GREMLIN Database
ENTC - Isochorismate synthase EntC
UniProt: P0AEJ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10261
Length: 391 (308)
Sequences: 5327 (3690)
Seq/√Len: 210.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
257_S283_G3.9401.00
304_L328_G3.8471.00
215_S274_L3.6551.00
126_Q130_E3.4371.00
216_A231_R3.2091.00
369_S372_G2.9691.00
206_R282_E2.9661.00
130_E371_L2.9441.00
129_F362_A2.7811.00
125_E128_T2.5951.00
155_D355_Q2.5611.00
155_D357_R2.5521.00
226_R230_N2.4121.00
139_L144_Q2.3791.00
263_P282_E2.3771.00
139_L318_E2.3751.00
126_Q371_L2.3631.00
235_S238_D2.3211.00
145_V148_V2.2561.00
219_Q224_L2.1901.00
218_R225_D2.1751.00
261_H282_E2.1651.00
124_P132_M2.1651.00
311_A314_Q2.1541.00
136_A148_V2.1321.00
138_A142_T2.0661.00
332_G342_W2.0631.00
229_G270_T2.0121.00
264_S267_Q1.9801.00
181_F193_G1.9751.00
191_L326_L1.9561.00
270_T275_W1.9541.00
157_T355_Q1.9441.00
230_N234_A1.9391.00
126_Q374_W1.9141.00
87_S90_I1.9091.00
209_S249_M1.8991.00
205_E284_K1.8811.00
289_E293_T1.8791.00
253_L257_S1.8641.00
224_L227_E1.8521.00
229_G268_L1.8041.00
301_T344_V1.7911.00
131_Q134_A1.7911.00
206_R284_K1.7901.00
163_D166_V1.7801.00
222_E226_R1.7751.00
164_S190_V1.6791.00
181_F331_V1.6791.00
286_N289_E1.6651.00
134_A137_A1.6651.00
212_L278_A1.6581.00
147_K363_G1.6481.00
219_Q228_A1.6461.00
371_L375_R1.6291.00
158_T162_I1.6201.00
153_L357_R1.6041.00
134_A370_P1.6031.00
198_L341_E1.5981.00
233_L277_L1.5851.00
145_V312_A1.5781.00
87_S91_P1.5771.00
351_L356_V1.5571.00
226_R229_G1.5341.00
315_V319_L1.5331.00
152_R377_T1.5301.00
349_A356_V1.5251.00
335_D339_N1.5211.00
138_A141_A1.5111.00
123_I322_F1.5071.00
268_L277_L1.5071.00
139_L315_V1.4901.00
184_P190_V1.4821.00
88_L91_P1.4641.00
203_D339_N1.4601.00
128_T131_Q1.4601.00
269_I278_A1.4311.00
145_V315_V1.4151.00
220_P224_L1.4151.00
90_I93_S1.4021.00
240_H244_L1.3901.00
227_E231_R1.3871.00
136_A150_L1.3811.00
210_I269_I1.3711.00
151_S359_F1.3571.00
362_A377_T1.3511.00
128_T132_M1.3421.00
224_L228_A1.3371.00
139_L311_A1.3331.00
375_R379_V1.3301.00
164_S351_L1.3231.00
137_A367_A1.3081.00
135_R139_L1.3041.00
372_G375_R1.3031.00
256_R297_L1.2791.00
192_L351_L1.2791.00
133_V370_P1.2601.00
93_S96_S1.2571.00
326_L345_T1.2521.00
120_R156_I1.2501.00
126_Q375_R1.2451.00
121_Q157_T1.2351.00
305_S313_T1.2341.00
127_T131_Q1.2311.00
148_V316_I1.2171.00
202_K294_L1.2141.00
182_H190_V1.2111.00
130_E134_A1.2101.00
304_L346_I1.2021.00
375_R378_G1.2001.00
238_D372_G1.1911.00
374_W378_G1.1891.00
221_D224_L1.1851.00
202_K205_E1.1831.00
216_A228_A1.1811.00
137_A141_A1.1781.00
130_E374_W1.1731.00
216_A238_D1.1731.00
167_L351_L1.1681.00
131_Q135_R1.1671.00
223_V227_E1.1501.00
130_E370_P1.1491.00
317_A323_D1.1441.00
121_Q155_D1.1391.00
326_L350_K1.1371.00
207_F294_L1.1291.00
263_P280_P1.1161.00
295_A334_C1.1141.00
253_L283_G1.1041.00
144_Q311_A1.0941.00
128_T321_P1.0911.00
193_G343_V1.0911.00
349_A384_M1.0841.00
254_R258_S1.0841.00
133_V364_I1.0811.00
253_L298_L1.0751.00
150_L364_I1.0721.00
331_V345_T1.0711.00
154_I381_L1.0671.00
210_I278_A1.0601.00
208_S280_P1.0601.00
201_R208_S1.0591.00
228_A231_R1.0581.00
167_L192_L1.0511.00
150_L362_A1.0481.00
161_A354_N1.0471.00
267_Q280_P1.0451.00
140_T366_P1.0441.00
233_L268_L1.0421.00
208_S282_E1.0411.00
358_L381_L1.0401.00
202_K285_A1.0381.00
181_F348_C1.0361.00
135_R318_E1.0341.00
137_A366_P1.0231.00
122_A152_R1.0231.00
349_A358_L1.0201.00
268_L275_W1.0201.00
360_A381_L1.0201.00
157_T354_N1.0101.00
141_A366_P1.0071.00
156_I356_V1.0031.00
207_F257_S1.0001.00
295_A342_W0.9941.00
230_N233_L0.9921.00
133_V137_A0.9871.00
136_A145_V0.9871.00
202_K291_A0.9841.00
246_T265_S0.9831.00
135_R138_A0.9821.00
134_A138_A0.9751.00
181_F191_L0.9711.00
93_S100_Q0.9701.00
149_V361_G0.9671.00
358_L385_L0.9641.00
333_W341_E0.9601.00
227_E230_N0.9581.00
285_A294_L0.9551.00
259_E284_K0.9551.00
210_I280_P0.9541.00
151_S322_F0.9490.99
205_E287_S0.9480.99
382_S386_N0.9460.99
191_L345_T0.9440.99
292_L334_C0.9410.99
229_G275_W0.9400.99
310_Q314_Q0.9370.99
175_N273_T0.9360.99
165_G182_H0.9340.99
217_R228_A0.9330.99
239_R266_P0.9310.99
239_R265_S0.9260.99
228_A275_W0.9260.99
124_P321_P0.9230.99
204_G339_N0.9030.99
154_I385_L0.8980.99
152_R374_W0.8960.99
124_P152_R0.8940.99
250_K262_V0.8940.99
136_A319_L0.8900.99
217_R379_V0.8870.99
199_L298_L0.8860.99
132_M136_A0.8830.99
248_A302_P0.8770.99
93_S97_F0.8730.99
200_L340_G0.8730.99
168_L172_I0.8680.99
78_I81_D0.8680.99
164_S182_H0.8670.99
209_S298_L0.8670.99
89_Y93_S0.8670.99
213_A242_H0.8590.99
81_D85_P0.8550.99
207_F253_L0.8540.99
180_N194_A0.8530.99
213_A303_A0.8510.99
245_V303_A0.8500.99
89_Y92_E0.8500.99
191_L331_V0.8470.99
202_K207_F0.8470.99
154_I378_G0.8390.99
374_W377_T0.8350.99
352_R355_Q0.8320.99
120_R385_L0.8300.99
210_I271_T0.8290.99
179_Y198_L0.8280.99
290_N293_T0.8270.99
327_F362_A0.8260.99
258_S284_K0.8260.99
243_E265_S0.8250.99
199_L213_A0.8250.99
158_T351_L0.8240.99
311_A318_E0.8230.99
93_S101_E0.8200.99
130_E369_S0.8160.98
239_R243_E0.8120.98
167_L349_A0.8110.98
149_V328_G0.8070.98
191_L348_C0.8030.98
149_V304_L0.8020.98
127_T130_E0.8020.98
83_R87_S0.7990.98
123_I155_D0.7980.98
213_A245_V0.7940.98
350_K357_R0.7940.98
200_L294_L0.7930.98
175_N383_T0.7920.98
310_Q313_T0.7900.98
98_S101_E0.7890.98
148_V315_V0.7840.98
248_A252_V0.7810.98
132_M319_L0.7790.98
174_Q386_N0.7780.98
291_A340_G0.7760.98
94_W101_E0.7750.98
193_G331_V0.7720.98
136_A315_V0.7720.98
95_Q98_S0.7640.98
198_L210_I0.7630.98
86_S90_I0.7620.98
132_M321_P0.7570.98
201_R341_E0.7570.98
177_V180_N0.7560.97
86_S89_Y0.7550.97
243_E266_P0.7540.97
96_S100_Q0.7480.97
94_W97_F0.7470.97
151_S377_T0.7460.97
152_R378_G0.7450.97
231_R234_A0.7440.97
187_D352_R0.7440.97
90_I104_A0.7420.97
315_V318_E0.7380.97
192_L349_A0.7380.97
97_F101_E0.7350.97
249_M328_G0.7310.97
242_H328_G0.7270.97
90_I100_Q0.7240.97
236_E240_H0.7240.97
153_L322_F0.7170.97
80_F83_R0.7150.96
88_L92_E0.7140.96
261_H284_K0.7140.96
271_T278_A0.7120.96
94_W100_Q0.7070.96
162_I167_L0.7060.96
330_I342_W0.7010.96
199_L209_S0.7000.96
175_N194_A0.6950.96
90_I101_E0.6950.96
242_H245_V0.6940.96
100_Q103_Q0.6940.96
209_S253_L0.6930.96
225_D229_G0.6900.96
210_I264_S0.6860.96
295_A340_G0.6770.95
250_K254_R0.6760.95
207_F285_A0.6750.95
266_P277_L0.6740.95
98_S102_K0.6740.95
235_S372_G0.6710.95
221_D227_E0.6690.95
238_D365_V0.6680.95
223_V230_N0.6680.95
264_S280_P0.6670.95
274_L379_V0.6640.95
149_V305_S0.6620.95
190_V351_L0.6620.95
243_E247_Q0.6570.94
91_P95_Q0.6560.94
90_I98_S0.6550.94
150_L319_L0.6550.94
149_V193_G0.6520.94
166_V170_R0.6510.94
225_D275_W0.6490.94
94_W98_S0.6480.94
135_R319_L0.6450.94
362_A372_G0.6400.94
198_L208_S0.6370.93
356_V388_F0.6360.93
249_M301_T0.6350.93
132_M150_L0.6340.93
156_I388_F0.6310.93
217_R375_R0.6300.93
202_K339_N0.6290.93
130_E133_V0.6280.93
257_S260_L0.6250.93
234_A239_R0.6230.93
86_S91_P0.6230.93
199_L242_H0.6220.93
137_A365_V0.6220.93
342_W385_L0.6220.93
212_L346_I0.6210.93
242_H279_T0.6200.93
247_Q250_K0.6170.92
168_L192_L0.6160.92
256_R294_L0.6160.92
210_I267_Q0.6140.92
139_L314_Q0.6140.92
93_S98_S0.6110.92
242_H303_A0.6100.92
84_Q87_S0.6090.92
94_W103_Q0.6090.92
192_L384_M0.6080.92
219_Q225_D0.6070.92
332_G340_G0.6060.92
216_A379_V0.6060.92
183_V331_V0.6040.92
379_V382_S0.6020.91
185_L188_G0.6010.91
122_A154_I0.6000.91
115_L118_V0.6000.91
199_L245_V0.5990.91
249_M298_L0.5960.91
358_L384_M0.5940.91
195_S343_V0.5940.91
245_V302_P0.5920.91
153_L359_F0.5910.91
314_Q318_E0.5890.91
256_R293_T0.5890.91
83_R90_I0.5890.91
247_Q251_E0.5870.90
378_G382_S0.5860.90
79_P82_P0.5860.90
136_A149_V0.5850.90
176_P272_P0.5850.90
385_L388_F0.5850.90
186_A190_V0.5820.90
79_P83_R0.5820.90
199_L249_M0.5810.90
85_P88_L0.5810.90
217_R372_G0.5800.90
273_T386_N0.5780.90
194_A333_W0.5760.90
217_R220_P0.5750.89
154_I360_A0.5720.89
207_F283_G0.5710.89
188_G352_R0.5710.89
247_Q252_V0.5690.89
90_I94_W0.5690.89
264_S269_I0.5680.89
84_Q88_L0.5670.89
199_L303_A0.5670.89
284_K287_S0.5660.89
149_V343_V0.5660.89
95_Q99_R0.5650.89
87_S93_S0.5640.89
218_R275_W0.5620.88
218_R270_T0.5610.88
139_L142_T0.5610.88
158_T161_A0.5580.88
99_R103_Q0.5550.88
204_G284_K0.5540.88
151_S327_F0.5540.88
330_I345_T0.5540.88
158_T356_V0.5540.88
244_L307_F0.5530.88
102_K105_S0.5520.87
236_E239_R0.5510.87
157_T353_E0.5500.87
134_A141_A0.5490.87
245_V344_V0.5480.87
129_F377_T0.5480.87
122_A125_E0.5460.87
92_E99_R0.5450.87
223_V226_R0.5440.87
158_T167_L0.5440.87
100_Q104_A0.5420.87
294_L346_I0.5410.86
198_L201_R0.5410.86
200_L298_L0.5400.86
101_E104_A0.5390.86
301_T343_V0.5390.86
322_F359_F0.5380.86
170_R173_A0.5360.86
258_S286_N0.5360.86
193_G301_T0.5360.86
345_T348_C0.5350.86
362_A368_S0.5340.86
92_E95_Q0.5330.86
121_Q125_E0.5310.85
94_W104_A0.5300.85
122_A377_T0.5290.85
146_D247_Q0.5260.85
250_K307_F0.5250.85
133_V362_A0.5250.85
311_A315_V0.5240.85
205_E288_Q0.5230.85
108_R161_A0.5220.84
181_F192_L0.5210.84
81_D84_Q0.5210.84
105_S113_Q0.5200.84
213_A365_V0.5200.84
123_I152_R0.5180.84
213_A363_G0.5170.84
242_H246_T0.5160.84
87_S98_S0.5160.84
229_G233_L0.5160.84
146_D250_K0.5150.84
233_L239_R0.5150.84
255_E297_L0.5150.84
301_T328_G0.5140.84
212_L345_T0.5140.84
299_H305_S0.5130.83
97_F100_Q0.5120.83
252_V309_H0.5120.83
170_R174_Q0.5110.83
107_R110_T0.5110.83
301_T304_L0.5110.83
167_L356_V0.5110.83
252_V255_E0.5110.83
146_D244_L0.5090.83
334_C340_G0.5080.83
299_H330_I0.5050.82
232_L268_L0.5040.82
80_F90_I0.5040.82
124_P150_L0.5040.82
125_E130_E0.5030.82
139_L145_V0.5020.82
154_I377_T0.5010.82
147_K245_V0.5000.82
175_N272_P0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hwoA 1 0.9693 100 0.131 Contact Map
3os6A 3 0.9412 100 0.163 Contact Map
1k0eA 1 0.9514 100 0.192 Contact Map
3h9mA 1 0.8721 100 0.192 Contact Map
1qdlA 1 0.9386 100 0.193 Contact Map
4grhA 1 0.9386 100 0.197 Contact Map
3bzmA 1 0.9361 100 0.199 Contact Map
3gseA 1 0.9207 100 0.203 Contact Map
1i1qA 2 0.9898 100 0.204 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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