GREMLIN Database
EMRB - Multidrug export protein EmrB
UniProt: P0AEJ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11439
Length: 512 (417)
Sequences: 36379 (25683)
Seq/√Len: 1257.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_S104_M5.2111.00
90_A178_G4.3771.00
88_A115_V3.7421.00
97_G172_F3.5161.00
95_A108_F3.3671.00
103_N107_F3.3441.00
208_L251_W3.0691.00
212_G245_I3.0081.00
350_W367_P2.9331.00
390_L398_A2.8871.00
78_E129_N2.8271.00
101_S104_M2.7121.00
12_L135_K2.6221.00
57_S110_V2.5441.00
263_S394_R2.5211.00
211_I244_A2.4551.00
302_T305_W2.4201.00
316_I369_F2.4111.00
320_L373_F2.4101.00
61_A110_V2.3821.00
46_S102_L2.3651.00
219_M238_T2.3451.00
83_L186_L2.3341.00
216_L241_A2.3261.00
92_A115_V2.3171.00
204_V251_W2.2801.00
65_S114_I2.2011.00
96_C108_F2.1661.00
165_Y169_W2.1011.00
83_L182_V2.0871.00
282_M413_G2.0511.00
235_I239_V2.0251.00
278_S409_A2.0171.00
161_I169_W2.0111.00
223_G228_W1.9881.00
347_C371_Q1.9691.00
391_P394_R1.9641.00
47_S50_Q1.9521.00
183_L187_Q1.9511.00
261_D394_R1.9321.00
246_C250_V1.9181.00
185_T189_L1.8911.00
135_K138_I1.8911.00
104_M108_F1.8881.00
92_A111_I1.8851.00
85_S118_P1.8591.00
36_A162_S1.8191.00
102_L106_I1.8181.00
92_A108_F1.8091.00
296_Q306_A1.8051.00
166_H169_W1.8001.00
20_S146_T1.7301.00
286_G417_T1.7281.00
94_W98_V1.7251.00
163_D304_T1.7241.00
96_C105_L1.7211.00
74_K396_A1.7161.00
57_S106_I1.7121.00
99_S104_M1.6971.00
131_Y139_A1.6951.00
294_L299_Y1.6931.00
69_T118_P1.6911.00
202_D205_G1.6911.00
79_V83_L1.6691.00
94_W175_V1.6691.00
212_G241_A1.6681.00
215_S237_L1.6581.00
16_T131_Y1.6541.00
169_W176_P1.6481.00
132_P135_K1.6431.00
285_F410_G1.6361.00
137_S329_H1.6301.00
347_C374_A1.5941.00
50_Q102_L1.5861.00
347_C367_P1.5861.00
22_A82_F1.5621.00
36_A170_I1.5581.00
46_S50_Q1.5521.00
93_S174_N1.5511.00
255_D258_P1.5491.00
24_F150_A1.5291.00
326_R330_K1.5281.00
54_V105_L1.5191.00
83_L185_T1.5141.00
236_I240_V1.5061.00
65_S117_G1.5011.00
99_S108_F1.4981.00
251_W255_D1.4971.00
215_S244_A1.4801.00
362_G366_W1.4781.00
301_Y309_A1.4671.00
15_M130_N1.4641.00
72_L81_L1.4631.00
95_A104_M1.4631.00
212_G244_A1.4611.00
340_S377_C1.4441.00
230_S233_E1.4411.00
253_L263_S1.4381.00
345_A349_Y1.4261.00
73_A78_E1.4161.00
163_D302_T1.4131.00
87_I182_V1.4091.00
219_M241_A1.4071.00
222_R226_L1.4001.00
200_R257_N1.3881.00
265_F271_T1.3861.00
271_T275_L1.3831.00
301_Y305_W1.3781.00
39_T42_G1.3741.00
215_S240_V1.3721.00
64_I210_V1.3711.00
90_A182_V1.3711.00
305_W308_L1.3671.00
361_F365_A1.3651.00
73_A122_L1.3641.00
41_A51_G1.3631.00
133_P136_R1.3481.00
249_I253_L1.3401.00
71_W75_R1.3381.00
80_K191_G1.3341.00
360_D363_A1.3321.00
343_M374_A1.3281.00
18_A181_V1.3201.00
91_I95_A1.3201.00
184_M188_T1.3201.00
84_W88_A1.3161.00
203_A207_A1.3151.00
58_F116_A1.3101.00
29_D32_I1.3051.00
32_I170_I1.3001.00
128_L136_R1.2981.00
273_G386_T1.2961.00
218_I222_R1.2891.00
344_Y374_A1.2781.00
13_V17_I1.2691.00
61_A113_G1.2631.00
335_R338_T1.2631.00
241_A245_I1.2631.00
205_G251_W1.2601.00
208_L244_A1.2581.00
313_V372_G1.2381.00
103_N106_I1.2361.00
325_G329_H1.2361.00
160_Y164_N1.2331.00
20_S142_L1.2221.00
18_A188_T1.2221.00
316_I320_L1.2201.00
219_M234_I1.2161.00
79_V186_L1.2141.00
249_I262_L1.1891.00
342_I346_V1.1841.00
72_L76_V1.1801.00
18_A184_M1.1791.00
324_I377_C1.1731.00
263_S266_K1.1701.00
12_L131_Y1.1681.00
340_S378_F1.1671.00
53_W57_S1.1661.00
29_D174_N1.1611.00
250_V254_T1.1581.00
179_V183_L1.1531.00
83_L87_I1.1511.00
88_A92_A1.1401.00
240_V244_A1.1401.00
248_L252_E1.1371.00
326_R329_H1.1361.00
21_L181_V1.1341.00
295_L364_S1.1341.00
182_V186_L1.1241.00
95_A98_V1.1241.00
78_E191_G1.1171.00
90_A175_V1.1161.00
274_C405_T1.1151.00
424_R428_H1.1131.00
228_W234_I1.1121.00
347_C370_I1.1111.00
208_L247_F1.1041.00
96_C171_F1.1031.00
90_A94_W1.1001.00
250_V253_L1.0981.00
27_V147_V1.0961.00
98_V172_F1.0941.00
211_I215_S1.0881.00
226_L234_I1.0761.00
270_F398_A1.0731.00
270_F274_C1.0651.00
320_L376_A1.0611.00
340_S374_A1.0611.00
159_G303_A1.0601.00
160_Y304_T1.0481.00
82_F126_L1.0451.00
32_I158_G1.0441.00
157_L160_Y1.0431.00
362_G365_A1.0401.00
82_F185_T1.0371.00
305_W309_A1.0351.00
366_W369_F1.0341.00
245_I249_I1.0301.00
127_L143_W1.0291.00
349_Y353_Y1.0271.00
280_A378_F1.0261.00
268_R272_I1.0241.00
247_F250_V1.0231.00
226_L233_E1.0131.00
70_G74_K1.0101.00
161_I173_I1.0091.00
175_V179_V1.0051.00
77_G80_K1.0041.00
30_S59_G0.9991.00
261_D397_A0.9981.00
226_L230_S0.9961.00
80_K84_W0.9961.00
74_K78_E0.9921.00
134_A138_I0.9911.00
100_S103_N0.9891.00
39_T43_N0.9881.00
327_F331_L0.9841.00
349_Y352_A0.9841.00
222_R225_E0.9831.00
363_A367_P0.9831.00
14_I188_T0.9791.00
40_I105_L0.9751.00
128_L395_L0.9741.00
68_L206_L0.9741.00
161_I165_Y0.9721.00
409_A413_G0.9701.00
19_L123_S0.9691.00
85_S115_V0.9691.00
267_S271_T0.9661.00
323_I326_R0.9611.00
238_T242_V0.9601.00
104_M107_F0.9591.00
366_W370_I0.9561.00
363_A366_W0.9551.00
90_A179_V0.9541.00
424_R427_M0.9531.00
201_I206_L0.9521.00
295_L309_A0.9511.00
86_T181_V0.9511.00
219_M237_L0.9491.00
205_G255_D0.9481.00
339_F377_C0.9471.00
184_M187_Q0.9461.00
57_S61_A0.9461.00
176_P180_A0.9451.00
251_W254_T0.9431.00
46_S51_G0.9421.00
229_F235_I0.9391.00
231_S236_I0.9391.00
267_S391_P0.9331.00
355_F360_D0.9311.00
332_D335_R0.9301.00
164_N304_T0.9281.00
350_W353_Y0.9281.00
224_K227_D0.9281.00
420_M424_R0.9271.00
25_M178_G0.9261.00
33_A54_V0.9251.00
290_L418_T0.9241.00
207_A211_I0.9231.00
267_S394_R0.9211.00
100_S168_G0.9211.00
187_Q190_R0.9201.00
416_I419_T0.9181.00
191_G194_T0.9131.00
107_F111_I0.9101.00
54_V102_L0.9101.00
242_V246_C0.9091.00
309_A312_P0.9071.00
320_L324_I0.9031.00
74_K397_A0.8971.00
220_L223_G0.8921.00
43_N168_G0.8921.00
61_A65_S0.8911.00
296_Q303_A0.8901.00
309_A361_F0.8891.00
84_W87_I0.8881.00
320_L377_C0.8871.00
320_L323_I0.8871.00
260_V401_L0.8861.00
277_I402_S0.8861.00
278_S405_T0.8821.00
56_T221_D0.8801.00
55_I289_V0.8801.00
291_L368_Q0.8791.00
322_P326_R0.8761.00
81_L84_W0.8761.00
63_A411_S0.8731.00
168_G172_F0.8671.00
107_F110_V0.8661.00
295_L299_Y0.8641.00
339_F343_M0.8591.00
355_F359_M0.8571.00
233_E237_L0.8521.00
217_Q411_S0.8521.00
258_P261_D0.8501.00
137_S325_G0.8491.00
268_R271_T0.8481.00
37_I51_G0.8461.00
13_V131_Y0.8461.00
386_T402_S0.8441.00
81_L118_P0.8401.00
247_F251_W0.8391.00
176_P179_V0.8391.00
313_V371_Q0.8381.00
234_I237_L0.8381.00
80_K83_L0.8351.00
78_E125_S0.8341.00
338_T342_I0.8321.00
92_A95_A0.8321.00
308_L312_P0.8311.00
274_C401_L0.8311.00
342_I345_A0.8301.00
357_P360_D0.8281.00
356_E359_M0.8221.00
243_V247_F0.8191.00
43_N167_W0.8171.00
413_G416_I0.8171.00
163_D303_A0.8161.00
348_F352_A0.8141.00
159_G307_G0.8121.00
365_A369_F0.8101.00
129_N395_L0.8101.00
26_Q119_L0.8091.00
206_L210_V0.8061.00
169_W172_F0.8061.00
190_R193_E0.8041.00
211_I240_V0.8041.00
316_I373_F0.8031.00
327_F336_L0.8001.00
123_S143_W0.7991.00
22_A86_T0.7981.00
336_L339_F0.7981.00
215_S241_A0.7971.00
22_A119_L0.7961.00
100_S108_F0.7951.00
211_I214_G0.7941.00
183_L186_L0.7911.00
339_F342_I0.7851.00
137_S141_A0.7841.00
93_S112_Q0.7841.00
96_C99_S0.7821.00
145_M149_V0.7811.00
359_M363_A0.7791.00
315_I319_I0.7781.00
98_V108_F0.7761.00
309_A365_A0.7751.00
67_P209_L0.7751.00
125_S396_A0.7721.00
210_V214_G0.7711.00
87_I91_I0.7711.00
28_L32_I0.7691.00
233_E236_I0.7691.00
36_A40_I0.7681.00
76_V81_L0.7631.00
23_T147_V0.7611.00
79_V191_G0.7591.00
64_I214_G0.7581.00
253_L262_L0.7571.00
343_M373_F0.7541.00
383_T402_S0.7531.00
344_Y347_C0.7511.00
246_C249_I0.7491.00
61_A114_I0.7471.00
44_L102_L0.7471.00
154_G158_G0.7461.00
199_R257_N0.7461.00
124_Q143_W0.7451.00
348_F371_Q0.7441.00
205_G252_E0.7441.00
218_I237_L0.7431.00
50_Q103_N0.7411.00
200_R256_D0.7411.00
127_L139_A0.7391.00
172_F175_V0.7391.00
331_L336_L0.7381.00
403_N406_R0.7341.00
350_W363_A0.7341.00
94_W172_F0.7331.00
270_F386_T0.7321.00
86_T182_V0.7311.00
95_A111_I0.7301.00
301_Y361_F0.7301.00
29_D89_F0.7291.00
212_G249_I0.7271.00
269_N389_G0.7251.00
312_P316_I0.7241.00
244_A247_F0.7241.00
73_A125_S0.7241.00
37_I55_I0.7221.00
152_I314_G0.7211.00
213_I408_L0.7211.00
97_G168_G0.7211.00
346_V350_W0.7191.00
238_T241_A0.7181.00
293_Q297_E0.7161.00
18_A185_T0.7161.00
62_N407_T0.7151.00
240_V247_F0.7141.00
295_L301_Y0.7121.00
138_I326_R0.7121.00
204_V207_A0.7101.00
174_N178_G0.7101.00
209_L213_I0.7101.00
377_C381_P0.7091.00
267_S389_G0.7091.00
324_I376_A0.7061.00
266_K271_T0.7051.00
343_M370_I0.7041.00
213_I404_F0.7041.00
292_P306_A0.7031.00
141_A145_M0.6981.00
40_I44_L0.6981.00
136_R388_S0.6971.00
34_N55_I0.6961.00
126_L130_N0.6951.00
40_I51_G0.6951.00
206_L259_I0.6941.00
236_I239_V0.6931.00
27_V150_A0.6931.00
150_A154_G0.6921.00
11_Q14_I0.6901.00
425_E429_H0.6881.00
70_G400_S0.6851.00
162_S170_I0.6831.00
79_V190_R0.6831.00
332_D336_L0.6781.00
108_F111_I0.6781.00
341_F378_F0.6781.00
13_V139_A0.6761.00
204_V208_L0.6731.00
78_E192_R0.6721.00
341_F345_A0.6711.00
74_K77_G0.6701.00
328_A381_P0.6701.00
147_V151_P0.6691.00
148_I317_P0.6671.00
201_I205_G0.6661.00
63_A408_L0.6651.00
138_I329_H0.6631.00
387_L399_S0.6591.00
219_M223_G0.6581.00
328_A332_D0.6581.00
223_G226_L0.6551.00
308_L311_A0.6541.00
158_G162_S0.6531.00
278_S412_I0.6531.00
209_L259_I0.6521.00
69_T85_S0.6521.00
65_S68_L0.6521.00
138_I142_L0.6461.00
276_C341_F0.6461.00
230_S236_I0.6461.00
230_S234_I0.6451.00
338_T345_A0.6401.00
128_L140_L0.6361.00
346_V349_Y0.6351.00
253_L266_K0.6331.00
160_Y165_Y0.6321.00
140_L384_T0.6321.00
269_N385_I0.6311.00
24_F146_T0.6311.00
89_F115_V0.6281.00
319_I322_P0.6271.00
355_F358_G0.6261.00
242_V245_I0.6251.00
227_D230_S0.6221.00
239_V243_V0.6221.00
161_I170_I0.6221.00
15_M18_A0.6211.00
16_T139_A0.6211.00
195_R198_R0.6201.00
39_T162_S0.6201.00
93_S175_V0.6181.00
92_A112_Q0.6171.00
269_N272_I0.6151.00
212_G216_L0.6151.00
40_I43_N0.6141.00
30_S406_R0.6131.00
64_I206_L0.6131.00
248_L260_V0.6121.00
212_G215_S0.6111.00
231_S235_I0.6111.00
59_G410_G0.6111.00
331_L335_R0.6091.00
351_R355_F0.6091.00
70_G396_A0.6091.00
312_P365_A0.6091.00
140_L144_S0.6081.00
153_C156_I0.6071.00
60_V411_S0.6031.00
231_S234_I0.6021.00
162_S166_H0.5981.00
419_T423_N0.5971.00
73_A396_A0.5971.00
172_F176_P0.5961.00
13_V138_I0.5961.00
265_F270_F0.5941.00
69_T121_P0.5941.00
270_F390_L0.5941.00
19_L130_N0.5921.00
284_Y375_V0.5921.00
387_L395_L0.5911.00
204_V255_D0.5891.00
76_V201_I0.5871.00
162_S165_Y0.5871.00
338_T341_F0.5871.00
70_G122_L0.5871.00
29_D109_R0.5861.00
14_I17_I0.5851.00
76_V80_K0.5851.00
222_R234_I0.5841.00
130_N190_R0.5831.00
75_R200_R0.5831.00
149_V153_C0.5821.00
109_R112_Q0.5811.00
42_G45_G0.5801.00
336_L377_C0.5801.00
58_F89_F0.5781.00
369_F373_F0.5781.00
337_V382_L0.5781.00
177_I180_A0.5781.00
19_L126_L0.5771.00
180_A184_M0.5761.00
224_K228_W0.5761.00
334_R338_T0.5761.00
271_T274_C0.5751.00
146_T150_A0.5751.00
384_T388_S0.5741.00
304_T308_L0.5701.00
200_R204_V0.5691.00
96_C112_Q0.5691.00
313_V368_Q0.5681.00
86_T178_G0.5671.00
367_P370_I0.5671.00
285_F288_I0.5661.00
58_F109_R0.5661.00
155_P307_G0.5651.00
128_L387_L0.5641.00
212_G246_C0.5631.00
274_C402_S0.5621.00
198_R202_D0.5611.00
276_C382_L0.5601.00
411_S415_S0.5601.00
228_W235_I0.5601.00
162_S303_A0.5591.00
24_F28_L0.5581.00
372_G376_A0.5571.00
356_E360_D0.5561.00
59_G411_S0.5561.00
335_R339_F0.5551.00
26_Q116_A0.5531.00
62_N116_A0.5511.00
302_T306_A0.5501.00
89_F178_G0.5501.00
131_Y135_K0.5481.00
11_Q190_R0.5481.00
78_E126_L0.5471.00
287_A371_Q0.5461.00
159_G304_T0.5461.00
198_R201_I0.5441.00
294_L298_V0.5431.00
144_S148_I0.5421.00
150_A155_P0.5401.00
134_A329_H0.5401.00
252_E255_D0.5391.00
230_S235_I0.5391.00
16_T127_L0.5391.00
54_V57_S0.5381.00
323_I327_F0.5381.00
414_T418_T0.5381.00
51_G102_L0.5361.00
28_L174_N0.5361.00
25_M174_N0.5351.00
124_Q399_S0.5351.00
269_N273_G0.5341.00
194_T197_E0.5321.00
22_A181_V0.5321.00
192_R195_R0.5311.00
289_V414_T0.5301.00
41_A48_L0.5291.00
62_N120_I0.5281.00
58_F62_N0.5271.00
29_D58_F0.5271.00
241_A246_C0.5271.00
125_S399_S0.5261.00
13_V135_K0.5261.00
86_T185_T0.5251.00
66_I403_N0.5251.00
13_V16_T0.5241.00
129_N192_R0.5231.00
419_T422_T0.5211.00
134_A137_S0.5211.00
24_F153_C0.5201.00
353_Y363_A0.5191.00
222_R237_L0.5191.00
191_G195_R0.5181.00
15_M126_L0.5181.00
82_F123_S0.5181.00
290_L417_T0.5181.00
291_L295_L0.5161.00
41_A46_S0.5161.00
340_S381_P0.5161.00
218_I226_L0.5161.00
209_L248_L0.5161.00
29_D173_I0.5151.00
264_L270_F0.5131.00
41_A47_S0.5121.00
28_L154_G0.5121.00
241_A244_A0.5111.00
61_A115_V0.5111.00
350_W366_W0.5111.00
392_P395_L0.5071.00
138_I141_A0.5061.00
373_F377_C0.5061.00
316_I365_A0.5051.00
25_M29_D0.5051.00
386_T389_G0.5041.00
51_G54_V0.5041.00
32_I173_I0.5031.00
33_A40_I0.5021.00
124_Q140_L0.5021.00
126_L189_L0.5021.00
252_E259_I0.5011.00
121_P124_Q0.5001.00
89_F116_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.8027 100 0.418 Contact Map
4j05A 3 0.7383 100 0.447 Contact Map
4pypA 1 0.8125 100 0.451 Contact Map
3wdoA 1 0.7773 100 0.464 Contact Map
2gfpA 2 0.7305 100 0.473 Contact Map
4xnjA 1 0.8496 100 0.481 Contact Map
4gc0A 1 0.8457 100 0.482 Contact Map
3o7qA 1 0.75 100 0.485 Contact Map
4zw9A 1 0.8535 100 0.492 Contact Map
4tphA 2 0.8281 100 0.495 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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