GREMLIN Database
NUDJ - Phosphatase NudJ
UniProt: P0AEI6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13446
Length: 153 (123)
Sequences: 4496 (3312)
Seq/√Len: 298.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_W59_S4.6601.00
22_E103_C3.7131.00
13_H17_K3.3571.00
38_L47_A3.2331.00
63_Q87_E2.6151.00
43_T46_E2.5721.00
61_Q87_E2.5591.00
17_K108_S2.3891.00
108_S111_E2.3561.00
10_C48_A2.3281.00
52_L60_A2.3091.00
60_A86_I2.1891.00
20_V107_V2.0451.00
65_F82_F2.0431.00
14_A17_K2.0141.00
22_E102_D1.9671.00
58_I88_L1.8751.00
69_H129_C1.8351.00
65_F68_M1.7481.00
70_Q78_P1.7081.00
6_V38_L1.6861.00
10_C52_L1.6831.00
49_A61_Q1.6151.00
21_V101_I1.5751.00
49_A62_P1.4881.00
19_L106_W1.4861.00
12_V52_L1.4421.00
10_C86_I1.4241.00
24_T102_D1.4211.00
62_P86_I1.4051.00
49_A53_W1.3811.00
16_G109_A1.3791.00
97_H100_D1.3511.00
124_A128_R1.3431.00
44_L84_F1.3321.00
37_H79_F1.2771.00
64_H85_A1.2601.00
9_A83_L1.2571.00
68_M82_F1.2561.00
119_R122_L1.2551.00
61_Q89_E1.2531.00
44_L82_F1.2371.00
107_V113_L1.2331.00
29_A102_D1.2271.00
31_W105_R1.2171.00
98_D101_I1.1871.00
63_Q85_A1.1761.00
46_E49_A1.1161.00
66_I85_A1.1091.00
88_L91_I1.1061.00
48_A52_L1.1051.00
31_W107_V1.1041.00
120_S123_V1.1031.00
7_T37_H1.0691.00
125_E128_R1.0501.00
113_L128_R1.0281.00
38_L44_L1.0241.00
111_E114_Q0.9801.00
23_E101_I0.9741.00
34_P56_T0.9721.00
109_A128_R0.9561.00
120_S124_A0.9551.00
109_A113_L0.9531.00
125_E129_C0.9411.00
48_A86_I0.9401.00
49_A60_A0.9381.00
105_R111_E0.9321.00
23_E32_N0.9241.00
59_S89_E0.9191.00
22_E29_A0.9111.00
48_A62_P0.8931.00
96_P99_S0.8771.00
44_L70_Q0.8741.00
16_G108_S0.8711.00
23_E26_N0.8671.00
52_L86_I0.8631.00
123_V126_S0.8461.00
126_S130_Y0.8391.00
42_E50_R0.8361.00
21_V104_C0.8331.00
49_A59_S0.8331.00
13_H16_G0.8301.00
13_H85_A0.8271.00
32_N35_A0.8241.00
21_V34_P0.8121.00
38_L80_L0.8051.00
59_S90_Q0.7910.99
22_E31_W0.7720.99
72_I78_P0.7720.99
89_E92_C0.7680.99
91_I94_T0.7680.99
116_S119_R0.7670.99
22_E105_R0.7610.99
62_P65_F0.7560.99
14_A88_L0.7540.99
94_T97_H0.7470.99
6_V82_F0.7430.99
118_L122_L0.7400.99
18_F130_Y0.7370.99
85_A130_Y0.7330.99
51_E54_E0.7320.99
49_A52_L0.7290.99
48_A84_F0.7260.99
10_C60_A0.7200.99
116_S120_S0.7110.99
63_Q86_I0.7070.99
13_H109_A0.6990.99
6_V80_L0.6990.99
31_W103_C0.6950.99
95_Q98_D0.6940.99
20_V31_W0.6920.99
71_W74_P0.6890.99
108_S113_L0.6860.99
22_E30_L0.6850.99
119_R123_V0.6850.99
7_T79_F0.6760.98
17_K111_E0.6740.98
14_A87_E0.6690.98
108_S112_I0.6680.98
97_H101_I0.6670.98
58_I91_I0.6670.98
24_T29_A0.6630.98
51_E55_E0.6600.98
42_E47_A0.6590.98
122_L126_S0.6520.98
65_F84_F0.6480.98
9_A81_R0.6470.98
69_H83_L0.6380.98
18_F108_S0.6350.98
33_Q83_L0.6220.97
127_I130_Y0.6170.97
21_V32_N0.6150.97
33_Q81_R0.6140.97
20_V105_R0.6120.97
122_L125_E0.6110.97
18_F109_A0.6080.97
10_C13_H0.6050.97
24_T28_K0.6000.97
32_N79_F0.5990.97
118_L121_P0.5980.97
68_M80_L0.5940.96
35_A79_F0.5940.96
57_G96_P0.5860.96
11_V18_F0.5860.96
120_S126_S0.5850.96
39_E46_E0.5790.96
45_V49_A0.5780.96
11_V66_I0.5760.96
66_I70_Q0.5720.96
94_T104_C0.5680.95
62_P88_L0.5660.95
53_W56_T0.5620.95
62_P84_F0.5610.95
121_P124_A0.5590.95
116_S124_A0.5560.95
9_A33_Q0.5550.95
70_Q80_L0.5520.95
123_V127_I0.5520.95
8_V47_A0.5500.94
118_L123_V0.5490.94
67_R70_Q0.5490.94
116_S121_P0.5390.94
35_A81_R0.5390.94
21_V97_H0.5370.94
92_C110_E0.5310.93
40_A78_P0.5280.93
32_N101_I0.5280.93
97_H104_C0.5270.93
92_C95_Q0.5250.93
79_F83_L0.5250.93
31_W102_D0.5240.93
32_N123_V0.5240.93
94_T100_D0.5220.93
126_S129_C0.5190.93
73_A77_T0.5180.93
34_P43_T0.5170.93
88_L106_W0.5150.92
113_L124_A0.5140.92
66_I69_H0.5140.92
9_A120_S0.5140.92
124_A127_I0.5130.92
107_V117_N0.5120.92
92_C129_C0.5030.91
52_L56_T0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nfwA 6 1 100 0.286 Contact Map
2b0vA 2 0.9477 99.9 0.351 Contact Map
2azwA 1 0.8301 99.9 0.404 Contact Map
3cngA 4 0.9216 99.9 0.406 Contact Map
2qjtB 2 0.8824 99.9 0.407 Contact Map
2qjoA 3 0.8758 99.9 0.41 Contact Map
4dywA 2 0.817 99.9 0.41 Contact Map
3q93A 1 0.9542 99.9 0.414 Contact Map
1vk6A 2 0.8693 99.9 0.418 Contact Map
1ryaA 2 0.8889 99.9 0.423 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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