GREMLIN Database
RSEP - Regulator of sigma-E protease RseP
UniProt: P0AEH1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12436
Length: 450 (428)
Sequences: 1532 (1172)
Seq/√Len: 56.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_V100_I10.2261.00
92_K96_Q5.9991.00
29_V99_A4.9181.00
75_E90_N4.3091.00
248_K275_E4.0551.00
232_N236_S3.7921.00
245_R277_E3.7441.00
276_I285_L3.5991.00
109_F113_I3.4331.00
111_F115_A3.2581.00
27_F59_Y3.2401.00
47_A62_A3.2331.00
28_W32_R3.1961.00
52_T56_G3.0751.00
153_A181_T2.8611.00
94_V98_A2.7801.00
145_I180_I2.7251.00
276_I283_L2.7071.00
82_P85_R2.6961.00
85_R91_N2.6681.00
102_A106_V2.6661.00
271_S286_T2.6311.00
24_F28_W2.5961.00
415_K419_V2.5421.00
322_G325_N2.5371.00
287_L302_V2.5271.00
359_S363_S2.4771.00
250_D267_N2.4461.00
267_N270_K2.4301.00
237_K290_E2.3821.00
225_V245_R2.3761.00
55_L59_Y2.3651.00
93_S96_Q2.3511.00
15_L19_I2.3151.00
249_V260_F2.3101.00
443_L447_F2.2731.00
240_L274_L2.2411.00
229_V233_S2.2291.00
84_L87_H2.2221.00
81_V84_L2.1731.00
275_E282_P2.1651.00
408_F427_C2.1321.00
101_I406_L2.1191.00
289_P302_V2.1051.00
51_R54_K2.0771.00
11_F15_L2.0671.00
101_I409_L2.0541.00
231_P236_S1.9991.00
277_E280_G1.9791.00
18_L390_L1.9761.00
247_V282_P1.9671.00
432_S436_V1.9591.00
88_A91_N1.9591.00
229_V242_A1.9551.00
39_R60_V1.9401.00
98_A413_K1.9301.00
151_L165_V1.8991.00
250_D263_L1.8450.99
94_V406_L1.8230.99
47_A50_R1.8220.99
56_G87_H1.8200.99
426_F430_I1.8110.99
322_G326_A1.7940.99
94_V413_K1.7880.99
324_F328_V1.7870.99
411_I419_V1.7550.99
327_I331_T1.7490.99
338_M342_V1.7440.99
50_R58_E1.7360.99
292_K301_F1.7330.99
114_F118_L1.7040.99
247_V275_E1.6990.99
419_V423_V1.6980.99
182_V189_Q1.6920.99
117_W330_A1.6840.99
116_Y384_A1.6820.99
244_D278_R1.6720.99
153_A156_G1.6640.99
41_S60_V1.6640.99
275_E284_S1.6460.99
345_L349_I1.6160.99
257_W306_P1.6130.99
415_K418_P1.5870.98
98_A406_L1.5800.98
273_A284_S1.5730.98
33_C96_Q1.5640.98
16_G20_T1.5620.98
8_L11_F1.5200.98
109_F391_G1.5180.98
268_P300_G1.4890.98
30_A72_M1.4810.97
263_L267_N1.4630.97
358_L441_L1.4590.97
20_T42_I1.4540.97
4_F8_L1.4470.97
159_T164_A1.4350.97
21_V111_F1.4320.97
341_T389_N1.4240.97
14_A383_L1.4210.97
120_F329_E1.4170.97
110_I113_I1.3940.96
145_I182_V1.3800.96
98_A409_L1.3790.96
391_G395_L1.3670.96
94_V101_I1.3640.96
30_A37_V1.3580.96
102_A395_L1.3520.96
352_D356_N1.3490.96
389_N393_I1.3490.96
98_A410_A1.3470.96
38_E71_K1.3420.95
138_S145_I1.3410.95
155_D172_K1.3220.95
343_S346_G1.3220.95
44_F66_L1.3180.95
184_P187_S1.2980.95
116_Y337_L1.2920.94
271_S289_P1.2900.94
31_R56_G1.2850.94
344_M353_V1.2850.94
107_A111_F1.2830.94
323_P326_A1.2720.94
227_E242_A1.2660.94
152_K183_A1.2650.94
234_A290_E1.2550.94
50_R60_V1.2530.93
335_W339_K1.2490.93
21_V107_A1.2470.93
95_G413_K1.2420.93
24_F107_A1.2410.93
444_F447_F1.2410.93
267_N272_L1.2400.93
259_T262_M1.2350.93
47_A60_V1.2340.93
75_E88_A1.2250.93
362_I366_K1.2180.92
278_R283_L1.2140.92
36_R87_H1.2060.92
11_F365_A1.1970.92
263_L272_L1.1960.92
17_V383_L1.1780.91
119_V381_P1.1780.91
150_E183_A1.1740.91
139_I142_E1.1600.91
236_S241_Q1.1500.90
257_W261_V1.1470.90
183_A186_G1.1430.90
249_V272_L1.1430.90
277_E282_P1.1320.89
10_S13_V1.1250.89
439_M443_L1.1240.89
4_F7_D1.1220.89
24_F32_R1.1200.89
272_L289_P1.1200.89
77_A80_V1.1170.89
89_F101_I1.1150.89
291_S298_A1.1130.89
408_F413_K1.1130.89
181_T190_R1.1000.88
415_K420_S1.0930.88
256_Q259_T1.0900.88
410_A413_K1.0900.88
210_V214_G1.0890.88
264_V272_L1.0770.87
18_L89_F1.0740.87
36_R84_L1.0740.87
339_K343_S1.0700.87
36_R73_L1.0660.86
437_L441_L1.0640.86
410_A414_I1.0580.86
246_I260_F1.0550.86
29_V103_A1.0520.86
182_V187_S1.0500.86
181_T188_D1.0470.85
51_R55_L1.0460.85
14_A379_Y1.0460.85
33_C72_M1.0450.85
411_I415_K1.0380.85
380_L398_L1.0310.84
140_A143_A1.0270.84
247_V277_E1.0270.84
119_V122_I1.0230.84
368_A372_A1.0230.84
436_V443_L1.0210.84
29_V32_R1.0190.84
321_Y329_E1.0150.84
423_V427_C1.0070.83
368_A371_T1.0040.83
228_N242_A1.0010.83
39_R58_E1.0000.83
39_R47_A1.0000.83
363_S366_K0.9990.83
436_V440_G0.9970.82
141_A146_A0.9960.82
41_S50_R0.9940.82
260_F302_V0.9930.82
131_V134_I0.9920.82
23_E26_H0.9920.82
41_S62_A0.9910.82
274_L287_L0.9900.82
47_A63_L0.9870.82
22_H26_H0.9760.81
140_A145_I0.9710.81
362_I443_L0.9700.81
405_H408_F0.9690.81
149_T184_P0.9590.80
333_K336_Q0.9590.80
194_K197_L0.9550.80
186_G193_V0.9540.80
324_F327_I0.9530.79
179_T190_R0.9500.79
16_G42_I0.9490.79
425_D429_R0.9460.79
135_A138_S0.9440.79
111_F383_L0.9430.79
262_M266_D0.9420.79
126_G161_D0.9400.79
116_Y302_V0.9380.78
13_V372_A0.9380.78
37_V72_M0.9360.78
155_D179_T0.9360.78
426_F429_R0.9340.78
154_V159_T0.9320.78
49_W61_I0.9290.78
338_M392_I0.9230.77
263_L266_D0.9200.77
28_W99_A0.9200.77
5_L8_L0.9140.77
422_R426_F0.9130.77
252_Q263_L0.9080.76
406_L409_L0.9050.76
101_I405_H0.9050.76
291_S296_G0.9040.76
74_D80_V0.9020.76
38_E73_L0.8980.75
195_L198_R0.8960.75
382_F386_I0.8960.75
10_S372_A0.8950.75
7_D10_S0.8930.75
87_H92_K0.8930.75
359_S385_L0.8920.75
233_S303_G0.8910.75
136_A141_A0.8900.75
72_M75_E0.8900.75
348_L357_N0.8890.75
226_L229_V0.8830.74
413_K427_C0.8820.74
75_E91_N0.8810.74
127_V316_K0.8810.74
105_P395_L0.8810.74
6_W19_I0.8770.74
255_T259_T0.8760.73
407_L411_I0.8740.73
18_L100_I0.8640.72
260_F274_L0.8610.72
108_N387_S0.8570.72
59_Y220_P0.8540.72
437_L440_G0.8520.71
41_S45_G0.8520.71
229_V305_E0.8510.71
109_F112_A0.8510.71
80_V90_N0.8510.71
29_V106_V0.8470.71
274_L285_L0.8460.71
11_F391_G0.8450.71
240_L285_L0.8440.71
94_V409_L0.8420.70
224_P348_L0.8400.70
386_I425_D0.8340.70
208_D211_S0.8330.70
137_N141_A0.8320.70
75_E85_R0.8300.69
76_R400_V0.8250.69
249_V254_L0.8230.69
6_W10_S0.8230.69
346_G349_I0.8190.68
13_V17_V0.8160.68
226_L287_L0.8160.68
261_V265_R0.8150.68
153_A158_E0.8140.68
430_I434_L0.8120.68
234_A289_P0.8110.68
92_K330_A0.8100.67
47_A58_E0.8080.67
64_I117_W0.8040.67
374_L386_I0.8030.67
113_I335_W0.8000.67
306_P348_L0.8000.67
325_N328_V0.7970.66
106_V110_I0.7970.66
145_I151_L0.7950.66
31_R55_L0.7920.66
48_L63_L0.7880.65
166_R379_Y0.7870.65
368_A388_V0.7840.65
183_A189_Q0.7820.65
160_P164_A0.7810.65
48_L332_D0.7800.65
94_V97_R0.7800.65
393_I439_M0.7800.65
248_K251_G0.7790.64
6_W9_A0.7780.64
77_A81_V0.7760.64
222_I257_W0.7730.64
264_V267_N0.7710.64
260_F264_V0.7700.64
21_V109_F0.7690.63
52_T55_L0.7670.63
118_L327_I0.7670.63
351_G369_G0.7640.63
103_A106_V0.7630.63
81_V86_H0.7610.63
424_Q428_Y0.7590.62
337_L341_T0.7590.62
409_L413_K0.7560.62
230_Q233_S0.7530.62
301_F305_E0.7510.62
240_L304_I0.7510.62
434_L438_L0.7500.62
247_V273_A0.7490.61
74_D90_N0.7450.61
324_F433_I0.7440.61
47_A51_R0.7440.61
327_I332_D0.7430.61
38_E77_A0.7430.61
19_I192_D0.7410.61
228_N305_E0.7410.61
235_A238_A0.7390.60
73_L84_L0.7380.60
229_V236_S0.7380.60
274_L316_K0.7360.60
114_F327_I0.7350.60
420_S423_V0.7350.60
211_S214_G0.7350.60
273_A286_T0.7340.60
113_I331_T0.7300.59
98_A408_F0.7270.59
223_E345_L0.7250.59
356_N445_N0.7240.59
131_V145_I0.7240.59
33_C66_L0.7240.59
43_G63_L0.7240.59
61_I255_T0.7220.59
246_I290_E0.7210.58
341_T344_M0.7210.58
432_S443_L0.7200.58
149_T182_V0.7180.58
80_V83_E0.7180.58
86_H226_L0.7140.58
119_V274_L0.7140.58
159_T165_V0.7140.58
351_G354_K0.7140.58
122_I377_V0.7120.58
240_L278_R0.7110.57
341_T380_L0.7100.57
21_V24_F0.7080.57
58_E238_A0.7080.57
154_V180_I0.7070.57
72_M105_P0.7060.57
98_A427_C0.7040.57
117_W121_I0.7040.57
7_D370_M0.7020.56
125_P318_V0.7010.56
290_E301_F0.7000.56
329_E332_D0.7000.56
43_G68_G0.7000.56
182_V193_V0.6970.56
191_R195_L0.6960.56
347_K362_I0.6940.56
112_A340_L0.6940.56
35_V72_M0.6930.55
344_M348_L0.6930.55
246_I254_L0.6920.55
265_R299_I0.6910.55
33_C379_Y0.6900.55
12_I316_K0.6870.55
62_A405_H0.6870.55
442_A449_R0.6850.55
45_G69_Y0.6840.55
368_A382_F0.6820.54
226_L285_L0.6800.54
42_I100_I0.6790.54
107_A400_V0.6790.54
102_A406_L0.6790.54
50_R54_K0.6790.54
76_R80_V0.6780.54
129_P315_Y0.6770.54
80_V85_R0.6740.53
271_S288_I0.6740.53
227_E305_E0.6730.53
440_G443_L0.6730.53
35_V73_L0.6720.53
248_K253_P0.6700.53
290_E300_G0.6680.53
41_S46_K0.6680.53
283_L286_T0.6670.53
267_N300_G0.6670.53
16_G66_L0.6660.53
227_E307_K0.6660.53
109_F334_T0.6660.53
72_M101_I0.6650.52
405_H418_P0.6650.52
178_T184_P0.6640.52
74_D77_A0.6640.52
427_C430_I0.6620.52
45_G105_P0.6620.52
117_W327_I0.6610.52
433_I437_L0.6600.52
232_N237_K0.6600.52
444_F448_S0.6600.52
184_P191_R0.6600.52
230_Q305_E0.6570.52
134_I141_A0.6570.52
441_L444_F0.6560.51
20_T24_F0.6550.51
356_N441_L0.6530.51
46_K63_L0.6510.51
337_L388_V0.6510.51
4_F436_V0.6480.51
235_A303_G0.6480.51
48_L58_E0.6480.51
226_L246_I0.6480.51
199_H202_F0.6470.50
17_V223_E0.6460.50
64_I69_Y0.6460.50
132_G162_W0.6450.50
152_K181_T0.6440.50
151_L417_G0.6420.50
15_L386_I0.6410.50
363_S367_G0.6370.49
326_A388_V0.6370.49
250_D273_A0.6350.49
281_S285_L0.6330.49
31_R250_D0.6330.49
183_A188_D0.6320.49
10_S369_G0.6310.49
42_I355_L0.6300.49
389_N392_I0.6300.49
45_G48_L0.6300.49
48_L60_V0.6300.49
189_Q281_S0.6300.49
146_A185_F0.6300.49
72_M368_A0.6290.49
360_G443_L0.6290.49
361_P365_A0.6290.49
97_R409_L0.6290.49
93_S98_A0.6280.48
333_K381_P0.6280.48
76_R79_P0.6280.48
180_I184_P0.6270.48
343_S347_K0.6270.48
93_S413_K0.6260.48
405_H424_Q0.6230.48
197_L200_W0.6220.48
134_I147_P0.6210.48
31_R59_Y0.6180.47
440_G444_F0.6170.47
39_R405_H0.6160.47
60_V345_L0.6160.47
33_C95_G0.6150.47
226_L283_L0.6150.47
141_A147_P0.6150.47
252_Q259_T0.6140.47
220_P227_E0.6130.47
29_V33_C0.6130.47
146_A149_T0.6120.47
260_F263_L0.6100.46
115_A383_L0.6090.46
328_V332_D0.6090.46
11_F14_A0.6080.46
344_M367_G0.6080.46
151_L168_Q0.6080.46
49_W148_G0.6070.46
41_S105_P0.6060.46
431_G438_L0.6040.46
254_L263_L0.6040.46
157_I168_Q0.6040.46
89_F390_L0.6030.46
33_C57_T0.6020.46
79_P146_A0.6020.46
146_A417_G0.6010.45
18_L30_A0.5980.45
378_Y381_P0.5980.45
367_G389_N0.5960.45
44_F359_S0.5960.45
19_I24_F0.5930.45
128_R317_V0.5920.44
226_L320_Q0.5900.44
365_A368_A0.5900.44
130_V150_E0.5900.44
161_D164_A0.5890.44
421_E425_D0.5880.44
371_T382_F0.5880.44
375_G382_F0.5880.44
249_V274_L0.5850.44
246_I276_I0.5840.44
78_E83_E0.5840.44
16_G393_I0.5830.44
131_V151_L0.5820.43
346_G435_L0.5780.43
84_L91_N0.5770.43
17_V380_L0.5770.43
116_Y120_F0.5730.42
432_S441_L0.5710.42
142_E250_D0.5710.42
425_D428_Y0.5690.42
432_S444_F0.5680.42
301_F414_I0.5660.42
203_E356_N0.5650.42
220_P257_W0.5650.42
198_R417_G0.5650.42
64_I136_A0.5650.42
7_D14_A0.5640.42
107_A289_P0.5640.42
223_E245_R0.5640.42
140_A144_Q0.5630.41
215_I283_L0.5630.41
371_T392_I0.5630.41
79_P85_R0.5620.41
115_A384_A0.5620.41
149_T435_L0.5620.41
414_I448_S0.5610.41
78_E81_V0.5610.41
27_F45_G0.5600.41
33_C99_A0.5600.41
226_L240_L0.5600.41
105_P109_F0.5590.41
359_S389_N0.5590.41
224_P254_L0.5580.41
14_A368_A0.5580.41
181_T280_G0.5580.41
407_L417_G0.5570.41
43_G375_G0.5570.41
62_A75_E0.5570.41
195_L200_W0.5570.41
341_T385_L0.5570.41
19_I100_I0.5570.41
335_W338_M0.5570.41
153_A298_A0.5560.41
316_K319_R0.5560.41
333_K432_S0.5560.41
64_I129_P0.5560.41
149_T193_V0.5560.41
291_S300_G0.5550.41
355_L358_L0.5550.41
95_G379_Y0.5540.40
76_R90_N0.5540.40
227_E257_W0.5540.40
101_I427_C0.5540.40
411_I418_P0.5530.40
151_L246_I0.5520.40
77_A88_A0.5520.40
407_L416_G0.5510.40
35_V45_G0.5510.40
69_Y426_F0.5510.40
42_I444_F0.5510.40
13_V186_G0.5500.40
264_V302_V0.5500.40
41_S58_E0.5490.40
155_D178_T0.5490.40
17_V411_I0.5480.40
20_T40_F0.5470.40
19_I333_K0.5470.40
20_T64_I0.5460.40
185_F279_Q0.5450.40
11_F19_I0.5440.39
72_M90_N0.5420.39
347_K351_G0.5420.39
22_H25_G0.5410.39
98_A119_V0.5400.39
348_L393_I0.5380.39
224_P230_Q0.5380.39
40_F68_G0.5370.39
89_F387_S0.5360.39
133_E345_L0.5350.38
138_S141_A0.5340.38
5_L132_G0.5340.38
134_I138_S0.5340.38
252_Q298_A0.5330.38
269_G291_S0.5320.38
39_R62_A0.5320.38
170_V435_L0.5320.38
250_D270_K0.5320.38
117_W120_F0.5310.38
21_V419_V0.5300.38
16_G61_I0.5290.38
327_I414_I0.5290.38
375_G389_N0.5290.38
252_Q273_A0.5270.38
328_V331_T0.5270.38
84_L88_A0.5260.38
118_L122_I0.5240.37
129_P152_K0.5240.37
144_Q182_V0.5230.37
97_R391_G0.5230.37
75_E80_V0.5220.37
431_G439_M0.5220.37
139_I279_Q0.5220.37
400_V409_L0.5220.37
441_L445_N0.5220.37
266_D270_K0.5220.37
90_N105_P0.5220.37
8_L432_S0.5210.37
11_F364_I0.5200.37
405_H427_C0.5200.37
418_P438_L0.5170.37
366_K370_M0.5170.37
8_L12_I0.5160.37
143_A197_L0.5150.36
110_I420_S0.5150.36
247_V281_S0.5150.36
15_L99_A0.5140.36
11_F17_V0.5130.36
241_Q285_L0.5130.36
226_L245_R0.5130.36
33_C107_A0.5120.36
109_F392_I0.5110.36
348_L389_N0.5100.36
277_E283_L0.5100.36
157_I274_L0.5090.36
227_E272_L0.5090.36
154_V165_V0.5080.36
340_L429_R0.5080.36
236_S239_G0.5080.36
32_R99_A0.5080.36
154_V279_Q0.5080.36
12_I197_L0.5070.36
38_E84_L0.5070.36
77_A90_N0.5060.36
196_D200_W0.5060.36
77_A82_P0.5060.36
36_R92_K0.5050.35
394_N403_G0.5050.35
394_N402_D0.5050.35
359_S366_K0.5050.35
284_S327_I0.5030.35
62_A69_Y0.5020.35
417_G420_S0.5020.35
438_L443_L0.5010.35
229_V241_Q0.5000.35
6_W398_L0.5000.35
419_V443_L0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wkmA 1 0.3933 100 0.804 Contact Map
1p1dA 1 0.4111 100 0.81 Contact Map
3rleA 1 0.4267 99.9 0.816 Contact Map
4kfvA 1 0.42 99.9 0.819 Contact Map
3pv2A 6 0.5311 99.9 0.83 Contact Map
1ky9A 5 0.5222 99.9 0.831 Contact Map
4a8cA 5 0.5378 99.9 0.832 Contact Map
3gslA 1 0.3956 99.9 0.836 Contact Map
3r0hA 2 0.4178 99.9 0.837 Contact Map
2qt5A 1 0.3956 99.9 0.842 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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