GREMLIN Database
DMA - DNA adenine methylase
UniProt: P0AEE8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10204
Length: 278 (250)
Sequences: 3320 (2717)
Seq/√Len: 171.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_Y226_S5.0221.00
166_A208_H4.2331.00
229_D234_R3.1441.00
69_R72_E2.8521.00
177_V224_L2.8211.00
36_V39_G2.7001.00
30_C51_I2.6631.00
70_T148_L2.5571.00
202_T205_Q2.4581.00
51_I161_Y2.4331.00
36_V52_L2.4061.00
24_H243_H2.3241.00
214_E240_A2.2851.00
213_A225_I2.2681.00
22_K44_N2.1441.00
64_N67_K2.1151.00
214_E239_R2.0641.00
164_S208_H2.0571.00
71_D149_Y2.0351.00
47_F50_Y2.0241.00
7_F62_L2.0051.00
42_F52_L1.9871.00
42_F158_A1.9841.00
20_D23_R1.9671.00
52_L160_F1.9661.00
213_A223_V1.9031.00
21_I265_L1.8791.00
224_L267_L1.8561.00
53_A161_Y1.8541.00
76_A106_R1.8411.00
21_I41_V1.8321.00
224_L265_L1.8281.00
210_A214_E1.8091.00
243_H267_L1.8071.00
32_V176_S1.7741.00
205_Q208_H1.7691.00
32_V51_I1.7641.00
53_A168_S1.7471.00
241_K267_L1.7161.00
30_C49_R1.7111.00
185_A232_L1.6951.00
30_C176_S1.6921.00
58_D107_R1.6911.00
173_D176_S1.6731.00
64_N68_M1.6701.00
163_E167_D1.6591.00
80_L90_V1.6511.00
204_E207_A1.6241.00
76_A109_V1.6181.00
210_A237_Y1.6111.00
13_G38_A1.6081.00
246_K262_D1.5971.00
94_F110_L1.5631.00
90_V93_Q1.5561.00
53_A162_C1.5451.00
103_D106_R1.5411.00
170_A212_I1.4761.00
248_R260_K1.4711.00
72_E76_A1.4711.00
163_E171_R1.4701.00
185_A230_T1.4691.00
163_E168_S1.4541.00
53_A163_E1.4381.00
229_D244_V1.4311.00
58_D110_L1.4181.00
216_L221_I1.4061.00
206_Q237_Y1.4041.00
244_V262_D1.4021.00
51_I159_F1.3941.00
185_A203_L1.3671.00
88_A92_Y1.3601.00
62_L66_V1.3391.00
43_L151_F1.3071.00
31_L45_T1.3001.00
7_F66_V1.2961.00
180_C213_A1.2961.00
29_E175_A1.2941.00
57_S162_C1.2911.00
167_D170_A1.2851.00
133_V136_G1.2791.00
70_T152_A1.2741.00
31_L42_F1.2691.00
246_K260_K1.2691.00
178_V216_L1.2631.00
169_M216_L1.2581.00
18_L44_N1.2421.00
31_L177_V1.2391.00
64_N104_P1.2391.00
178_V221_I1.2341.00
36_V42_F1.2261.00
216_L223_V1.2181.00
203_L207_A1.2051.00
34_P180_C1.1981.00
161_Y168_S1.1961.00
71_D75_Q1.1891.00
138_Y141_P1.1781.00
61_S104_P1.1721.00
32_V168_S1.1701.00
229_D262_D1.1691.00
20_D24_H1.1551.00
92_Y95_R1.1541.00
126_N129_G1.1481.00
49_R159_F1.1461.00
234_R244_V1.1381.00
73_Y105_F1.1361.00
65_I108_A1.1321.00
25_L177_V1.1291.00
97_E106_R1.1241.00
78_R145_E1.1221.00
62_L112_L1.1051.00
32_V172_A1.1031.00
242_L266_A1.0921.00
65_I73_Y1.0911.00
211_E214_E1.0851.00
203_L232_L1.0851.00
75_Q78_R1.0791.00
60_I160_F1.0751.00
73_Y77_A1.0711.00
60_I162_C1.0681.00
207_A211_E1.0651.00
116_R121_G1.0641.00
65_I105_F1.0621.00
32_V178_V1.0530.99
74_V149_Y1.0530.99
25_L224_L1.0460.99
75_Q79_E1.0370.99
18_L41_V1.0360.99
169_M180_C1.0350.99
227_N233_T1.0280.99
11_A251_I1.0240.99
76_A105_F1.0230.99
165_Y208_H1.0160.99
132_N136_G1.0100.99
166_A212_I1.0100.99
98_F110_L0.9880.99
78_R146_A0.9810.99
225_I266_A0.9670.99
172_A221_I0.9630.99
129_G132_N0.9370.99
73_Y76_A0.9340.99
230_T233_T0.9270.99
230_T234_R0.9180.99
96_E100_K0.9180.99
99_N110_L0.9100.99
17_L245_V0.9070.98
39_G42_F0.9050.98
5_R15_Y0.9050.98
8_L111_F0.9050.98
118_G131_F0.9010.98
126_N131_F0.9010.98
208_H212_I0.8950.98
70_T149_Y0.8930.98
29_E49_R0.8920.98
9_K122_L0.8870.98
61_S65_I0.8860.98
88_A137_R0.8840.98
166_A215_G0.8830.98
73_Y112_L0.8830.98
165_Y209_L0.8820.98
66_V148_L0.8780.98
231_M235_E0.8750.98
61_S108_A0.8750.98
88_A91_Y0.8740.98
59_L111_F0.8710.98
72_E105_F0.8670.98
142_Y145_E0.8660.98
180_C216_L0.8630.98
234_R238_Q0.8630.98
93_Q97_E0.8600.98
39_G63_Y0.8600.98
126_N130_E0.8590.98
90_V94_F0.8590.98
132_N135_F0.8570.98
57_S61_S0.8550.98
39_G52_L0.8510.98
28_G45_T0.8490.98
24_H267_L0.8420.98
172_A178_V0.8410.98
77_A81_F0.8400.98
169_M178_V0.8300.97
234_R242_L0.8270.97
8_L38_A0.8230.97
10_W111_F0.8200.97
52_L63_Y0.8180.97
105_F109_V0.8160.97
66_V73_Y0.8110.97
227_N264_L0.8090.97
55_I164_S0.8050.97
226_S263_E0.8010.97
18_L40_S0.7990.97
232_L235_E0.7970.97
106_R110_L0.7960.97
40_S43_L0.7950.97
29_E176_S0.7840.96
245_V265_L0.7800.96
113_Y117_Y0.7790.96
155_A158_A0.7790.96
252_S257_T0.7750.96
254_N257_T0.7740.96
168_S172_A0.7730.96
98_F102_Q0.7720.96
76_A80_L0.7710.96
60_I64_N0.7680.96
65_I69_R0.7660.96
62_L111_F0.7650.96
42_F50_Y0.7640.96
32_V173_D0.7620.96
51_I168_S0.7590.96
207_A236_W0.7570.95
43_L63_Y0.7560.95
97_E110_L0.7530.95
48_S157_N0.7520.95
185_A233_T0.7510.95
6_A40_S0.7500.95
92_Y96_E0.7480.95
206_Q209_L0.7430.95
169_M213_A0.7410.95
5_R147_E0.7410.95
185_A206_Q0.7410.95
16_P248_R0.7380.95
165_Y201_F0.7340.95
56_N199_N0.7330.95
33_E42_F0.7320.95
102_Q167_D0.7320.95
104_P107_R0.7320.95
127_L130_E0.7310.94
231_M234_R0.7290.94
72_E75_Q0.7280.94
233_T266_A0.7250.94
20_D245_V0.7230.94
24_H265_L0.7210.94
87_C90_V0.7200.94
29_E48_S0.7130.94
147_E151_F0.7120.94
39_G43_L0.7090.94
18_L22_K0.7080.94
214_E217_V0.7080.94
212_I215_G0.7050.93
18_L23_R0.7040.93
178_V223_V0.7030.93
9_K40_S0.6970.93
66_V152_A0.6960.93
94_F97_E0.6920.93
49_R157_N0.6910.93
207_A235_E0.6890.93
107_R110_L0.6840.92
229_D264_L0.6840.92
149_Y153_E0.6830.92
151_F154_K0.6830.92
209_L225_I0.6810.92
49_R173_D0.6800.92
92_Y131_F0.6720.92
25_L45_T0.6700.92
206_Q227_N0.6690.91
161_Y171_R0.6670.91
254_N258_R0.6640.91
143_F147_E0.6600.91
179_Y263_E0.6600.91
69_R105_F0.6590.91
207_A210_A0.6540.91
117_Y138_Y0.6540.91
76_A79_E0.6510.90
207_A232_L0.6510.90
89_E92_Y0.6510.90
155_A160_F0.6470.90
17_L263_E0.6470.90
126_N132_N0.6470.90
180_C225_I0.6450.90
176_S221_I0.6420.90
229_D242_L0.6370.89
52_L60_I0.6330.89
8_L115_N0.6300.89
125_Y129_G0.6300.89
227_N266_A0.6290.89
61_S107_R0.6270.89
9_K115_N0.6210.88
67_K155_A0.6160.88
22_K46_D0.6150.88
46_D50_Y0.6140.88
167_D171_R0.6140.88
172_A212_I0.6130.88
233_T247_V0.6110.87
235_E238_Q0.6090.87
240_A266_A0.6080.87
22_K26_P0.6080.87
10_W59_L0.6070.87
97_E100_K0.6070.87
201_F209_L0.6050.87
174_D222_P0.6000.86
96_E130_E0.5980.86
56_N197_H0.5960.86
59_L63_Y0.5950.86
151_F155_A0.5950.86
252_S255_G0.5940.86
52_L158_A0.5940.86
141_P145_E0.5920.86
247_V261_V0.5910.86
233_T237_Y0.5910.86
213_A240_A0.5900.85
203_L236_W0.5900.85
86_N113_Y0.5870.85
56_N59_L0.5850.85
64_N69_R0.5850.85
204_E208_H0.5840.85
115_N121_G0.5840.85
115_N122_L0.5770.84
206_Q233_T0.5750.84
11_A115_N0.5750.84
245_V248_R0.5750.84
58_D98_F0.5740.84
142_Y150_H0.5730.84
14_K181_D0.5720.84
161_Y172_A0.5720.84
144_P151_F0.5710.84
36_V60_I0.5700.83
17_L179_Y0.5700.83
210_A236_W0.5690.83
226_S265_L0.5660.83
181_D184_Y0.5650.83
146_A149_Y0.5650.83
8_L62_L0.5650.83
67_K160_F0.5640.83
180_C209_L0.5630.83
97_E102_Q0.5630.83
87_C113_Y0.5610.83
16_P249_R0.5600.82
102_Q110_L0.5590.82
99_N111_F0.5580.82
128_R131_F0.5580.82
27_K174_D0.5570.82
9_K138_Y0.5540.82
89_E93_Q0.5530.82
27_K49_R0.5530.82
201_F204_E0.5520.81
88_A161_Y0.5490.81
77_A112_L0.5490.81
28_G222_P0.5470.81
166_A205_Q0.5450.81
15_Y18_L0.5410.80
35_F54_D0.5410.80
60_I63_Y0.5400.80
15_Y44_N0.5390.80
137_R141_P0.5380.80
45_T50_Y0.5360.80
14_K184_Y0.5340.79
80_L110_L0.5330.79
169_M172_A0.5330.79
142_Y146_A0.5260.78
173_D221_I0.5260.78
152_A155_A0.5250.78
9_K141_P0.5250.78
166_A170_A0.5250.78
192_N196_Y0.5230.78
33_E52_L0.5190.77
20_D265_L0.5190.77
208_H211_E0.5160.77
150_H153_E0.5160.77
22_K45_T0.5150.77
104_P235_E0.5130.77
35_F201_F0.5120.76
9_K121_G0.5120.76
195_A200_S0.5120.76
33_E63_Y0.5110.76
31_L47_F0.5090.76
6_A15_Y0.5080.76
19_D23_R0.5080.76
54_D181_D0.5070.76
25_L44_N0.5070.76
154_K158_A0.5070.76
30_C159_F0.5050.76
12_G181_D0.5050.76
80_L109_V0.5020.75
8_L116_R0.5020.75
116_R122_L0.5010.75
31_L34_P0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2g1pA 1 0.8777 100 0.101 Contact Map
2dpmA 1 0.8957 100 0.121 Contact Map
1yf3A 1 0.9029 100 0.188 Contact Map
3tmaA 2 0.6043 97.4 0.882 Contact Map
4bluA 2 0.6259 97.2 0.886 Contact Map
2oo3A 1 0.6367 97.2 0.887 Contact Map
4onqA 1 0.4532 96.1 0.9 Contact Map
3tm4A 1 0.6115 96.1 0.9 Contact Map
3ll7A 1 0.6403 96.1 0.901 Contact Map
1g60A 2 0.4388 96 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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