GREMLIN Database
ELAB - Protein ElaB
UniProt: P0AEH5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13185
Length: 101 (96)
Sequences: 407 (247)
Seq/√Len: 25.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_Y81_W3.2801.00
73_D77_H2.6530.99
83_G92_L2.4750.99
79_K82_Q2.4650.99
92_L98_L2.4570.99
24_V72_A2.3620.98
49_D53_R2.1890.97
66_K73_D1.9240.94
35_K38_E1.9210.94
51_K64_R1.9060.94
36_Y65_A1.8620.93
90_V98_L1.7920.91
81_W84_I1.7080.89
93_V98_L1.7050.89
10_I54_V1.6590.88
28_S36_Y1.6430.87
38_E42_R1.6250.86
20_T23_E1.6020.86
86_V90_V1.5610.84
62_Y69_V1.5590.84
18_S50_V1.5570.84
80_P100_R1.4850.81
36_Y44_E1.4670.80
43_A58_S1.4650.80
70_Y77_H1.4370.79
54_V101_R1.4110.77
51_K55_S1.4000.77
25_L68_A1.3950.77
24_V53_R1.3850.76
23_E42_R1.3540.74
8_T38_E1.3450.74
13_D16_L1.2840.70
73_D84_I1.2780.70
70_Y79_K1.2650.69
26_R85_G1.2640.69
21_L58_S1.2340.67
18_S43_A1.2210.66
37_V84_I1.2150.66
41_A45_K1.2030.65
12_D15_T1.1650.63
84_I89_A1.1560.62
79_K92_L1.1430.61
32_A36_Y1.1270.60
26_R42_R1.1090.59
34_Q63_Y1.0840.57
37_V40_K1.0730.56
62_Y66_K1.0670.56
73_D76_V1.0490.54
36_Y47_L1.0130.52
39_L74_D1.0080.51
35_K92_L0.9910.50
13_D64_R0.9810.49
7_D16_L0.9770.49
20_T33_D0.9750.49
26_R79_K0.9680.49
6_G98_L0.9640.48
18_S33_D0.9600.48
89_A96_L0.9560.48
71_R75_Y0.9370.46
40_K99_A0.9260.46
73_D87_G0.9240.45
72_A79_K0.9060.44
72_A87_G0.8920.43
29_G41_A0.8900.43
7_D32_A0.8730.42
43_A46_A0.8660.41
22_E71_R0.8480.40
70_Y73_D0.8320.39
57_A60_S0.8290.39
56_Q67_Q0.8270.39
17_L37_V0.8140.38
31_P83_G0.8090.37
50_V58_S0.8070.37
55_S59_D0.8050.37
25_L81_W0.8030.37
32_A75_Y0.7980.37
41_A48_D0.7970.36
19_E43_A0.7870.36
45_K48_D0.7860.36
80_P88_A0.7840.36
19_E77_H0.7760.35
24_V28_S0.7710.35
35_K42_R0.7710.35
19_E71_R0.7650.34
15_T69_V0.7640.34
12_D34_Q0.7590.34
6_G94_L0.7530.34
89_A94_L0.7490.33
29_G40_K0.7470.33
86_V93_V0.7150.31
66_K100_R0.6980.30
44_E87_G0.6960.30
55_S64_R0.6940.30
67_Q86_V0.6880.29
20_T89_A0.6860.29
55_S98_L0.6860.29
48_D90_V0.6840.29
13_D29_G0.6730.29
73_D92_L0.6710.28
23_E26_R0.6670.28
13_D17_L0.6560.28
30_D94_L0.6510.27
13_D47_L0.6500.27
12_D85_G0.6460.27
18_S87_G0.6420.27
56_Q60_S0.6400.27
39_L84_I0.6390.27
15_T90_V0.6180.25
28_S31_P0.6140.25
73_D78_E0.6140.25
35_K65_A0.6080.25
79_K99_A0.6060.25
53_R100_R0.6040.25
27_S42_R0.5980.24
35_K63_Y0.5950.24
13_D26_R0.5950.24
28_S69_V0.5940.24
87_G99_A0.5900.24
49_D67_Q0.5810.23
20_T28_S0.5810.23
7_D10_I0.5790.23
9_R23_E0.5770.23
60_S64_R0.5770.23
21_L80_P0.5720.23
18_S24_V0.5660.23
15_T62_Y0.5620.22
14_L50_V0.5620.22
38_E94_L0.5600.22
45_K99_A0.5560.22
39_L82_Q0.5550.22
28_S32_A0.5540.22
55_S70_Y0.5390.21
87_G91_G0.5370.21
26_R56_Q0.5370.21
52_K70_Y0.5290.21
18_S21_L0.5150.20
71_R83_G0.5140.20
18_S46_A0.5120.20
55_S78_E0.5110.20
28_S101_R0.5100.20
57_A66_K0.5070.20
83_G87_G0.5070.20
11_D21_L0.5060.20
18_S36_Y0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dndA 1 0.7327 71.4 0.879 Contact Map
4j2cA 1 0.8119 63.4 0.886 Contact Map
2qywA 1 0.6139 40.6 0.9 Contact Map
2f9yA 2 0.8416 33.6 0.905 Contact Map
4aurA 1 1 28.7 0.908 Contact Map
2wvqA 2 0.6832 25.6 0.91 Contact Map
1vcsA 1 0.7129 22.6 0.912 Contact Map
4kboA 1 0.7228 19.8 0.914 Contact Map
2f9iA 2 0.8515 16 0.918 Contact Map
2lomA 1 0.4752 15.9 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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