GREMLIN Database
DSBA - Thiol:disulfide interchange protein DsbA
UniProt: P0AEG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11297
Length: 208 (179)
Sequences: 5832 (4673)
Seq/√Len: 349.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_V144_A4.5941.00
128_R142_D3.0901.00
103_V106_K2.7991.00
68_K191_D2.7211.00
47_F108_T2.7091.00
137_K140_E2.6631.00
40_Q74_K2.3931.00
41_V73_V2.3261.00
191_D195_Q2.1151.00
42_L78_Y2.0901.00
138_G142_D2.0691.00
64_N185_M2.0181.00
90_D124_A2.0131.00
47_F95_W2.0031.00
41_V174_V1.9801.00
89_K155_A1.9401.00
80_V161_A1.9391.00
40_Q76_T1.9281.00
152_S156_Q1.9241.00
124_A146_N1.9101.00
93_Q151_K1.8681.00
110_P133_N1.8221.00
51_H54_Q1.8141.00
126_D129_D1.7721.00
79_H96_A1.7671.00
64_N68_K1.7501.00
30_T33_K1.7231.00
140_E144_A1.6851.00
55_F172_M1.6741.00
159_K163_D1.6011.00
53_Y57_E1.5621.00
45_F77_K1.5321.00
81_N158_E1.5321.00
101_L144_A1.5231.00
33_K36_A1.5151.00
151_K155_A1.5121.00
64_N67_K1.5061.00
132_I138_G1.4911.00
95_W104_E1.4731.00
65_V69_L1.4681.00
69_L72_G1.4611.00
98_A102_G1.4591.00
42_L76_T1.4351.00
107_V134_A1.4241.00
123_S126_D1.4101.00
129_D133_N1.4001.00
100_A150_V1.3691.00
94_A141_Y1.3561.00
173_F178_Y1.3501.00
69_L195_Q1.3491.00
101_L140_E1.3481.00
159_K162_A1.3441.00
128_R138_G1.3241.00
44_F160_A1.3201.00
193_F197_Y1.3141.00
142_D146_N1.3131.00
56_E109_V1.3011.00
113_E118_T1.2951.00
185_M191_D1.2941.00
187_T192_V1.2591.00
110_P114_G1.2421.00
100_A149_V1.2351.00
100_A144_A1.2271.00
107_V131_F1.2191.00
129_D132_I1.2161.00
83_M88_G1.2101.00
140_E143_A1.1991.00
43_E75_M1.1951.00
110_P130_V1.1851.00
43_E172_M1.1771.00
78_Y160_A1.1611.00
15_F18_S1.1601.00
171_A178_Y1.1561.00
148_F152_S1.1501.00
24_D30_T1.1281.00
79_H157_Q1.1211.00
107_V111_L1.1131.00
139_E142_D1.1071.00
184_G187_T1.0991.00
54_Q58_V1.0911.00
16_S19_A1.0891.00
59_L172_M1.0861.00
59_L75_M1.0831.00
109_V113_E1.0761.00
63_D67_K1.0731.00
63_D109_V1.0711.00
96_A153_L1.0601.00
129_D138_G1.0581.00
56_E108_T1.0571.00
68_K185_M1.0551.00
96_A157_Q1.0521.00
89_K93_Q1.0481.00
91_L111_L1.0301.00
94_A107_V1.0301.00
48_F88_G1.0251.00
66_K70_P1.0211.00
168_G171_A1.0181.00
23_E26_K1.0071.00
49_C52_C1.0061.00
57_E63_D1.0041.00
124_A128_R1.0001.00
158_E162_A0.9991.00
44_F78_Y0.9991.00
47_F79_H0.9891.00
93_Q150_V0.9821.00
155_A158_E0.9801.00
31_L34_P0.9791.00
148_F151_K0.9541.00
172_M188_S0.9451.00
93_Q148_F0.9381.00
139_E143_A0.9331.00
90_D93_Q0.9331.00
114_G130_V0.9201.00
25_G28_Y0.9001.00
107_V141_Y0.8991.00
46_S88_G0.8961.00
113_E117_K0.8951.00
14_A18_S0.8931.00
98_A141_Y0.8851.00
155_A159_K0.8841.00
39_P175_N0.8771.00
101_L137_K0.8661.00
46_S91_L0.8651.00
90_D127_I0.8621.00
95_W107_V0.8541.00
48_F87_L0.8541.00
192_V196_Q0.8531.00
160_A164_V0.8531.00
186_D192_V0.8511.00
93_Q145_W0.8491.00
98_A107_V0.8461.00
69_L191_D0.8411.00
68_K72_G0.8361.00
29_T33_K0.8311.00
18_S21_Q0.8271.00
44_F164_V0.8271.00
98_A131_F0.8141.00
65_V185_M0.8101.00
147_S150_V0.8031.00
98_A136_I0.7991.00
156_Q160_A0.7931.00
53_Y115_V0.7801.00
84_G88_G0.7791.00
149_V152_S0.7791.00
94_A127_I0.7771.00
125_S129_D0.7741.00
177_K197_Y0.7741.00
55_F59_L0.7741.00
66_K71_E0.7711.00
66_K72_G0.7701.00
95_W99_M0.7691.00
124_A142_D0.7681.00
47_F92_T0.7661.00
175_N197_Y0.7651.00
97_V145_W0.7611.00
37_G74_K0.7601.00
24_D27_Q0.7571.00
101_L138_G0.7561.00
128_R132_I0.7561.00
152_S155_A0.7531.00
13_L16_S0.7471.00
79_H104_E0.7421.00
143_A147_S0.7411.00
28_Y33_K0.7401.00
183_Q187_T0.7401.00
96_A100_A0.7371.00
84_G87_L0.7351.00
42_L173_F0.7341.00
80_V158_E0.7320.99
166_L173_F0.7310.99
174_V193_F0.7260.99
110_P134_A0.7240.99
16_S20_A0.7170.99
51_H168_G0.7160.99
130_V134_A0.7120.99
77_K108_T0.7090.99
160_A163_D0.7070.99
77_K105_D0.6970.99
14_A17_A0.6970.99
94_A111_L0.6900.99
105_D109_V0.6880.99
91_L127_I0.6880.99
22_Y25_G0.6810.99
94_A98_A0.6790.99
17_A20_A0.6790.99
58_V64_N0.6770.99
96_A150_V0.6730.99
110_P113_E0.6730.99
38_A72_G0.6720.99
31_L35_V0.6680.99
48_F91_L0.6650.99
95_W111_L0.6620.99
56_E63_D0.6470.99
87_L122_R0.6460.99
89_K151_K0.6460.99
80_V166_L0.6430.99
136_I141_Y0.6400.99
187_T193_F0.6390.99
95_W108_T0.6350.99
149_V153_L0.6320.99
166_L171_A0.6300.98
24_D28_Y0.6290.98
177_K193_F0.6270.98
161_A166_L0.6240.98
126_D130_V0.6240.98
97_V150_V0.6200.98
98_A101_L0.6110.98
193_F196_Q0.6070.98
26_K33_K0.6030.98
16_S21_Q0.6020.98
106_K134_A0.6010.98
26_K30_T0.5990.98
65_V68_K0.5990.98
15_F20_A0.5980.98
128_R131_F0.5930.98
130_V133_N0.5870.98
39_P194_V0.5850.98
179_Q193_F0.5840.98
90_D145_W0.5830.97
45_F112_F0.5820.97
23_E27_Q0.5800.97
28_Y31_L0.5800.97
66_K69_L0.5780.97
81_N169_V0.5770.97
38_A74_K0.5750.97
22_Y27_Q0.5740.97
25_G29_T0.5690.97
81_N92_T0.5680.97
131_F136_I0.5670.97
26_K29_T0.5660.97
28_Y32_E0.5630.97
50_P54_Q0.5580.97
39_P73_V0.5570.97
43_E56_E0.5570.97
82_F88_G0.5540.97
167_R178_Y0.5530.97
120_T123_S0.5520.97
17_A21_Q0.5490.96
122_R126_D0.5450.96
96_A154_V0.5450.96
44_F161_A0.5430.96
99_M153_L0.5410.96
94_A131_F0.5380.96
89_K158_E0.5380.96
103_V134_A0.5360.96
101_L136_I0.5350.96
108_T112_F0.5350.96
67_K70_P0.5340.96
111_L127_I0.5330.96
184_G188_S0.5330.96
63_D66_K0.5320.96
29_T32_E0.5320.96
48_F121_I0.5320.96
131_F141_Y0.5280.96
174_V179_Q0.5270.96
65_V73_V0.5240.95
79_H95_W0.5210.95
30_T36_A0.5190.95
31_L74_K0.5180.95
81_N88_G0.5160.95
158_E161_A0.5150.95
45_F105_D0.5130.95
124_A145_W0.5070.94
27_Q30_T0.5040.94
49_C169_V0.5010.94
188_S193_F0.5000.94
141_Y145_W0.5000.94
96_A99_M0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l9sA 1 0.8894 100 0.34 Contact Map
4od7A 1 0.8558 100 0.343 Contact Map
3l9vA 1 0.8702 100 0.362 Contact Map
4dvcA 1 0.8798 100 0.38 Contact Map
3f4sA 1 0.8798 100 0.4 Contact Map
2znmA 3 0.8606 100 0.405 Contact Map
4n30A 1 0.8221 100 0.405 Contact Map
4jrrA 1 0.8606 100 0.407 Contact Map
4pwoA 1 0.9615 100 0.408 Contact Map
3hz8A 1 0.8798 100 0.409 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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