.908	1.00
209_G	213_V	0.907	1.00
340_A	416_H	0.904	1.00
341_V	371_V	0.903	1.00
185_P	189_L	0.902	1.00
378_I	384_K	0.897	1.00
207_E	218_R	0.896	1.00
85_G	98_G	0.895	1.00
413_V	436_L	0.893	1.00
53_E	56_M	0.893	1.00
377_G	430_L	0.892	1.00
342_A	346_V	0.892	1.00
54_V	58_M	0.890	1.00
309_I	323_L	0.889	1.00
320_E	357_K	0.887	1.00
232_D	235_T	0.879	1.00
108_L	112_M	0.879	1.00
274_I	278_N	0.877	1.00
344_M	434_A	0.875	1.00
43_L	47_N	0.874	1.00
190_E	193_A	0.873	1.00
312_E	345_V	0.871	1.00
308_V	345_V	0.869	1.00
351_Y	376_P	0.862	1.00
311_A	342_A	0.861	1.00
245_L	277_C	0.858	1.00
204_P	224_A	0.851	1.00
244_D	248_P	0.851	1.00
272_K	307_E	0.849	1.00
295_P	333_H	0.848	1.00
309_I	313_S	0.848	1.00
306_G	310_A	0.842	1.00
95_E	98_G	0.841	1.00
179_I	182_Q	0.840	1.00
196_V	223_M	0.839	1.00
301_L	369_F	0.837	1.00
410_Q	419_M	0.836	1.00
305_L	341_V	0.831	1.00
157_F	161_F	0.824	1.00
36_N	39_I	0.822	1.00
217_T	220_F	0.820	1.00
312_E	346_V	0.818	1.00
247_T	251_R	0.818	1.00
358_V	371_V	0.818	1.00
87_S	95_E	0.815	1.00
265_Y	268_E	0.812	1.00
345_V	358_V	0.811	1.00
215_S	218_R	0.809	1.00
379_A	393_G	0.807	1.00
158_S	161_F	0.806	1.00
338_K	342_A	0.806	1.00
216_V	221_N	0.805	1.00
411_R	415_N	0.804	1.00
135_L	138_W	0.804	1.00
95_E	99_L	0.803	1.00
127_N	130_S	0.800	1.00
197_G	222_H	0.799	1.00
49_V	52_Y	0.799	1.00
335_L	338_K	0.798	1.00
376_P	399_I	0.798	1.00
228_K	232_D	0.797	1.00
45_Q	49_V	0.796	1.00
50_L	54_V	0.795	1.00
225_A	229_Q	0.794	1.00
300_D	328_I	0.791	1.00
238_M	241_V	0.790	1.00
22_L	26_S	0.790	1.00
36_N	40_L	0.785	1.00
270_I	274_I	0.785	1.00
263_D	266_L	0.784	1.00
366_R	437_P	0.784	1.00
46_F	49_V	0.781	1.00
130_S	134_W	0.780	1.00
90_S	93_A	0.778	1.00
79_E	83_E	0.778	1.00
214_R	217_T	0.778	1.00
380_P	384_K	0.776	1.00
115_Q	119_P	0.773	1.00
392_R	401_G	0.771	1.00
277_C	281_I	0.770	1.00
275_E	278_N	0.770	1.00
54_V	57_L	0.770	1.00
214_R	218_R	0.769	1.00
255_A	273_D	0.767	1.00
279_A	283_Q	0.764	1.00
205_L	217_T	0.762	1.00
48_K	51_A	0.762	1.00
28_V	32_L	0.762	1.00
45_Q	48_K	0.760	1.00
317_R	349_A	0.760	1.00
268_E	271_N	0.759	1.00
366_R	438_V	0.757	1.00
296_M	332_M	0.755	1.00
260_S	267_A	0.753	1.00
216_V	219_A	0.753	1.00
176_W	180_R	0.752	1.00
286_D	339_R	0.751	1.00
187_V	191_H	0.750	1.00
230_L	233_D	0.750	1.00
233_D	236_L	0.750	1.00
203_P	207_E	0.749	1.00
301_L	367_A	0.747	1.00
192_A	203_P	0.745	1.00
191_H	195_Q	0.744	1.00
246_R	278_N	0.743	1.00
314_G	349_A	0.742	1.00
317_R	322_A	0.739	1.00
249_L	281_I	0.737	1.00
418_G	434_A	0.737	1.00
96_E	99_L	0.736	1.00
409_V	413_V	0.735	1.00
380_P	425_S	0.734	1.00
287_Y	407_A	0.731	1.00
188_D	191_H	0.731	1.00
378_I	424_T	0.730	1.00
215_S	219_A	0.730	1.00
181_I	184_R	0.729	1.00
296_M	417_N	0.727	1.00
339_R	412_I	0.726	1.00
319_I	323_L	0.725	1.00
194_L	219_A	0.724	1.00
310_A	313_S	0.724	1.00
286_D	336_S	0.724	1.00
383_R	423_G	0.722	1.00
350_R	399_I	0.719	1.00
90_S	96_E	0.718	1.00
131_P	135_L	0.717	1.00
255_A	270_I	0.716	1.00
152_I	156_D	0.716	1.00
373_D	376_P	0.715	1.00
139_L	142_N	0.715	1.00
131_P	139_L	0.715	1.00
241_V	284_F	0.714	1.00
55_R	58_M	0.713	1.00
244_D	408_I	0.712	1.00
112_M	116_L	0.711	1.00
306_G	309_I	0.710	1.00
186_L	189_L	0.709	1.00
269_S	272_K	0.708	1.00
421_E	434_A	0.708	1.00
193_A	216_V	0.707	1.00
138_W	141_P	0.706	1.00
276_E	338_K	0.705	1.00
133_V	137_T	0.705	1.00
44_Q	47_N	0.704	1.00
283_Q	339_R	0.704	1.00
109_S	113_A	0.701	1.00
328_I	331_K	0.700	1.00
41_P	45_Q	0.699	1.00
42_S	45_Q	0.698	1.00
307_E	311_A	0.697	1.00
294_M	415_N	0.695	1.00
372_E	427_R	0.695	1.00
285_I	289_R	0.694	1.00
243_H	247_T	0.693	1.00
74_P	78_R	0.692	1.00
336_S	340_A	0.692	1.00
350_R	401_G	0.691	1.00
46_F	50_L	0.685	1.00
324_Y	361_G	0.684	1.00
327_S	330_V	0.684	1.00
43_L	46_F	0.683	1.00
59_T	63_Q	0.683	1.00
185_P	211_S	0.683	1.00
383_R	432_I	0.682	1.00
205_L	221_N	0.681	1.00
378_I	432_I	0.681	1.00
161_F	165_L	0.677	1.00
171_A	175_A	0.676	1.00
299_A	334_P	0.675	1.00
111_Q	115_Q	0.675	1.00
382_Q	395_S	0.674	1.00
299_A	331_K	0.674	1.00
223_M	226_G	0.672	1.00
60_D	63_Q	0.671	1.00
308_V	311_A	0.671	1.00
129_S	132_V	0.671	1.00
408_I	412_I	0.671	1.00
370_Q	423_G	0.669	1.00
203_P	206_R	0.667	1.00
344_M	413_V	0.665	1.00
250_T	253_R	0.665	1.00
251_R	269_S	0.662	1.00
320_E	323_L	0.662	1.00
318_E	353_N	0.661	1.00
73_P	77_R	0.660	1.00
317_R	352_G	0.660	1.00
237_L	244_D	0.660	1.00
235_T	291_G	0.659	1.00
192_A	195_Q	0.658	1.00
55_R	59_T	0.657	1.00
204_P	209_G	0.655	1.00
418_G	437_P	0.655	1.00
193_A	223_M	0.654	1.00
159_P	163_Y	0.653	1.00
360_S	369_F	0.651	1.00
207_E	217_T	0.650	1.00
291_G	389_P	0.649	1.00
184_R	188_D	0.649	1.00
49_V	53_E	0.647	1.00
194_L	198_K	0.645	1.00
328_I	362_T	0.644	1.00
218_R	222_H	0.644	1.00
115_Q	118_G	0.643	1.00
409_V	412_I	0.643	1.00
322_A	359_S	0.643	1.00
305_L	358_V	0.643	1.00
73_P	76_F	0.643	1.00
116_L	120_T	0.642	1.00
328_I	360_S	0.642	1.00
185_P	190_E	0.640	1.00
324_Y	359_S	0.639	1.00
386_L	407_A	0.637	1.00
255_A	259_M	0.637	1.00
258_M	266_L	0.637	1.00
130_S	136_K	0.635	1.00
219_A	223_M	0.635	1.00
262_Q	266_L	0.634	1.00
61_K	65_E	0.633	1.00
360_S	367_A	0.628	1.00
37_F	40_L	0.626	1.00
240_G	244_D	0.625	1.00
40_L	44_Q	0.623	1.00
330_V	367_A	0.622	1.00
345_V	356_I	0.622	1.00
44_Q	48_K	0.621	1.00
348_A	371_V	0.620	1.00
131_P	134_W	0.619	1.00
130_S	133_V	0.619	1.00
77_R	81_Y	0.617	1.00
386_L	391_V	0.616	1.00
273_D	311_A	0.616	1.00
266_L	270_I	0.616	1.00
210_A	217_T	0.616	1.00
217_T	224_A	0.615	1.00
238_M	242_S	0.613	1.00
136_K	139_L	0.612	1.00
188_D	192_A	0.612	1.00
13_A	17_L	0.611	1.00
52_Y	55_R	0.610	1.00
301_L	330_V	0.610	1.00
206_R	209_G	0.610	1.00
162_R	166_A	0.609	1.00
221_N	225_A	0.608	1.00
35_L	39_I	0.607	1.00
191_H	194_L	0.607	1.00
302_N	325_P	0.606	1.00
216_V	223_M	0.604	1.00
185_P	188_D	0.603	1.00
312_E	349_A	0.603	1.00
309_I	321_T	0.603	1.00
336_S	416_H	0.603	1.00
197_G	226_G	0.603	1.00
136_K	140_S	0.602	1.00
40_L	43_L	0.601	1.00
303_A	306_G	0.601	1.00
131_P	137_T	0.601	1.00
185_P	193_A	0.601	1.00
255_A	274_I	0.600	1.00
32_L	35_L	0.600	1.00
218_R	221_N	0.600	1.00
116_L	119_P	0.598	1.00
74_P	77_R	0.596	1.00
76_F	80_I	0.596	1.00
356_I	371_V	0.594	1.00
59_T	62_L	0.593	1.00
78_R	81_Y	0.592	1.00
62_L	66_D	0.591	1.00
47_N	50_L	0.589	1.00
165_L	169_L	0.589	1.00
324_Y	327_S	0.588	1.00
317_R	323_L	0.588	1.00
420_L	432_I	0.587	1.00
277_C	285_I	0.587	1.00
368_W	421_E	0.587	1.00
384_K	388_Q	0.587	1.00
159_P	162_R	0.587	1.00
107_F	111_Q	0.585	1.00
284_F	288_L	0.585	1.00
357_K	360_S	0.585	1.00
21_T	24_F	0.584	1.00
383_R	430_L	0.584	1.00
271_N	274_I	0.584	1.00
267_A	271_N	0.582	1.00
60_D	64_L	0.581	1.00
50_L	53_E	0.581	1.00
245_L	248_P	0.580	1.00
309_I	358_V	0.579	1.00
194_L	197_G	0.578	1.00
275_E	279_A	0.578	1.00
244_D	280_I	0.573	1.00
318_E	355_W	0.572	1.00
110_H	114_Q	0.570	1.00
18_L	22_L	0.570	1.00
388_Q	410_Q	0.570	1.00
149_L	152_I	0.570	1.00
78_R	82_R	0.566	1.00
201_I	224_A	0.565	1.00
57_L	61_K	0.564	1.00
72_V	75_A	0.563	1.00
93_A	99_L	0.562	1.00
392_R	400_S	0.561	1.00
12_F	187_V	0.561	1.00
87_S	90_S	0.561	1.00
188_D	206_R	0.560	1.00
259_M	266_L	0.559	1.00
21_T	28_V	0.558	1.00
81_Y	84_L	0.558	1.00
304_V	337_I	0.558	1.00
57_L	60_D	0.557	1.00
14_R	181_I	0.556	1.00
111_Q	114_Q	0.556	1.00
345_V	349_A	0.556	1.00
212_E	216_V	0.556	1.00
75_A	79_E	0.555	1.00
238_M	284_F	0.554	1.00
48_K	52_Y	0.553	1.00
77_R	80_I	0.552	1.00
63_Q	66_D	0.551	1.00
247_T	254_L	0.551	1.00
302_N	328_I	0.551	1.00
229_Q	233_D	0.550	1.00
29_T	33_V	0.548	1.00
337_I	436_L	0.546	1.00
186_L	190_E	0.545	1.00
244_D	247_T	0.545	1.00
105_Y	109_S	0.544	1.00
189_L	220_F	0.544	1.00
183_N	187_V	0.543	1.00
254_L	274_I	0.543	1.00
287_Y	411_R	0.543	1.00
379_A	383_R	0.542	1.00
407_A	411_R	0.542	1.00
246_R	277_C	0.541	1.00
121_E	125_E	0.540	1.00
137_T	140_S	0.539	1.00
37_F	41_P	0.539	1.00
287_Y	389_P	0.537	1.00
239_A	242_S	0.537	1.00
307_E	310_A	0.537	1.00
184_R	187_V	0.537	1.00
186_L	216_V	0.536	1.00
302_N	323_L	0.535	1.00
427_R	430_L	0.534	1.00
38_A	41_P	0.534	1.00
339_R	342_A	0.533	1.00
293_E	296_M	0.532	1.00
413_V	419_M	0.532	1.00
160_L	163_Y	0.531	1.00
185_P	209_G	0.530	1.00
119_P	123_R	0.525	1.00
348_A	352_G	0.524	1.00
134_W	137_T	0.524	1.00
189_L	217_T	0.523	1.00
396_A	400_S	0.523	1.00
132_V	136_K	0.522	1.00
72_V	77_R	0.522	1.00
222_H	225_A	0.521	1.00
104_H	107_F	0.521	1.00
225_A	228_K	0.520	1.00
304_V	311_A	0.518	1.00
189_L	192_A	0.517	1.00
294_M	416_H	0.517	1.00
57_L	65_E	0.516	1.00
283_Q	335_L	0.514	1.00
75_A	78_R	0.513	1.00
52_Y	56_M	0.513	1.00
249_L	274_I	0.512	1.00
377_G	429_G	0.512	1.00
195_Q	199_G	0.512	1.00
235_T	240_G	0.511	1.00
242_S	248_P	0.510	1.00
128_K	132_V	0.509	1.00
390_F	407_A	0.509	1.00
303_A	334_P	0.509	1.00
262_Q	265_Y	0.508	1.00
106_E	110_H	0.508	1.00
362_T	367_A	0.508	1.00
19_I	175_A	0.507	1.00
143_I	146_R	0.506	1.00
20_V	23_L	0.505	1.00
186_L	213_V	0.504	1.00
12_F	16_L	0.504	1.00
207_E	214_R	0.503	1.00
236_L	411_R	0.503	1.00
131_P	142_N	0.503	1.00
237_L	390_F	0.502	1.00
257_E	260_S	0.501	1.00
376_P	430_L	0.501	1.00
33_V	36_N	0.501	1.00
211_S	215_S	0.500	1.00
319_I	352_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ctiA	2	0.5067	100	0.364	Contact Map
4i5sA	2	0.58	100	0.368	Contact Map
4bixA	2	0.4911	100	0.391	Contact Map
4q20A	2	0.4844	100	0.486	Contact Map
4gczA	2	0.7778	100	0.496	Contact Map
4mpcA	2	0.6489	100	0.504	Contact Map
3d36A	2	0.4689	100	0.505	Contact Map
3a0rA	2	0.7111	100	0.505	Contact Map
2q8gA	2	0.6556	100	0.507	Contact Map
3jz3A	2	0.3289	100	0.51	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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