ENTC - ECOLI - GREMLIN Contacts

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ENTC - Isochorismate synthase EntC

UniProt:	P0AEJ2	Sequences: MDTSLAEEVQQTMATLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPFDPRQPSSLYIPESWQSFSRQEKQASARRFTRSQSLNVVERQAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDAAIDSGVLLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHPTPALSGFPHQAATQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10261
Length:	391 (308)
Sequences:	5327 (3690)
Seq/√Len:	210.3

ECOLI - ENTC PABB TRPE MENF
BACSU - DHBC MENF PABB TRPE
HALSA - TRPE2 Q9HQN2 TRPE1
SULSO - TRPE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
257_S	283_G	3.940	1.00
304_L	328_G	3.847	1.00
215_S	274_L	3.655	1.00
126_Q	130_E	3.437	1.00
216_A	231_R	3.209	1.00
369_S	372_G	2.969	1.00
206_R	282_E	2.966	1.00
130_E	371_L	2.944	1.00
129_F	362_A	2.781	1.00
125_E	128_T	2.595	1.00
155_D	355_Q	2.561	1.00
155_D	357_R	2.552	1.00
226_R	230_N	2.412	1.00
139_L	144_Q	2.379	1.00
263_P	282_E	2.377	1.00
139_L	318_E	2.375	1.00
126_Q	371_L	2.363	1.00
235_S	238_D	2.321	1.00
145_V	148_V	2.256	1.00
219_Q	224_L	2.190	1.00
218_R	225_D	2.175	1.00
261_H	282_E	2.165	1.00
124_P	132_M	2.165	1.00
311_A	314_Q	2.154	1.00
136_A	148_V	2.132	1.00
138_A	142_T	2.066	1.00
332_G	342_W	2.063	1.00
229_G	270_T	2.012	1.00
264_S	267_Q	1.980	1.00
181_F	193_G	1.975	1.00
191_L	326_L	1.956	1.00
270_T	275_W	1.954	1.00
157_T	355_Q	1.944	1.00
230_N	234_A	1.939	1.00
126_Q	374_W	1.914	1.00
87_S	90_I	1.909	1.00
209_S	249_M	1.899	1.00
205_E	284_K	1.881	1.00
289_E	293_T	1.879	1.00
253_L	257_S	1.864	1.00
224_L	227_E	1.852	1.00
229_G	268_L	1.804	1.00
301_T	344_V	1.791	1.00
131_Q	134_A	1.791	1.00
206_R	284_K	1.790	1.00
163_D	166_V	1.780	1.00
222_E	226_R	1.775	1.00
164_S	190_V	1.679	1.00
181_F	331_V	1.679	1.00
286_N	289_E	1.665	1.00
134_A	137_A	1.665	1.00
212_L	278_A	1.658	1.00
147_K	363_G	1.648	1.00
219_Q	228_A	1.646	1.00
371_L	375_R	1.629	1.00
158_T	162_I	1.620	1.00
153_L	357_R	1.604	1.00
134_A	370_P	1.603	1.00
198_L	341_E	1.598	1.00
233_L	277_L	1.585	1.00
145_V	312_A	1.578	1.00
87_S	91_P	1.577	1.00
351_L	356_V	1.557	1.00
226_R	229_G	1.534	1.00
315_V	319_L	1.533	1.00
152_R	377_T	1.530	1.00
349_A	356_V	1.525	1.00
335_D	339_N	1.521	1.00
138_A	141_A	1.511	1.00
123_I	322_F	1.507	1.00
268_L	277_L	1.507	1.00
139_L	315_V	1.490	1.00
184_P	190_V	1.482	1.00
88_L	91_P	1.464	1.00
203_D	339_N	1.460	1.00
128_T	131_Q	1.460	1.00
269_I	278_A	1.431	1.00
145_V	315_V	1.415	1.00
220_P	224_L	1.415	1.00
90_I	93_S	1.402	1.00
240_H	244_L	1.390	1.00
227_E	231_R	1.387	1.00
136_A	150_L	1.381	1.00
210_I	269_I	1.371	1.00
151_S	359_F	1.357	1.00
362_A	377_T	1.351	1.00
128_T	132_M	1.342	1.00
224_L	228_A	1.337	1.00
139_L	311_A	1.333	1.00
375_R	379_V	1.330	1.00
164_S	351_L	1.323	1.00
137_A	367_A	1.308	1.00
135_R	139_L	1.304	1.00
372_G	375_R	1.303	1.00
256_R	297_L	1.279	1.00
192_L	351_L	1.279	1.00
133_V	370_P	1.260	1.00
93_S	96_S	1.257	1.00
326_L	345_T	1.252	1.00
120_R	156_I	1.250	1.00
126_Q	375_R	1.245	1.00
121_Q	157_T	1.235	1.00
305_S	313_T	1.234	1.00
127_T	131_Q	1.231	1.00
148_V	316_I	1.217	1.00
202_K	294_L	1.214	1.00
182_H	190_V	1.211	1.00
130_E	134_A	1.210	1.00
304_L	346_I	1.202	1.00
375_R	378_G	1.200	1.00
238_D	372_G	1.191	1.00
374_W	378_G	1.189	1.00
221_D	224_L	1.185	1.00
202_K	205_E	1.183	1.00
216_A	228_A	1.181	1.00
137_A	141_A	1.178	1.00
130_E	374_W	1.173	1.00
216_A	238_D	1.173	1.00
167_L	351_L	1.168	1.00
131_Q	135_R	1.167	1.00
223_V	227_E	1.150	1.00
130_E	370_P	1.149	1.00
317_A	323_D	1.144	1.00
121_Q	155_D	1.139	1.00
326_L	350_K	1.137	1.00
207_F	294_L	1.129	1.00
263_P	280_P	1.116	1.00
295_A	334_C	1.114	1.00
253_L	283_G	1.104	1.00
144_Q	311_A	1.094	1.00
128_T	321_P	1.091	1.00
193_G	343_V	1.091	1.00
349_A	384_M	1.084	1.00
254_R	258_S	1.084	1.00
133_V	364_I	1.081	1.00
253_L	298_L	1.075	1.00
150_L	364_I	1.072	1.00
331_V	345_T	1.071	1.00
154_I	381_L	1.067	1.00
210_I	278_A	1.060	1.00
208_S	280_P	1.060	1.00
201_R	208_S	1.059	1.00
228_A	231_R	1.058	1.00
167_L	192_L	1.051	1.00
150_L	362_A	1.048	1.00
161_A	354_N	1.047	1.00
267_Q	280_P	1.045	1.00
140_T	366_P	1.044	1.00
233_L	268_L	1.042	1.00
208_S	282_E	1.041	1.00
358_L	381_L	1.040	1.00
202_K	285_A	1.038	1.00
181_F	348_C	1.036	1.00
135_R	318_E	1.034	1.00
137_A	366_P	1.023	1.00
122_A	152_R	1.023	1.00
349_A	358_L	1.020	1.00
268_L	275_W	1.020	1.00
360_A	381_L	1.020	1.00
157_T	354_N	1.010	1.00
141_A	366_P	1.007	1.00
156_I	356_V	1.003	1.00
207_F	257_S	1.000	1.00
295_A	342_W	0.994	1.00
230_N	233_L	0.992	1.00
133_V	137_A	0.987	1.00
136_A	145_V	0.987	1.00
202_K	291_A	0.984	1.00
246_T	265_S	0.983	1.00
135_R	138_A	0.982	1.00
134_A	138_A	0.975	1.00
181_F	191_L	0.971	1.00
93_S	100_Q	0.970	1.00
149_V	361_G	0.967	1.00
358_L	385_L	0.964	1.00
333_W	341_E	0.960	1.00
227_E	230_N	0.958	1.00
285_A	294_L	0.955	1.00
259_E	284_K	0.955	1.00
210_I	280_P	0.954	1.00
151_S	322_F	0.949	0.99
205_E	287_S	0.948	0.99
382_S	386_N	0.946	0.99
191_L	345_T	0.944	0.99
292_L	334_C	0.941	0.99
229_G	275_W	0.940	0.99
310_Q	314_Q	0.937	0.99
175_N	273_T	0.936	0.99
165_G	182_H	0.934	0.99
217_R	228_A	0.933	0.99
239_R	266_P	0.931	0.99
239_R	265_S	0.926	0.99
228_A	275_W	0.926	0.99
124_P	321_P	0.923	0.99
204_G	339_N	0.903	0.99
154_I	385_L	0.898	0.99
152_R	374_W	0.896	0.99
124_P	152_R	0.894	0.99
250_K	262_V	0.894	0.99
136_A	319_L	0.890	0.99
217_R	379_V	0.887	0.99
199_L	298_L	0.886	0.99
132_M	136_A	0.883	0.99
248_A	302_P	0.877	0.99
93_S	97_F	0.873	0.99
200_L	340_G	0.873	0.99
168_L	172_I	0.868	0.99
78_I	81_D	0.868	0.99
164_S	182_H	0.867	0.99
209_S	298_L	0.867	0.99
89_Y	93_S	0.867	0.99
213_A	242_H	0.859	0.99
81_D	85_P	0.855	0.99
207_F	253_L	0.854	0.99
180_N	194_A	0.853	0.99
213_A	303_A	0.851	0.99
245_V	303_A	0.850	0.99
89_Y	92_E	0.850	0.99
191_L	331_V	0.847	0.99
202_K	207_F	0.847	0.99
154_I	378_G	0.839	0.99
374_W	377_T	0.835	0.99
352_R	355_Q	0.832	0.99
120_R	385_L	0.830	0.99
210_I	271_T	0.829	0.99
179_Y	198_L	0.828	0.99
290_N	293_T	0.827	0.99
327_F	362_A	0.826	0.99
258_S	284_K	0.826	0.99
243_E	265_S	0.825	0.99
199_L	213_A	0.825	0.99
158_T	351_L	0.824	0.99
311_A	318_E	0.823	0.99
93_S	101_E	0.820	0.99
130_E	369_S	0.816	0.98
239_R	243_E	0.812	0.98
167_L	349_A	0.811	0.98
149_V	328_G	0.807	0.98
191_L	348_C	0.803	0.98
149_V	304_L	0.802	0.98
127_T	130_E	0.802	0.98
83_R	87_S	0.799	0.98
123_I	155_D	0.798	0.98
213_A	245_V	0.794	0.98
350_K	357_R	0.794	0.98
200_L	294_L	0.793	0.98
175_N	383_T	0.792	0.98
310_Q	313_T	0.790	0.98
98_S	101_E	0.789	0.98
148_V	315_V	0.784	0.98
248_A	252_V	0.781	0.98
132_M	319_L	0.779	0.98
174_Q	386_N	0.778	0.98
291_A	340_G	0.776	0.98
94_W	101_E	0.775	0.98
193_G	331_V	0.772	0.98
136_A	315_V	0.772	0.98
95_Q	98_S	0.764	0.98
198_L	210_I	0.763	0.98
86_S	90_I	0.762	0.98
132_M	321_P	0.757	0.98
201_R	341_E	0.757	0.98
177_V	180_N	0.756	0.97
86_S	89_Y	0.755	0.97
243_E	266_P	0.754	0.97
96_S	100_Q	0.748	0.97
94_W	97_F	0.747	0.97
151_S	377_T	0.746	0.97
152_R	378_G	0.745	0.97
231_R	234_A	0.744	0.97
187_D	352_R	0.744	0.97
90_I	104_A	0.742	0.97
315_V	318_E	0.738	0.97
192_L	349_A	0.738	0.97
97_F	101_E	0.735	0.97
249_M	328_G	0.731	0.97
242_H	328_G	0.727	0.97
90_I	100_Q	0.724	0.97
236_E	240_H	0.724	0.97
153_L	322_F	0.717	0.97
80_F	83_R	0.715	0.96
88_L	92_E	0.714	0.96
261_H	284_K	0.714	0.96
271_T	278_A	0.712	0.96
94_W	100_Q	0.707	0.96
162_I	167_L	0.706	0.96
330_I	342_W	0.701	0.96
199_L	209_S	0.700	0.96
175_N	194_A	0.695	0.96
90_I	101_E	0.695	0.96
242_H	245_V	0.694	0.96
100_Q	103_Q	0.694	0.96
209_S	253_L	0.693	0.96
225_D	229_G	0.690	0.96
210_I	264_S	0.686	0.96
295_A	340_G	0.677	0.95
250_K	254_R	0.676	0.95
207_F	285_A	0.675	0.95
266_P	277_L	0.674	0.95
98_S	102_K	0.674	0.95
235_S	372_G	0.671	0.95
221_D	227_E	0.669	0.95
238_D	365_V	0.668	0.95
223_V	230_N	0.668	0.95
264_S	280_P	0.667	0.95
274_L	379_V	0.664	0.95
149_V	305_S	0.662	0.95
190_V	351_L	0.662	0.95
243_E	247_Q	0.657	0.94
91_P	95_Q	0.656	0.94
90_I	98_S	0.655	0.94
150_L	319_L	0.655	0.94
149_V	193_G	0.652	0.94
166_V	170_R	0.651	0.94
225_D	275_W	0.649	0.94
94_W	98_S	0.648	0.94
135_R	319_L	0.645	0.94
362_A	372_G	0.640	0.94
198_L	208_S	0.637	0.93
356_V	388_F	0.636	0.93
249_M	301_T	0.635	0.93
132_M	150_L	0.634	0.93
156_I	388_F	0.631	0.93
217_R	375_R	0.630	0.93
202_K	339_N	0.629	0.93
130_E	133_V	0.628	0.93
257_S	260_L	0.625	0.93
234_A	239_R	0.623	0.93
86_S	91_P	0.623	0.93
199_L	242_H	0.622	0.93
137_A	365_V	0.622	0.93
342_W	385_L	0.622	0.93
212_L	346_I	0.621	0.93
242_H	279_T	0.620	0.93
247_Q	250_K	0.617	0.92
168_L	192_L	0.616	0.92
256_R	294_L	0.616	0.92
210_I	267_Q	0.614	0.92
139_L	314_Q	0.614	0.92
93_S	98_S	0.611	0.92
242_H	303_A	0.610	0.92
84_Q	87_S	0.609	0.92
94_W	103_Q	0.609	0.92
192_L	384_M	0.608	0.92
219_Q	225_D	0.607	0.92
332_G	340_G	0.606	0.92
216_A	379_V	0.606	0.92
183_V	331_V	0.604	0.92
379_V	382_S	0.602	0.91
185_L	188_G	0.601	0.91
122_A	154_I	0.600	0.91
115_L	118_V	0.600	0.91
199_L	245_V	0.599	0.91
249_M	298_L	0.596	0.91
358_L	384_M	0.594	0.91
195_S	343_V	0.594	0.91
245_V	302_P	0.592	0.91
153_L	359_F	0.591	0.91
314_Q	318_E	0.589	0.91
256_R	293_T	0.589	0.91
83_R	90_I	0.589	0.91
247_Q	251_E	0.587	0.90
378_G	382_S	0.586	0.90
79_P	82_P	0.586	0.90
136_A	149_V	0.585	0.90
176_P	272_P	0.585	0.90
385_L	388_F	0.585	0.90
186_A	190_V	0.582	0.90
79_P	83_R	0.582	0.90
199_L	249_M	0.581	0.90
85_P	88_L	0.581	0.90
217_R	372_G	0.580	0.90
273_T	386_N	0.578	0.90
194_A	333_W	0.576	0.90
217_R	220_P	0.575	0.89
154_I	360_A	0.572	0.89
207_F	283_G	0.571	0.89
188_G	352_R	0.571	0.89
247_Q	252_V	0.569	0.89
90_I	94_W	0.569	0.89
264_S	269_I	0.568	0.89
84_Q	88_L	0.567	0.89
199_L	303_A	0.567	0.89
284_K	287_S	0.566	0.89
149_V	343_V	0.566	0.89
95_Q	99_R	0.565	0.89
87_S	93_S	0.564	0.89
218_R	275_W	0.562	0.88
218_R	270_T	0.561	0.88
139_L	142_T	0.561	0.88
158_T	161_A	0.558	0.88
99_R	103_Q	0.555	0.88
204_G	284_K	0.554	0.88
151_S	327_F	0.554	0.88
330_I	345_T	0.554	0.88
158_T	356_V	0.554	0.88
244_L	307_F	0.553	0.88
102_K	105_S	0.552	0.87
236_E	239_R	0.551	0.87
157_T	353_E	0.550	0.87
134_A	141_A	0.549	0.87
245_V	344_V	0.548	0.87
129_F	377_T	0.548	0.87
122_A	125_E	0.546	0.87
92_E	99_R	0.545	0.87
223_V	226_R	0.544	0.87
158_T	167_L	0.544	0.87
100_Q	104_A	0.542	0.87
294_L	346_I	0.541	0.86
198_L	201_R	0.541	0.86
200_L	298_L	0.540	0.86
101_E	104_A	0.539	0.86
301_T	343_V	0.539	0.86
322_F	359_F	0.538	0.86
170_R	173_A	0.536	0.86
258_S	286_N	0.536	0.86
193_G	301_T	0.536	0.86
345_T	348_C	0.535	0.86
362_A	368_S	0.534	0.86
92_E	95_Q	0.533	0.86
121_Q	125_E	0.531	0.85
94_W	104_A	0.530	0.85
122_A	377_T	0.529	0.85
146_D	247_Q	0.526	0.85
250_K	307_F	0.525	0.85
133_V	362_A	0.525	0.85
311_A	315_V	0.524	0.85
205_E	288_Q	0.523	0.85
108_R	161_A	0.522	0.84
181_F	192_L	0.521	0.84
81_D	84_Q	0.521	0.84
105_S	113_Q	0.520	0.84
213_A	365_V	0.520	0.84
123_I	152_R	0.518	0.84
213_A	363_G	0.517	0.84
242_H	246_T	0.516	0.84
87_S	98_S	0.516	0.84
229_G	233_L	0.516	0.84
146_D	250_K	0.515	0.84
233_L	239_R	0.515	0.84
255_E	297_L	0.515	0.84
301_T	328_G	0.514	0.84
212_L	345_T	0.514	0.84
299_H	305_S	0.513	0.83
97_F	100_Q	0.512	0.83
252_V	309_H	0.512	0.83
170_R	174_Q	0.511	0.83
107_R	110_T	0.511	0.83
301_T	304_L	0.511	0.83
167_L	356_V	0.511	0.83
252_V	255_E	0.511	0.83
146_D	244_L	0.509	0.83
334_C	340_G	0.508	0.83
299_H	330_I	0.505	0.82
232_L	268_L	0.504	0.82
80_F	90_I	0.504	0.82
124_P	150_L	0.504	0.82
125_E	130_E	0.503	0.82
139_L	145_V	0.502	0.82
154_I	377_T	0.501	0.82
147_K	245_V	0.500	0.82
175_N	272_P	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hwoA	1	0.9693	100	0.131	Contact Map
3os6A	3	0.9412	100	0.163	Contact Map
1k0eA	1	0.9514	100	0.192	Contact Map
3h9mA	1	0.8721	100	0.192	Contact Map
1qdlA	1	0.9386	100	0.193	Contact Map
4grhA	1	0.9386	100	0.197	Contact Map
3bzmA	1	0.9361	100	0.199	Contact Map
3gseA	1	0.9207	100	0.203	Contact Map
1i1qA	2	0.9898	100	0.204	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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