GREMLIN Database
DSBC - Thiol:disulfide interchange protein DsbC
UniProt: P0AEG6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11070
Length: 236 (217)
Sequences: 1558 (1230)
Seq/√Len: 83.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_K171_D3.9361.00
143_F194_G3.8231.00
164_D167_K3.0601.00
109_V139_R3.0601.00
117_T155_E3.0531.00
106_E137_T2.9981.00
161_C183_C2.9661.00
127_Q219_P2.9061.00
117_T152_A2.7951.00
153_E157_K2.7611.00
70_P79_P2.7561.00
49_T84_N2.4431.00
73_D76_G2.4351.00
79_P82_V2.2711.00
127_Q216_Y2.2531.00
109_V137_T2.2291.00
193_L197_L2.2111.00
103_A106_E2.2011.00
97_E190_H2.1871.00
151_D155_E2.1001.00
117_T146_Q2.0981.00
146_Q152_A2.0911.00
159_I172_V2.0511.00
132_N135_G2.0421.00
206_V212_L2.0311.00
145_R152_A2.0151.00
102_K106_E1.9611.00
152_A156_M1.9601.00
26_Q30_A1.9551.00
101_Y170_D1.9381.00
221_E224_E1.9381.00
103_A137_T1.9251.00
123_K127_Q1.8931.00
64_K73_D1.8501.00
97_E189_D1.7981.00
98_M141_L1.7451.00
102_K137_T1.6991.00
192_A196_Q1.6861.00
44_V47_M1.6421.00
110_I205_V1.6371.00
100_V139_R1.6341.00
67_I71_M1.6251.00
27_Q31_K1.5671.00
21_D24_A1.5421.00
197_L206_V1.5401.00
124_L205_V1.5180.99
146_Q150_S1.4760.99
199_V206_V1.4500.99
98_M139_R1.4440.99
13_A16_G1.4360.99
52_T55_G1.4350.99
111_T141_L1.4300.99
116_I159_I1.4090.99
116_I155_E1.4080.99
11_L18_A1.4020.99
101_Y140_Y1.3840.99
164_D168_A1.3780.99
189_D192_A1.3590.99
117_T145_R1.3570.99
207_L213_V1.2940.98
48_K61_D1.2800.98
127_Q130_D1.2800.98
111_T139_R1.2740.98
160_W186_D1.2690.98
142_A156_M1.2620.98
14_F19_Q1.2500.98
13_A20_A1.2360.98
124_L222_M1.2170.98
110_I131_Y1.1950.97
13_A17_F1.1870.97
204_A212_L1.1750.97
15_S19_Q1.1740.97
157_K185_V1.1740.97
131_Y136_I1.1730.97
50_V59_I1.1730.97
13_A18_A1.1710.97
14_F18_A1.1650.97
134_L223_K1.1640.97
128_M138_V1.1390.96
37_S53_N1.1350.96
169_F173_M1.1350.96
127_Q218_P1.1320.96
100_V103_A1.1260.96
12_A17_F1.1260.96
218_P221_E1.1210.96
93_A196_Q1.1110.96
130_D133_A1.1100.96
108_H223_K1.1070.96
113_F193_L1.0870.95
187_I190_H1.0820.95
99_I169_F1.0810.95
16_G20_A1.0790.95
129_A132_N1.0680.95
171_D175_G1.0560.94
16_G23_A1.0540.94
134_L220_K1.0460.94
153_E188_A1.0460.94
144_P194_G1.0440.94
157_K187_I1.0380.94
10_L13_A1.0320.94
130_D134_L1.0310.94
42_A47_M1.0270.94
129_A133_A1.0260.93
44_V71_M1.0160.93
36_S39_I1.0150.93
70_P85_K1.0120.93
159_I186_D1.0020.93
12_A16_G0.9890.92
177_S180_P0.9890.92
81_N84_N0.9850.92
185_V189_D0.9820.92
152_A155_E0.9810.92
217_Q221_E0.9750.92
68_Q72_Y0.9710.91
78_A83_T0.9560.91
60_T63_G0.9560.91
192_A195_V0.9510.91
107_K135_G0.9500.91
14_F17_F0.9490.91
112_V125_H0.9460.90
112_V205_V0.9440.90
199_V204_A0.9410.90
142_A190_H0.9370.90
176_K179_A0.9340.90
12_A15_S0.9340.90
142_A160_W0.9310.90
128_M131_Y0.9170.89
119_G152_A0.9120.89
9_T16_G0.9090.89
11_L14_F0.9050.88
8_F13_A0.9050.88
204_A218_P0.9050.88
100_V137_T0.9030.88
64_K75_S0.9000.88
81_N87_L0.8990.88
201_G204_A0.8950.88
12_A20_A0.8940.88
213_V217_Q0.8920.88
47_M71_M0.8840.87
16_G19_Q0.8820.87
8_F12_A0.8810.87
211_T225_F0.8810.87
125_H140_Y0.8780.87
11_L16_G0.8770.87
188_A192_A0.8640.86
213_V225_F0.8620.86
183_C186_D0.8500.85
117_T122_H0.8480.85
82_V85_K0.8420.84
123_K216_Y0.8410.84
161_C177_S0.8390.84
22_D25_I0.8340.84
25_I59_I0.8340.84
58_Y81_N0.8330.84
221_E225_F0.8320.84
119_G145_R0.8300.84
144_P199_V0.8230.83
217_Q225_F0.8220.83
50_V66_I0.8220.83
121_C203_P0.8210.83
42_A45_A0.8170.83
110_I138_V0.8100.82
114_T125_H0.8080.82
22_D26_Q0.8080.82
90_Q93_A0.8050.82
57_L68_Q0.8030.81
106_E139_R0.8020.81
79_P87_L0.7970.81
99_I159_I0.7930.81
108_H208_S0.7850.80
116_I156_M0.7830.80
18_A21_D0.7790.79
12_A19_Q0.7750.79
220_K224_E0.7750.79
13_A19_Q0.7730.79
217_Q222_M0.7670.78
37_S51_L0.7620.78
106_E156_M0.7600.78
163_K181_A0.7580.78
99_I140_Y0.7480.77
14_F20_A0.7460.77
112_V124_L0.7450.76
71_M82_V0.7430.76
208_S211_T0.7420.76
98_M111_T0.7420.76
91_L111_T0.7390.76
73_D77_T0.7380.76
171_D176_K0.7370.76
119_G122_H0.7360.76
79_P84_N0.7360.76
205_V222_M0.7330.75
35_K38_D0.7270.75
131_Y219_P0.7270.75
164_D200_S0.7260.75
23_A28_T0.7250.74
160_W165_K0.7240.74
127_Q131_Y0.7230.74
118_C203_P0.7180.74
187_I204_A0.7140.73
13_A21_D0.7080.73
47_M94_L0.7040.72
43_P73_D0.7030.72
116_I142_A0.6950.71
8_F11_L0.6940.71
8_F15_S0.6940.71
130_D219_P0.6930.71
49_T56_V0.6920.71
118_C121_C0.6850.70
135_G139_R0.6830.70
114_T119_G0.6780.69
24_A28_T0.6730.69
99_I160_W0.6720.69
47_M67_I0.6720.69
182_S186_D0.6620.68
123_K201_G0.6610.67
168_A171_D0.6600.67
60_T65_H0.6600.67
162_A168_A0.6600.67
205_V226_L0.6590.67
110_I226_L0.6570.67
166_N170_D0.6530.67
110_I128_M0.6510.66
8_F23_A0.6490.66
17_F24_A0.6460.66
90_Q94_L0.6450.66
158_A162_A0.6440.65
191_Y195_V0.6420.65
30_A33_G0.6410.65
109_V112_V0.6400.65
14_F220_K0.6400.65
25_I28_T0.6370.65
57_L62_D0.6360.65
120_Y123_K0.6340.64
8_F27_Q0.6320.64
153_E187_I0.6270.63
10_L75_S0.6270.63
106_E109_V0.6200.63
199_V212_L0.6190.62
60_T64_K0.6150.62
141_L190_H0.6120.62
125_H172_V0.6120.62
27_Q45_A0.6100.61
110_I188_A0.6090.61
187_I191_Y0.6070.61
143_F191_Y0.6040.61
170_D174_A0.6030.60
100_V104_P0.6030.60
51_L56_V0.6020.60
194_G213_V0.6010.60
10_L16_G0.6010.60
154_K157_K0.5950.59
104_P163_K0.5950.59
101_Y138_V0.5930.59
72_Y165_K0.5930.59
82_V86_M0.5920.59
28_T31_K0.5920.59
9_T13_A0.5860.58
46_G69_G0.5860.58
119_G150_S0.5860.58
43_P46_G0.5820.58
101_Y114_T0.5810.58
95_E139_R0.5800.57
145_R150_S0.5790.57
72_Y93_A0.5760.57
171_D200_S0.5750.57
140_Y190_H0.5730.57
86_M176_K0.5700.56
150_S214_P0.5670.56
19_Q22_D0.5660.56
79_P86_M0.5630.55
25_I63_G0.5610.55
122_H175_G0.5600.55
111_T137_T0.5600.55
14_F224_E0.5580.55
114_T173_M0.5570.54
19_Q24_A0.5550.54
165_K169_F0.5520.54
9_T12_A0.5520.54
68_Q224_E0.5510.54
17_F21_D0.5500.54
105_Q137_T0.5500.54
124_L183_C0.5490.53
119_G202_T0.5480.53
182_S185_V0.5480.53
140_Y144_P0.5450.53
23_A26_Q0.5440.53
73_D108_H0.5410.52
106_E111_T0.5400.52
78_A86_M0.5390.52
116_I139_R0.5380.52
83_T196_Q0.5350.52
156_M159_I0.5340.51
159_I168_A0.5340.51
11_L15_S0.5330.51
117_T150_S0.5320.51
9_T30_A0.5300.51
16_G21_D0.5300.51
113_F183_C0.5300.51
194_G204_A0.5280.51
171_D178_V0.5270.50
39_I50_V0.5270.50
11_L19_Q0.5270.50
135_G169_F0.5260.50
8_F28_T0.5260.50
43_P71_M0.5220.50
17_F93_A0.5220.50
20_A23_A0.5200.50
99_I135_G0.5200.50
25_I50_V0.5160.49
108_H111_T0.5120.49
97_E100_V0.5110.48
119_G147_G0.5110.48
59_I63_G0.5100.48
118_C202_T0.5090.48
143_F146_Q0.5080.48
51_L54_S0.5050.48
15_S18_A0.5050.48
29_L63_G0.5050.48
101_Y125_H0.5040.47
8_F14_F0.5030.47
105_Q135_G0.5020.47
64_K74_V0.5010.47
27_Q30_A0.5010.47
114_T169_F0.5010.47
162_A165_K0.5010.47
41_P45_A0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t3bA 2 0.8771 100 0.311 Contact Map
4npbA 2 0.9025 100 0.32 Contact Map
1v58A 2 0.8686 100 0.333 Contact Map
1eejA 2 0.9068 100 0.344 Contact Map
4ml1A 4 0.8178 100 0.365 Contact Map
3tdgA 2 0.7712 100 0.377 Contact Map
4pwoA 1 0.8602 100 0.414 Contact Map
3f4sA 1 0.6229 99.9 0.575 Contact Map
4n30A 1 0.6059 99.9 0.577 Contact Map
3ghaA 1 0.6144 99.9 0.582 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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