GREMLIN Database
DPPC - Dipeptide transport system permease protein DppC
UniProt: P0AEG1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12626
Length: 300 (253)
Sequences: 28838 (18016)
Seq/√Len: 1132.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
184_V211_I2.7491.00
51_W78_A2.6171.00
131_D181_R2.5861.00
201_A205_R2.4361.00
187_E192_Y2.4011.00
205_R209_I2.3691.00
197_R203_A2.3671.00
107_L165_A2.3601.00
119_L134_I2.3391.00
111_L169_T2.3031.00
100_L239_F2.2701.00
187_E190_R2.2611.00
202_G205_R2.2401.00
76_S80_L2.1961.00
204_M208_F2.1941.00
61_F64_A2.1021.00
253_T257_D2.0781.00
77_M80_L2.0631.00
191_D194_T2.0501.00
193_V206_Q2.0131.00
193_V211_I1.9771.00
43_L79_H1.9551.00
121_L184_V1.9421.00
122_I126_F1.9191.00
93_R254_M1.9051.00
126_F130_V1.9021.00
224_S287_G1.8801.00
89_D92_S1.8781.00
126_F203_A1.8781.00
114_I118_I1.8241.00
176_Y226_G1.7691.00
129_L133_I1.7291.00
192_Y214_N1.7231.00
125_Y203_A1.7041.00
56_N59_E1.6991.00
187_E215_C1.6981.00
124_G184_V1.6901.00
46_A98_A1.6881.00
84_D88_R1.6671.00
86_V93_R1.6611.00
91_L95_M1.6321.00
115_M173_L1.6211.00
122_I130_V1.6141.00
112_S172_A1.6041.00
81_L271_F1.6011.00
115_M118_I1.5891.00
188_V211_I1.5871.00
103_L107_L1.5831.00
130_V134_I1.5691.00
90_V271_F1.5451.00
183_A186_V1.5401.00
125_Y207_M1.5071.00
134_I177_V1.5051.00
138_V177_V1.5041.00
96_Y99_R1.5041.00
113_L223_A1.4991.00
165_A169_T1.4951.00
79_H89_D1.4901.00
88_R92_S1.4851.00
44_F79_H1.4821.00
85_D257_D1.4771.00
258_V268_V1.4681.00
32_A289_G1.4421.00
116_G176_Y1.4341.00
186_V190_R1.4271.00
48_F51_W1.4221.00
120_G124_G1.4181.00
255_L272_P1.4151.00
40_V44_F1.4101.00
109_V223_A1.3931.00
260_Q263_Q1.3751.00
35_G282_A1.3411.00
64_A67_A1.3381.00
195_A199_A1.3301.00
129_L132_N1.3281.00
136_R139_D1.3201.00
148_L152_V1.3061.00
119_L177_V1.3001.00
120_G180_T1.2971.00
181_R185_L1.2901.00
94_L275_A1.2901.00
116_G180_T1.2861.00
221_V291_R1.2831.00
33_V37_V1.2801.00
228_S280_V1.2741.00
100_L103_L1.2631.00
162_G166_L1.2611.00
124_G188_V1.2571.00
187_E193_V1.2551.00
81_L91_L1.2531.00
123_A134_I1.2511.00
153_L167_A1.2461.00
42_V277_L1.2451.00
290_L293_A1.2441.00
121_L207_M1.2321.00
30_K33_V1.2271.00
291_R295_D1.2171.00
266_W270_T1.2171.00
179_L222_Q1.2161.00
169_T173_L1.2051.00
187_E211_I1.1991.00
44_F48_F1.1871.00
196_S210_N1.1811.00
220_I294_L1.1601.00
196_S206_Q1.1591.00
196_S201_A1.1551.00
104_V234_M1.1541.00
88_R93_R1.1521.00
184_V215_C1.1171.00
127_G188_V1.1141.00
141_M174_P1.1131.00
39_V278_L1.1031.00
194_T197_R1.1031.00
88_R96_Y1.1001.00
289_G293_A1.0971.00
121_L212_F1.0901.00
132_N136_R1.0771.00
117_V180_T1.0741.00
81_L94_L1.0691.00
118_I121_L1.0681.00
180_T184_V1.0631.00
272_P276_I1.0601.00
160_S163_N1.0541.00
144_L149_L1.0521.00
137_V141_M1.0511.00
205_R208_F1.0481.00
173_L177_V1.0431.00
183_A187_E1.0431.00
180_T219_L1.0431.00
83_T89_D1.0431.00
90_V268_V1.0321.00
99_R103_L1.0271.00
167_A171_V1.0221.00
162_G165_A1.0201.00
254_M268_V1.0131.00
37_V41_I1.0131.00
258_V269_V1.0101.00
150_A167_A1.0091.00
131_D135_M1.0071.00
49_A96_Y0.9941.00
199_A210_N0.9901.00
35_G289_G0.9841.00
108_V169_T0.9811.00
127_G189_N0.9781.00
55_Y78_A0.9781.00
103_L161_I0.9771.00
39_V282_A0.9751.00
34_V37_V0.9741.00
42_V279_T0.9741.00
135_M177_V0.9651.00
35_G281_L0.9631.00
197_R206_Q0.9601.00
41_I45_I0.9591.00
90_V254_M0.9571.00
53_A92_S0.9551.00
267_W271_F0.9501.00
196_S199_A0.9481.00
271_F274_L0.9481.00
97_G254_M0.9471.00
38_Y282_A0.9431.00
93_R268_V0.9361.00
180_T215_C0.9331.00
94_L271_F0.9331.00
146_S233_D0.9321.00
130_V133_I0.9311.00
103_L106_C0.9281.00
227_F283_F0.9251.00
133_I137_V0.9231.00
108_V112_S0.9231.00
201_A206_Q0.9221.00
131_D185_L0.9151.00
217_A291_R0.9141.00
40_V79_H0.9111.00
92_S96_Y0.9061.00
128_G131_D0.9051.00
37_V40_V0.9031.00
38_Y278_L0.9001.00
108_V168_L0.8971.00
65_L69_P0.8941.00
35_G285_L0.8881.00
132_N135_M0.8841.00
83_T87_G0.8821.00
120_G184_V0.8821.00
157_F163_N0.8811.00
36_L40_V0.8801.00
203_A206_Q0.8781.00
117_V219_L0.8751.00
36_L286_M0.8651.00
128_G132_N0.8611.00
282_A286_M0.8561.00
93_R96_Y0.8531.00
138_V174_P0.8521.00
168_L233_D0.8511.00
113_L117_V0.8451.00
61_F65_L0.8441.00
63_D67_A0.8401.00
95_M99_R0.8391.00
114_I117_V0.8371.00
222_Q226_G0.8351.00
45_I95_M0.8281.00
220_I287_G0.8281.00
283_F287_G0.8231.00
54_P92_S0.8221.00
166_L169_T0.8221.00
161_I165_A0.8201.00
215_C218_P0.8191.00
55_Y92_S0.8181.00
55_Y79_H0.8161.00
182_A185_L0.8161.00
208_F211_I0.8151.00
66_L69_P0.8091.00
92_S95_M0.8051.00
184_V188_V0.8041.00
113_L118_I0.8041.00
270_T274_L0.8001.00
48_F52_I0.7991.00
159_P163_N0.7991.00
98_A279_T0.7931.00
203_A207_M0.7921.00
108_V230_A0.7921.00
190_R194_T0.7891.00
146_S150_A0.7881.00
119_L173_L0.7851.00
118_I122_I0.7831.00
187_E214_N0.7831.00
254_M272_P0.7771.00
163_N166_L0.7731.00
256_S259_L0.7721.00
153_L163_N0.7661.00
67_A76_S0.7631.00
124_G185_L0.7531.00
106_C110_V0.7531.00
32_A285_L0.7521.00
107_L110_V0.7501.00
31_G35_G0.7471.00
194_T198_V0.7461.00
111_L165_A0.7451.00
257_D260_Q0.7431.00
158_G163_N0.7391.00
201_A210_N0.7371.00
113_L176_Y0.7361.00
142_L174_P0.7341.00
292_D298_L0.7341.00
32_A36_L0.7341.00
107_L239_F0.7331.00
123_A131_D0.7311.00
45_I98_A0.7301.00
183_A218_P0.7291.00
101_S105_G0.7251.00
276_I280_V0.7171.00
206_Q211_I0.7091.00
180_T183_A0.7081.00
84_D265_A0.7061.00
271_F275_A0.7061.00
76_S79_H0.6991.00
278_L282_A0.6981.00
291_R298_L0.6971.00
95_M98_A0.6971.00
58_A62_R0.6951.00
44_F76_S0.6901.00
232_L235_A0.6901.00
34_V38_Y0.6891.00
204_M207_M0.6871.00
62_R65_L0.6861.00
183_A215_C0.6851.00
115_M169_T0.6851.00
228_S283_F0.6841.00
172_A175_H0.6841.00
43_L274_L0.6781.00
116_G120_G0.6771.00
112_S169_T0.6701.00
42_V278_L0.6691.00
30_K34_V0.6681.00
50_N99_R0.6641.00
270_T273_G0.6631.00
54_P91_L0.6601.00
159_P162_G0.6591.00
79_H83_T0.6591.00
171_V174_P0.6571.00
63_D66_L0.6541.00
286_M290_L0.6461.00
47_I51_W0.6451.00
39_V283_F0.6431.00
224_S283_F0.6431.00
164_A234_M0.6391.00
234_M238_G0.6391.00
35_G38_Y0.6391.00
133_I136_R0.6381.00
51_W266_W0.6371.00
232_L236_A0.6351.00
146_S149_L0.6331.00
280_V284_N0.6321.00
65_L68_P0.6291.00
185_L188_V0.6271.00
123_A135_M0.6251.00
109_V226_G0.6241.00
115_M119_L0.6241.00
125_Y188_V0.6151.00
127_G131_D0.6131.00
269_V273_G0.6121.00
135_M138_V0.6111.00
110_V114_I0.6111.00
33_V36_L0.6101.00
221_V224_S0.6101.00
134_I138_V0.6081.00
94_L272_P0.6061.00
105_G230_A0.6051.00
233_D236_A0.6041.00
201_A204_M0.6031.00
61_F79_H0.6031.00
235_A253_T0.6021.00
254_M257_D0.5981.00
98_A102_L0.5981.00
49_A52_I0.5971.00
138_V173_L0.5971.00
102_L106_C0.5941.00
53_A96_Y0.5931.00
261_F264_S0.5921.00
46_A273_G0.5911.00
175_H226_G0.5891.00
126_F207_M0.5881.00
170_F173_L0.5881.00
176_Y180_T0.5851.00
85_D261_F0.5841.00
127_G185_L0.5841.00
107_L162_G0.5831.00
256_S260_Q0.5821.00
176_Y222_Q0.5821.00
149_L171_V0.5821.00
109_V227_F0.5801.00
125_Y208_F0.5791.00
231_I235_A0.5771.00
136_R140_I0.5751.00
152_V156_I0.5731.00
141_M173_L0.5721.00
38_Y42_V0.5721.00
67_A83_T0.5691.00
230_A233_D0.5631.00
255_L276_I0.5621.00
45_I49_A0.5601.00
146_S170_F0.5591.00
163_N167_A0.5551.00
208_F213_P0.5551.00
59_E63_D0.5521.00
62_R66_L0.5501.00
55_Y264_S0.5481.00
99_R102_L0.5481.00
285_L289_G0.5441.00
254_M258_V0.5441.00
119_L122_I0.5431.00
235_A257_D0.5431.00
139_D142_L0.5421.00
93_R97_G0.5401.00
235_A256_S0.5361.00
31_G285_L0.5361.00
64_A79_H0.5351.00
166_L170_F0.5321.00
193_V197_R0.5311.00
109_V113_L0.5311.00
50_N96_Y0.5291.00
169_T172_A0.5271.00
226_G230_A0.5261.00
124_G131_D0.5231.00
123_A181_R0.5231.00
39_V286_M0.5221.00
113_L219_L0.5221.00
104_V164_A0.5211.00
116_G177_V0.5201.00
172_A226_G0.5131.00
105_G227_F0.5111.00
288_D291_R0.5101.00
216_L220_I0.5051.00
267_W270_T0.5051.00
202_G206_Q0.5051.00
42_V46_A0.5041.00
148_L151_L0.5041.00
175_H222_Q0.5041.00
35_G39_V0.5031.00
261_F268_V0.5011.00
179_L183_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.8433 99.9 0.62 Contact Map
3d31C 2 0.7667 99.9 0.635 Contact Map
3tuiA 2 0.6767 99.9 0.643 Contact Map
2onkC 2 0.79 99.9 0.651 Contact Map
3rlfF 1 0.9067 99.9 0.663 Contact Map
4tquN 1 0.87 99.9 0.676 Contact Map
4ymuD 2 0.6967 99.9 0.676 Contact Map
3rlfG 1 0.85 99.8 0.679 Contact Map
3j9pD 4 0.7533 75.1 0.934 Contact Map
2kogA 1 0.1767 21 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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