GREMLIN Database
ELAA - Protein ElaA
UniProt: P0AEH3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13184
Length: 153 (132)
Sequences: 3274 (2476)
Seq/√Len: 215.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_L129_F2.9291.00
63_A99_T2.9211.00
121_Q131_P2.6021.00
115_G136_Y2.5161.00
25_C38_D2.1601.00
98_K101_E2.0671.00
118_A135_V2.0621.00
135_V142_P1.9741.00
23_L81_I1.9341.00
93_Q127_F1.9171.00
23_L83_S1.8241.00
19_A54_W1.8001.00
100_L148_R1.7911.00
66_L78_G1.7781.00
60_V86_L1.7451.00
13_S16_Q1.7341.00
121_Q144_I1.7041.00
52_L59_L1.7011.00
96_M127_F1.6921.00
53_G91_V1.6851.00
132_V145_G1.6811.00
26_A83_S1.6521.00
77_I96_M1.6151.00
54_W59_L1.6141.00
111_P147_A1.5981.00
17_L21_L1.5841.00
62_Y81_I1.5461.00
53_G61_A1.5411.00
26_A30_V1.5371.00
61_A82_V1.5331.00
132_V147_A1.5301.00
136_Y145_G1.5191.00
125_Q131_P1.5081.00
100_L112_V1.4711.00
93_Q126_S1.4621.00
121_Q125_Q1.4441.00
137_E140_G1.4271.00
51_I102_T1.3921.00
137_E142_P1.3891.00
34_C141_I1.3591.00
133_T145_G1.3591.00
115_G145_G1.3581.00
122_N125_Q1.3541.00
34_C139_D1.3531.00
93_Q97_S1.3531.00
74_P113_Y1.3041.00
22_Q26_A1.2931.00
58_E85_A1.2841.00
68_S76_V1.2831.00
20_L52_L1.2631.00
63_A80_V1.2621.00
49_R102_T1.2551.00
115_G138_E1.2371.00
51_I99_T1.2361.00
80_V96_M1.2311.00
113_Y145_G1.2111.00
32_Q117_Q1.2021.00
25_C36_Y1.1931.00
102_T105_H1.1701.00
26_A37_Q1.1641.00
94_Q98_K1.1551.00
131_P144_I1.1461.00
25_C29_V1.1421.00
21_L39_I1.1341.00
55_K86_L1.0991.00
104_T148_R1.0651.00
15_S19_A1.0291.00
111_P149_E1.0141.00
113_Y147_A1.0001.00
20_L62_Y0.9901.00
55_K60_V0.9851.00
117_Q143_H0.9811.00
86_L89_E0.9651.00
29_V36_Y0.9571.00
118_A121_Q0.9551.00
44_L48_N0.9521.00
25_C30_V0.9491.00
41_G44_L0.9380.99
31_E87_R0.9370.99
25_C39_I0.9370.99
97_S101_E0.9370.99
103_C112_V0.9310.99
77_I80_V0.9240.99
65_I103_C0.9220.99
18_Y21_L0.9150.99
51_I63_A0.8930.99
74_P111_P0.8870.99
76_V113_Y0.8850.99
98_K102_T0.8830.99
19_A22_Q0.8810.99
101_E105_H0.8800.99
120_L123_F0.8720.99
42_D66_L0.8700.99
76_V114_L0.8690.99
49_R107_W0.8590.99
42_D45_T0.8550.99
61_A95_L0.8540.99
116_A146_M0.8530.99
102_T107_W0.8530.99
77_I99_T0.8370.99
63_A95_L0.8350.99
75_V109_D0.8290.99
12_L20_L0.8200.99
67_K109_D0.8190.99
94_Q97_S0.8180.99
30_V35_P0.8160.99
48_N66_L0.8110.99
15_S44_L0.8050.98
14_V18_Y0.8000.98
60_V91_V0.7960.98
65_I102_T0.7950.98
130_I149_E0.7850.98
92_G123_F0.7840.98
55_K89_E0.7800.98
23_L59_L0.7740.98
45_T48_N0.7640.98
66_L76_V0.7610.98
58_E83_S0.7600.98
83_S86_L0.7580.98
16_Q52_L0.7480.98
26_A85_A0.7440.97
118_A142_P0.7430.97
129_F148_R0.7320.97
97_S127_F0.7260.97
31_E84_E0.7250.97
54_W57_D0.7240.97
90_K93_Q0.7210.97
21_L25_C0.7110.97
61_A91_V0.7080.97
112_V129_F0.7050.96
22_Q41_G0.6990.96
45_T49_R0.6970.96
53_G94_Q0.6940.96
14_V17_L0.6860.96
25_C35_P0.6790.96
91_V94_Q0.6770.96
34_C138_E0.6750.95
55_K58_E0.6730.95
76_V115_G0.6620.95
51_I98_K0.6610.95
77_I112_V0.6580.95
114_L124_Y0.6570.95
50_H62_Y0.6560.95
100_L127_F0.6550.95
89_E92_G0.6540.95
75_V103_C0.6530.95
77_I129_F0.6500.94
138_E141_I0.6490.94
29_V38_D0.6480.94
48_N67_K0.6450.94
28_F117_Q0.6440.94
67_K70_D0.6430.94
118_A144_I0.6410.94
131_P135_V0.6380.94
28_F31_E0.6330.94
51_I65_I0.6320.94
121_Q135_V0.6130.93
101_E104_T0.6080.92
43_D78_G0.6070.92
23_L62_Y0.6050.92
125_Q130_I0.6020.92
134_E144_I0.6020.92
78_G117_Q0.6000.92
114_L146_M0.5980.92
53_G60_V0.5970.92
28_F32_Q0.5950.91
77_I114_L0.5940.91
32_Q143_H0.5930.91
95_L98_K0.5920.91
12_L62_Y0.5900.91
66_L75_V0.5740.90
40_D64_R0.5700.90
61_A92_G0.5670.89
67_K75_V0.5630.89
35_P38_D0.5630.89
78_G143_H0.5610.89
29_V35_P0.5610.89
35_P139_D0.5600.89
103_C109_D0.5550.88
82_V91_V0.5540.88
18_Y41_G0.5450.87
18_Y39_I0.5390.87
75_V107_W0.5380.87
88_G93_Q0.5370.87
25_C37_Q0.5350.87
143_H146_M0.5350.87
86_L91_V0.5310.86
28_F64_R0.5300.86
69_D74_P0.5300.86
135_V144_I0.5290.86
92_G120_L0.5210.85
65_I75_V0.5170.85
31_E117_Q0.5160.85
51_I95_L0.5110.84
119_H141_I0.5020.83
31_E139_D0.5020.83
26_A84_E0.5010.83
31_E79_R0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xebA 2 0.9739 100 0.431 Contact Map
1kzfA 1 0.8954 100 0.436 Contact Map
3p2hA 1 0.9281 100 0.44 Contact Map
1ro5A 5 0.9804 99.9 0.446 Contact Map
2g0bA 4 0.9804 99.9 0.466 Contact Map
1q2yA 1 0.902 99.9 0.497 Contact Map
3efaA 2 0.9281 99.9 0.501 Contact Map
2jdcA 1 0.915 99.9 0.506 Contact Map
1y9wA 2 0.902 99.8 0.6 Contact Map
1yvkA 3 0.8954 99.7 0.614 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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