GREMLIN Database
DNAC - DNA replication protein DnaC
UniProt: P0AEF0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10237
Length: 245 (208)
Sequences: 4744 (3524)
Seq/√Len: 244.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_C167_V4.4801.00
219_D235_S4.1521.00
120_C130_V3.6361.00
122_E125_L3.1761.00
135_V168_I3.0311.00
116_A201_L2.9241.00
122_E126_R2.8911.00
31_A34_K2.6021.00
128_K164_D2.5441.00
71_F118_A2.5411.00
191_R198_T2.5231.00
200_M221_M2.3171.00
88_A119_I2.2951.00
114_H118_A2.2921.00
85_L89_R2.2541.00
116_A199_G2.2291.00
50_A54_Q2.2071.00
192_S223_L2.0821.00
173_V216_R2.0081.00
234_D239_R2.0071.00
100_A227_L1.9941.00
84_A88_A1.9711.00
164_D196_R1.9671.00
116_A167_V1.9171.00
103_I202_T1.9071.00
158_N162_N1.9021.00
129_S164_D1.8821.00
44_L48_N1.8751.00
110_T231_F1.8671.00
131_L163_V1.8641.00
132_I201_L1.8461.00
133_I160_L1.8131.00
79_E82_M1.7731.00
94_E97_G1.7591.00
52_K56_T1.7431.00
137_D190_R1.6921.00
73_N114_H1.6811.00
139_M180_E1.6361.00
71_F92_V1.6341.00
26_G31_A1.6191.00
47_E51_M1.5961.00
152_S155_Q1.5881.00
62_I120_C1.5231.00
71_F91_Y1.5221.00
171_I200_M1.5141.00
26_G29_L1.5121.00
188_V198_T1.5121.00
87_K227_L1.4881.00
141_A160_L1.4871.00
92_V122_E1.4861.00
105_S202_T1.4671.00
166_L187_I1.4541.00
27_E30_L1.4501.00
134_T189_D1.4361.00
110_T233_W1.4041.00
25_T28_E1.3911.00
189_D193_S1.3561.00
104_F229_V1.3391.00
205_N208_E1.3031.00
30_L33_Q1.2971.00
26_G30_L1.2781.00
92_V123_L1.2771.00
74_Y115_L1.2751.00
123_L165_L1.2701.00
69_C114_H1.2671.00
161_S190_R1.2641.00
90_Q94_E1.2511.00
154_E158_N1.2461.00
46_R50_A1.2411.00
42_A46_R1.2371.00
57_F124_L1.2351.00
70_S125_L1.2291.00
97_G128_K1.2201.00
141_A156_L1.2161.00
119_I199_G1.2151.00
104_F231_F1.1881.00
57_F62_I1.1861.00
145_T153_E1.1831.00
74_Y114_H1.1541.00
50_A53_M1.1521.00
121_N125_L1.1451.00
124_L130_V1.1211.00
168_I184_I1.1111.00
26_G32_W1.0881.00
72_E122_E1.0881.00
90_Q93_E1.0841.00
53_M56_T1.0811.00
101_S224_G1.0801.00
208_E211_K1.0791.00
26_G33_Q1.0761.00
170_E201_L1.0691.00
163_V166_L1.0681.00
89_R93_E1.0651.00
47_E50_A1.0651.00
51_M54_Q1.0641.00
133_I141_A1.0621.00
129_S163_V1.0591.00
29_L34_K1.0481.00
130_V167_V1.0451.00
145_T156_L1.0351.00
135_V171_I1.0341.00
29_L32_W1.0281.00
84_A115_L1.0121.00
101_S197_P0.9921.00
146_F183_I0.9881.00
131_L159_D0.9771.00
35_E39_I0.9731.00
165_L197_P0.9701.00
91_Y95_F0.9701.00
107_K110_T0.9691.00
160_L163_V0.9691.00
204_S208_E0.9641.00
38_A42_A0.9581.00
40_R44_L0.9571.00
42_A45_E0.9531.00
185_N189_D0.9391.00
114_H236_Y0.9261.00
55_R59_R0.9221.00
146_F179_Y0.9221.00
75_R236_Y0.9181.00
157_L183_I0.9051.00
134_T137_D0.9031.00
177_S180_E0.8981.00
28_E31_A0.8971.00
143_K177_S0.8941.00
156_L159_D0.8871.00
144_D154_E0.8730.99
30_L34_K0.8710.99
108_P219_D0.8700.99
172_G203_N0.8620.99
54_Q58_N0.8620.99
25_T29_L0.8570.99
94_E98_N0.8440.99
141_A159_D0.8420.99
144_D150_G0.8390.99
134_T185_N0.8320.99
96_D165_L0.8310.99
132_I167_V0.8300.99
76_V85_L0.8210.99
27_E34_K0.8200.99
133_I138_I0.8160.99
81_Q231_F0.8150.99
206_M228_W0.8130.99
138_I187_I0.8120.99
234_D238_S0.8030.99
27_E31_A0.8020.99
62_I117_A0.7960.99
53_M125_L0.7950.99
93_E122_E0.7920.99
105_S228_W0.7920.99
102_F119_I0.7910.99
123_L128_K0.7900.99
27_E32_W0.7870.99
117_A121_N0.7860.99
43_A47_E0.7850.99
41_S44_L0.7830.99
171_I184_I0.7820.99
146_F153_E0.7810.99
82_M86_S0.7790.99
178_K182_V0.7760.99
38_A41_S0.7760.99
56_T128_K0.7710.99
147_R151_T0.7680.99
39_I43_A0.7670.99
236_Y240_V0.7570.98
33_Q46_R0.7560.98
142_M156_L0.7530.98
86_S90_Q0.7520.98
167_V201_L0.7510.98
84_A229_V0.7500.98
142_M153_E0.7430.98
38_A47_E0.7420.98
236_Y239_R0.7370.98
29_L33_Q0.7320.98
191_R196_R0.7290.98
69_C117_A0.7290.98
28_E32_W0.7260.98
117_A132_I0.7260.98
143_K147_R0.7260.98
69_C113_N0.7220.98
91_Y102_F0.7180.98
83_N90_Q0.7180.98
170_E173_V0.7160.98
34_K38_A0.7140.98
37_G40_R0.7120.98
74_Y85_L0.7080.98
71_F119_I0.7070.98
174_Q213_L0.7050.98
108_P210_T0.7040.98
165_L199_G0.7030.98
48_N55_R0.6970.97
82_M90_Q0.6960.97
93_E96_D0.6960.97
218_M222_R0.6930.97
33_Q36_Q0.6910.97
49_R52_K0.6860.97
75_R78_C0.6850.97
26_G36_Q0.6820.97
136_A186_Q0.6810.97
87_K90_Q0.6800.97
56_T129_S0.6770.97
182_V186_Q0.6770.97
70_S121_N0.6760.97
39_I42_A0.6650.97
113_N132_I0.6610.96
140_S144_D0.6600.96
93_E126_R0.6570.96
91_Y197_P0.6530.96
61_G131_L0.6510.96
70_S118_A0.6510.96
137_D161_S0.6500.96
181_K214_G0.6500.96
105_S206_M0.6500.96
36_Q39_I0.6480.96
203_N216_R0.6470.96
139_M179_Y0.6460.96
136_A140_S0.6440.96
134_T186_Q0.6420.96
176_E180_E0.6400.96
209_M218_M0.6400.96
120_C124_L0.6390.96
83_N87_K0.6380.96
139_M143_K0.6370.96
25_T32_W0.6350.96
170_E220_R0.6330.95
49_R53_M0.6320.95
233_W237_R0.6320.95
88_A102_F0.6300.95
135_V139_M0.6270.95
116_A165_L0.6260.95
51_M55_R0.6230.95
138_I160_L0.6230.95
173_V221_M0.6210.95
136_A187_I0.6210.95
104_F115_L0.6160.95
26_G39_I0.6090.94
80_G232_N0.6090.94
143_K146_F0.6070.94
115_L231_F0.6070.94
203_N237_R0.6060.94
222_R228_W0.6010.94
143_K180_E0.5990.94
29_L36_Q0.5970.94
36_Q40_R0.5960.94
44_L47_E0.5960.94
222_R238_S0.5950.94
78_C81_Q0.5930.94
145_T150_G0.5890.93
142_M187_I0.5880.93
210_T218_M0.5870.93
83_N86_S0.5820.93
48_N51_M0.5800.93
102_F199_G0.5790.93
95_F102_F0.5780.93
26_G34_K0.5750.93
102_F165_L0.5710.92
70_S73_N0.5700.92
57_F125_L0.5700.92
88_A91_Y0.5690.92
27_E33_Q0.5680.92
43_A46_R0.5670.92
170_E174_Q0.5670.92
101_S198_T0.5670.92
28_E33_Q0.5650.92
140_S143_K0.5640.92
161_S186_Q0.5630.92
140_S186_Q0.5630.92
57_F121_N0.5610.92
157_L161_S0.5590.92
89_R94_E0.5590.92
204_S212_L0.5550.91
25_T38_A0.5540.91
55_R58_N0.5540.91
163_V187_I0.5540.91
28_E34_K0.5480.91
89_R92_V0.5470.91
167_V199_G0.5470.91
68_N195_K0.5420.90
63_R117_A0.5410.90
163_V191_R0.5410.90
41_S45_E0.5380.90
56_T127_G0.5360.90
176_E213_L0.5340.90
32_W35_E0.5330.90
192_S213_L0.5280.89
35_E43_A0.5260.89
135_V180_E0.5220.89
97_G126_R0.5210.88
190_R193_S0.5210.88
175_T178_K0.5200.88
135_V184_I0.5200.88
174_Q182_V0.5170.88
153_E183_I0.5160.88
29_L35_E0.5160.88
133_I137_D0.5160.88
42_A47_E0.5160.88
171_I202_T0.5150.88
74_Y81_Q0.5150.88
92_V119_I0.5150.88
142_M183_I0.5140.88
140_S183_I0.5130.88
64_P117_A0.5110.88
130_V164_D0.5100.87
172_G202_T0.5090.87
103_I221_M0.5070.87
56_T59_R0.5060.87
63_R189_D0.5050.87
56_T60_S0.5040.87
117_A120_C0.5040.87
72_E75_R0.5020.87
80_G84_A0.5010.86
171_I174_Q0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m4wJ 3 0.902 100 0.41 Contact Map
2qgzA 1 0.7224 100 0.413 Contact Map
2w58A 2 0.7469 100 0.476 Contact Map
3ec2A 1 0.6816 100 0.512 Contact Map
1l8qA 1 0.7184 99.9 0.584 Contact Map
2z4sA 1 0.7184 99.9 0.599 Contact Map
2vhjA 3 0.9184 99.9 0.613 Contact Map
3bosA 2 0.702 99.9 0.623 Contact Map
2kjqA 1 0.6 99.7 0.689 Contact Map
4blqA 3 0.9306 99.7 0.701 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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