GREMLIN Database
DPPB - Dipeptide transport system permease protein DppB
UniProt: P0AEF8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12625
Length: 339 (299)
Sequences: 21682 (13601)
Seq/√Len: 786.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_K64_Q3.3521.00
60_K68_H3.2551.00
28_H65_Q3.1931.00
71_W75_H2.7311.00
67_L71_W2.7301.00
228_M255_A2.6981.00
54_A59_D2.6041.00
20_T66_Y2.5911.00
46_P50_A2.4581.00
105_C209_A2.4051.00
241_R247_R2.3931.00
292_R296_D2.3801.00
249_R253_V2.3551.00
117_V133_A2.3271.00
98_A287_W2.3011.00
33_D53_L2.2931.00
21_L66_Y2.2511.00
231_V236_Y2.2401.00
237_I255_A2.1901.00
130_D225_R2.0901.00
231_V234_E2.0881.00
63_W67_L2.0771.00
248_M252_I2.0541.00
91_E293_W2.0461.00
246_T249_R2.0251.00
49_H53_L1.9931.00
268_G324_V1.9831.00
3_Q7_R1.9731.00
87_P90_E1.9721.00
112_A116_P1.8901.00
48_R51_Q1.8761.00
163_T203_A1.8661.00
232_L255_A1.8611.00
245_L249_R1.8491.00
109_F213_G1.8471.00
124_K127_S1.8231.00
19_I314_A1.8011.00
51_Q55_E1.7961.00
45_S48_R1.7701.00
237_I250_V1.7401.00
163_T206_I1.7281.00
64_Q68_H1.7271.00
128_I132_T1.7241.00
120_L124_K1.7191.00
86_I90_E1.7151.00
157_S165_V1.6931.00
88_V308_G1.6671.00
89_W93_V1.6671.00
124_K129_F1.6621.00
50_A53_L1.6601.00
72_G77_D1.6481.00
235_D238_R1.6231.00
264_V331_V1.6011.00
50_A54_A1.5991.00
122_A228_M1.5961.00
119_V228_M1.5931.00
129_F133_A1.5881.00
113_V116_P1.5481.00
120_L129_F1.5361.00
68_H71_W1.5341.00
239_T243_K1.5301.00
123_V251_I1.5221.00
16_F315_T1.5021.00
231_V259_A1.4931.00
168_R287_W1.4891.00
101_E168_R1.4741.00
209_A213_G1.4731.00
327_L330_V1.4681.00
265_T328_Y1.4681.00
294_L309_G1.4541.00
113_V217_L1.4411.00
236_Y258_N1.4281.00
33_D36_M1.4281.00
154_M159_H1.4201.00
110_A216_P1.4171.00
231_V255_A1.4071.00
73_V78_L1.4001.00
98_A168_R1.3951.00
147_W151_M1.3891.00
123_V247_R1.3891.00
52_L55_E1.3851.00
17_I66_Y1.3851.00
231_V237_I1.3791.00
86_I94_P1.3781.00
78_L308_G1.3771.00
220_I270_Q1.3691.00
68_H72_G1.3651.00
297_A305_V1.3621.00
10_G14_P1.3501.00
52_L56_L1.3441.00
17_I21_L1.3311.00
101_E105_C1.3281.00
152_L211_V1.3241.00
74_M77_D1.3231.00
111_T267_I1.3181.00
124_K247_R1.3161.00
78_L89_W1.3121.00
94_P97_Q1.3071.00
12_V318_I1.3041.00
243_K254_H1.2881.00
64_Q67_L1.2851.00
114_G224_T1.2821.00
155_L159_H1.2811.00
35_V49_H1.2801.00
122_A232_L1.2491.00
118_G122_A1.2451.00
213_G217_L1.2441.00
91_E305_V1.2411.00
225_R229_L1.2401.00
107_M267_I1.2331.00
126_G130_D1.2231.00
114_G220_I1.2181.00
293_W305_V1.2151.00
133_A221_V1.2111.00
86_I91_E1.2111.00
61_P64_Q1.2051.00
140_G218_A1.2051.00
6_L10_G1.2031.00
25_A28_H1.2031.00
155_L160_W1.2011.00
80_I87_P1.1921.00
118_G224_T1.1891.00
223_M266_V1.1881.00
57_G60_K1.1841.00
60_K63_W1.1821.00
143_M148_W1.1821.00
20_T69_Y1.1771.00
21_L25_A1.1691.00
57_G68_H1.1401.00
117_V221_V1.1351.00
98_A101_E1.1311.00
137_A221_V1.1241.00
206_I210_I1.1201.00
228_M259_A1.1181.00
261_L328_Y1.1141.00
224_T263_V1.1121.00
121_A133_A1.1111.00
128_I131_H1.1101.00
81_S86_I1.0931.00
170_S204_H1.0911.00
326_L330_V1.0901.00
272_G317_I1.0891.00
309_G313_V1.0891.00
51_Q54_A1.0771.00
90_E94_P1.0661.00
211_V215_I1.0631.00
156_V160_W1.0611.00
91_E94_P1.0511.00
83_K300_R1.0451.00
240_A250_V1.0431.00
101_E205_M1.0391.00
36_M49_H1.0331.00
72_G75_H1.0231.00
240_A245_L1.0151.00
54_A60_K1.0121.00
320_V324_V1.0101.00
122_A229_L1.0021.00
106_A213_G1.0011.00
5_I326_L1.0011.00
119_V251_I0.9991.00
136_L140_G0.9881.00
18_G22_L0.9821.00
93_V97_Q0.9801.00
295_I299_Q0.9791.00
149_G211_V0.9761.00
152_L207_L0.9741.00
328_Y332_N0.9731.00
81_S302_D0.9731.00
14_P17_I0.9621.00
12_V322_L0.9551.00
23_T96_F0.9551.00
245_L250_V0.9541.00
169_V204_H0.9531.00
224_T228_M0.9531.00
130_D229_L0.9481.00
145_I281_T0.9461.00
247_R250_V0.9381.00
28_H62_M0.9311.00
249_R252_I0.9281.00
9_L322_L0.9281.00
323_L327_L0.9271.00
4_F329_G0.9241.00
303_Y307_Q0.9201.00
116_P119_V0.9161.00
90_E93_V0.9141.00
92_F308_G0.9121.00
21_L62_M0.9061.00
205_M209_A0.9061.00
103_G274_L0.9061.00
241_R250_V0.9031.00
240_A254_H0.9001.00
271_V320_V0.8991.00
70_I73_V0.8971.00
115_I224_T0.8941.00
16_F318_I0.8931.00
230_E234_E0.8931.00
39_A52_L0.8931.00
20_T311_L0.8931.00
163_T207_L0.8901.00
217_L221_V0.8901.00
17_I70_I0.8891.00
151_M155_L0.8881.00
80_I85_R0.8871.00
95_R293_W0.8851.00
296_D300_R0.8821.00
71_W74_M0.8751.00
126_G131_H0.8731.00
259_A262_P0.8721.00
25_A62_M0.8701.00
134_V221_V0.8681.00
227_S231_V0.8681.00
132_T136_L0.8681.00
101_E104_V0.8661.00
264_V324_V0.8611.00
106_A110_A0.8561.00
10_G326_L0.8531.00
88_V293_W0.8531.00
106_A212_L0.8511.00
210_I213_G0.8501.00
38_M41_E0.8501.00
35_V39_A0.8421.00
13_I17_I0.8411.00
227_S230_E0.8401.00
73_V311_L0.8361.00
224_T259_A0.8331.00
109_F209_A0.8321.00
32_G301_R0.8301.00
250_V255_A0.8291.00
131_H134_V0.8291.00
28_H303_Y0.8291.00
104_V108_I0.8281.00
111_T116_P0.8271.00
293_W297_A0.8271.00
319_L323_L0.8171.00
329_G335_I0.8151.00
119_V256_L0.8141.00
149_G284_I0.8141.00
47_E51_Q0.8121.00
70_I74_M0.8101.00
116_P120_L0.8091.00
39_A44_I0.8091.00
115_I263_V0.8041.00
114_G118_G0.8021.00
118_G228_M0.8011.00
252_I255_A0.7981.00
129_F132_T0.7911.00
69_Y73_V0.7891.00
105_C287_W0.7891.00
227_S259_A0.7871.00
14_P18_G0.7861.00
328_Y335_I0.7851.00
107_M271_V0.7841.00
272_G320_V0.7821.00
326_L329_G0.7821.00
123_V252_I0.7791.00
67_L70_I0.7781.00
82_M304_P0.7771.00
156_V163_T0.7761.00
164_P167_G0.7731.00
206_I209_A0.7681.00
117_V217_L0.7641.00
99_T103_G0.7631.00
315_T319_L0.7591.00
21_L63_W0.7581.00
114_G221_V0.7571.00
238_R241_R0.7551.00
110_A213_G0.7531.00
297_A306_V0.7511.00
35_V53_L0.7491.00
88_V305_V0.7461.00
294_L297_A0.7451.00
145_I149_G0.7421.00
113_V213_G0.7391.00
307_Q310_V0.7381.00
92_F309_G0.7361.00
66_Y70_I0.7321.00
104_V271_V0.7291.00
100_L104_V0.7281.00
46_P49_H0.7261.00
148_W214_T0.7231.00
283_T292_R0.7221.00
156_V207_L0.7141.00
35_V52_L0.7121.00
23_T310_V0.7111.00
224_T227_S0.7081.00
159_H162_L0.7071.00
240_A243_K0.7041.00
329_G336_R0.7021.00
168_R205_M0.7021.00
156_V162_L0.7011.00
141_Y218_A0.7001.00
278_A281_T0.7001.00
247_R251_I0.6971.00
38_M52_L0.6971.00
78_L92_F0.6951.00
293_W309_G0.6941.00
137_A218_A0.6931.00
25_A29_M0.6921.00
308_G312_L0.6901.00
283_T295_I0.6851.00
47_E50_A0.6841.00
16_F319_L0.6841.00
97_Q101_E0.6841.00
313_V317_I0.6821.00
121_A130_D0.6811.00
216_P219_V0.6781.00
93_V96_F0.6771.00
298_L301_R0.6771.00
19_I316_M0.6721.00
106_A278_A0.6711.00
317_I321_N0.6701.00
145_I214_T0.6661.00
97_Q100_L0.6601.00
96_F100_L0.6601.00
113_V117_V0.6561.00
135_G138_L0.6551.00
71_W76_G0.6501.00
130_D134_V0.6431.00
245_L254_H0.6411.00
7_R10_G0.6401.00
131_H135_G0.6341.00
82_M296_D0.6341.00
91_E95_R0.6331.00
153_I165_V0.6321.00
133_A137_A0.6311.00
140_G214_T0.6301.00
132_T135_G0.6291.00
166_S286_S0.6261.00
211_V281_T0.6261.00
111_T220_I0.6241.00
36_M40_G0.6221.00
223_M227_S0.6221.00
105_C108_I0.6221.00
44_I49_H0.6201.00
219_V270_Q0.6191.00
296_D299_Q0.6181.00
102_L209_A0.6181.00
238_R242_A0.6151.00
294_L313_V0.6121.00
112_A115_I0.6101.00
288_P292_R0.6081.00
307_Q311_L0.6081.00
204_H207_L0.6071.00
105_C206_I0.6061.00
261_L335_I0.6051.00
22_L93_V0.6051.00
220_I224_T0.6031.00
15_T318_I0.6021.00
145_I148_W0.6021.00
268_G320_V0.6021.00
207_L211_V0.6011.00
213_G216_P0.6001.00
99_T278_A0.6001.00
219_V266_V0.6001.00
154_M158_V0.5991.00
135_G139_T0.5991.00
157_S207_L0.5981.00
48_R52_L0.5981.00
15_T319_L0.5981.00
224_T256_L0.5961.00
20_T70_I0.5951.00
170_S203_A0.5931.00
50_A59_D0.5921.00
35_V56_L0.5911.00
8_R11_L0.5911.00
99_T282_E0.5901.00
266_V270_Q0.5891.00
167_G204_H0.5891.00
264_V327_L0.5891.00
279_I283_T0.5851.00
92_F312_L0.5851.00
283_T296_D0.5851.00
103_G278_A0.5831.00
245_L248_M0.5801.00
248_M251_I0.5791.00
105_C109_F0.5791.00
76_G80_I0.5761.00
121_A134_V0.5741.00
73_V76_G0.5721.00
215_I218_A0.5711.00
203_A206_I0.5691.00
127_S131_H0.5671.00
108_I112_A0.5651.00
127_S132_T0.5651.00
227_S262_P0.5651.00
218_A221_V0.5631.00
324_V328_Y0.5621.00
103_G107_M0.5621.00
252_I257_R0.5621.00
5_I11_L0.5611.00
111_T115_I0.5611.00
279_I295_I0.5601.00
234_E238_R0.5581.00
95_R292_R0.5581.00
260_M264_V0.5571.00
102_L282_E0.5561.00
11_L14_P0.5561.00
220_I266_V0.5551.00
53_L58_L0.5551.00
260_M263_V0.5511.00
41_E44_I0.5501.00
246_T250_V0.5471.00
27_V306_V0.5471.00
24_F28_H0.5461.00
127_S130_D0.5451.00
124_K130_D0.5421.00
4_F322_L0.5421.00
231_V258_N0.5421.00
30_I90_E0.5411.00
306_V310_V0.5401.00
55_E85_R0.5381.00
124_K251_I0.5381.00
251_I255_A0.5381.00
123_V232_L0.5371.00
76_G87_P0.5351.00
228_M232_L0.5351.00
28_H307_Q0.5341.00
109_F210_I0.5331.00
145_I215_I0.5331.00
147_W211_V0.5321.00
322_L326_L0.5311.00
210_I214_T0.5291.00
53_L59_D0.5291.00
219_V223_M0.5291.00
152_L210_I0.5271.00
105_C213_G0.5271.00
304_P307_Q0.5241.00
134_V137_A0.5241.00
64_Q71_W0.5221.00
316_M320_V0.5211.00
237_I241_R0.5211.00
44_I48_R0.5211.00
96_F316_M0.5211.00
107_M111_T0.5211.00
216_P270_Q0.5211.00
226_S229_L0.5211.00
77_D89_W0.5141.00
236_Y240_A0.5141.00
143_M147_W0.5131.00
228_M256_L0.5121.00
214_T217_L0.5101.00
32_G76_G0.5101.00
122_A130_D0.5091.00
147_W150_M0.5081.00
9_L13_I0.5081.00
137_A140_G0.5061.00
26_F94_P0.5041.00
105_C205_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.6165 99.9 0.678 Contact Map
4tquM 1 0.7935 99.9 0.691 Contact Map
3rlfF 1 0.7876 99.9 0.698 Contact Map
4ymuD 2 0.6195 99.8 0.71 Contact Map
3d31C 2 0.7286 99.8 0.715 Contact Map
2onkC 2 0.6991 99.8 0.715 Contact Map
4tquN 1 0.7522 99.7 0.742 Contact Map
3rlfG 1 0.8171 99.7 0.752 Contact Map
2p02A 2 0.2566 7.6 0.965 Contact Map
1p7lA 4 0.2714 7.5 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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