EMRB - ECOLI - GREMLIN Contacts

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EMRB - Multidrug export protein EmrB

UniProt:	P0AEJ0	Sequences: MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVVAICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTNRESMHHAQLTESVNPFNPNAQAMYSQLEGLGMTQQQASGWIAQQITNQGLIISANEIFWMSAGIFLVLLGLVWFAKPPFGAGGGGGGAH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11439
Length:	512 (417)
Sequences:	36379 (25683)
Seq/√Len:	1257.7

ECOLI - EMRB EMRY MDTD HSRA YEBQ RHMT NANT UHPT PROP XYLE MDFA YIHN YDJE GALP YJJL MHPT YQCE UHPC GARP GLPT ARAE MDTM SHIA DGOT EXUT GUDP SETC YAAU YDJK YGCS MDTG MDTL BCR YHJX NEPI TSGA KGTP YNFM ENTS SOTB YBJJ NUPG ARAJ EMRD YDHC YHJE NARU XAPB YDIM YIHO YJHB YDFJ YAJR MDTH UIDB NARK SETB YDIN SETA FSR FUCP YIHP YDHP AMPG YEGT YGAY MELB CYNX LPLT YAGG YEAN YDEE YICJ YHHS YJIJ YCAD LACY
BACSU - YHCA BMR3 YFIU YUSP LMRB YUBD YCNB TCRB MMR YVKA YWOD YVMA YBFB YYBF EXUT YWFA YFHI YNCC CSBC YCXA ARAE NASA YTBD YYBO GUDP IOLT YYCB YWTG GLPT YDGK YFIG YHJO IOLF YFNC YFIS BMR2 YCEJ YITG YOAB YYAJ GUTA YVQJ YDER YFMO YJBB YFKL NARK YUXJ YBCL BMR1 YKUC YDEG NAIP YXAM BBEX YFMI PBUE YDDS YJMB YQJV YXLH YWOG CSBX YTTB YFKF YNAJ GLCP YQGE YWBF
HALSA - Q9HSM8 O54630 Q9HS33 Q9HN67 Q9HPD6 Q9HRX5 Q9HSK3 Q9HMR5 Q9HMQ8
SULSO - Q97VC8 Q97YH0 Q97U91 Q97Y15 Q97WR9 Q97X47 Q97VB9 Q97YY8 Q97U43 Q7LX65 Q97WR1 Q97U99 Q7LX71 Q97YL8 Q97UD8 Q97VV2 Q97Y43 Q97UY7 Q97V89 Q97UR4 Q97VU3 Q97VT2 Q97U76 Q97U80 Q97WS7 Q97U98 Q97VB7 Q97WT1 Q97Y11 Q980K3 Q97XW7 Q97YG2 Q97X63 Q97ZC9 Q97X02 Q97X92

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
100_S	104_M	5.211	1.00
90_A	178_G	4.377	1.00
88_A	115_V	3.742	1.00
97_G	172_F	3.516	1.00
95_A	108_F	3.367	1.00
103_N	107_F	3.344	1.00
208_L	251_W	3.069	1.00
212_G	245_I	3.008	1.00
350_W	367_P	2.933	1.00
390_L	398_A	2.887	1.00
78_E	129_N	2.827	1.00
101_S	104_M	2.712	1.00
12_L	135_K	2.622	1.00
57_S	110_V	2.544	1.00
263_S	394_R	2.521	1.00
211_I	244_A	2.455	1.00
302_T	305_W	2.420	1.00
316_I	369_F	2.411	1.00
320_L	373_F	2.410	1.00
61_A	110_V	2.382	1.00
46_S	102_L	2.365	1.00
219_M	238_T	2.345	1.00
83_L	186_L	2.334	1.00
216_L	241_A	2.326	1.00
92_A	115_V	2.317	1.00
204_V	251_W	2.280	1.00
65_S	114_I	2.201	1.00
96_C	108_F	2.166	1.00
165_Y	169_W	2.101	1.00
83_L	182_V	2.087	1.00
282_M	413_G	2.051	1.00
235_I	239_V	2.025	1.00
278_S	409_A	2.017	1.00
161_I	169_W	2.011	1.00
223_G	228_W	1.988	1.00
347_C	371_Q	1.969	1.00
391_P	394_R	1.964	1.00
47_S	50_Q	1.952	1.00
183_L	187_Q	1.951	1.00
261_D	394_R	1.932	1.00
246_C	250_V	1.918	1.00
185_T	189_L	1.891	1.00
135_K	138_I	1.891	1.00
104_M	108_F	1.888	1.00
92_A	111_I	1.885	1.00
85_S	118_P	1.859	1.00
36_A	162_S	1.819	1.00
102_L	106_I	1.818	1.00
92_A	108_F	1.809	1.00
296_Q	306_A	1.805	1.00
166_H	169_W	1.800	1.00
20_S	146_T	1.730	1.00
286_G	417_T	1.728	1.00
94_W	98_V	1.725	1.00
163_D	304_T	1.724	1.00
96_C	105_L	1.721	1.00
74_K	396_A	1.716	1.00
57_S	106_I	1.712	1.00
99_S	104_M	1.697	1.00
131_Y	139_A	1.695	1.00
294_L	299_Y	1.693	1.00
69_T	118_P	1.691	1.00
202_D	205_G	1.691	1.00
79_V	83_L	1.669	1.00
94_W	175_V	1.669	1.00
212_G	241_A	1.668	1.00
215_S	237_L	1.658	1.00
16_T	131_Y	1.654	1.00
169_W	176_P	1.648	1.00
132_P	135_K	1.643	1.00
285_F	410_G	1.636	1.00
137_S	329_H	1.630	1.00
347_C	374_A	1.594	1.00
50_Q	102_L	1.586	1.00
347_C	367_P	1.586	1.00
22_A	82_F	1.562	1.00
36_A	170_I	1.558	1.00
46_S	50_Q	1.552	1.00
93_S	174_N	1.551	1.00
255_D	258_P	1.549	1.00
24_F	150_A	1.529	1.00
326_R	330_K	1.528	1.00
54_V	105_L	1.519	1.00
83_L	185_T	1.514	1.00
236_I	240_V	1.506	1.00
65_S	117_G	1.501	1.00
99_S	108_F	1.498	1.00
251_W	255_D	1.497	1.00
215_S	244_A	1.480	1.00
362_G	366_W	1.478	1.00
301_Y	309_A	1.467	1.00
15_M	130_N	1.464	1.00
72_L	81_L	1.463	1.00
95_A	104_M	1.463	1.00
212_G	244_A	1.461	1.00
340_S	377_C	1.444	1.00
230_S	233_E	1.441	1.00
253_L	263_S	1.438	1.00
345_A	349_Y	1.426	1.00
73_A	78_E	1.416	1.00
163_D	302_T	1.413	1.00
87_I	182_V	1.409	1.00
219_M	241_A	1.407	1.00
222_R	226_L	1.400	1.00
200_R	257_N	1.388	1.00
265_F	271_T	1.386	1.00
271_T	275_L	1.383	1.00
301_Y	305_W	1.378	1.00
39_T	42_G	1.374	1.00
215_S	240_V	1.372	1.00
64_I	210_V	1.371	1.00
90_A	182_V	1.371	1.00
305_W	308_L	1.367	1.00
361_F	365_A	1.365	1.00
73_A	122_L	1.364	1.00
41_A	51_G	1.363	1.00
133_P	136_R	1.348	1.00
249_I	253_L	1.340	1.00
71_W	75_R	1.338	1.00
80_K	191_G	1.334	1.00
360_D	363_A	1.332	1.00
343_M	374_A	1.328	1.00
18_A	181_V	1.320	1.00
91_I	95_A	1.320	1.00
184_M	188_T	1.320	1.00
84_W	88_A	1.316	1.00
203_A	207_A	1.315	1.00
58_F	116_A	1.310	1.00
29_D	32_I	1.305	1.00
32_I	170_I	1.300	1.00
128_L	136_R	1.298	1.00
273_G	386_T	1.296	1.00
218_I	222_R	1.289	1.00
344_Y	374_A	1.278	1.00
13_V	17_I	1.269	1.00
61_A	113_G	1.263	1.00
335_R	338_T	1.263	1.00
241_A	245_I	1.263	1.00
205_G	251_W	1.260	1.00
208_L	244_A	1.258	1.00
313_V	372_G	1.238	1.00
103_N	106_I	1.236	1.00
325_G	329_H	1.236	1.00
160_Y	164_N	1.233	1.00
20_S	142_L	1.222	1.00
18_A	188_T	1.222	1.00
316_I	320_L	1.220	1.00
219_M	234_I	1.216	1.00
79_V	186_L	1.214	1.00
249_I	262_L	1.189	1.00
342_I	346_V	1.184	1.00
72_L	76_V	1.180	1.00
18_A	184_M	1.179	1.00
324_I	377_C	1.173	1.00
263_S	266_K	1.170	1.00
12_L	131_Y	1.168	1.00
340_S	378_F	1.167	1.00
53_W	57_S	1.166	1.00
29_D	174_N	1.161	1.00
250_V	254_T	1.158	1.00
179_V	183_L	1.153	1.00
83_L	87_I	1.151	1.00
88_A	92_A	1.140	1.00
240_V	244_A	1.140	1.00
248_L	252_E	1.137	1.00
326_R	329_H	1.136	1.00
21_L	181_V	1.134	1.00
295_L	364_S	1.134	1.00
182_V	186_L	1.124	1.00
95_A	98_V	1.124	1.00
78_E	191_G	1.117	1.00
90_A	175_V	1.116	1.00
274_C	405_T	1.115	1.00
424_R	428_H	1.113	1.00
228_W	234_I	1.112	1.00
347_C	370_I	1.111	1.00
208_L	247_F	1.104	1.00
96_C	171_F	1.103	1.00
90_A	94_W	1.100	1.00
250_V	253_L	1.098	1.00
27_V	147_V	1.096	1.00
98_V	172_F	1.094	1.00
211_I	215_S	1.088	1.00
226_L	234_I	1.076	1.00
270_F	398_A	1.073	1.00
270_F	274_C	1.065	1.00
320_L	376_A	1.061	1.00
340_S	374_A	1.061	1.00
159_G	303_A	1.060	1.00
160_Y	304_T	1.048	1.00
82_F	126_L	1.045	1.00
32_I	158_G	1.044	1.00
157_L	160_Y	1.043	1.00
362_G	365_A	1.040	1.00
82_F	185_T	1.037	1.00
305_W	309_A	1.035	1.00
366_W	369_F	1.034	1.00
245_I	249_I	1.030	1.00
127_L	143_W	1.029	1.00
349_Y	353_Y	1.027	1.00
280_A	378_F	1.026	1.00
268_R	272_I	1.024	1.00
247_F	250_V	1.023	1.00
226_L	233_E	1.013	1.00
70_G	74_K	1.010	1.00
161_I	173_I	1.009	1.00
175_V	179_V	1.005	1.00
77_G	80_K	1.004	1.00
30_S	59_G	0.999	1.00
261_D	397_A	0.998	1.00
226_L	230_S	0.996	1.00
80_K	84_W	0.996	1.00
74_K	78_E	0.992	1.00
134_A	138_I	0.991	1.00
100_S	103_N	0.989	1.00
39_T	43_N	0.988	1.00
327_F	331_L	0.984	1.00
349_Y	352_A	0.984	1.00
222_R	225_E	0.983	1.00
363_A	367_P	0.983	1.00
14_I	188_T	0.979	1.00
40_I	105_L	0.975	1.00
128_L	395_L	0.974	1.00
68_L	206_L	0.974	1.00
161_I	165_Y	0.972	1.00
409_A	413_G	0.970	1.00
19_L	123_S	0.969	1.00
85_S	115_V	0.969	1.00
267_S	271_T	0.966	1.00
323_I	326_R	0.961	1.00
238_T	242_V	0.960	1.00
104_M	107_F	0.959	1.00
366_W	370_I	0.956	1.00
363_A	366_W	0.955	1.00
90_A	179_V	0.954	1.00
424_R	427_M	0.953	1.00
201_I	206_L	0.952	1.00
295_L	309_A	0.951	1.00
86_T	181_V	0.951	1.00
219_M	237_L	0.949	1.00
205_G	255_D	0.948	1.00
339_F	377_C	0.947	1.00
184_M	187_Q	0.946	1.00
57_S	61_A	0.946	1.00
176_P	180_A	0.945	1.00
251_W	254_T	0.943	1.00
46_S	51_G	0.942	1.00
229_F	235_I	0.939	1.00
231_S	236_I	0.939	1.00
267_S	391_P	0.933	1.00
355_F	360_D	0.931	1.00
332_D	335_R	0.930	1.00
164_N	304_T	0.928	1.00
350_W	353_Y	0.928	1.00
224_K	227_D	0.928	1.00
420_M	424_R	0.927	1.00
25_M	178_G	0.926	1.00
33_A	54_V	0.925	1.00
290_L	418_T	0.924	1.00
207_A	211_I	0.923	1.00
267_S	394_R	0.921	1.00
100_S	168_G	0.921	1.00
187_Q	190_R	0.920	1.00
416_I	419_T	0.918	1.00
191_G	194_T	0.913	1.00
107_F	111_I	0.910	1.00
54_V	102_L	0.910	1.00
242_V	246_C	0.909	1.00
309_A	312_P	0.907	1.00
320_L	324_I	0.903	1.00
74_K	397_A	0.897	1.00
220_L	223_G	0.892	1.00
43_N	168_G	0.892	1.00
61_A	65_S	0.891	1.00
296_Q	303_A	0.890	1.00
309_A	361_F	0.889	1.00
84_W	87_I	0.888	1.00
320_L	377_C	0.887	1.00
320_L	323_I	0.887	1.00
260_V	401_L	0.886	1.00
277_I	402_S	0.886	1.00
278_S	405_T	0.882	1.00
56_T	221_D	0.880	1.00
55_I	289_V	0.880	1.00
291_L	368_Q	0.879	1.00
322_P	326_R	0.876	1.00
81_L	84_W	0.876	1.00
63_A	411_S	0.873	1.00
168_G	172_F	0.867	1.00
107_F	110_V	0.866	1.00
295_L	299_Y	0.864	1.00
339_F	343_M	0.859	1.00
355_F	359_M	0.857	1.00
233_E	237_L	0.852	1.00
217_Q	411_S	0.852	1.00
258_P	261_D	0.850	1.00
137_S	325_G	0.849	1.00
268_R	271_T	0.848	1.00
37_I	51_G	0.846	1.00
13_V	131_Y	0.846	1.00
386_T	402_S	0.844	1.00
81_L	118_P	0.840	1.00
247_F	251_W	0.839	1.00
176_P	179_V	0.839	1.00
313_V	371_Q	0.838	1.00
234_I	237_L	0.838	1.00
80_K	83_L	0.835	1.00
78_E	125_S	0.834	1.00
338_T	342_I	0.832	1.00
92_A	95_A	0.832	1.00
308_L	312_P	0.831	1.00
274_C	401_L	0.831	1.00
342_I	345_A	0.830	1.00
357_P	360_D	0.828	1.00
356_E	359_M	0.822	1.00
243_V	247_F	0.819	1.00
43_N	167_W	0.817	1.00
413_G	416_I	0.817	1.00
163_D	303_A	0.816	1.00
348_F	352_A	0.814	1.00
159_G	307_G	0.812	1.00
365_A	369_F	0.810	1.00
129_N	395_L	0.810	1.00
26_Q	119_L	0.809	1.00
206_L	210_V	0.806	1.00
169_W	172_F	0.806	1.00
190_R	193_E	0.804	1.00
211_I	240_V	0.804	1.00
316_I	373_F	0.803	1.00
327_F	336_L	0.800	1.00
123_S	143_W	0.799	1.00
22_A	86_T	0.798	1.00
336_L	339_F	0.798	1.00
215_S	241_A	0.797	1.00
22_A	119_L	0.796	1.00
100_S	108_F	0.795	1.00
211_I	214_G	0.794	1.00
183_L	186_L	0.791	1.00
339_F	342_I	0.785	1.00
137_S	141_A	0.784	1.00
93_S	112_Q	0.784	1.00
96_C	99_S	0.782	1.00
145_M	149_V	0.781	1.00
359_M	363_A	0.779	1.00
315_I	319_I	0.778	1.00
98_V	108_F	0.776	1.00
309_A	365_A	0.775	1.00
67_P	209_L	0.775	1.00
125_S	396_A	0.772	1.00
210_V	214_G	0.771	1.00
87_I	91_I	0.771	1.00
28_L	32_I	0.769	1.00
233_E	236_I	0.769	1.00
36_A	40_I	0.768	1.00
76_V	81_L	0.763	1.00
23_T	147_V	0.761	1.00
79_V	191_G	0.759	1.00
64_I	214_G	0.758	1.00
253_L	262_L	0.757	1.00
343_M	373_F	0.754	1.00
383_T	402_S	0.753	1.00
344_Y	347_C	0.751	1.00
246_C	249_I	0.749	1.00
61_A	114_I	0.747	1.00
44_L	102_L	0.747	1.00
154_G	158_G	0.746	1.00
199_R	257_N	0.746	1.00
124_Q	143_W	0.745	1.00
348_F	371_Q	0.744	1.00
205_G	252_E	0.744	1.00
218_I	237_L	0.743	1.00
50_Q	103_N	0.741	1.00
200_R	256_D	0.741	1.00
127_L	139_A	0.739	1.00
172_F	175_V	0.739	1.00
331_L	336_L	0.738	1.00
403_N	406_R	0.734	1.00
350_W	363_A	0.734	1.00
94_W	172_F	0.733	1.00
270_F	386_T	0.732	1.00
86_T	182_V	0.731	1.00
95_A	111_I	0.730	1.00
301_Y	361_F	0.730	1.00
29_D	89_F	0.729	1.00
212_G	249_I	0.727	1.00
269_N	389_G	0.725	1.00
312_P	316_I	0.724	1.00
244_A	247_F	0.724	1.00
73_A	125_S	0.724	1.00
37_I	55_I	0.722	1.00
152_I	314_G	0.721	1.00
213_I	408_L	0.721	1.00
97_G	168_G	0.721	1.00
346_V	350_W	0.719	1.00
238_T	241_A	0.718	1.00
293_Q	297_E	0.716	1.00
18_A	185_T	0.716	1.00
62_N	407_T	0.715	1.00
240_V	247_F	0.714	1.00
295_L	301_Y	0.712	1.00
138_I	326_R	0.712	1.00
204_V	207_A	0.710	1.00
174_N	178_G	0.710	1.00
209_L	213_I	0.710	1.00
377_C	381_P	0.709	1.00
267_S	389_G	0.709	1.00
324_I	376_A	0.706	1.00
266_K	271_T	0.705	1.00
343_M	370_I	0.704	1.00
213_I	404_F	0.704	1.00
292_P	306_A	0.703	1.00
141_A	145_M	0.698	1.00
40_I	44_L	0.698	1.00
136_R	388_S	0.697	1.00
34_N	55_I	0.696	1.00
126_L	130_N	0.695	1.00
40_I	51_G	0.695	1.00
206_L	259_I	0.694	1.00
236_I	239_V	0.693	1.00
27_V	150_A	0.693	1.00
150_A	154_G	0.692	1.00
11_Q	14_I	0.690	1.00
425_E	429_H	0.688	1.00
70_G	400_S	0.685	1.00
162_S	170_I	0.683	1.00
79_V	190_R	0.683	1.00
332_D	336_L	0.678	1.00
108_F	111_I	0.678	1.00
341_F	378_F	0.678	1.00
13_V	139_A	0.676	1.00
204_V	208_L	0.673	1.00
78_E	192_R	0.672	1.00
341_F	345_A	0.671	1.00
74_K	77_G	0.670	1.00
328_A	381_P	0.670	1.00
147_V	151_P	0.669	1.00
148_I	317_P	0.667	1.00
201_I	205_G	0.666	1.00
63_A	408_L	0.665	1.00
138_I	329_H	0.663	1.00
387_L	399_S	0.659	1.00
219_M	223_G	0.658	1.00
328_A	332_D	0.658	1.00
223_G	226_L	0.655	1.00
308_L	311_A	0.654	1.00
158_G	162_S	0.653	1.00
278_S	412_I	0.653	1.00
209_L	259_I	0.652	1.00
69_T	85_S	0.652	1.00
65_S	68_L	0.652	1.00
138_I	142_L	0.646	1.00
276_C	341_F	0.646	1.00
230_S	236_I	0.646	1.00
230_S	234_I	0.645	1.00
338_T	345_A	0.640	1.00
128_L	140_L	0.636	1.00
346_V	349_Y	0.635	1.00
253_L	266_K	0.633	1.00
160_Y	165_Y	0.632	1.00
140_L	384_T	0.632	1.00
269_N	385_I	0.631	1.00
24_F	146_T	0.631	1.00
89_F	115_V	0.628	1.00
319_I	322_P	0.627	1.00
355_F	358_G	0.626	1.00
242_V	245_I	0.625	1.00
227_D	230_S	0.622	1.00
239_V	243_V	0.622	1.00
161_I	170_I	0.622	1.00
15_M	18_A	0.621	1.00
16_T	139_A	0.621	1.00
195_R	198_R	0.620	1.00
39_T	162_S	0.620	1.00
93_S	175_V	0.618	1.00
92_A	112_Q	0.617	1.00
269_N	272_I	0.615	1.00
212_G	216_L	0.615	1.00
40_I	43_N	0.614	1.00
30_S	406_R	0.613	1.00
64_I	206_L	0.613	1.00
248_L	260_V	0.612	1.00
212_G	215_S	0.611	1.00
231_S	235_I	0.611	1.00
59_G	410_G	0.611	1.00
331_L	335_R	0.609	1.00
351_R	355_F	0.609	1.00
70_G	396_A	0.609	1.00
312_P	365_A	0.609	1.00
140_L	144_S	0.608	1.00
153_C	156_I	0.607	1.00
60_V	411_S	0.603	1.00
231_S	234_I	0.602	1.00
162_S	166_H	0.598	1.00
419_T	423_N	0.597	1.00
73_A	396_A	0.597	1.00
172_F	176_P	0.596	1.00
13_V	138_I	0.596	1.00
265_F	270_F	0.594	1.00
69_T	121_P	0.594	1.00
270_F	390_L	0.594	1.00
19_L	130_N	0.592	1.00
284_Y	375_V	0.592	1.00
387_L	395_L	0.591	1.00
204_V	255_D	0.589	1.00
76_V	201_I	0.587	1.00
162_S	165_Y	0.587	1.00
338_T	341_F	0.587	1.00
70_G	122_L	0.587	1.00
29_D	109_R	0.586	1.00
14_I	17_I	0.585	1.00
76_V	80_K	0.585	1.00
222_R	234_I	0.584	1.00
130_N	190_R	0.583	1.00
75_R	200_R	0.583	1.00
149_V	153_C	0.582	1.00
109_R	112_Q	0.581	1.00
42_G	45_G	0.580	1.00
336_L	377_C	0.580	1.00
58_F	89_F	0.578	1.00
369_F	373_F	0.578	1.00
337_V	382_L	0.578	1.00
177_I	180_A	0.578	1.00
19_L	126_L	0.577	1.00
180_A	184_M	0.576	1.00
224_K	228_W	0.576	1.00
334_R	338_T	0.576	1.00
271_T	274_C	0.575	1.00
146_T	150_A	0.575	1.00
384_T	388_S	0.574	1.00
304_T	308_L	0.570	1.00
200_R	204_V	0.569	1.00
96_C	112_Q	0.569	1.00
313_V	368_Q	0.568	1.00
86_T	178_G	0.567	1.00
367_P	370_I	0.567	1.00
285_F	288_I	0.566	1.00
58_F	109_R	0.566	1.00
155_P	307_G	0.565	1.00
128_L	387_L	0.564	1.00
212_G	246_C	0.563	1.00
274_C	402_S	0.562	1.00
198_R	202_D	0.561	1.00
276_C	382_L	0.560	1.00
411_S	415_S	0.560	1.00
228_W	235_I	0.560	1.00
162_S	303_A	0.559	1.00
24_F	28_L	0.558	1.00
372_G	376_A	0.557	1.00
356_E	360_D	0.556	1.00
59_G	411_S	0.556	1.00
335_R	339_F	0.555	1.00
26_Q	116_A	0.553	1.00
62_N	116_A	0.551	1.00
302_T	306_A	0.550	1.00
89_F	178_G	0.550	1.00
131_Y	135_K	0.548	1.00
11_Q	190_R	0.548	1.00
78_E	126_L	0.547	1.00
287_A	371_Q	0.546	1.00
159_G	304_T	0.546	1.00
198_R	201_I	0.544	1.00
294_L	298_V	0.543	1.00
144_S	148_I	0.542	1.00
150_A	155_P	0.540	1.00
134_A	329_H	0.540	1.00
252_E	255_D	0.539	1.00
230_S	235_I	0.539	1.00
16_T	127_L	0.539	1.00
54_V	57_S	0.538	1.00
323_I	327_F	0.538	1.00
414_T	418_T	0.538	1.00
51_G	102_L	0.536	1.00
28_L	174_N	0.536	1.00
25_M	174_N	0.535	1.00
124_Q	399_S	0.535	1.00
269_N	273_G	0.534	1.00
194_T	197_E	0.532	1.00
22_A	181_V	0.532	1.00
192_R	195_R	0.531	1.00
289_V	414_T	0.530	1.00
41_A	48_L	0.529	1.00
62_N	120_I	0.528	1.00
58_F	62_N	0.527	1.00
29_D	58_F	0.527	1.00
241_A	246_C	0.527	1.00
125_S	399_S	0.526	1.00
13_V	135_K	0.526	1.00
86_T	185_T	0.525	1.00
66_I	403_N	0.525	1.00
13_V	16_T	0.524	1.00
129_N	192_R	0.523	1.00
419_T	422_T	0.521	1.00
134_A	137_S	0.521	1.00
24_F	153_C	0.520	1.00
353_Y	363_A	0.519	1.00
222_R	237_L	0.519	1.00
191_G	195_R	0.518	1.00
15_M	126_L	0.518	1.00
82_F	123_S	0.518	1.00
290_L	417_T	0.518	1.00
291_L	295_L	0.516	1.00
41_A	46_S	0.516	1.00
340_S	381_P	0.516	1.00
218_I	226_L	0.516	1.00
209_L	248_L	0.516	1.00
29_D	173_I	0.515	1.00
264_L	270_F	0.513	1.00
41_A	47_S	0.512	1.00
28_L	154_G	0.512	1.00
241_A	244_A	0.511	1.00
61_A	115_V	0.511	1.00
350_W	366_W	0.511	1.00
392_P	395_L	0.507	1.00
138_I	141_A	0.506	1.00
373_F	377_C	0.506	1.00
316_I	365_A	0.505	1.00
25_M	29_D	0.505	1.00
386_T	389_G	0.504	1.00
51_G	54_V	0.504	1.00
32_I	173_I	0.503	1.00
33_A	40_I	0.502	1.00
124_Q	140_L	0.502	1.00
126_L	189_L	0.502	1.00
252_E	259_I	0.501	1.00
121_P	124_Q	0.500	1.00
89_F	116_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pw4A	1	0.8027	100	0.418	Contact Map
4j05A	3	0.7383	100	0.447	Contact Map
4pypA	1	0.8125	100	0.451	Contact Map
3wdoA	1	0.7773	100	0.464	Contact Map
2gfpA	2	0.7305	100	0.473	Contact Map
4xnjA	1	0.8496	100	0.481	Contact Map
4gc0A	1	0.8457	100	0.482	Contact Map
3o7qA	1	0.75	100	0.485	Contact Map
4zw9A	1	0.8535	100	0.492	Contact Map
4tphA	2	0.8281	100	0.495	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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