GREMLIN Database
DAPE - Succinyl-diaminopimelate desuccinylase
UniProt: P0AED7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10208
Length: 375 (344)
Sequences: 29424 (20645)
Seq/√Len: 1113.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_W126_A3.3831.00
186_T249_E3.1521.00
186_T251_F2.9681.00
30_I34_Q2.9121.00
11_Q28_L2.8881.00
91_M353_C2.7431.00
30_I42_R2.6361.00
206_R280_L2.5351.00
184_N251_F2.5011.00
192_G200_A2.4811.00
113_R367_Q2.4571.00
187_I210_F2.4431.00
60_T124_R2.4431.00
268_K272_L2.4291.00
272_L276_E2.3731.00
188_H281_R2.3501.00
36_I112_E2.3431.00
188_H249_E2.3341.00
28_L32_R2.2631.00
237_Q251_F2.2581.00
32_R35_A2.2581.00
60_T126_A2.2531.00
186_T283_T2.2421.00
54_W124_R2.2261.00
33_L53_A2.1981.00
184_N253_Q2.1971.00
207_A236_I2.1751.00
188_H283_T2.1671.00
310_H368_R2.1501.00
207_A250_L2.1471.00
113_R117_Q2.0931.00
184_N285_D2.0601.00
235_N253_Q2.0601.00
207_A252_V2.0551.00
269_A273_A2.0321.00
209_P212_N1.9731.00
305_V309_E1.9451.00
15_R28_L1.9431.00
208_A211_L1.8651.00
311_Y368_R1.8581.00
80_N88_R1.8481.00
186_T285_D1.8451.00
32_R36_I1.7801.00
142_V146_E1.7761.00
201_D206_R1.7671.00
81_P84_E1.7571.00
31_E35_A1.7201.00
304_V369_I1.7081.00
28_L31_E1.7051.00
79_I351_N1.6851.00
8_L32_R1.6801.00
208_A212_N1.6781.00
210_F275_L1.6781.00
10_Q14_R1.6631.00
24_G27_A1.6581.00
190_V201_D1.6581.00
27_A31_E1.6511.00
38_F55_R1.6411.00
205_H215_V1.6411.00
270_Q273_A1.6301.00
30_I51_F1.6081.00
143_K146_E1.5921.00
191_Q248_G1.5791.00
112_E116_A1.5781.00
203_P250_L1.5641.00
11_Q24_G1.5451.00
5_V363_A1.5411.00
265_E269_A1.5341.00
263_T266_M1.5311.00
368_R371_E1.5261.00
238_A250_L1.5131.00
302_D305_V1.5061.00
26_Q67_T1.5051.00
213_E274_L1.5031.00
11_Q15_R1.4991.00
27_A42_R1.4941.00
29_L67_T1.4901.00
11_Q14_R1.4851.00
309_E315_K1.4621.00
62_A128_L1.4611.00
266_M270_Q1.4581.00
106_A362_L1.4491.00
143_K147_A1.4481.00
31_E34_Q1.4401.00
34_Q40_V1.4291.00
7_E11_Q1.4281.00
187_I207_A1.4101.00
30_I40_V1.4081.00
62_A155_L1.3951.00
268_K286_W1.3931.00
34_Q42_R1.3811.00
32_R112_E1.3621.00
14_R87_I1.3581.00
361_L364_R1.3471.00
5_V109_V1.3391.00
229_T267_I1.3371.00
305_V318_L1.3351.00
63_F107_M1.3221.00
55_R115_V1.3141.00
87_I356_A1.3131.00
213_E277_K1.3101.00
181_L264_D1.2981.00
27_A30_I1.2951.00
197_P200_A1.2881.00
269_A272_L1.2831.00
102_G359_L1.2821.00
185_L252_V1.2641.00
90_G357_A1.2641.00
183_C254_F1.2621.00
80_N84_E1.2571.00
209_P278_H1.2561.00
184_N287_W1.2541.00
115_V118_H1.2461.00
308_V365_M1.2441.00
7_E10_Q1.2421.00
8_L109_V1.2341.00
204_V238_A1.2311.00
102_G354_V1.2301.00
360_Q364_R1.2291.00
6_I10_Q1.2291.00
65_G100_M1.2241.00
23_A49_Q1.2211.00
63_F370_M1.2171.00
19_S135_A1.2161.00
357_A361_L1.2101.00
117_Q367_Q1.2071.00
273_A277_K1.2001.00
227_P260_T1.2001.00
307_A368_R1.1961.00
303_A307_A1.1951.00
331_A337_V1.1921.00
17_S25_C1.1901.00
204_V236_I1.1811.00
187_I206_R1.1791.00
41_E54_W1.1791.00
272_L284_V1.1751.00
311_Y364_R1.1731.00
221_Q270_Q1.1651.00
23_A27_A1.1641.00
8_L28_L1.1531.00
12_L25_C1.1411.00
217_I270_Q1.1371.00
91_M355_N1.1331.00
355_N358_D1.1331.00
307_A311_Y1.1311.00
117_Q371_E1.1261.00
10_Q87_I1.1251.00
78_W81_P1.1241.00
275_L282_Y1.1231.00
201_D280_L1.1221.00
13_I94_G1.1201.00
111_A127_F1.1201.00
260_T263_T1.1191.00
80_N86_T1.1191.00
298_G302_D1.1191.00
212_N216_A1.1181.00
24_G28_L1.1181.00
59_E123_G1.1151.00
15_R24_G1.1111.00
266_M269_A1.1061.00
59_E156_D1.0911.00
213_E216_A1.0851.00
334_G337_V1.0691.00
302_D306_N1.0681.00
11_Q32_R1.0571.00
273_A276_E1.0521.00
211_L252_V1.0431.00
142_V329_F1.0421.00
367_Q371_E1.0381.00
29_L104_L1.0361.00
13_I97_A1.0361.00
173_V302_D1.0281.00
270_Q274_L1.0281.00
306_N309_E1.0151.00
12_L28_L1.0151.00
14_R84_E1.0141.00
5_V105_A1.0061.00
10_Q356_A0.9961.00
205_H211_L0.9951.00
243_N253_Q0.9921.00
183_C268_K0.9891.00
107_M127_F0.9881.00
33_L108_V0.9871.00
268_K288_L0.9861.00
20_P132_D0.9831.00
73_G89_D0.9771.00
80_N83_F0.9771.00
26_Q51_F0.9751.00
209_P216_A0.9691.00
307_A310_H0.9691.00
304_V338_V0.9681.00
274_L277_K0.9651.00
109_V112_E0.9651.00
26_Q30_I0.9631.00
55_R121_H0.9611.00
67_T129_I0.9591.00
233_I254_F0.9521.00
38_F53_A0.9511.00
339_E342_P0.9501.00
297_R300_L0.9501.00
87_I90_G0.9471.00
50_N131_S0.9431.00
113_R364_R0.9431.00
188_H248_G0.9431.00
110_A367_Q0.9431.00
303_A306_N0.9401.00
36_I115_V0.9401.00
155_L158_C0.9381.00
358_D361_L0.9351.00
78_W82_P0.9351.00
161_G366_Y0.9341.00
179_G258_F0.9331.00
113_R363_A0.9311.00
209_P213_E0.9291.00
211_L233_I0.9281.00
364_R368_R0.9261.00
207_A211_L0.9221.00
65_G104_L0.9211.00
363_A367_Q0.9161.00
237_Q240_T0.9131.00
32_R108_V0.9121.00
184_N243_N0.9081.00
299_K303_A0.9081.00
55_R111_A0.9051.00
90_G355_N0.9051.00
40_V43_M0.9041.00
354_V359_L0.9031.00
241_G245_V0.9021.00
111_A115_V0.9011.00
306_N310_H0.9001.00
309_E314_I0.9001.00
67_T104_L0.8921.00
303_A369_I0.8911.00
214_L271_V0.8901.00
39_T54_W0.8901.00
40_V53_A0.8841.00
261_E265_E0.8791.00
301_V305_V0.8771.00
5_V359_L0.8771.00
110_A366_Y0.8761.00
38_F111_A0.8721.00
176_G320_T0.8691.00
60_T156_D0.8681.00
181_L268_K0.8651.00
258_F264_D0.8591.00
56_G124_R0.8551.00
185_L210_F0.8551.00
117_Q120_N0.8541.00
291_Q332_R0.8511.00
205_H208_A0.8511.00
52_W126_A0.8511.00
204_V250_L0.8501.00
26_Q42_R0.8451.00
211_L236_I0.8451.00
156_D160_V0.8451.00
196_Y199_L0.8401.00
209_P215_V0.8361.00
25_C67_T0.8341.00
212_N215_V0.8311.00
299_K302_D0.8241.00
156_D162_E0.8241.00
236_I250_L0.8221.00
339_E343_V0.8181.00
185_L275_L0.8171.00
86_T89_D0.8171.00
44_D49_Q0.8161.00
265_E268_K0.8161.00
88_R91_M0.8151.00
63_F110_A0.8151.00
182_T255_N0.8151.00
11_Q31_E0.8131.00
264_D268_K0.8061.00
79_I88_R0.8021.00
8_L112_E0.8001.00
20_P135_A0.8001.00
113_R116_A0.7941.00
357_A360_Q0.7941.00
340_L365_M0.7901.00
41_E148_L0.7841.00
6_I87_I0.7841.00
205_H216_A0.7831.00
337_V341_G0.7831.00
301_V338_V0.7821.00
106_A363_A0.7761.00
38_F115_V0.7731.00
327_G337_V0.7731.00
160_V163_P0.7731.00
329_F332_R0.7721.00
88_R93_F0.7701.00
256_F267_I0.7691.00
110_A363_A0.7681.00
304_V365_M0.7661.00
233_I252_V0.7641.00
9_T92_L0.7631.00
167_E317_Q0.7611.00
359_L363_A0.7601.00
214_L231_M0.7601.00
41_E52_W0.7601.00
158_C335_A0.7591.00
335_A338_V0.7561.00
8_L105_A0.7501.00
60_T123_G0.7501.00
106_A366_Y0.7431.00
190_V349_K0.7411.00
201_D279_Q0.7411.00
17_S101_K0.7391.00
8_L11_Q0.7381.00
175_N318_L0.7371.00
36_I108_V0.7351.00
141_T145_V0.7341.00
40_V51_F0.7331.00
72_P83_F0.7321.00
153_E160_V0.7281.00
61_L370_M0.7271.00
231_M256_F0.7261.00
109_V363_A0.7251.00
182_T243_N0.7241.00
262_L266_M0.7231.00
62_A158_C0.7231.00
29_L129_I0.7221.00
57_Q122_T0.7191.00
183_C271_V0.7181.00
84_E95_R0.7181.00
187_I252_V0.7181.00
173_V298_G0.7131.00
311_Y314_I0.7131.00
218_E231_M0.7111.00
364_R367_Q0.7101.00
308_V311_Y0.7091.00
153_E162_E0.7091.00
163_P347_I0.7081.00
185_L284_V0.7081.00
265_E288_L0.7051.00
157_Y300_L0.7051.00
12_L104_L0.6971.00
179_G292_P0.6971.00
183_C286_W0.6961.00
346_T349_K0.6921.00
128_L144_V0.6911.00
61_L157_Y0.6911.00
153_E156_D0.6911.00
173_V305_V0.6901.00
132_D135_A0.6891.00
104_L129_I0.6891.00
286_W289_S0.6881.00
192_G246_I0.6871.00
237_Q253_Q0.6861.00
336_Q342_P0.6861.00
79_I83_F0.6861.00
69_V83_F0.6861.00
18_L71_P0.6801.00
29_L51_F0.6791.00
177_R325_S0.6771.00
79_I84_E0.6761.00
29_L108_V0.6751.00
205_H209_P0.6751.00
100_M103_S0.6721.00
78_W351_N0.6711.00
107_M161_G0.6701.00
307_A369_I0.6701.00
10_Q92_L0.6661.00
343_V354_V0.6661.00
8_L108_V0.6641.00
57_Q124_R0.6591.00
18_L21_D0.6591.00
342_P362_L0.6591.00
112_E115_V0.6591.00
50_N55_R0.6571.00
346_T353_C0.6571.00
26_Q49_Q0.6561.00
35_A112_E0.6561.00
235_N251_F0.6521.00
51_F129_I0.6521.00
290_G293_F0.6521.00
272_L286_W0.6511.00
24_G31_E0.6501.00
210_F252_V0.6491.00
93_F353_C0.6471.00
203_P247_P0.6461.00
33_L38_F0.6461.00
8_L12_L0.6451.00
10_Q13_I0.6421.00
6_I360_Q0.6401.00
261_E291_Q0.6391.00
12_L105_A0.6381.00
202_N247_P0.6381.00
298_G336_Q0.6361.00
158_C162_E0.6361.00
183_C284_V0.6351.00
18_L91_M0.6311.00
337_V342_P0.6301.00
163_P166_I0.6291.00
84_E87_I0.6291.00
307_A365_M0.6281.00
65_G107_M0.6271.00
55_R127_F0.6271.00
106_A110_A0.6261.00
158_C161_G0.6241.00
174_K319_L0.6241.00
114_F119_P0.6241.00
206_R278_H0.6231.00
220_D270_Q0.6221.00
261_E332_R0.6211.00
187_I203_P0.6201.00
335_A341_G0.6201.00
239_G249_E0.6191.00
365_M369_I0.6181.00
38_F127_F0.6171.00
43_M147_A0.6171.00
126_A155_L0.6161.00
41_E44_D0.6161.00
92_L356_A0.6151.00
275_L284_V0.6151.00
64_A128_L0.6131.00
237_Q249_E0.6111.00
346_T351_N0.6081.00
210_F274_L0.6071.00
37_G40_V0.6071.00
344_N358_D0.6061.00
194_V232_Q0.6061.00
144_V148_L0.6051.00
292_P295_T0.6021.00
338_V341_G0.5981.00
9_T105_A0.5971.00
157_Y160_V0.5971.00
300_L303_A0.5951.00
356_A360_Q0.5941.00
206_R209_P0.5931.00
325_S339_E0.5901.00
109_V113_R0.5901.00
18_L83_F0.5881.00
87_I92_L0.5881.00
177_R341_G0.5881.00
205_H212_N0.5871.00
336_Q341_G0.5851.00
134_E348_H0.5851.00
10_Q84_E0.5851.00
254_F271_V0.5841.00
72_P94_G0.5821.00
347_I352_E0.5821.00
264_D291_Q0.5821.00
62_A153_E0.5821.00
221_Q266_M0.5821.00
283_T286_W0.5801.00
360_Q363_A0.5781.00
162_E165_S0.5771.00
6_I356_A0.5751.00
81_P86_T0.5711.00
15_R88_R0.5711.00
269_A276_E0.5711.00
241_G244_N0.5701.00
244_N257_R0.5691.00
160_V327_G0.5691.00
258_F267_I0.5661.00
142_V145_V0.5631.00
15_R25_C0.5631.00
37_G115_V0.5601.00
69_V95_R0.5601.00
297_R302_D0.5591.00
6_I92_L0.5581.00
45_F143_K0.5581.00
203_P246_I0.5561.00
42_R49_Q0.5541.00
337_V340_L0.5531.00
185_L254_F0.5511.00
158_C163_P0.5511.00
45_F147_A0.5491.00
145_V148_L0.5461.00
217_I220_D0.5441.00
178_R230_S0.5441.00
236_I252_V0.5431.00
52_W128_L0.5421.00
60_T154_R0.5411.00
196_Y321_T0.5401.00
33_L111_A0.5401.00
305_V317_Q0.5391.00
8_L36_I0.5381.00
336_Q339_E0.5381.00
208_A215_V0.5371.00
182_T253_Q0.5351.00
19_S136_S0.5321.00
341_G344_N0.5321.00
16_P21_D0.5301.00
290_G295_T0.5291.00
162_E166_I0.5291.00
34_Q39_T0.5281.00
54_W60_T0.5271.00
78_W83_F0.5261.00
214_L233_I0.5251.00
128_L330_I0.5251.00
227_P263_T0.5251.00
5_V9_T0.5231.00
185_L271_V0.5221.00
43_M52_W0.5211.00
119_P371_E0.5201.00
311_Y365_M0.5191.00
194_V234_A0.5191.00
194_V255_N0.5191.00
345_A353_C0.5181.00
50_N144_V0.5181.00
215_V278_H0.5161.00
159_L163_P0.5161.00
210_F214_L0.5161.00
49_Q55_R0.5121.00
264_D289_S0.5121.00
20_P143_K0.5091.00
94_G97_A0.5081.00
211_L254_F0.5071.00
175_N294_L0.5061.00
92_L97_A0.5041.00
180_S255_N0.5021.00
9_T356_A0.5021.00
338_V342_P0.5011.00
79_I82_P0.5011.00
105_A109_V0.5011.00
256_F262_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iszA 2 0.9867 100 0.18 Contact Map
4pqaA 2 0.9947 100 0.181 Contact Map
3pfoA 2 0.9707 100 0.207 Contact Map
4mmoA 2 0.9893 100 0.24 Contact Map
1cg2A 4 0.9493 100 0.263 Contact Map
2pokA 2 0.9947 100 0.264 Contact Map
3gb0A 2 0.9333 100 0.264 Contact Map
2f7vA 2 0.912 100 0.266 Contact Map
3rzaA 2 0.9307 100 0.267 Contact Map
4g1pA 2 0.9947 100 0.27 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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