GREMLIN Database
RIMO - Ribosomal protein S12 methylthiotransferase RimO
UniProt: P0AEI4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13478
Length: 441 (418)
Sequences: 7240 (4274)
Seq/√Len: 209.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_S315_D3.6261.00
268_S318_M3.6121.00
144_L178_A3.5431.00
269_P282_D3.5201.00
384_L425_R3.3171.00
327_R373_E3.2511.00
245_D290_Q3.1881.00
285_L325_E3.1271.00
382_E425_R3.0951.00
270_R315_D3.0571.00
387_I412_L2.9921.00
429_E439_S2.9451.00
427_K439_S2.9411.00
249_P294_I2.9241.00
320_L366_L2.7581.00
358_E362_R2.7071.00
225_Q228_K2.6431.00
321_D325_E2.5411.00
324_K369_Q2.5311.00
270_R274_L2.5031.00
382_E427_K2.4831.00
224_E253_E2.3671.00
178_A189_I2.3201.00
285_L326_A2.2941.00
291_W298_L2.2581.00
355_V358_E2.2581.00
260_L298_L2.2221.00
14_S24_S2.2201.00
176_S179_K2.1931.00
108_Q111_E2.1851.00
324_K366_L2.1691.00
338_P350_Q2.1281.00
286_A289_K2.0991.00
249_P253_E2.0841.00
321_D324_K2.0471.00
313_E355_V2.0441.00
9_K37_D2.0261.00
316_F362_R2.0261.00
252_A294_I2.0121.00
258_P405_E2.0021.00
227_S254_G1.9821.00
227_S255_K1.9771.00
335_K360_W1.9721.00
352_P355_V1.9721.00
384_L423_I1.9681.00
182_V229_L1.9661.00
281_V318_M1.9631.00
178_A226_L1.9461.00
179_K183_D1.9361.00
320_L362_R1.9301.00
281_V285_L1.9201.00
289_K325_E1.8961.00
379_V431_A1.8591.00
218_S246_D1.8561.00
41_S44_D1.8331.00
372_A376_Q1.8301.00
266_H319_L1.7911.00
289_K293_E1.7861.00
34_E114_H1.7571.00
353_E356_K1.7501.00
317_Q321_D1.7481.00
218_S221_S1.7461.00
327_R370_I1.7421.00
171_I225_Q1.7401.00
264_L322_F1.7381.00
283_R286_A1.7381.00
338_P345_N1.7281.00
317_Q362_R1.7051.00
374_R377_E1.6961.00
384_L405_E1.6781.00
280_S283_R1.6651.00
312_T315_D1.6601.00
12_F24_S1.6551.00
153_R165_D1.6221.00
281_V321_D1.6211.00
378_K383_I1.6181.00
269_P281_V1.5951.00
282_D286_A1.5921.00
271_I274_L1.5831.00
10_I38_V1.5811.00
258_P297_E1.5711.00
224_E250_L1.5701.00
387_I424_L1.5671.00
78_I99_E1.5441.00
313_E317_Q1.5411.00
329_D374_R1.5351.00
410_V428_V1.5331.00
227_S250_L1.5191.00
88_D92_E1.4981.00
315_D318_M1.4921.00
248_I291_W1.4771.00
84_G100_I1.4631.00
245_D249_P1.4541.00
54_G162_M1.4461.00
260_L291_W1.4331.00
49_I78_I1.4311.00
176_S180_R1.4201.00
318_M321_D1.4121.00
27_I80_T1.4081.00
155_T276_K1.3961.00
281_V322_F1.3941.00
72_N75_G1.3901.00
155_T308_F1.3851.00
169_R177_E1.3731.00
180_R184_A1.3611.00
170_P173_E1.3461.00
357_E361_N1.3341.00
426_V438_G1.3311.00
251_M256_I1.3251.00
385_V402_D1.3241.00
175_L179_K1.3071.00
361_N365_Q1.3011.00
274_L347_L1.2981.00
153_R161_S1.2971.00
327_R374_R1.2951.00
250_L256_I1.2921.00
304_F323_L1.2921.00
221_S225_Q1.2881.00
175_L225_Q1.2881.00
314_E318_M1.2851.00
221_S246_D1.2801.00
105_S108_Q1.2761.00
297_E381_R1.2741.00
223_C256_I1.2711.00
274_L315_D1.2661.00
169_R173_E1.2651.00
378_K381_R1.2591.00
67_I79_V1.2541.00
54_G60_V1.2521.00
376_Q379_V1.2511.00
71_L77_V1.2461.00
274_L308_F1.2421.00
333_C360_W1.2351.00
366_L370_I1.2271.00
52_T79_V1.2271.00
232_W237_Y1.2171.00
353_E357_E1.2151.00
286_A290_Q1.2141.00
323_L363_F1.2111.00
180_R183_D1.2081.00
430_H437_W1.2071.00
230_G255_K1.2041.00
220_V250_L1.2041.00
428_V436_L1.1981.00
295_C298_L1.1911.00
313_E362_R1.1911.00
343_D346_A1.1861.00
335_K357_E1.1861.00
85_A102_G1.1761.00
61_Q65_E1.1721.00
335_K353_E1.1711.00
200_G203_V1.1661.00
274_L310_G1.1661.00
9_K44_D1.1611.00
290_Q293_E1.1471.00
158_I162_M1.1441.00
182_V231_I1.1441.00
276_K343_D1.1431.00
317_Q320_L1.1401.00
57_D61_Q1.1301.00
101_T112_H1.1281.00
227_S256_I1.1281.00
367_Q370_I1.1281.00
122_H126_L1.1241.00
287_R290_Q1.1221.00
383_I428_V1.1221.00
306_V316_F1.1161.00
224_E246_D1.1151.00
50_V70_A1.1151.00
365_Q369_Q1.1131.00
99_E112_H1.1121.00
235_L238_V1.1081.00
9_K39_V1.1041.00
169_R174_V1.0961.00
288_I300_L1.0931.00
251_M295_C1.0921.00
99_E116_Y1.0891.00
13_V66_A1.0851.00
350_Q356_K1.0821.00
151_N165_D1.0821.00
12_F49_I1.0781.00
89_Q92_E1.0781.00
333_C364_M1.0771.00
80_T101_T1.0741.00
310_G349_D1.0701.00
314_E317_Q1.0671.00
327_R377_E1.0641.00
220_V246_D1.0621.00
269_P280_S1.0601.00
323_L331_V1.0601.00
206_R218_S1.0541.00
369_Q373_E1.0491.00
366_L369_Q1.0451.00
304_F331_V1.0421.00
31_L113_V1.0371.00
288_I326_A1.0201.00
171_I175_L1.0201.00
292_R327_R1.0191.00
115_H120_P1.0171.00
187_K423_I1.0161.00
251_M260_L1.0161.00
142_A181_L1.0151.00
259_Y407_D1.0141.00
252_A295_C1.0121.00
239_Y242_P1.0091.00
248_I294_I1.0081.00
52_T63_S1.0081.00
173_E176_S1.0071.00
331_V367_Q1.0071.00
196_T235_L1.0061.00
376_Q431_A1.0051.00
158_I161_S1.0051.00
302_S328_L1.0041.00
375_L408_G1.0031.00
86_K162_M1.0021.00
144_L174_V1.0021.00
233_T255_K0.9961.00
379_V430_H0.9951.00
316_F363_F0.9951.00
403_A409_A0.9911.00
155_T343_D0.9871.00
246_D249_P0.9811.00
97_V100_I0.9801.00
217_T221_S0.9781.00
391_D394_G0.9781.00
248_I295_C0.9721.00
226_L233_T0.9721.00
48_V70_A0.9721.00
74_N98_L0.9691.00
306_V360_W0.9661.00
269_P318_M0.9661.00
12_F28_L0.9651.00
11_G42_Y0.9641.00
232_W236_H0.9631.00
290_Q294_I0.9520.99
219_M247_V0.9490.99
10_I36_Y0.9480.99
320_L324_K0.9470.99
147_S166_L0.9470.99
302_S331_V0.9410.99
297_E377_E0.9390.99
144_L189_I0.9330.99
372_A431_A0.9320.99
10_I28_L0.9300.99
313_E358_E0.9300.99
179_K225_Q0.9290.99
268_S271_I0.9280.99
360_W364_M0.9210.99
123_N126_L0.9180.99
399_S413_N0.9110.99
14_S51_N0.9100.99
179_K230_G0.9040.99
87_E90_I0.9030.99
345_N350_Q0.9000.99
28_L38_V0.8970.99
172_G176_S0.8960.99
181_L186_V0.8930.99
111_E115_H0.8920.99
66_A69_E0.8900.99
372_A375_L0.8810.99
187_K422_D0.8770.99
50_V67_I0.8760.99
365_Q368_Q0.8740.99
400_M414_G0.8730.99
171_I199_Y0.8700.99
10_I32_R0.8700.99
217_T225_Q0.8690.99
172_G204_K0.8670.99
432_D437_W0.8670.99
414_G417_N0.8670.99
34_E111_E0.8660.99
151_N201_V0.8650.99
71_L94_H0.8640.99
152_H195_D0.8630.99
15_L63_S0.8620.99
19_K194_Q0.8600.99
411_Y435_D0.8580.99
283_R287_R0.8550.99
308_F347_L0.8540.99
323_L328_L0.8530.99
412_L426_V0.8520.99
328_L331_V0.8510.99
274_L349_D0.8500.99
367_Q371_S0.8480.99
71_L98_L0.8480.99
371_S375_L0.8460.99
258_P295_C0.8440.99
417_N422_D0.8410.99
39_V45_A0.8380.99
271_I315_D0.8350.99
301_R330_R0.8350.99
36_Y47_M0.8350.99
90_I97_V0.8320.99
204_K217_T0.8320.99
347_L350_Q0.8260.99
322_F326_A0.8220.99
386_I423_I0.8210.99
362_R366_L0.8200.98
259_Y301_R0.8200.98
153_R276_K0.8190.98
285_L289_K0.8190.98
237_Y242_P0.8180.98
299_T406_I0.8180.98
30_E110_L0.8170.98
15_L66_A0.8150.98
248_I290_Q0.8150.98
8_P117_V0.8140.98
89_Q93_V0.8130.98
399_S402_D0.8130.98
232_W235_L0.8120.98
324_K370_I0.8120.98
385_V426_V0.8100.98
182_V230_G0.8080.98
140_H388_D0.8060.98
232_W238_V0.8050.98
267_A318_M0.8050.98
306_V356_K0.8050.98
284_Q328_L0.8050.98
299_T329_D0.8020.98
114_H118_P0.8010.98
390_V395_A0.8000.98
79_V97_V0.7990.98
264_L284_Q0.7930.98
178_A229_L0.7920.98
142_A186_V0.7920.98
370_I374_R0.7910.98
306_V363_F0.7900.98
264_L304_F0.7890.98
166_L198_A0.7880.98
244_V247_V0.7860.98
370_I373_E0.7840.98
204_K218_S0.7810.98
103_P106_Y0.7800.98
125_F129_V0.7790.98
410_V438_G0.7790.98
270_R318_M0.7790.98
115_H119_K0.7770.98
235_L239_Y0.7770.98
144_L181_L0.7760.98
236_H239_Y0.7740.98
385_V410_V0.7740.98
304_F363_F0.7740.98
260_L300_L0.7730.98
373_E376_Q0.7720.98
323_L370_I0.7710.98
414_G418_V0.7680.98
126_L129_V0.7670.98
402_D410_V0.7670.98
122_H125_F0.7660.98
338_P356_K0.7660.98
219_M223_C0.7620.98
236_H242_P0.7620.98
218_S222_L0.7620.98
428_V438_G0.7600.98
161_S343_D0.7600.98
179_K229_L0.7600.98
47_M78_I0.7590.98
238_V242_P0.7570.97
368_Q434_Y0.7560.97
267_A284_Q0.7530.97
78_I101_T0.7520.97
249_P252_A0.7490.97
168_S202_D0.7490.97
235_L242_P0.7470.97
28_L32_R0.7450.97
147_S193_S0.7450.97
378_K408_G0.7440.97
320_L363_F0.7430.97
316_F320_L0.7420.97
310_G350_Q0.7410.97
220_V244_V0.7370.97
282_D285_L0.7370.97
245_D248_I0.7370.97
133_G136_L0.7360.97
18_P406_I0.7350.97
64_L68_G0.7340.97
11_G39_V0.7330.97
123_N127_S0.7330.97
42_Y48_V0.7320.97
238_V241_Y0.7320.97
126_L131_E0.7320.97
390_V416_T0.7310.97
175_L226_L0.7300.97
319_L363_F0.7300.97
413_N439_S0.7280.97
39_V44_D0.7270.97
31_L49_I0.7270.97
223_C227_S0.7250.97
223_C247_V0.7240.97
221_S224_E0.7190.97
224_E228_K0.7190.97
331_V370_I0.7180.97
351_V356_K0.7170.96
220_V247_V0.7170.96
42_Y70_A0.7160.96
34_E110_L0.7160.96
25_E29_T0.7150.96
378_K406_I0.7150.96
156_F279_G0.7150.96
231_I255_K0.7140.96
152_H198_A0.7130.96
317_Q324_K0.7120.96
271_I308_F0.7100.96
116_Y119_K0.7100.96
329_D408_G0.7090.96
58_S61_Q0.7080.96
24_S51_N0.7080.96
233_T237_Y0.7070.96
11_G45_A0.7070.96
182_V233_T0.7060.96
372_A433_E0.7040.96
8_P36_Y0.7030.96
182_V186_V0.7030.96
22_V145_K0.7020.96
125_F128_L0.7020.96
145_K148_E0.6950.96
243_H287_R0.6950.96
27_I109_V0.6940.96
383_I404_P0.6920.96
387_I426_V0.6910.96
66_A70_A0.6900.96
161_S341_G0.6890.96
418_V422_D0.6880.96
127_S130_P0.6880.96
143_Y190_L0.6860.96
374_R378_K0.6840.95
42_Y73_E0.6830.95
11_G48_V0.6800.95
245_D294_I0.6790.95
220_V224_E0.6790.95
368_Q433_E0.6770.95
48_V73_E0.6750.95
378_K382_E0.6750.95
232_W423_I0.6740.95
362_R365_Q0.6740.95
144_L191_V0.6720.95
29_T33_T0.6700.95
243_H247_V0.6700.95
127_S131_E0.6700.95
18_P192_I0.6690.95
429_E438_G0.6690.95
391_D411_Y0.6690.95
323_L367_Q0.6680.95
141_Y190_L0.6670.95
24_S28_L0.6660.95
233_T239_Y0.6650.95
32_R38_V0.6630.95
195_D242_P0.6620.95
364_M367_Q0.6610.95
36_Y114_H0.6580.94
72_N76_K0.6570.94
198_A241_Y0.6570.94
182_V255_K0.6570.94
319_L323_L0.6540.94
71_L75_G0.6540.94
172_G225_Q0.6520.94
416_T422_D0.6520.94
23_D148_E0.6510.94
285_L322_F0.6510.94
237_Y241_Y0.6500.94
15_L50_V0.6480.94
385_V438_G0.6480.94
152_H278_P0.6470.94
340_E345_N0.6460.94
128_L131_E0.6450.94
233_T242_P0.6430.94
267_A319_L0.6410.94
260_L295_C0.6410.94
377_E381_R0.6400.94
58_S337_S0.6370.93
68_G71_L0.6370.93
14_S21_L0.6350.93
10_I31_L0.6340.93
232_W239_Y0.6340.93
124_P128_L0.6330.93
68_G94_H0.6330.93
175_L229_L0.6320.93
65_E68_G0.6300.93
235_L241_Y0.6300.93
237_Y243_H0.6280.93
229_L255_K0.6230.93
267_A281_V0.6220.93
225_Q229_L0.6210.92
109_V113_V0.6190.92
232_W257_L0.6190.92
54_G86_K0.6180.92
205_H221_S0.6140.92
197_S263_P0.6140.92
270_R310_G0.6130.92
227_S233_T0.6120.92
117_V120_P0.6110.92
241_Y278_P0.6110.92
32_R37_D0.6100.92
171_I206_R0.6100.92
132_Q136_L0.6080.92
239_Y243_H0.6070.92
412_L424_L0.6060.92
62_E65_E0.6040.91
382_E438_G0.6030.91
116_Y120_P0.6030.91
323_L366_L0.6030.91
270_R273_K0.6020.91
306_V335_K0.6010.91
313_E359_R0.6010.91
257_L405_E0.6000.91
155_T274_L0.6000.91
354_E358_E0.6000.91
317_Q358_E0.5990.91
171_I221_S0.5940.91
50_V63_S0.5940.91
146_I196_T0.5940.91
267_A322_F0.5940.91
136_L184_A0.5940.91
124_P127_S0.5930.91
401_A409_A0.5920.91
270_R314_E0.5910.91
11_G40_P0.5910.91
387_I400_M0.5910.91
19_K22_V0.5900.90
197_S242_P0.5850.90
176_S183_D0.5850.90
233_T236_H0.5850.90
330_R371_S0.5840.90
270_R312_T0.5820.90
41_S70_A0.5800.90
394_G413_N0.5800.90
32_R35_G0.5800.90
60_V86_K0.5780.90
94_H97_V0.5780.90
171_I217_T0.5760.89
335_K356_K0.5760.89
197_S238_V0.5740.89
88_D91_R0.5720.89
308_F344_A0.5720.89
126_L130_P0.5710.89
122_H127_S0.5710.89
156_F276_K0.5700.89
55_F158_I0.5700.89
30_E33_T0.5690.89
316_F323_L0.5690.89
182_V189_I0.5690.89
403_A407_D0.5680.89
13_V50_V0.5670.89
122_H129_V0.5670.89
357_E360_W0.5660.89
333_C363_F0.5660.89
426_V429_E0.5660.89
39_V42_Y0.5640.88
52_T67_I0.5640.88
69_E73_E0.5630.88
58_S62_E0.5630.88
171_I222_L0.5620.88
236_H241_Y0.5600.88
232_W242_P0.5590.88
189_I226_L0.5590.88
198_A263_P0.5550.88
379_V382_E0.5550.88
323_L327_R0.5550.88
140_H386_I0.5550.88
375_L436_L0.5550.88
376_Q430_H0.5550.88
304_F319_L0.5540.88
375_L431_A0.5530.87
374_R408_G0.5520.87
238_V243_H0.5510.87
11_G41_S0.5500.87
358_E361_N0.5480.87
26_R30_E0.5460.87
123_N128_L0.5450.87
390_V394_G0.5450.87
144_L169_R0.5440.87
187_K386_I0.5430.86
429_E437_W0.5430.86
400_M420_P0.5400.86
152_H162_M0.5390.86
224_E227_S0.5390.86
106_Y110_L0.5370.86
333_C367_Q0.5360.86
431_A436_L0.5350.86
138_P186_V0.5340.86
235_L251_M0.5330.85
236_H243_H0.5330.85
264_L328_L0.5330.85
222_L226_L0.5320.85
371_S433_E0.5310.85
245_D287_R0.5310.85
390_V414_G0.5300.85
177_E181_L0.5290.85
355_V359_R0.5280.85
206_R221_S0.5270.85
193_S196_T0.5260.85
151_N166_L0.5260.85
336_Y347_L0.5250.85
395_A418_V0.5250.85
71_L96_K0.5230.84
387_I418_V0.5190.84
174_V222_L0.5180.84
123_N131_E0.5170.84
13_V70_A0.5170.84
269_P286_A0.5170.84
379_V428_V0.5160.84
205_H217_T0.5160.84
309_P350_Q0.5140.83
69_E72_N0.5130.83
408_G436_L0.5120.83
250_L253_E0.5120.83
219_M235_L0.5120.83
218_S244_V0.5110.83
232_W241_Y0.5100.83
68_G96_K0.5080.83
206_R217_T0.5080.83
91_R100_I0.5080.83
238_V260_L0.5080.83
70_A77_V0.5070.83
198_A262_I0.5060.82
141_Y388_D0.5060.82
198_A242_P0.5060.82
205_H218_S0.5050.82
249_P290_Q0.5040.82
172_G179_K0.5040.82
191_V226_L0.5020.82
320_L358_E0.5020.82
179_K231_I0.5010.82
151_N198_A0.5000.82
223_C226_L0.5000.82
371_S431_A0.5000.82
203_V217_T0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jc0A 1 0.9252 100 0.382 Contact Map
2qgqA 1 0.5986 100 0.576 Contact Map
1oltA 1 0.7302 100 0.78 Contact Map
4u0oB 1 0.5941 99.9 0.826 Contact Map
4wcxA 1 0.7506 99.9 0.848 Contact Map
3iixA 1 0.7256 99.9 0.851 Contact Map
2yx0A 1 0.6621 99.9 0.852 Contact Map
3t7vA 1 0.7302 99.8 0.858 Contact Map
3c8fA 1 0.5238 99.8 0.859 Contact Map
4r33A 2 0.737 99.8 0.86 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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