GREMLIN Database
DEGS - Serine endoprotease DegS
UniProt: P0AEE3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11652
Length: 355 (310)
Sequences: 8981 (6107)
Seq/√Len: 346.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
207_N211_E5.8071.00
52_R150_H4.6401.00
306_S334_V4.2151.00
335_V344_L3.8881.00
145_A239_Q3.7601.00
308_D325_I3.4161.00
95_K121_S3.2081.00
142_P211_E3.1201.00
141_I212_L2.9351.00
330_V345_Q2.8651.00
145_A148_V2.8061.00
332_P343_T2.7201.00
334_V341_Q2.7171.00
116_A130_L2.6481.00
104_I118_L2.6301.00
57_A140_T2.5891.00
147_R239_Q2.5701.00
117_L133_N2.3691.00
83_V215_I2.3281.00
129_V249_I2.2761.00
332_P345_Q2.2391.00
196_I233_G2.1681.00
335_V342_L2.1261.00
114_F132_I2.1141.00
83_V204_A2.0781.00
306_S309_N2.0551.00
83_V212_L2.0351.00
48_N153_D2.0141.00
305_I336_M1.9901.00
173_I190_L1.9871.00
105_I113_V1.9871.00
92_I241_A1.9871.00
143_I238_F1.9791.00
127_L215_I1.9681.00
51_V168_I1.9611.00
83_V141_I1.9471.00
103_Q115_E1.9441.00
306_S311_P1.9031.00
143_I242_T1.8991.00
330_V347_T1.8671.00
259_I346_V1.8621.00
313_I317_E1.8411.00
290_D294_A1.8391.00
334_V343_T1.7801.00
64_R103_Q1.7621.00
298_I335_V1.7301.00
141_I206_V1.7271.00
298_I333_V1.7221.00
154_V170_Q1.6851.00
302_D337_R1.6841.00
92_I245_M1.6701.00
326_R329_S1.6651.00
247_K251_D1.6641.00
251_D255_I1.6511.00
204_A212_L1.6431.00
263_G315_A1.6421.00
262_G286_E1.6091.00
48_N150_H1.5851.00
258_Y292_P1.5771.00
305_I341_Q1.5741.00
84_I138_L1.5731.00
54_A206_V1.5681.00
246_D250_R1.5531.00
325_I348_I1.5371.00
54_A141_I1.5321.00
117_L131_K1.5231.00
255_I350_E1.5191.00
149_P213_M1.4981.00
105_I115_E1.4921.00
265_E315_A1.4881.00
253_R350_E1.4821.00
108_L114_F1.4801.00
84_I108_L1.4761.00
295_N349_Q1.4561.00
305_I334_V1.4521.00
314_S317_E1.4431.00
47_Y154_V1.4371.00
134_A138_L1.4361.00
325_I329_S1.4291.00
90_Y131_K1.4101.00
337_R342_L1.4101.00
90_Y119_V1.4081.00
90_Y249_I1.3711.00
215_I241_A1.3681.00
284_V298_I1.3611.00
82_G91_I1.3611.00
146_R239_Q1.3571.00
242_T246_D1.3471.00
310_K321_Q1.3421.00
46_S153_D1.3141.00
307_V325_I1.3051.00
86_D90_Y1.3031.00
50_A206_V1.3021.00
257_G327_P1.3021.00
63_N104_I1.2941.00
62_Y107_A1.2921.00
120_G248_L1.2751.00
96_H126_D1.2731.00
57_A141_I1.2681.00
154_V208_S1.2661.00
280_Q311_P1.2551.00
87_Q137_G1.2481.00
162_Y220_F1.2471.00
176_T190_L1.2461.00
177_G188_N1.2411.00
96_H201_S1.2361.00
298_I344_L1.2351.00
222_K230_E1.2311.00
122_D125_T1.2311.00
85_M245_M1.2311.00
91_I132_I1.2291.00
144_N238_F1.2281.00
47_Y170_Q1.2241.00
81_S204_A1.2081.00
144_N149_P1.2071.00
289_P294_A1.2051.00
292_P349_Q1.2041.00
157_A205_L1.2041.00
219_S229_P1.2021.00
308_D332_P1.1921.00
59_V91_I1.1861.00
114_F134_A1.1841.00
336_M341_Q1.1841.00
325_I331_I1.1791.00
61_V130_L1.1621.00
53_R142_P1.1571.00
149_P190_L1.1511.00
149_P173_I1.1491.00
192_T205_L1.1431.00
151_I176_T1.1381.00
288_S291_G1.1121.00
49_L150_H1.1081.00
331_I348_I1.1061.00
47_Y156_L1.0921.00
219_S230_E1.0851.00
95_K99_N1.0841.00
162_Y229_P1.0841.00
258_Y288_S1.0811.00
308_D321_Q1.0801.00
155_V173_I1.0781.00
284_V304_I1.0751.00
157_A216_N1.0531.00
156_L208_S1.0511.00
307_V318_T1.0511.00
50_A156_L1.0451.00
59_V82_G1.0441.00
280_Q313_I1.0411.00
205_L216_N1.0401.00
51_V156_L1.0371.00
118_L121_S1.0291.00
307_V333_V1.0261.00
286_E300_V1.0201.00
65_G76_I1.0191.00
267_A270_H1.0191.00
107_A113_V1.0181.00
46_S49_L1.0161.00
283_V301_N1.0121.00
61_V106_V0.9971.00
287_V291_G0.9931.00
80_G97_V0.9881.00
90_Y129_V0.9881.00
245_M249_I0.9871.00
124_L351_Y0.9841.00
101_A104_I0.9811.00
108_L132_I0.9781.00
246_D249_I0.9721.00
96_H199_G0.9661.00
160_N165_G0.9661.00
57_A139_P0.9411.00
125_T244_I0.9391.00
143_I212_L0.9341.00
56_P139_P0.9301.00
125_T256_R0.9231.00
86_D249_I0.9231.00
95_K123_S0.9221.00
134_A137_G0.9201.00
333_V344_L0.9201.00
260_G292_P0.9201.00
108_L112_R0.9101.00
264_R285_N0.9101.00
54_A158_I0.9101.00
50_A54_A0.9091.00
196_I216_N0.9081.00
168_I172_I0.9051.00
149_P176_T0.9041.00
47_Y51_V0.9021.00
51_V55_A0.9021.00
257_G348_I0.9001.00
312_A321_Q0.9001.00
299_Q337_R0.8941.00
162_Y230_E0.8891.00
307_V322_V0.8891.00
119_V131_K0.8841.00
307_V331_I0.8821.00
126_D201_S0.8821.00
122_D256_R0.8801.00
336_M339_D0.8791.00
243_K247_K0.8771.00
88_R131_K0.8691.00
106_V132_I0.8661.00
241_A245_M0.8641.00
127_L245_M0.8631.00
150_H153_D0.8581.00
155_V213_M0.8571.00
120_G129_V0.8551.00
91_I130_L0.8521.00
87_Q140_T0.8441.00
287_V297_G0.8431.00
309_N332_P0.8431.00
281_G303_L0.8361.00
266_I276_I0.8321.00
263_G282_I0.8301.00
146_R149_P0.8291.00
287_V300_V0.8271.00
106_V116_A0.8261.00
244_I248_L0.8241.00
64_R75_E0.8241.00
155_V208_S0.8231.00
221_D229_P0.8171.00
94_N236_I0.8161.00
89_G131_K0.8151.00
265_E314_S0.8151.00
194_A233_G0.8101.00
55_A166_Q0.8091.00
261_I282_I0.8021.00
99_N123_S0.8001.00
178_R191_Q0.7931.00
191_Q234_F0.7901.00
282_I312_A0.7861.00
60_N78_T0.7841.00
238_F242_T0.7751.00
266_I279_L0.7661.00
327_P349_Q0.7591.00
63_N79_L0.7581.00
258_Y351_Y0.7561.00
64_R105_I0.7551.00
129_V245_M0.7531.00
50_A53_R0.7531.00
58_V204_A0.7511.00
94_N126_D0.7471.00
337_R340_K0.7421.00
129_V248_L0.7401.00
85_M129_V0.7401.00
205_L235_A0.7371.00
64_R77_R0.7360.99
238_F241_A0.7310.99
53_R139_P0.7280.99
262_G288_S0.7260.99
299_Q338_D0.7260.99
180_G189_F0.7240.99
85_M249_I0.7240.99
263_G318_T0.7200.99
94_N216_N0.7200.99
68_T73_Q0.7160.99
66_L102_D0.7110.99
126_D199_G0.7080.99
288_S294_A0.7080.99
63_N78_T0.7070.99
63_N102_D0.7040.99
86_D140_T0.7040.99
49_L53_R0.7030.99
87_Q139_P0.7030.99
259_I348_I0.7020.99
85_M92_I0.7000.99
97_V201_S0.7000.99
333_V346_V0.6990.99
259_I333_V0.6970.99
84_I140_T0.6940.99
66_L73_Q0.6910.99
262_G285_N0.6890.99
322_V325_I0.6890.99
55_A109_Q0.6880.99
330_V348_I0.6880.99
247_K252_G0.6830.99
223_S229_P0.6820.99
84_I132_I0.6810.99
120_G244_I0.6800.99
43_T46_S0.6800.99
340_K345_Q0.6780.99
183_P186_R0.6780.99
264_R270_H0.6760.99
60_N160_N0.6760.99
264_R283_V0.6750.99
197_N200_N0.6730.99
160_N163_N0.6670.99
83_V92_I0.6660.99
270_H273_G0.6650.99
46_S154_V0.6650.99
98_I121_S0.6650.99
50_A141_I0.6610.99
94_N97_V0.6600.99
287_V294_A0.6590.99
104_I130_L0.6570.99
284_V344_L0.6560.99
293_A296_A0.6560.99
268_P272_Q0.6550.99
212_L238_F0.6520.99
257_G329_S0.6510.99
132_I135_T0.6490.99
198_H222_K0.6480.99
153_D207_N0.6470.99
261_I298_I0.6470.99
304_I312_A0.6450.99
174_S191_Q0.6450.99
296_A346_V0.6430.99
247_K254_V0.6430.99
156_L168_I0.6430.99
43_T154_V0.6430.99
186_R323_A0.6420.99
178_R234_F0.6400.99
337_R344_L0.6360.99
162_Y219_S0.6350.99
204_A216_N0.6340.99
63_N101_A0.6300.98
216_N235_A0.6280.98
65_G78_T0.6270.98
335_V343_T0.6210.98
295_N347_T0.6200.98
308_D331_I0.6200.98
331_I346_V0.6130.98
265_E316_L0.6120.98
94_N200_N0.6100.98
115_E133_N0.6100.98
294_A297_G0.6080.98
149_P155_V0.6080.98
188_N240_L0.6080.98
170_Q193_D0.6030.98
184_T187_Q0.6030.98
306_S341_Q0.6030.98
321_Q325_I0.6020.98
62_Y105_I0.6020.98
91_I138_L0.6020.98
94_N201_S0.6010.98
44_P48_N0.5990.98
60_N79_L0.5980.98
247_K250_R0.5980.98
258_Y263_G0.5980.98
125_T254_V0.5970.98
137_G140_T0.5970.98
96_H191_Q0.5970.98
299_Q302_D0.5970.98
291_G294_A0.5960.98
98_I104_I0.5940.98
267_A271_A0.5930.98
69_N73_Q0.5930.98
156_L170_Q0.5920.98
62_Y79_L0.5910.98
248_L254_V0.5910.98
40_T43_T0.5910.98
310_K324_E0.5890.98
308_D329_S0.5880.98
239_Q242_T0.5880.98
191_Q197_N0.5860.98
195_S229_P0.5860.98
319_M322_V0.5850.97
84_I91_I0.5840.97
317_E321_Q0.5840.97
190_L205_L0.5840.97
329_S348_I0.5820.97
91_I106_V0.5820.97
155_V205_L0.5810.97
251_D254_V0.5800.97
67_N76_I0.5780.97
312_A318_T0.5740.97
290_D295_N0.5720.97
44_P153_D0.5710.97
182_N218_L0.5700.97
321_Q324_E0.5690.97
65_G102_D0.5680.97
146_R238_F0.5670.97
220_F229_P0.5670.97
255_I348_I0.5660.97
271_A276_I0.5660.97
189_F217_T0.5660.97
207_N213_M0.5650.97
179_I189_F0.5650.97
169_T200_N0.5650.97
127_L238_F0.5650.97
162_Y232_I0.5630.97
81_S161_P0.5630.97
45_A49_L0.5620.97
219_S232_I0.5620.97
265_E282_I0.5620.97
62_Y113_V0.5620.97
129_V177_G0.5610.97
319_M323_A0.5580.97
86_D89_G0.5570.97
60_N165_G0.5570.97
155_V170_Q0.5570.97
214_G235_A0.5540.97
93_T128_A0.5540.97
200_N203_G0.5540.97
182_N189_F0.5530.96
312_A333_V0.5520.96
47_Y168_I0.5500.96
45_A48_N0.5480.96
222_K228_T0.5450.96
92_I127_L0.5440.96
270_H274_G0.5440.96
145_A242_T0.5440.96
317_E320_D0.5420.96
307_V312_A0.5420.96
53_R56_P0.5400.96
88_R140_T0.5390.96
67_N75_E0.5390.96
99_N121_S0.5390.96
174_S200_N0.5390.96
187_Q217_T0.5370.96
248_L257_G0.5370.96
56_P109_Q0.5360.96
292_P296_A0.5360.96
125_T240_L0.5360.96
114_F138_L0.5350.96
259_I318_T0.5340.96
40_T44_P0.5340.96
66_L75_E0.5320.96
158_I206_V0.5320.96
309_N334_V0.5300.96
86_D131_K0.5300.96
263_G319_M0.5290.96
286_E289_P0.5290.96
60_N166_Q0.5290.96
46_S208_S0.5280.95
128_A203_G0.5270.95
161_P200_N0.5270.95
107_A111_G0.5260.95
112_R134_A0.5250.95
299_Q342_L0.5250.95
169_T174_S0.5230.95
112_R137_G0.5230.95
244_I254_V0.5230.95
221_D228_T0.5220.95
94_N199_G0.5190.95
293_A297_G0.5180.95
164_L232_I0.5180.95
61_V82_G0.5170.95
240_L244_I0.5170.95
45_A208_S0.5160.95
318_T333_V0.5160.95
92_I238_F0.5140.95
160_N218_L0.5140.95
144_N213_M0.5140.95
97_V199_G0.5130.95
51_V158_I0.5130.95
144_N148_V0.5130.95
197_N231_G0.5120.95
294_A299_Q0.5110.95
108_L138_L0.5110.95
183_P187_Q0.5100.95
244_I252_G0.5100.95
89_G138_L0.5090.94
143_I241_A0.5080.94
198_H219_S0.5080.94
342_L345_Q0.5080.94
174_S197_N0.5070.94
167_T178_R0.5070.94
282_I315_A0.5050.94
127_L241_A0.5040.94
98_I128_A0.5040.94
69_N74_L0.5030.94
80_G201_S0.5020.94
61_V116_A0.5020.94
328_G347_T0.5020.94
161_P164_L0.5010.94
155_V192_T0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ky9A 5 0.8563 100 0.295 Contact Map
3stjA 6 0.8423 100 0.303 Contact Map
3pv2A 6 0.8169 100 0.312 Contact Map
4a8cA 5 0.8563 100 0.316 Contact Map
1te0A 6 0.8958 100 0.346 Contact Map
1lcyA 3 0.8169 100 0.354 Contact Map
4ri0A 3 0.8507 100 0.36 Contact Map
3qo6A 5 0.8789 100 0.364 Contact Map
4ic6A 4 0.8732 100 0.367 Contact Map
3numA 3 0.5352 100 0.371 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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