GREMLIN Database
DCM - DNA-cytosine methyltransferase
UniProt: P0AED9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10211
Length: 472 (370)
Sequences: 490 (331)
Seq/√Len: 17.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_F447_A4.5481.00
94_A115_E4.2031.00
221_F283_G4.2021.00
173_A209_V4.0001.00
439_V442_V3.9501.00
405_R408_A3.7071.00
91_D100_R3.4781.00
409_R419_A3.4431.00
141_I145_T3.1780.99
218_P250_Y3.0280.99
179_P203_G2.8590.98
423_I434_F2.8130.98
400_R406_E2.7660.98
412_G441_P2.7080.97
119_H429_Q2.6580.97
405_R409_R2.5970.97
78_P82_H2.5120.96
273_P313_L2.4380.95
268_G439_V2.4090.95
218_P435_G2.3980.95
250_Y435_G2.3850.94
142_R145_T2.3360.94
229_L241_I2.2720.93
98_G102_G2.1700.91
295_T299_I2.1530.91
339_H344_N2.1160.90
92_L114_S2.1050.90
280_V442_V2.0960.89
405_R419_A2.0680.89
167_E216_R2.0420.88
128_H421_F2.0150.87
426_S429_Q1.9420.85
59_A65_E1.9010.84
362_T380_W1.8670.83
49_I56_N1.8490.82
115_E121_V1.8310.82
125_K138_N1.8190.81
103_F172_L1.8110.81
331_Y335_Y1.8050.81
273_P451_E1.7930.80
174_G419_A1.7830.80
123_T433_Q1.7790.80
320_A403_T1.7520.79
125_K265_I1.7350.78
101_R105_S1.7350.78
337_K340_Q1.7330.78
63_L66_K1.7270.78
413_F437_S1.7230.77
49_I54_L1.7210.77
51_K55_A1.6980.76
178_Q405_R1.6730.75
92_L212_I1.6640.75
311_A403_T1.6590.75
184_G206_F1.6580.75
73_T217_R1.6380.74
136_H312_Q1.6330.73
102_G106_I1.6320.73
316_P409_R1.6320.73
102_G222_V1.6300.73
50_L56_N1.6290.73
96_I433_Q1.6250.73
103_F166_P1.6200.73
98_G413_F1.6040.72
91_D413_F1.5750.71
170_V450_L1.5650.70
285_R288_L1.5630.70
177_C276_R1.5570.70
86_A234_Q1.5360.69
91_D94_A1.5280.68
120_A432_R1.5270.68
176_P400_R1.5120.67
103_F165_I1.5120.67
50_L59_A1.5110.67
177_C224_E1.5020.67
224_E276_R1.4960.67
82_H109_Q1.4950.67
67_E75_L1.4850.66
449_L452_P1.4740.65
408_A423_I1.4660.65
227_K277_E1.4620.65
274_Q411_M1.4600.65
223_L412_G1.4590.65
59_A67_E1.4580.65
347_G350_M1.4470.64
53_A56_N1.4430.64
414_E419_A1.4310.63
167_E265_I1.4230.63
233_D236_K1.4190.62
54_L58_S1.4160.62
115_E123_T1.4050.62
340_Q344_N1.4020.61
346_F350_M1.3970.61
118_K122_R1.3840.60
171_L282_V1.3810.60
347_G351_V1.3780.60
57_D61_H1.3750.60
339_H343_G1.3590.59
49_I53_A1.3520.59
178_Q433_Q1.3480.58
352_Y355_N1.3470.58
97_G176_P1.3450.58
52_R56_N1.3430.58
177_C278_R1.3310.57
267_D275_H1.3270.57
224_E250_Y1.3270.57
55_A58_S1.3230.57
201_T204_T1.3130.56
408_A433_Q1.3110.56
439_V443_F1.3100.56
121_V136_H1.2940.55
98_G178_Q1.2920.55
98_G175_F1.2870.55
58_S61_H1.2850.55
353_P358_S1.2820.54
362_T365_A1.2820.54
96_I437_S1.2790.54
308_V334_R1.2730.54
233_D237_T1.2670.53
98_G437_S1.2640.53
123_T228_N1.2630.53
211_R215_A1.2620.53
283_G408_A1.2590.53
82_H85_Y1.2510.53
224_E278_R1.2460.52
245_L412_G1.2450.52
242_M456_Q1.2410.52
97_G205_L1.2300.51
68_F73_T1.2280.51
363_L383_A1.2250.51
251_D291_K1.2240.51
221_F241_I1.2150.50
295_T298_D1.2110.50
346_F349_G1.2090.50
119_H122_R1.2010.50
98_G433_Q1.2010.50
169_D219_A1.1970.49
286_R290_L1.1930.49
114_S212_I1.1920.49
251_D286_R1.1920.49
222_V443_F1.1860.49
174_G184_G1.1800.48
367_Y375_L1.1740.48
113_T128_H1.1740.48
74_L82_H1.1650.47
201_T213_I1.1650.47
139_E144_I1.1600.47
335_Y340_Q1.1590.47
283_G454_I1.1500.46
60_W63_L1.1460.46
100_R113_T1.1440.46
220_M450_L1.1410.46
203_G206_F1.1400.46
60_W64_S1.1310.45
69_A73_T1.1210.45
174_G447_A1.1160.44
53_A60_W1.1070.44
171_L213_I1.1030.44
396_Q433_Q1.1030.44
50_L54_L1.0870.43
395_Q419_A1.0860.43
141_I144_I1.0850.43
213_I397_H1.0840.43
95_G177_C1.0800.42
231_S310_L1.0800.42
95_G276_R1.0780.42
229_L279_I1.0740.42
104_E223_L1.0690.42
98_G408_A1.0640.41
414_E454_I1.0620.41
378_R395_Q1.0490.40
185_V195_H1.0480.40
321_K342_R1.0460.40
111_V273_P1.0440.40
65_E69_A1.0390.40
79_P82_H1.0390.40
325_T342_R1.0380.40
291_K295_T1.0370.40
88_R109_Q1.0370.40
376_I380_W1.0350.40
331_Y402_L1.0330.40
174_G225_N1.0290.39
268_G274_Q1.0270.39
369_K397_H1.0260.39
280_V443_F1.0260.39
95_G224_E1.0200.39
174_G409_R1.0180.39
59_A63_L1.0140.38
382_M401_R1.0140.38
171_L450_L1.0120.38
62_R67_E1.0090.38
49_I61_H1.0070.38
66_K72_Q1.0060.38
172_L222_V1.0040.38
280_V420_K0.9920.37
288_L421_F0.9880.37
184_G203_G0.9730.36
362_T378_R0.9730.36
171_L447_A0.9710.36
120_A436_N0.9680.36
87_F108_G0.9670.36
58_S62_R0.9660.36
407_C431_Y0.9610.36
56_N62_R0.9580.35
50_L53_A0.9570.35
56_N59_A0.9560.35
209_V425_V0.9540.35
343_G364_S0.9520.35
107_G110_C0.9510.35
245_L370_D0.9480.35
203_G237_T0.9430.35
229_L240_I0.9410.34
170_V444_A0.9400.34
71_L289_N0.9390.34
308_V316_P0.9380.34
366_R395_Q0.9380.34
404_P427_D0.9360.34
58_S65_E0.9350.34
129_Y136_H0.9330.34
99_I104_E0.9250.34
244_T248_L0.9240.33
175_F223_L0.9230.33
97_G124_Y0.9230.33
109_Q130_C0.9220.33
362_T367_Y0.9160.33
118_K311_A0.9160.33
208_D211_R0.9080.33
367_Y373_E0.9070.33
268_G419_A0.9050.32
71_L81_H0.9050.32
327_V330_K0.9040.32
116_W209_V0.9000.32
117_N432_R0.8920.32
49_I57_D0.8900.32
341_A344_N0.8900.32
267_D270_H0.8880.32
425_V430_A0.8830.31
174_G226_V0.8830.31
446_V453_K0.8810.31
335_Y339_H0.8810.31
437_S443_F0.8770.31
61_H64_S0.8760.31
231_S247_E0.8740.31
316_P419_A0.8740.31
246_D251_D0.8710.31
335_Y437_S0.8690.31
360_T390_D0.8680.31
62_R84_H0.8660.30
118_K236_K0.8620.30
407_C412_G0.8590.30
233_D240_I0.8590.30
115_E363_L0.8580.30
338_K342_R0.8560.30
141_I171_L0.8540.30
396_Q408_A0.8490.30
310_L376_I0.8470.30
70_H109_Q0.8450.29
94_A394_N0.8450.29
95_G278_R0.8420.29
72_Q77_K0.8410.29
444_A448_K0.8410.29
363_L366_R0.8400.29
360_T363_L0.8360.29
91_D98_G0.8270.29
126_A422_R0.8240.28
234_Q321_K0.8230.28
225_N273_P0.8230.28
59_A62_R0.8150.28
142_R167_E0.8150.28
353_P380_W0.8120.28
49_I58_S0.8110.28
295_T316_P0.8100.28
381_D401_R0.8050.27
49_I59_A0.8020.27
51_K62_R0.7990.27
55_A59_A0.7990.27
126_A129_Y0.7960.27
242_M252_V0.7940.27
57_D60_W0.7930.27
396_Q414_E0.7890.27
321_K326_P0.7880.27
71_L78_P0.7870.27
304_P307_R0.7860.27
54_L60_W0.7850.27
282_V446_V0.7830.26
51_K54_L0.7820.26
398_R407_C0.7810.26
331_Y340_Q0.7810.26
50_L63_L0.7800.26
206_F244_T0.7770.26
280_V439_V0.7740.26
369_K374_I0.7720.26
127_N436_N0.7720.26
325_T329_W0.7670.26
59_A66_K0.7670.26
75_L217_R0.7650.26
405_R421_F0.7630.25
328_L336_A0.7590.25
125_K246_D0.7580.25
53_A57_D0.7580.25
123_T229_L0.7560.25
126_A424_P0.7480.25
171_L209_V0.7470.25
171_L220_M0.7470.25
204_T237_T0.7450.25
124_Y180_F0.7440.25
184_G202_Q0.7430.25
99_I210_V0.7420.25
52_R60_W0.7380.24
139_E455_K0.7380.24
69_A72_Q0.7380.24
390_D393_L0.7380.24
373_E410_L0.7370.24
204_T285_R0.7360.24
66_K74_L0.7360.24
58_S311_A0.7360.24
100_R223_L0.7340.24
219_A457_A0.7330.24
170_V282_V0.7310.24
184_G398_R0.7310.24
382_M390_D0.7310.24
177_C406_E0.7310.24
377_D434_F0.7300.24
232_H237_T0.7290.24
51_K56_N0.7280.24
276_R406_E0.7270.24
56_N61_H0.7260.24
74_L130_C0.7260.24
197_F431_Y0.7250.24
178_Q202_Q0.7250.24
99_I221_F0.7240.24
111_V446_V0.7240.24
51_K65_E0.7200.24
61_H66_K0.7200.24
180_F274_Q0.7200.24
179_P185_V0.7150.23
335_Y344_N0.7110.23
93_F249_G0.7110.23
268_G283_G0.7100.23
177_C226_V0.7100.23
317_M320_A0.7090.23
65_E70_H0.7070.23
94_A363_L0.7070.23
202_Q411_M0.7050.23
226_V276_R0.7040.23
225_N249_G0.7030.23
329_W333_Y0.7030.23
177_C435_G0.7020.23
55_A61_H0.7020.23
62_R65_E0.6990.23
228_N363_L0.6950.23
203_G232_H0.6950.23
71_L75_L0.6950.23
202_Q238_F0.6920.22
368_Y448_K0.6920.22
276_R435_G0.6910.22
66_K125_K0.6910.22
88_R168_H0.6890.22
65_E77_K0.6890.22
213_I402_L0.6890.22
211_R216_R0.6880.22
423_I437_S0.6850.22
75_L78_P0.6840.22
431_Y440_V0.6830.22
185_V202_Q0.6820.22
166_P211_R0.6810.22
173_A425_V0.6810.22
395_Q425_V0.6810.22
143_D147_S0.6800.22
177_C250_Y0.6790.22
168_H284_F0.6780.22
225_N250_Y0.6780.22
67_E78_P0.6760.22
243_Q420_K0.6740.22
71_L74_L0.6740.22
51_K58_S0.6720.22
49_I55_A0.6700.21
58_S66_K0.6680.21
411_M419_A0.6650.21
375_L380_W0.6640.21
121_V138_N0.6640.21
250_Y276_R0.6640.21
231_S454_I0.6630.21
212_I410_L0.6630.21
59_A68_F0.6630.21
224_E406_E0.6620.21
50_L61_H0.6620.21
98_G440_V0.6620.21
77_K82_H0.6620.21
91_D421_F0.6590.21
264_K295_T0.6580.21
175_F440_V0.6570.21
289_N293_D0.6550.21
326_P342_R0.6550.21
182_L344_N0.6550.21
54_L59_A0.6530.21
58_S74_L0.6530.21
200_D313_L0.6520.21
106_I439_V0.6520.21
226_V438_V0.6520.21
173_A283_G0.6520.21
183_A264_K0.6520.21
121_V403_T0.6470.21
396_Q437_S0.6450.20
103_F449_L0.6450.20
91_D178_Q0.6440.20
127_N278_R0.6430.20
223_L265_I0.6430.20
49_I52_R0.6420.20
171_L453_K0.6400.20
59_A73_T0.6400.20
71_L82_H0.6390.20
101_R128_H0.6390.20
357_Q360_T0.6390.20
78_P85_Y0.6380.20
115_E372_A0.6370.20
206_F241_I0.6370.20
312_Q323_I0.6360.20
411_M439_V0.6350.20
113_T175_F0.6340.20
405_R413_F0.6340.20
362_T390_D0.6310.20
222_V399_P0.6270.20
311_A316_P0.6240.20
222_V414_E0.6240.20
95_G181_S0.6230.20
207_F233_D0.6220.20
246_D263_P0.6220.20
186_S202_Q0.6210.20
303_F306_Q0.6210.20
73_T76_P0.6190.19
141_I235_G0.6180.19
223_L245_L0.6170.19
96_I424_P0.6170.19
202_Q277_E0.6140.19
265_I342_R0.6130.19
158_A161_I0.6120.19
328_L331_Y0.6120.19
96_I421_F0.6120.19
271_F437_S0.6120.19
339_H342_R0.6100.19
434_F439_V0.6100.19
224_E435_G0.6090.19
204_T207_F0.6080.19
364_S378_R0.6070.19
53_A61_H0.6070.19
94_A237_T0.6060.19
51_K57_D0.6040.19
196_G229_L0.6020.19
200_D413_F0.6010.19
380_W391_D0.6010.19
67_E71_L0.5960.19
67_E70_H0.5940.19
422_R449_L0.5940.19
297_R414_E0.5930.19
297_R309_T0.5920.18
222_V268_G0.5910.18
334_R351_V0.5910.18
50_L57_D0.5890.18
402_L407_C0.5890.18
275_H373_E0.5880.18
252_V279_I0.5870.18
164_H167_E0.5850.18
203_G238_F0.5850.18
391_D395_Q0.5820.18
331_Y350_M0.5810.18
96_I430_A0.5790.18
396_Q405_R0.5780.18
239_R376_I0.5780.18
327_V336_A0.5770.18
335_Y341_A0.5760.18
179_P184_G0.5760.18
89_F108_G0.5760.18
105_S444_A0.5750.18
335_Y338_K0.5710.18
158_A220_M0.5700.18
113_T131_D0.5690.18
361_R365_A0.5680.18
64_S67_E0.5670.18
405_R423_I0.5660.18
407_C434_F0.5660.18
194_A231_S0.5660.18
163_Q166_P0.5660.18
366_R378_R0.5650.18
400_R409_R0.5620.17
367_Y442_V0.5610.17
361_R403_T0.5610.17
50_L58_S0.5600.17
371_G407_C0.5580.17
427_D430_A0.5580.17
448_K458_V0.5550.17
360_T391_D0.5540.17
233_D285_R0.5530.17
103_F164_H0.5520.17
219_A288_L0.5520.17
321_K343_G0.5500.17
53_A63_L0.5480.17
59_A311_A0.5460.17
97_G295_T0.5450.17
51_K75_L0.5440.17
173_A419_A0.5440.17
143_D146_L0.5440.17
411_M423_I0.5430.17
370_D434_F0.5420.17
311_A337_K0.5420.17
360_T379_G0.5420.17
365_A373_E0.5410.17
268_G282_V0.5400.17
382_M393_L0.5390.17
360_T365_A0.5370.17
290_L432_R0.5370.17
244_T403_T0.5370.17
336_A339_H0.5360.17
174_G222_V0.5360.17
422_R444_A0.5330.16
103_F451_E0.5320.16
108_G170_V0.5310.16
438_V442_V0.5280.16
309_T312_Q0.5270.16
98_G423_I0.5270.16
395_Q405_R0.5250.16
174_G205_L0.5240.16
363_L371_G0.5220.16
273_P338_K0.5220.16
366_R370_D0.5210.16
97_G400_R0.5200.16
173_A226_V0.5190.16
194_A200_D0.5180.16
405_R437_S0.5180.16
89_F100_R0.5170.16
53_A59_A0.5160.16
331_Y334_R0.5150.16
238_F362_T0.5150.16
266_I287_D0.5150.16
145_T287_D0.5150.16
408_A437_S0.5140.16
52_R61_H0.5140.16
184_G208_D0.5130.16
395_Q447_A0.5110.16
377_D381_D0.5110.16
217_R285_R0.5100.16
61_H65_E0.5100.16
272_L442_V0.5100.16
81_H84_H0.5100.16
298_D451_E0.5090.16
67_E73_T0.5090.16
401_R407_C0.5060.16
195_H450_L0.5060.16
147_S157_A0.5030.15
99_I222_V0.5020.15
177_C181_S0.5020.15
92_L428_T0.5020.15
331_Y344_N0.5020.15
219_A458_V0.5020.15
141_I431_Y0.5000.15
265_I303_F0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3swrA 1 0.8602 100 0.307 Contact Map
3me5A 1 0.8602 100 0.313 Contact Map
4ft4B 1 0.8644 100 0.333 Contact Map
4wxxA 1 0.8665 100 0.336 Contact Map
3g7uA 1 0.6547 100 0.381 Contact Map
4dkjA 1 0.6716 100 0.397 Contact Map
2c7pA 1 0.6886 100 0.41 Contact Map
3ubtY 2 0.6674 100 0.42 Contact Map
3qv2A 1 0.6356 100 0.427 Contact Map
4h0nA 1 0.6737 100 0.43 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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