GREMLIN Database
DGAL - D-galactose-binding periplasmic protein
UniProt: P0AEE5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10593
Length: 332 (284)
Sequences: 38555 (28996)
Seq/√Len: 1720.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_K187_K3.4991.00
163_Q228_E3.3701.00
85_A292_A2.7921.00
142_Q256_F2.6711.00
182_T186_I2.6191.00
260_A278_L2.5901.00
129_Y295_L2.5481.00
163_Q254_P2.4771.00
50_D53_A2.3131.00
140_I191_D2.2931.00
212_K247_A2.2911.00
216_D248_H2.2471.00
140_I187_K2.1791.00
50_D290_D2.1621.00
144_D188_E2.1371.00
140_I188_E2.1311.00
137_E141_I2.1011.00
287_A290_D2.0881.00
216_D244_A2.0701.00
51_A289_F2.0431.00
136_K183_T2.0181.00
146_I229_V1.9961.00
138_S258_V1.9881.00
294_N299_K1.9561.00
139_G143_G1.9541.00
165_Q197_E1.9411.00
50_D286_K1.9341.00
46_A285_A1.9231.00
144_D148_K1.9101.00
147_A192_K1.9091.00
211_A240_G1.8801.00
149_H326_L1.8331.00
29_G83_V1.8081.00
144_D192_K1.7991.00
49_Q282_N1.7931.00
220_S248_H1.7931.00
139_G231_I1.7741.00
245_L253_I1.7671.00
143_G185_V1.7491.00
278_L319_V1.7461.00
167_V227_I1.7401.00
140_I144_D1.7381.00
232_A241_A1.7121.00
168_L233_N1.6871.00
212_K244_A1.6711.00
215_M241_A1.6661.00
280_D283_N1.6611.00
113_F288_T1.6481.00
183_T187_K1.6401.00
165_Q226_K1.6311.00
145_L149_H1.6201.00
46_A282_N1.6181.00
137_E140_I1.6081.00
246_K270_S1.6051.00
244_A248_H1.5691.00
145_L148_K1.5691.00
141_I318_Y1.5611.00
287_A314_V1.5581.00
147_A188_E1.5461.00
16_L19_A1.5391.00
202_D217_A1.5021.00
293_K297_D1.5011.00
180_A183_T1.4991.00
186_I190_N1.4921.00
272_A324_D1.4871.00
50_D55_P1.4771.00
283_N287_A1.4591.00
134_D137_E1.4561.00
205_M210_Q1.4541.00
212_K243_E1.4521.00
244_A247_A1.4211.00
26_T84_K1.4171.00
55_P293_K1.4161.00
283_N286_K1.4091.00
50_D289_F1.4031.00
29_G78_L1.3911.00
165_Q228_E1.3881.00
143_G147_A1.3761.00
101_E105_G1.3711.00
167_V218_W1.3661.00
139_G184_Y1.3551.00
145_L322_D1.3501.00
138_S318_Y1.3401.00
216_D247_A1.3381.00
76_D102_K1.3341.00
212_K216_D1.3251.00
143_G184_Y1.3191.00
136_K140_I1.3021.00
215_M245_L1.3011.00
26_T57_V1.2961.00
290_D294_N1.2931.00
51_A59_L1.2891.00
163_Q229_V1.2841.00
143_G188_E1.2801.00
87_A288_T1.2801.00
62_N74_Q1.2761.00
184_Y188_E1.2721.00
260_A323_K1.2711.00
215_M230_V1.2631.00
246_K272_A1.2631.00
216_D220_S1.2561.00
188_E191_D1.2461.00
141_I144_D1.2441.00
27_R58_Q1.2441.00
164_I228_E1.2251.00
48_E52_K1.2241.00
47_I289_F1.2201.00
62_N78_L1.2181.00
197_E200_Q1.2111.00
28_I51_A1.2031.00
30_V47_I1.1961.00
282_N286_K1.1841.00
209_A213_D1.1711.00
27_R60_L1.1711.00
185_V189_L1.1701.00
242_V255_V1.1531.00
240_G244_A1.1461.00
136_K184_Y1.1451.00
217_A221_G1.1411.00
207_D210_Q1.1391.00
148_K192_K1.1371.00
168_L182_T1.1261.00
136_K180_A1.1181.00
224_A227_I1.1161.00
185_V231_I1.0981.00
144_D191_D1.0951.00
256_F274_A1.0931.00
179_E183_T1.0831.00
169_L241_A1.0811.00
254_P326_L1.0781.00
230_V241_A1.0761.00
291_L314_V1.0721.00
187_K191_D1.0711.00
30_V59_L1.0631.00
149_H254_P1.0621.00
142_Q231_I1.0571.00
213_D217_A1.0561.00
235_D276_T1.0551.00
72_N76_D1.0531.00
221_G224_A1.0511.00
214_K217_A1.0511.00
15_M18_G1.0481.00
47_I87_A1.0481.00
232_A237_M1.0471.00
210_Q213_D1.0441.00
166_F189_L1.0431.00
52_K70_K1.0421.00
287_A291_L1.0421.00
44_R48_E1.0381.00
55_P290_D1.0361.00
70_K73_D1.0351.00
208_T243_E1.0321.00
183_T186_I1.0311.00
11_V14_S1.0291.00
235_D257_G1.0211.00
165_Q225_N1.0181.00
149_H322_D1.0171.00
285_A289_F1.0141.00
211_A215_M1.0141.00
286_K290_D1.0131.00
67_D70_K1.0101.00
76_D80_A0.9961.00
55_P297_D0.9931.00
53_A286_K0.9811.00
137_E317_P0.9811.00
171_G206_W0.9801.00
292_A296_A0.9791.00
145_L326_L0.9791.00
57_V293_K0.9781.00
45_K49_Q0.9771.00
202_D214_K0.9761.00
215_M219_L0.9661.00
173_P203_T0.9621.00
188_E192_K0.9601.00
232_A238_A0.9591.00
142_Q277_V0.9521.00
143_G189_L0.9511.00
176_P180_A0.9451.00
39_F281_A0.9311.00
242_V269_K0.9301.00
97_G101_E0.9291.00
166_F229_V0.9281.00
319_V322_D0.9241.00
287_A316_V0.9161.00
129_Y291_L0.9141.00
28_I87_A0.9121.00
235_D260_A0.9081.00
147_A194_I0.9081.00
189_L194_I0.9011.00
134_D315_R0.8891.00
174_G179_E0.8861.00
47_I285_A0.8831.00
87_A292_A0.8821.00
49_Q286_K0.8811.00
49_Q53_A0.8801.00
213_D216_D0.8771.00
219_L244_A0.8771.00
133_T280_D0.8761.00
200_Q221_G0.8751.00
27_R81_K0.8721.00
149_H163_Q0.8701.00
85_A296_A0.8571.00
14_S17_F0.8551.00
230_V253_I0.8541.00
133_T279_N0.8531.00
280_D319_V0.8511.00
43_V113_F0.8511.00
245_L255_V0.8451.00
210_Q214_K0.8451.00
13_A18_G0.8441.00
204_A237_M0.8411.00
187_K190_N0.8391.00
238_A257_G0.8391.00
47_I59_L0.8341.00
243_E246_K0.8331.00
31_T74_Q0.8291.00
130_Y313_V0.8281.00
186_I196_T0.8251.00
70_K74_Q0.8221.00
167_V230_V0.8221.00
30_V44_R0.8191.00
12_M80_A0.8171.00
102_K105_G0.8151.00
257_G276_T0.8121.00
131_V291_L0.8121.00
291_L294_N0.8121.00
147_A164_I0.8071.00
196_T199_L0.8041.00
135_S181_R0.8041.00
170_K182_T0.8031.00
60_L81_K0.7971.00
289_F293_K0.7941.00
25_D84_K0.7911.00
164_I194_I0.7901.00
44_R61_M0.7891.00
280_D316_V0.7871.00
146_I256_F0.7861.00
73_D76_D0.7841.00
116_E313_V0.7821.00
259_D279_N0.7771.00
60_L83_V0.7771.00
219_L248_H0.7761.00
168_L231_I0.7751.00
46_A286_K0.7731.00
33_Y40_M0.7681.00
132_G313_V0.7671.00
45_K48_E0.7671.00
215_M218_W0.7651.00
14_S20_A0.7631.00
215_M244_A0.7571.00
278_L321_V0.7561.00
65_Q70_K0.7531.00
133_T318_Y0.7531.00
85_A111_V0.7491.00
103_A110_V0.7471.00
137_E318_Y0.7461.00
186_I201_L0.7451.00
42_V282_N0.7441.00
180_A184_Y0.7421.00
145_L274_A0.7421.00
235_D238_A0.7401.00
132_G315_R0.7391.00
10_A13_A0.7381.00
169_L232_A0.7371.00
266_A270_S0.7371.00
104_R128_A0.7361.00
165_Q200_Q0.7351.00
140_I184_Y0.7351.00
145_L320_G0.7341.00
217_A220_S0.7271.00
25_D58_Q0.7251.00
260_A321_V0.7221.00
234_N259_D0.7201.00
267_L272_A0.7191.00
178_A206_W0.7151.00
87_A113_F0.7151.00
134_D317_P0.7141.00
99_V102_K0.7121.00
29_G86_L0.7121.00
182_T201_L0.7101.00
69_S73_D0.7091.00
24_A84_K0.7051.00
189_L196_T0.6991.00
198_Q201_L0.6971.00
101_E104_R0.6961.00
111_V295_L0.6951.00
221_G227_I0.6931.00
46_A50_D0.6911.00
204_A210_Q0.6911.00
24_A297_D0.6901.00
112_F117_P0.6891.00
72_N99_V0.6861.00
79_L106_Q0.6861.00
260_A266_A0.6841.00
147_A193_G0.6831.00
8_L11_V0.6821.00
28_I289_F0.6781.00
75_I86_L0.6771.00
202_D221_G0.6771.00
202_D218_W0.6751.00
206_W233_N0.6731.00
221_G225_N0.6711.00
243_E272_A0.6701.00
37_D236_A0.6701.00
19_A22_H0.6701.00
114_N177_D0.6671.00
48_E59_L0.6661.00
79_L108_V0.6631.00
211_A214_K0.6631.00
141_I277_V0.6621.00
231_I256_F0.6601.00
85_A288_T0.6581.00
322_D326_L0.6571.00
168_L185_V0.6541.00
114_N135_S0.6471.00
298_G301_A0.6461.00
294_N298_G0.6441.00
221_G226_K0.6411.00
147_A189_L0.6411.00
167_V200_Q0.6401.00
266_A269_K0.6351.00
28_I85_A0.6341.00
243_E247_A0.6341.00
12_M76_D0.6281.00
234_N237_M0.6281.00
239_M269_K0.6241.00
242_V246_K0.6221.00
199_L202_D0.6221.00
171_G178_A0.6201.00
68_Q72_N0.6191.00
111_V131_V0.6171.00
146_I231_I0.6171.00
12_M16_L0.6161.00
186_I198_Q0.6151.00
112_F130_Y0.6131.00
28_I296_A0.6121.00
98_T101_E0.6101.00
245_L248_H0.6101.00
40_M89_N0.6061.00
12_M15_M0.6051.00
228_E254_P0.6051.00
104_R110_V0.6021.00
46_A281_A0.6011.00
235_D261_L0.6001.00
163_Q195_K0.5981.00
215_M240_G0.5971.00
181_R279_N0.5941.00
231_I258_V0.5911.00
142_Q229_V0.5911.00
57_V84_K0.5881.00
42_V281_A0.5861.00
39_F43_V0.5841.00
206_W237_M0.5811.00
258_V279_N0.5801.00
43_V281_A0.5791.00
51_A57_V0.5771.00
238_A273_L0.5751.00
166_F228_E0.5741.00
45_K65_Q0.5741.00
86_L108_V0.5731.00
282_N285_A0.5721.00
209_A212_K0.5721.00
111_V292_A0.5671.00
45_K282_N0.5661.00
214_K218_W0.5661.00
243_E270_S0.5641.00
135_S180_A0.5621.00
208_T240_G0.5621.00
73_D77_V0.5601.00
102_K106_Q0.5591.00
232_A257_G0.5581.00
18_G22_H0.5581.00
165_Q227_I0.5571.00
74_Q77_V0.5571.00
135_S177_D0.5571.00
165_Q224_A0.5561.00
114_N284_Q0.5561.00
116_E130_Y0.5551.00
11_V17_F0.5551.00
243_E267_L0.5541.00
62_N77_V0.5511.00
27_R84_K0.5511.00
27_R83_V0.5511.00
57_V296_A0.5511.00
239_M261_L0.5481.00
28_I57_V0.5481.00
141_I145_L0.5451.00
145_L256_F0.5451.00
132_G135_S0.5441.00
78_L83_V0.5441.00
178_A233_N0.5431.00
26_T296_A0.5431.00
229_V254_P0.5421.00
111_V291_L0.5411.00
238_A255_V0.5391.00
166_F185_V0.5381.00
120_K128_A0.5371.00
291_L295_L0.5351.00
196_T201_L0.5341.00
212_K215_M0.5291.00
140_I143_G0.5291.00
104_R121_A0.5281.00
315_R318_Y0.5251.00
272_A323_K0.5231.00
295_L298_G0.5221.00
72_N102_K0.5221.00
111_V288_T0.5221.00
241_A245_L0.5201.00
212_K240_G0.5201.00
77_V80_A0.5191.00
48_E63_D0.5181.00
17_F20_A0.5161.00
112_F128_A0.5161.00
284_Q316_V0.5161.00
38_N236_A0.5161.00
51_A293_K0.5151.00
26_T297_D0.5111.00
181_R259_D0.5101.00
110_V128_A0.5081.00
64_S71_Q0.5061.00
85_A109_P0.5061.00
208_T236_A0.5041.00
77_V81_K0.5011.00
198_Q202_D0.5011.00
169_L214_K0.5001.00
164_I229_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hsgA 1 0.8735 100 0.221 Contact Map
2iksA 2 0.8223 100 0.224 Contact Map
3huuA 2 0.7922 100 0.225 Contact Map
3brqA 2 0.8193 100 0.228 Contact Map
3dbiA 2 0.8253 100 0.239 Contact Map
4wt7A 1 0.8524 100 0.241 Contact Map
1qpzA 2 0.9006 100 0.241 Contact Map
2o20A 2 0.8193 100 0.243 Contact Map
3e3mA 2 0.7982 100 0.244 Contact Map
3h5oA 2 0.8042 100 0.245 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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